Mark Hedglin, PhD - Penn State Cancer Institute
Researcher Profile
Mark Hedglin, PhD
Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Associate Research Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Norris, JL & Hedglin, M 2024, Direct, ensemble FRET approaches to monitor transient state kinetics of human DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis. in BF Eichman (ed.), Chemical and Genomic Methods in Nucleic Acid Biology. Methods in Enzymology, vol. 705, Academic Press Inc., pp. 271-309. https://doi.org/10.1016/bs.mie.2024.08.002
Muoio, D, Laspata, N, Dannenberg, RL, Curry, C, Darkoa-Larbi, S, Hedglin, M, Uttam, S & Fouquerel, E 2024, 'PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress', Nature communications, vol. 15, no. 1, 2857. https://doi.org/10.1038/s41467-024-47222-7
Pytko, KG, Dannenberg, RL, Eckert, KA & Hedglin, M 2024, 'Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels', Biochemistry, vol. 63, no. 8, pp. 969-983. https://doi.org/10.1021/acs.biochem.4c00006
Norris, JL, Rogers, LO, Pytko, KG, Dannenberg, RL, Perreault, S, Kaushik, V, Kuppa, S, Antony, E & Hedglin, M 2024, 'Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis', Nucleic acids research, vol. 52, no. 13, pp. 7650-7664. https://doi.org/10.1093/nar/gkae475
2023
Hoitsma, NM, Norris, J, Khoang, TH, Kaushik, V, Chadda, R, Antony, E, Hedglin, M & Freudenthal, BD 2023, 'Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics', Nucleic acids research, vol. 51, no. 13, pp. 6738-6753. https://doi.org/10.1093/nar/gkad481
Stroik, S, Carvajal-Garcia, J, Gupta, D, Edwards, A, Luthman, A, Wyatt, DW, Dannenberg, RL, Feng, W, Kunkel, TA, Gupta, GP, Hedglin, M, Wood, R, Doublié, S, Rothenberg, E & Ramsden, DA 2023, 'Stepwise requirements for polymerases δ and θ in theta-mediated end joining', Nature, vol. 623, no. 7988, pp. 836-841. https://doi.org/10.1038/s41586-023-06729-7
2022
Dannenberg, RL, Cardina, JA, Pytko, KG & Hedglin, M 2022, 'Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities', Nucleic acids research, vol. 50, no. 17, pp. 9893-9908. https://doi.org/10.1093/nar/gkac745