Scott A. Showalter - Penn State Cancer Institute
Researcher Profile
Scott A. Showalter
Biochemistry & Molecular Biology
Professor, Chemistry
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Dewing, SM, Phan, TM, Kraft, EJ, Mittal, J & Showalter, SA 2024, 'Acetylation-Dependent Compaction of the Histone H4 Tail Ensemble', Journal of Physical Chemistry B, vol. 128, no. 43, pp. 10636-10649. https://doi.org/10.1021/acs.jpcb.4c05701
Chen, W, Fraser, OA, George, C & Showalter, SA 2024, 'From molecular descriptions to cellular functions of intrinsically disordered protein regions', Biophysics Reviews, vol. 5, no. 4, 041306. https://doi.org/10.1063/5.0225900
Mitra, R, Usher, ET, Dedeoǧlu, S, Crotteau, MJ, Fraser, OA, Yennawar, NH, Gadkari, VV, Ruotolo, BT, Holehouse, AS, Salmon, L, Showalter, SA & Bardwell, JCA 2024, 'Molecular insights into the interaction between a disordered protein and a folded RNA', Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 49, e2409139121. https://doi.org/10.1073/pnas.2409139121
2023
Fraser, OA, Dewing, SM, Usher, ET, George, C & Showalter, SA 2023, 'A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins', Frontiers in Molecular Biosciences, vol. 9, 1074743. https://doi.org/10.3389/fmolb.2022.1074743
Fraser, OA, Namitz, KEW & Showalter, SA 2023, 'Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using 13C-enriched cofactors', Methods, vol. 218, pp. 72-83. https://doi.org/10.1016/j.ymeth.2023.07.010
Namitz, KEW, Showalter, SA & Cosgrove, MS 2023, 'Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation', Journal of Biological Chemistry, vol. 299, no. 10, 105204. https://doi.org/10.1016/j.jbc.2023.105204
2022
Usher, ET & Showalter, SA 2022, 'Biophysical insights into glucose-dependent transcriptional regulation by PDX1', Journal of Biological Chemistry, vol. 298, no. 12, 102623. https://doi.org/10.1016/j.jbc.2022.102623
2021
Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693. https://doi.org/10.1016/j.jbc.2021.100693
Usher, ET, Namitz, KEW, Cosgrove, MS & Showalter, SA 2021, 'Probing multiple enzymatic methylation events in real time with NMR spectroscopy', Biophysical journal, vol. 120, no. 21, pp. 4710-4721. https://doi.org/10.1016/j.bpj.2021.09.034
Prieto, VA, Namitz, KEW & Showalter, SA 2021, 'Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity', Journal of Physical Chemistry B, vol. 125, no. 39, pp. 10917-10927. https://doi.org/10.1021/acs.jpcb.1c05131