Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Phosphorylation
  • Transcription Factors
  • Magnetic Resonance Spectroscopy
  • RNA Polymerase III
  • Thermodynamics

Recent Publications


Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9.
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335.
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, T, Showalter, SA, Glick, AB, Simon, J & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073.


Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116.
Cook, EC, Featherston, ER, Showalter, SA & Cotruvo, JA 2019, 'Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin', Biochemistry, vol. 58, no. 2, pp. 120-125.


Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297.
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Methods in Enzymology. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100.


Gibbs, EB, Cook, EC & Showalter, SA 2017, 'Application of NMR to studies of intrinsically disordered proteins', Archives of Biochemistry and Biophysics, vol. 628, pp. 57-70.
Kranick, JC, Chadalavada, DM, Sahu, D & Showalter, SA 2017, 'Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function', PloS one, vol. 12, no. 8, e0182445.
Gibbs, EB, Lu, F, Portz, B, Fisher, MJ, Medellin, BP, Laremore, TN, Zhang, YJ, Gilmour, DS & Showalter, SA 2017, 'Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15233.
Portz, B, Lu, F, Gibbs, EB, Mayfield, JE, Rachel Mehaffey, M, Zhang, YJ, Brodbelt, JS, Showalter, SA & Gilmour, DS 2017, 'Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain', Nature communications, vol. 8, 15231.
Gibbs, EB, Laremore, TN, Usher, GA, Portz, B, Cook, EC & Showalter, SA 2017, 'Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain', Biophysical journal, vol. 113, no. 9, pp. 1909-1911.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)