Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Magnetic Resonance Spectroscopy
  • Phosphorylation
  • Transcription Factors
  • RNA Polymerase III
  • Thermodynamics

Recent Publications


Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693.


Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17.
Pabit, SA, Chen, YL, Usher, ET, Cook, EC, Pollack, L & Showalter, SA 2020, 'Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures', Biophysical journal, vol. 119, no. 12, pp. 2524-2536.
Usher, ET & Showalter, SA 2020, 'Mapping invisible epitopes by NMR spectroscopy', Journal of Biological Chemistry, vol. 295, no. 51, pp. 17411-17412.
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335.
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073.


Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116.
Cook, EC, Featherston, ER, Showalter, SA & Cotruvo, JA 2019, 'Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin', Biochemistry, vol. 58, no. 2, pp. 120-125.


Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297.
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Intrinsically Disordered Proteins. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100.


Gibbs, EB, Cook, EC & Showalter, SA 2017, 'Application of NMR to studies of intrinsically disordered proteins', Archives of Biochemistry and Biophysics, vol. 628, pp. 57-70.
Kranick, JC, Chadalavada, DM, Sahu, D & Showalter, SA 2017, 'Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function', PloS one, vol. 12, no. 8, e0182445.
Gibbs, EB, Lu, F, Portz, B, Fisher, MJ, Medellin, BP, Laremore, TN, Zhang, YJ, Gilmour, DS & Showalter, SA 2017, 'Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15233.
Portz, B, Lu, F, Gibbs, EB, Mayfield, JE, Rachel Mehaffey, M, Zhang, YJ, Brodbelt, JS, Showalter, SA & Gilmour, DS 2017, 'Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15231.
Gibbs, EB, Laremore, TN, Usher, GA, Portz, B, Cook, EC & Showalter, SA 2017, 'Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain', Biophysical journal, vol. 113, no. 9, pp. 1909-1911.

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