Joshua Warrick, MD - Penn State Cancer Institute
Researcher Profile
Joshua Warrick, MD
Professor, Department of Pathology and Laboratory Medicine
Chief, Division of Anatomic Pathology
Professor, Department of Urology
Chief, Division of Anatomic Pathology
Professor, Department of Urology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Degraff, D, Wu, XR, Warrick, JI, Lawrence, S & Tang, MS 2025, Cell Cycle Regulators as Oncogenic Drivers in Bladder Cancer. in Biology of Bladder Cancer: From Molecular Insights to Clinical Strategies. Springer Nature, pp. 149-160. https://doi.org/10.1007/978-3-031-68505-7_8
Lawrence, SS, Yamashita, H, Shuman, L, Raman, JD, Joshi, M, Yochum, GS, Wu, XR, Al-Ahmadie, HA, Warrick, JI, Walter, V & DeGraff, DJ 2025, 'Interferon-γ/Janus Kinase 1/STAT1 Signaling Represses Forkhead Box A1 and Drives a Basal Transcriptional State in Muscle-Invasive Bladder Cancer', American Journal of Pathology, vol. 195, no. 5, pp. 1013-1030. https://doi.org/10.1016/j.ajpath.2025.01.013
Downes, MR, Lajkosz, K, Algaba, F, Allory, Y, Amin, MB, Cheng, L, Desai, S, Eckstein, M, Hartmann, A, Lopez-Beltran, A, Mannweiler, S, van Montfoort, ML, Oxley, J, Paner, GP, Samaratunga, H, Shen, S, Warrick, J, Williamson, SR, Wobker, SE & van der Kwast, TH 2025, 'Interobserver reproducibility of a hybrid three-tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study', Histopathology. https://doi.org/10.1111/his.15438
Majeed, AJJ, Warrick, J & Raman, JD 2025, 'The diagnostic dilemma of squamous differentiation in prostate cancer: A case report', Urology Case Reports, vol. 60, 103034. https://doi.org/10.1016/j.eucr.2025.103034
2024
Zhang, Y, Wu, Q, Warrick, JI, DeGraff, DJ, Raman, JD, Truong, H & Chen, G 2024, 'Clinicopathological risk factors associated with tumor relapse of upper tract urothelial carcinoma after radical nephroureterectomy: A single institution 20-year experience', Annals of Diagnostic Pathology, vol. 73, 152357. https://doi.org/10.1016/j.anndiagpath.2024.152357
Paner, GP, Kamat, A, Netto, GJ, Samaratunga, H, Varma, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Bhattarai, YAS, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hansel, D, Hartmann, A, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, O'Rourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, 'International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas', American Journal of Surgical Pathology, vol. 48, no. 1, pp. E11-E23. https://doi.org/10.1097/PAS.0000000000002077
Warrick, JI, Al-Ahmadie, H, Berman, DM, Black, PC, Flaig, TW, Höglund, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Allory, Y, Bhattarai, S, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hanselarndt Hartmann, D, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, O'Rourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, 'International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer - Principles of Classification and Emerging Clinical Utility', American Journal of Surgical Pathology, vol. 48, no. 1, pp. E32-E42. https://doi.org/10.1097/PAS.0000000000002053
Polimera, HV, Bhatia, P, Wheelden, M, Perimbeti, S, Warrick, J & Joshi, M 2024, 'Management Options for Node-Positive Muscle-Invasive Bladder Cancer', Clinical Advances in Hematology and Oncology, vol. 22, no. 8, pp. 392-402.
Warrick, J 2024, 'Molecular Subtypes of Bladder Cancer: Component Signatures and Potential Value in Clinical Decision-making', Advances in Anatomic Pathology, vol. 31, no. 3, pp. 178-187. https://doi.org/10.1097/PAP.0000000000000430
Segel, JE, Wong, WG, Kaag, M, Joshi, M, Warrick, J, Lengerich, EJ & Shen, C 2024, 'Relationship Between Availability of Urologists and Primary Care Providers and Stage of Diagnosis for Invasive Urinary Bladder Cancer', Urology Practice, vol. 11, no. 2, pp. 339-346. https://doi.org/10.1097/UPJ.0000000000000503
2023
Zhu, Y, Feldman, S, Leung, SOA, Creer, MH, Warrick, J, Williams, N & Mastorides, S 2023, 'AACC Guidance Document on Cervical Cancer Detection: Screening, Surveillance, and Diagnosis', Journal of Applied Laboratory Medicine, vol. 8, no. 2, pp. 382-406. https://doi.org/10.1093/jalm/jfac142
Huang, W, Warrick, JI & Chen, G 2023, 'Clinical and pathological characteristics of metastatic tumors to the urinary bladder', Annals of Diagnostic Pathology, vol. 66, 152179. https://doi.org/10.1016/j.anndiagpath.2023.152179
Joshi, M, Tuanquin, L, Zhu, J, Walter, V, Schell, T, Kaag, M, Kilari, D, Liao, J, Holder, SL, Emamekhoo, H, Sankin, A, Merrill, S, Zheng, H, Warrick, J, Hauke, R, Gartrel, B, Stein, M, Drabick, J, Degraff, DJ & Zakharia, Y 2023, 'Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023', Journal for ImmunoTherapy of Cancer, vol. 11, no. 2, e006551. https://doi.org/10.1136/jitc-2022-006551
Patel, A, LaBarge, B, King, T, Pradhan, S, Warrick, J & Goyal, N 2023, 'Defining the clinical characteristics of mammary analog secretory carcinoma of the salivary gland: Analysis of the National Cancer Database', SAGE Open Medicine, vol. 11. https://doi.org/10.1177/20503121231200103
MacDonald, SM, Decter, RM, DeGraff, DJ, Raman, JD & Warrick, JI 2023, 'Histologic Analysis of Buccal Graft Quality Stratified by Tobacco Use in Patients Undergoing Substitution Urethroplasty', Urology, vol. 172, pp. 203-209. https://doi.org/10.1016/j.urology.2022.08.068
Shuman, L, Pham, J, Wildermuth, T, Wu, XR, Walter, V, Warrick, JI & DeGraff, DJ 2023, 'Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer', American Journal of Pathology, vol. 193, no. 12, pp. 2133-2143. https://doi.org/10.1016/j.ajpath.2023.07.001
2022
Warrick, JI, Knowles, MA, Hurst, CD, Shuman, L, Raman, JD, Walter, V, Putt, J, Dyrskjøt, L, Groeneveld, C, Castro, MAA, Robertson, AG & DeGraff, DJ 2022, 'A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma', Scientific reports, vol. 12, no. 1, 16538. https://doi.org/10.1038/s41598-022-20927-9
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation (Nature Communications, (2022), 13, 1, (6575), 10.1038/s41467-022-34251-3)', Nature communications, vol. 13, no. 1, 7920. https://doi.org/10.1038/s41467-022-35644-0
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation', Nature communications, vol. 13, no. 1, 6575. https://doi.org/10.1038/s41467-022-34251-3
Woolbright, BL, Rajendran, G, Abbott, E, Martin, A, Amalraj, S, Dennis, K, Li, X, Warrick, J & Taylor, JA 2023, 'Role of MIF1/MIF2/CD74 interactions in bladder cancer', Journal of Pathology, vol. 259, no. 1, pp. 46-55. https://doi.org/10.1002/path.6018
2021
Lindskrog, SV, Prip, F, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, JB, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, DG, Goel, A, Hurst, CD, Raman, JD, Warrick, JI, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, RT, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w
Joshi, M, Holder, SL, Zhu, J, Zheng, H, Komanduri, S, Warrick, J, Yasin, H, Gajre, R, Jia, B, Drabick, JJ, DeGraff, DJ & Zakharia, Y 2022, 'Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study', European Urology Focus, vol. 8, no. 2, pp. 483-490. https://doi.org/10.1016/j.euf.2021.03.005
Torab, P, Yan, Y, Ahmed, M, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2021, 'Intratumoral heterogeneity promotes collective cancer invasion through notch1 variation', Cells, vol. 10, no. 11, 3084. https://doi.org/10.3390/cells10113084
Hommerding, O, Allory, Y, Argani, P, Bismar, TA, Bubendorf, L, Canete-Portillo, S, Chaux, A, Chen, YB, Cheng, L, Cubilla, AL, Egevad, L, Gill, AJ, Grignon, DJ, Hartmann, A, Hes, O, Idrees, MT, Kao, CS, Knowles, MA, Looijenga, LHJ, Lotan, TL, Pritchard, CC, Rubin, MA, Tomlins, SA, Van der Kwast, TH, Velazquez, EF, Warrick, JI, Williamson, SR & Kristiansen, G 2021, 'Molekularpathologie bei urologischen Tumoren: Empfehlungen der Konsenskonferenz der Internationalen Gesellschaft für Uropathologie (ISUP) 2019', Pathologe, vol. 42, no. 3, pp. 310-318. https://doi.org/10.1007/s00292-020-00888-4
Keane, A, Warrick, J, Andrews, GA & Choi, KY 2021, 'Pediatric dermoid cyst of the parotid: Case report and review of the literature', Otolaryngology Case Reports, vol. 18, 100258. https://doi.org/10.1016/j.xocr.2020.100258
Iyyanki, T, Zhang, B, Wang, Q, Hou, Y, Jin, Q, Xu, J, Yang, H, Liu, T, Wang, X, Song, F, Luan, Y, Yamashita, H, Chien, R, Lyu, H, Zhang, L, Wang, L, Warrick, J, Raman, JD, Meeks, JJ, DeGraff, DJ & Yue, F 2021, 'Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer', Genome biology, vol. 22, no. 1, 105. https://doi.org/10.1186/s13059-021-02325-y