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Mark Hedglin, PhD

Mark Hedglin, PhD

Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA
  • Proliferating Cell Nuclear Antigen
  • Proteins
  • 3-methyladenine-DNA glycosylase
  • DNA-Directed DNA Polymerase
  • DNA Damage
  • Replication Protein A
  • Holoenzymes
  • Single-Stranded DNA
  • DNA Repair
  • Facilitated Diffusion
  • human PCNA protein

Recent Publications


Muoio, D, Laspata, N, Dannenberg, RL, Curry, C, Darkoa-Larbi, S, Hedglin, M, Uttam, S & Fouquerel, E 2024, 'PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress', Nature communications, vol. 15, no. 1, 2857.
Pytko, KG, Dannenberg, RL, Eckert, KA & Hedglin, M 2024, 'Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels', Biochemistry, vol. 63, no. 8, pp. 969-983.


Hoitsma, NM, Norris, J, Khoang, TH, Kaushik, V, Chadda, R, Antony, E, Hedglin, M & Freudenthal, BD 2023, 'Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics', Nucleic acids research, vol. 51, no. 13, pp. 6738-6753.
Stroik, S, Carvajal-Garcia, J, Gupta, D, Edwards, A, Luthman, A, Wyatt, DW, Dannenberg, RL, Feng, W, Kunkel, TA, Gupta, GP, Hedglin, M, Wood, R, Doublié, S, Rothenberg, E & Ramsden, DA 2023, 'Stepwise requirements for polymerases δ and θ in theta-mediated end joining', Nature, vol. 623, no. 7988, pp. 836-841.


Dannenberg, RL, Cardina, JA, Pytko, KG & Hedglin, M 2022, 'Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities', Nucleic acids research, vol. 50, no. 17, pp. 9893-9908.


Li, M, Sengupta, B, Benkovic, SJ, Lee, TH & Hedglin, M 2020, 'PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments', Biochemistry, vol. 59, no. 49, pp. 4694-4702.
Li, M, Larsen, L & Hedglin, M 2020, 'Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA', Biochemistry, vol. 59, no. 4, pp. 407-416.
Shin, Y, Hedglin, M & Murakami, KS 2020, 'Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase', Nucleic acids research, vol. 48, no. 4, pp. 2144-2155.
Gaubitz, C, Liu, X, Magrino, J, Stone, NP, Landeck, J, Hedglin, M & Kelch, BA 2020, 'Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23571-23580.