Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
sas76@psu.edu

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Phosphorylation
  • Transcription Factors
  • Magnetic Resonance Spectroscopy
  • RNA Polymerase III
  • Thermodynamics

Recent Publications

2019

Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116. https://doi.org/10.1021/acs.jpcb.8b10051
Cook, EC, Featherston, ER, Showalter, SA & Cotruvo, Jr., JA 2019, 'Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin', Biochemistry, vol. 58, no. 2, pp. 120-125. https://doi.org/10.1021/acs.biochem.8b01019

2018

Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297. https://doi.org/10.1016/bs.mie.2018.04.020
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Methods in Enzymology. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100. https://doi.org/10.1016/bs.mie.2018.08.025

2017

Gibbs, EB, Cook, EC & Showalter, SA 2017, 'Application of NMR to studies of intrinsically disordered proteins', Archives of Biochemistry and Biophysics, vol. 628, pp. 57-70. https://doi.org/10.1016/j.abb.2017.05.008
Kranick, JC, Chadalavada, DM, Sahu, D & Showalter, SA 2017, 'Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function', PloS one, vol. 12, no. 8, e0182445. https://doi.org/10.1371/journal.pone.0182445
Gibbs, EB, Lu, F, Portz, B, Fisher, MJ, Medellin, BP, Laremore, TN, Zhang, YJ, Gilmour, DS & Showalter, SA 2017, 'Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15233. https://doi.org/10.1038/ncomms15233
Portz, B, Lu, F, Gibbs, EB, Mayfield, JE, Rachel Mehaffey, M, Zhang, YJ, Brodbelt, JS, Showalter, SA & Gilmour, DS 2017, 'Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15231. https://doi.org/10.1038/ncomms15231
Gibbs, EB, Laremore, TN, Usher, GA, Portz, B, Cook, EC & Showalter, SA 2017, 'Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain' Biophysical journal, vol. 113, no. 9, pp. 1909-1911. https://doi.org/10.1016/j.bpj.2017.09.011

2016

Yennawar, N, Fecko, JA, Showalter, SA & Bevilacqua, PC 2016, A High-Throughput Biological Calorimetry Core: Steps to Startup, Run, and Maintain a Multiuser Facility. in Methods in Enzymology. Methods in Enzymology, vol. 567, Academic Press Inc., pp. 435-460. https://doi.org/10.1016/bs.mie.2015.07.024
Sahu, D, Bastidas, M, Lawrence, CW, Noid, WG & Showalter, SA 2016, Assessing Coupled Protein Folding and Binding Through Temperature-Dependent Isothermal Titration Calorimetry. in Methods in Enzymology. Methods in Enzymology, vol. 567, Academic Press Inc., pp. 23-45. https://doi.org/10.1016/bs.mie.2015.07.032
Acevedo, R, Evans, D, Penrod, KA & Showalter, SA 2016, 'Binding by TRBP-dsRBD2 Does Not Induce Bending of Double-Stranded RNA' Biophysical journal, vol. 110, no. 12, pp. 2610-2617. https://doi.org/10.1016/j.bpj.2016.05.012
Gibbs, EB & Showalter, SA 2016, 'Quantification of Compactness and Local Order in the Ensemble of the Intrinsically Disordered Protein FCP1', Journal of Physical Chemistry B, vol. 120, no. 34, pp. 8960-8969. https://doi.org/10.1021/acs.jpcb.6b06934

2015

Bastidas, M, Gibbs, EB, Sahu, D & Showalter, SA 2015, 'A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution', Concepts in Magnetic Resonance Part A: Bridging Education and Research, vol. 44, no. 1, pp. 54-66. https://doi.org/10.1002/cmr.a.21327
Quarles, KA, Chadalavada, D & Showalter, SA 2015, 'Deformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8' Proteins: Structure, Function and Bioinformatics, vol. 83, no. 6, pp. 1165-1179. https://doi.org/10.1002/prot.24810
Acevedo, R, Orench-Rivera, N, Quarles, KA & Showalter, SA 2015, 'Helical defects in MicroRNA influence protein binding by TAR RNA binding protein', PloS one, vol. 10, no. 1, e0116749. https://doi.org/10.1371/journal.pone.0116749
Gibbs, EB & Showalter, SA 2015, 'Quantitative biophysical characterization of intrinsically disordered proteins' Biochemistry, vol. 54, no. 6, pp. 1314-1326. https://doi.org/10.1021/bi501460a

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