Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
sas76@psu.edu

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Magnetic Resonance Spectroscopy
  • Phosphorylation
  • Transcription Factors
  • RNA Polymerase III
  • Thermodynamics

Recent Publications

2021

Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693. https://doi.org/10.1016/j.jbc.2021.100693

2020

Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17. https://doi.org/10.7554/eLife.58147
Pabit, SA, Chen, YL, Usher, ET, Cook, EC, Pollack, L & Showalter, SA 2020, 'Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures', Biophysical journal, vol. 119, no. 12, pp. 2524-2536. https://doi.org/10.1016/j.bpj.2020.10.038
Usher, ET & Showalter, SA 2020, 'Mapping invisible epitopes by NMR spectroscopy', Journal of Biological Chemistry, vol. 295, no. 51, pp. 17411-17412. https://doi.org/10.1074/jbc.H120.016607
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335. https://doi.org/10.1016/j.bpj.2020.04.003
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745

2019

Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116. https://doi.org/10.1021/acs.jpcb.8b10051
Cook, EC, Featherston, ER, Showalter, SA & Cotruvo, JA 2019, 'Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin', Biochemistry, vol. 58, no. 2, pp. 120-125. https://doi.org/10.1021/acs.biochem.8b01019

2018

Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297. https://doi.org/10.1016/bs.mie.2018.04.020
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Intrinsically Disordered Proteins. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100. https://doi.org/10.1016/bs.mie.2018.08.025

2017

Gibbs, EB, Cook, EC & Showalter, SA 2017, 'Application of NMR to studies of intrinsically disordered proteins', Archives of Biochemistry and Biophysics, vol. 628, pp. 57-70. https://doi.org/10.1016/j.abb.2017.05.008
Kranick, JC, Chadalavada, DM, Sahu, D & Showalter, SA 2017, 'Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function', PloS one, vol. 12, no. 8, e0182445. https://doi.org/10.1371/journal.pone.0182445
Gibbs, EB, Lu, F, Portz, B, Fisher, MJ, Medellin, BP, Laremore, TN, Zhang, YJ, Gilmour, DS & Showalter, SA 2017, 'Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15233. https://doi.org/10.1038/ncomms15233
Portz, B, Lu, F, Gibbs, EB, Mayfield, JE, Rachel Mehaffey, M, Zhang, YJ, Brodbelt, JS, Showalter, SA & Gilmour, DS 2017, 'Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15231. https://doi.org/10.1038/ncomms15231
Gibbs, EB, Laremore, TN, Usher, GA, Portz, B, Cook, EC & Showalter, SA 2017, 'Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain', Biophysical journal, vol. 113, no. 9, pp. 1909-1911. https://doi.org/10.1016/j.bpj.2017.09.011

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