Researcher Profile

Researcher Profile

Scott A. Showalter

Scott A. Showalter

Biochemistry & Molecular Biology
Associate Professor of Chemistry, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
sas76@psu.edu

Research Interests

  • Proteins
  • RNA
  • Intrinsically Disordered Proteins
  • MicroRNAs
  • RNA Polymerase II
  • Molecular Dynamics Simulation
  • Double-Stranded RNA
  • Phosphorylation
  • Transcription Factors
  • Magnetic Resonance Spectroscopy
  • RNA Polymerase III
  • Thermodynamics

Recent Publications

2019

Cook, EC, Sahu, D, Bastidas, M & Showalter, SA 2019, 'Solution Ensemble of the C-Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer', Journal of Physical Chemistry B, vol. 123, no. 1, pp. 106-116. https://doi.org/10.1021/acs.jpcb.8b10051
[C@3bc7d656

2018

Burkholder, NT, Medellin, B, Irani, S, Matthews, W, Showalter, SA & Zhang, YJ 2018, Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity. in KN Allen (ed.), Methods in Enzymology. Methods in Enzymology, vol. 607, Academic Press Inc., pp. 269-297. https://doi.org/10.1016/bs.mie.2018.04.020
Cook, EC, Usher, GA & Showalter, SA 2018, The Use of 13C Direct-Detect NMR to Characterize Flexible and Disordered Proteins. in E Rhoades (ed.), Methods in Enzymology. Methods in Enzymology, vol. 611, Academic Press Inc., pp. 81-100. https://doi.org/10.1016/bs.mie.2018.08.025

2017

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Gibbs, EB, Laremore, TN, Usher, GA, Portz, B, Cook, EC & Showalter, SA 2017, 'Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain', Biophysical journal, vol. 113, no. 9, pp. 1909-1911. https://doi.org/10.1016/j.bpj.2017.09.011

2016

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[C@7613b8b2

2015

Bastidas, M, Gibbs, EB, Sahu, D & Showalter, SA 2015, 'A primer for carbon-detected NMR applications to intrinsically disordered proteins in solution', Concepts in Magnetic Resonance Part A: Bridging Education and Research, vol. 44, no. 1, pp. 54-66. https://doi.org/10.1002/cmr.a.21327
Quarles, KA, Chadalavada, D & Showalter, SA 2015, 'Deformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8' Proteins: Structure, Function and Bioinformatics, vol. 83, no. 6, pp. 1165-1179. https://doi.org/10.1002/prot.24810
Acevedo, R, Orench-Rivera, N, Quarles, KA & Showalter, SA 2015, 'Helical defects in MicroRNA influence protein binding by TAR RNA binding protein', PloS one, vol. 10, no. 1, e0116749. https://doi.org/10.1371/journal.pone.0116749
Gibbs, EB & Showalter, SA 2015, 'Quantitative biophysical characterization of intrinsically disordered proteins', Biochemistry, vol. 54, no. 6, pp. 1314-1326. https://doi.org/10.1021/bi501460a

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