Researcher Profile

Researcher Profile

Mark Hedglin, PhD

Mark Hedglin, PhD

Associate Research Professor, Chemistry
Associate Research Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA
  • Proliferating Cell Nuclear Antigen
  • Proteins
  • 3-methyladenine-DNA glycosylase
  • Replication Protein A
  • DNA-Directed DNA Polymerase
  • DNA Damage
  • Single-Stranded DNA
  • Holoenzymes
  • DNA Repair
  • Facilitated Diffusion
  • human PCNA protein

Recent Publications


Li, M, Sengupta, B, Benkovic, SJ, Lee, TH & Hedglin, M 2020, 'PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments', Biochemistry, vol. 59, no. 49, pp. 4694-4702.
Li, M, Larsen, L & Hedglin, M 2020, 'Rad6/Rad18 Competes with DNA Polymerases ν and δfor PCNA Encircling DNA', Biochemistry, vol. 59, no. 4, pp. 407-416.
Shin, Y, Hedglin, M & Murakami, KS 2020, 'Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase', Nucleic acids research, vol. 48, no. 4, pp. 2144-2155.
Gaubitz, C, Liu, X, Magrino, J, Stone, NP, Landeck, J, Hedglin, M & Kelch, BA 2020, 'Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23571-23580.


Hedglin, M, Aitha, M, Pedley, A & Benkovic, S 2019, 'Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen', Journal of Biological Chemistry, vol. 294, no. 13, pp. 5157-5168.


Hedglin, M & Benkovic, SJ 2017, 'Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle', Chemical Reviews, vol. 117, no. 12, pp. 7857-7877.
Hedglin, M, Aitha, M & Benkovic, SJ 2017, 'Monitoring the Retention of Human Proliferating Cell Nuclear Antigen at Primer/Template Junctions by Proteins That Bind Single-Stranded DNA', Biochemistry, vol. 56, no. 27, pp. 3415-3421.
Hedglin, M & Benkovic, SJ 2017, 'Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA', Biochemistry, vol. 56, no. 13, pp. 1824-1835.

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