Researcher Profile
Researcher Profile
Mark Hedglin, PhD
Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Associate Research Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- DNA
- Proliferating Cell Nuclear Antigen
- Proteins
- 3-methyladenine-DNA glycosylase
- Replication Protein A
- DNA-Directed DNA Polymerase
- DNA Damage
- Single-Stranded DNA
- Holoenzymes
- DNA Repair
- Facilitated Diffusion
- human PCNA protein
Recent Publications
2020
Li, M, Sengupta, B, Benkovic, SJ, Lee, TH & Hedglin, M 2020, 'PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments', Biochemistry, vol. 59, no. 49, pp. 4694-4702. https://doi.org/10.1021/acs.biochem.0c00849
Li, M, Larsen, L & Hedglin, M 2020, 'Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA', Biochemistry, vol. 59, no. 4, pp. 407-416. https://doi.org/10.1021/acs.biochem.9b00938
Shin, Y, Hedglin, M & Murakami, KS 2020, 'Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase', Nucleic acids research, vol. 48, no. 4, pp. 2144-2155. https://doi.org/10.1093/nar/gkz1221
Gaubitz, C, Liu, X, Magrino, J, Stone, NP, Landeck, J, Hedglin, M & Kelch, BA 2020, 'Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23571-23580. https://doi.org/10.1073/pnas.2007437117
2019
Hedglin, M, Aitha, M, Pedley, A & Benkovic, SJ 2019, 'Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen', Journal of Biological Chemistry, vol. 294, no. 13, pp. 5157-5168. https://doi.org/10.1074/jbc.RA118.005297