Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
sas76@psu.edu

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Magnetic Resonance Spectroscopy
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Phosphorylation
  • Transcription Factors
  • RNA Polymerase III
  • Thermodynamics

Recent Publications

2021

Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693. https://doi.org/10.1016/j.jbc.2021.100693
Usher, ET, Namitz, KEW, Cosgrove, MS & Showalter, SA 2021, 'Probing multiple enzymatic methylation events in real time with NMR spectroscopy', Biophysical journal, vol. 120, no. 21, pp. 4710-4721. https://doi.org/10.1016/j.bpj.2021.09.034
Prieto, VA, Namitz, KEW & Showalter, SA 2021, 'Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity', Journal of Physical Chemistry B, vol. 125, no. 39, pp. 10917-10927. https://doi.org/10.1021/acs.jpcb.1c05131

2020

Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17. https://doi.org/10.7554/eLife.58147
Pabit, SA, Chen, YL, Usher, ET, Cook, EC, Pollack, L & Showalter, SA 2020, 'Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures', Biophysical journal, vol. 119, no. 12, pp. 2524-2536. https://doi.org/10.1016/j.bpj.2020.10.038
Usher, ET & Showalter, SA 2020, 'Mapping invisible epitopes by NMR spectroscopy', Journal of Biological Chemistry, vol. 295, no. 51, pp. 17411-17412. https://doi.org/10.1074/jbc.H120.016607
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335. https://doi.org/10.1016/j.bpj.2020.04.003
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745

2019

Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116. https://doi.org/10.1021/acs.jpcb.8b10051
Cook, EC, Featherston, ER, Showalter, SA & Cotruvo, JA 2019, 'Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin', Biochemistry, vol. 58, no. 2, pp. 120-125. https://doi.org/10.1021/acs.biochem.8b01019

2018

Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297. https://doi.org/10.1016/bs.mie.2018.04.020
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Intrinsically Disordered Proteins. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100. https://doi.org/10.1016/bs.mie.2018.08.025

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)