Scott A. Showalter - Penn State Cancer Institute
Researcher Profile
Scott A. Showalter
Biochemistry & Molecular Biology
Professor, Chemistry
Professor, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Chen, W, Laremore, TN, Yennawar, NH & Showalter, SA 2025, 'Phosphorylation modulates secondary structure of intrinsically disorder regions in RNA polymerase II', Journal of Biological Chemistry, vol. 301, no. 6, 108533. https://doi.org/10.1016/j.jbc.2025.108533
Dewing, SM & Showalter, SA 2025, 'Probing Enzymatic Acetylation Events in Real Time With NMR Spectroscopy: Insights Into Acyl-Cofactor Dependent p300 Modification of Histone H4', Proteins: Structure, Function and Bioinformatics, vol. 93, no. 10, pp. 1837-1847. https://doi.org/10.1002/prot.26848
2024
Dewing, SM, Phan, TM, Kraft, EJ, Mittal, J & Showalter, SA 2024, 'Acetylation-Dependent Compaction of the Histone H4 Tail Ensemble', Journal of Physical Chemistry B, vol. 128, no. 43, pp. 10636-10649. https://doi.org/10.1021/acs.jpcb.4c05701
Chen, W, Fraser, OA, George, C & Showalter, SA 2024, 'From molecular descriptions to cellular functions of intrinsically disordered protein regions', Biophysics Reviews, vol. 5, no. 4, 041306. https://doi.org/10.1063/5.0225900
Mitra, R, Usher, ET, Dedeoǧlu, S, Crotteau, MJ, Fraser, OA, Yennawar, NH, Gadkari, VV, Ruotolo, BT, Holehouse, AS, Salmon, L, Showalter, SA & Bardwell, JCA 2024, 'Molecular insights into the interaction between a disordered protein and a folded RNA', Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 49, e2409139121. https://doi.org/10.1073/pnas.2409139121
2023
Fraser, OA, Dewing, SM, Usher, ET, George, C & Showalter, SA 2023, 'A direct nuclear magnetic resonance method to investigate lysine acetylation of intrinsically disordered proteins', Frontiers in Molecular Biosciences, vol. 9, 1074743. https://doi.org/10.3389/fmolb.2022.1074743
Fraser, OA, Namitz, KEW & Showalter, SA 2023, 'Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using 13C-enriched cofactors', Methods, vol. 218, pp. 72-83. https://doi.org/10.1016/j.ymeth.2023.07.010
Namitz, KEW, Showalter, SA & Cosgrove, MS 2023, 'Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation', Journal of Biological Chemistry, vol. 299, no. 10, 105204. https://doi.org/10.1016/j.jbc.2023.105204
2022
Usher, ET & Showalter, SA 2022, 'Biophysical insights into glucose-dependent transcriptional regulation by PDX1', Journal of Biological Chemistry, vol. 298, no. 12, 102623. https://doi.org/10.1016/j.jbc.2022.102623