Mark Hedglin, PhD - Penn State Cancer Institute
Researcher Profile
Mark Hedglin, PhD
Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Associate Research Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- DNA
- Proliferating Cell Nuclear Antigen
- Proteins
- 3-methyladenine-DNA glycosylase
- DNA-Directed DNA Polymerase
- DNA Damage
- Replication Protein A
- Holoenzymes
- Single-Stranded DNA
- DNA Repair
- Facilitated Diffusion
- human PCNA protein
Recent Publications
2023
Hoitsma, NM, Norris, J, Khoang, TH, Kaushik, V, Chadda, R, Antony, E, Hedglin, M & Freudenthal, BD 2023, 'Mechanistic insight into AP-endonuclease 1 cleavage of abasic sites at stalled replication fork mimics', Nucleic acids research, vol. 51, no. 13, pp. 6738-6753. https://doi.org/10.1093/nar/gkad481
Stroik, S, Carvajal-Garcia, J, Gupta, D, Edwards, A, Luthman, A, Wyatt, DW, Dannenberg, RL, Feng, W, Kunkel, TA, Gupta, GP, Hedglin, M, Wood, R, Doublié, S, Rothenberg, E & Ramsden, DA 2023, 'Stepwise requirements for polymerases δ and θ in theta-mediated end joining', Nature, vol. 623, no. 7988, pp. 836-841. https://doi.org/10.1038/s41586-023-06729-7
2022
Dannenberg, RL, Cardina, JA, Pytko, KG & Hedglin, M 2022, 'Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities', Nucleic acids research, vol. 50, no. 17, pp. 9893-9908. https://doi.org/10.1093/nar/gkac745
2020
Li, M, Sengupta, B, Benkovic, SJ, Lee, TH & Hedglin, M 2020, 'PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments', Biochemistry, vol. 59, no. 49, pp. 4694-4702. https://doi.org/10.1021/acs.biochem.0c00849
Li, M, Larsen, L & Hedglin, M 2020, 'Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA', Biochemistry, vol. 59, no. 4, pp. 407-416. https://doi.org/10.1021/acs.biochem.9b00938
Shin, Y, Hedglin, M & Murakami, KS 2020, 'Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase', Nucleic acids research, vol. 48, no. 4, pp. 2144-2155. https://doi.org/10.1093/nar/gkz1221
Gaubitz, C, Liu, X, Magrino, J, Stone, NP, Landeck, J, Hedglin, M & Kelch, BA 2020, 'Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23571-23580. https://doi.org/10.1073/pnas.2007437117