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Researcher Profile

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Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Proteins
  • Intrinsically Disordered Proteins
  • RNA
  • MicroRNAs
  • Magnetic Resonance Spectroscopy
  • Molecular Dynamics Simulation
  • RNA Polymerase II
  • Double-Stranded RNA
  • Phosphorylation
  • Transcription Factors
  • Thermodynamics
  • RNA Polymerase III

Recent Publications


Fraser, OA, Dewing, SM, Usher, ET, George, C & Showalter, SA 2023, 'A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins', Frontiers in Molecular Biosciences, vol. 9, 1074743.
Fraser, OA, Namitz, KEW & Showalter, SA 2023, 'Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using 13C-enriched cofactors', Methods, vol. 218, pp. 72-83.
Namitz, KEW, Showalter, SA & Cosgrove, MS 2023, 'Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation', Journal of Biological Chemistry, vol. 299, no. 10, 105204.


Usher, ET & Showalter, SA 2022, 'Biophysical insights into glucose-dependent transcriptional regulation by PDX1', Journal of Biological Chemistry, vol. 298, no. 12, 102623.


Usher, ET, Sabri, N, Rohac, R, Boal, AK, Mittag, T & Showalter, SA 2021, 'Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity', Journal of Biological Chemistry, vol. 296, 100693.
Usher, ET, Namitz, KEW, Cosgrove, MS & Showalter, SA 2021, 'Probing multiple enzymatic methylation events in real time with NMR spectroscopy', Biophysical journal, vol. 120, no. 21, pp. 4710-4721.
Prieto, VA, Namitz, KEW & Showalter, SA 2021, 'Transient Electrostatic Interactions between Fcp1 and Rap74 Bias the Conformational Ensemble of the Complex with Minimal Impact on Binding Affinity', Journal of Physical Chemistry B, vol. 125, no. 39, pp. 10917-10927.


Morley, VJ, Kinnear, CL, Sim, DG, Olson, SN, Jackson, LM, Hansen, E, Usher, GA, Showalter, SA, Pai, MP, Woods, RJ & Read, AF 2020, 'An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen', eLife, vol. 9, e58147, pp. 1-17.
Pabit, SA, Chen, YL, Usher, ET, Cook, EC, Pollack, L & Showalter, SA 2020, 'Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures', Biophysical journal, vol. 119, no. 12, pp. 2524-2536.
Usher, ET & Showalter, SA 2020, 'Mapping invisible epitopes by NMR spectroscopy', Journal of Biological Chemistry, vol. 295, no. 51, pp. 17411-17412.
Showalter, SA 2020, 'Reviving Protein-Observed 19F Lineshape Analysis for Deep Insight into Protein-Ligand Binding Events', Biophysical journal, vol. 118, no. 10, pp. 2333-2335.
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073.