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Joshua Warrick, MD

Joshua Warrick, MD

Professor, Department of Pathology and Laboratory Medicine
Professor, Department of Urology
Associate Professor, Department of Pathology and Laboratory Medicine
Chief, Division of Anatomic Pathology
Associate Professor, Department of Urology
Associate Professor, Department of Surgery
Scientific Program:Mechanisms of Carcinogenesis
JIW11@psu.edu

Research Interests

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  • Neoplasms
  • Urinary Bladder Neoplasms
  • Carcinoma
  • Mutation
  • Survival
  • Thyroid Neoplasms
  • Biomarkers
  • Urinary Bladder
  • Recurrence
  • Neoplasm Metastasis
  • Hyperplasia
  • Genome
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Recent Publications

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2024

Zhang, Y, Wu, Q, Warrick, JI, Degraff, D, Raman, JD, Truong, H & Chen, G 2024, 'Clinicopathological risk factors associated with tumor relapse of upper tract urothelial carcinoma after radical nephroureterectomy: A single institution 20-year experience', Annals of Diagnostic Pathology, vol. 73, 152357. https://doi.org/10.1016/j.anndiagpath.2024.152357
Paner, GP, Kamat, A, Netto, GJ, Samaratunga, H, Varma, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Bhattarai, YAS, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hansel, D, Hartmann, A, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, O'Rourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, 'International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas', American Journal of Surgical Pathology, vol. 48, no. 1, pp. E11-E23. https://doi.org/10.1097/PAS.0000000000002077
Warrick, JI, Al-Ahmadie, H, Berman, DM, Black, PC, Flaig, TW, Höglund, M, Bubendorf, L, Van Der Kwast, TH, Cheng, L, Adeniran, A, Al-Ahimadie, H, Algaba, F, Allory, Y, Bhattarai, S, Black, P, Berman, D, Bertz, S, Bubendorf, L, Carlsen, B, Carvalho, R, Chijioke, O, Cho, YM, Comperat, E, Di Cunha, I, Dagher, J, De Cunha, I, Delahunt, B, Downes, M, Flaig, T, Fleischmann, A, Florescu, C, Fontugne, J, Genitsch, V, Gløersen, GH, Von Gunten, M, Grobholz, R, Hanselarndt Hartmann, D, Hernandez, LH, Hogland, M, Huang, J, Jensen, B, Iczkowski, K, Jimenez, R, Jovanovic, B, Kamat, A, Koellermann, J, Levin, T, Liedberg, F, Lopez-Beltran, A, Loya, AC, Lyngra, M, McHale, T, Mokeddem, K, Netto, G, Nourieh, M, O'Rourke, D, Ostahi, IA, Paner, G, Picken, MM, Pineda, FG, Raspollini, CRM, Reis, H, Ruoyu, S, Samaratunga, H, Semba, R, Shah, N, Shen, S, Smith, S, Smith, T, Srigley, J, Suzigan, S, Swarbrick, N, Szalay, I, Talleraas, I, Tille, JC, Toma, M, Trias, I, Tsuzuki, T, Van Der Kwast, T, Van Rhijn, B, Varma, M, Verbeke, S, Verma, S, Vlajnic, T, Vlatkovic, L, Warren, A, Warrick, J, Williamson, S, Wobker, S, Woods, C, Yang, C & Yoon, G 2024, 'International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer - Principles of Classification and Emerging Clinical Utility', American Journal of Surgical Pathology, vol. 48, no. 1, pp. E32-E42. https://doi.org/10.1097/PAS.0000000000002053
Warrick, J 2024, 'Molecular Subtypes of Bladder Cancer: Component Signatures and Potential Value in Clinical Decision-making', Advances in Anatomic Pathology, vol. 31, no. 3, pp. 178-187. https://doi.org/10.1097/PAP.0000000000000430
Segel, JE, Wong, WG, Kaag, M, Joshi, M, Warrick, J, Lengerich, EJ & Shen, C 2024, 'Relationship Between Availability of Urologists and Primary Care Providers and Stage of Diagnosis for Invasive Urinary Bladder Cancer', Urology Practice, vol. 11, no. 2, pp. 339-346. https://doi.org/10.1097/UPJ.0000000000000503

2023

Zhu, Y, Feldman, S, Leung, SOA, Creer, MH, Warrick, J, Williams, N & Mastorides, S 2023, 'AACC Guidance Document on Cervical Cancer Detection: Screening, Surveillance, and Diagnosis', Journal of Applied Laboratory Medicine, vol. 8, no. 2, pp. 382-406. https://doi.org/10.1093/jalm/jfac142
Huang, W, Warrick, JI & Chen, G 2023, 'Clinical and pathological characteristics of metastatic tumors to the urinary bladder', Annals of Diagnostic Pathology, vol. 66, 152179. https://doi.org/10.1016/j.anndiagpath.2023.152179
Joshi, M, Tuanquin, L, Zhu, J, Walter, V, Schell, T, Kaag, M, Kilari, D, Liao, J, Holder, SL, Emamekhoo, H, Sankin, A, Merrill, S, Zheng, H, Warrick, J, Hauke, R, Gartrel, B, Stein, M, Drabick, J, Degraff, DJ & Zakharia, Y 2023, 'Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023', Journal for ImmunoTherapy of Cancer, vol. 11, no. 2, e006551. https://doi.org/10.1136/jitc-2022-006551
Patel, A, LaBarge, B, King, T, Pradhan, S, Warrick, J & Goyal, N 2023, 'Defining the clinical characteristics of mammary analog secretory carcinoma of the salivary gland: Analysis of the National Cancer Database', SAGE Open Medicine, vol. 11. https://doi.org/10.1177/20503121231200103
MacDonald, SM, Decter, RM, DeGraff, DJ, Raman, JD & Warrick, JI 2023, 'Histologic Analysis of Buccal Graft Quality Stratified by Tobacco Use in Patients Undergoing Substitution Urethroplasty', Urology, vol. 172, pp. 203-209. https://doi.org/10.1016/j.urology.2022.08.068
Shuman, L, Pham, J, Wildermuth, T, Wu, XR, Walter, V, Warrick, JI & DeGraff, DJ 2023, 'Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer', American Journal of Pathology, vol. 193, no. 12, pp. 2133-2143. https://doi.org/10.1016/j.ajpath.2023.07.001

2022

Warrick, JI, Knowles, MA, Hurst, CD, Shuman, L, Raman, JD, Walter, V, Putt, J, Dyrskjøt, L, Groeneveld, C, Castro, MAA, Robertson, AG & DeGraff, DJ 2022, 'A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma', Scientific reports, vol. 12, no. 1, 16538. https://doi.org/10.1038/s41598-022-20927-9
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation (Nature Communications, (2022), 13, 1, (6575), 10.1038/s41467-022-34251-3)', Nature communications, vol. 13, no. 1, 7920. https://doi.org/10.1038/s41467-022-35644-0
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation', Nature communications, vol. 13, no. 1, 6575. https://doi.org/10.1038/s41467-022-34251-3
Woolbright, BL, Rajendran, G, Abbott, E, Martin, A, Amalraj, S, Dennis, K, Li, X, Warrick, J & Taylor, JA 2023, 'Role of MIF1/MIF2/CD74 interactions in bladder cancer', Journal of Pathology, vol. 259, no. 1, pp. 46-55. https://doi.org/10.1002/path.6018

2021

Lindskrog, SV, Prip, F, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, JB, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, DG, Goel, A, Hurst, CD, Raman, JD, Warrick, JI, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, RT, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w
Joshi, M, Holder, SL, Zhu, J, Zheng, H, Komanduri, S, Warrick, J, Yasin, H, Gajre, R, Jia, B, Drabick, JJ, DeGraff, DJ & Zakharia, Y 2022, 'Avelumab in Combination with Eribulin Mesylate in Metastatic Urothelial Carcinoma: BTCRC GU-051, a Phase 1b Study', European Urology Focus, vol. 8, no. 2, pp. 483-490. https://doi.org/10.1016/j.euf.2021.03.005
Torab, P, Yan, Y, Ahmed, M, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2021, 'Intratumoral heterogeneity promotes collective cancer invasion through notch1 variation', Cells, vol. 10, no. 11, 3084. https://doi.org/10.3390/cells10113084
Hommerding, O, Allory, Y, Argani, P, Bismar, TA, Bubendorf, L, Canete-Portillo, S, Chaux, A, Chen, YB, Cheng, L, Cubilla, AL, Egevad, L, Gill, AJ, Grignon, DJ, Hartmann, A, Hes, O, Idrees, MT, Kao, CS, Knowles, MA, Looijenga, LHJ, Lotan, TL, Pritchard, CC, Rubin, MA, Tomlins, SA, Van der Kwast, TH, Velazquez, EF, Warrick, JI, Williamson, SR & Kristiansen, G 2021, 'Molekularpathologie bei urologischen Tumoren: Empfehlungen der Konsenskonferenz der Internationalen Gesellschaft für Uropathologie (ISUP) 2019', Pathologe, vol. 42, no. 3, pp. 310-318. https://doi.org/10.1007/s00292-020-00888-4
Keane, A, Warrick, J, Andrews, GA & Choi, KY 2021, 'Pediatric dermoid cyst of the parotid: Case report and review of the literature', Otolaryngology Case Reports, vol. 18, 100258. https://doi.org/10.1016/j.xocr.2020.100258
Iyyanki, T, Zhang, B, Wang, Q, Hou, Y, Jin, Q, Xu, J, Yang, H, Liu, T, Wang, X, Song, F, Luan, Y, Yamashita, H, Chien, R, Lyu, H, Zhang, L, Wang, L, Warrick, J, Raman, JD, Meeks, JJ, DeGraff, DJ & Yue, F 2021, 'Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer', Genome biology, vol. 22, no. 1, 105. https://doi.org/10.1186/s13059-021-02325-y

2020

Hwang, G, Goldenberg, D, Warrick, J & Slonimsky, G 2020, 'A Hyalinizing Clear Cell Carcinoma of the Base of Tongue', Ear, Nose and Throat Journal, vol. 99, no. 4, pp. 237-238. https://doi.org/10.1177/0145561319840513
Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Moynihan, MJ, Sullivan, TB, Burks, E, Schober, J, Calabrese, M, Fredrick, A, Kalantzakos, T, Warrick, J, Canes, D, Raman, JD & Rieger-Christ, K 2020, 'MicroRNA profile in stage I clear cell renal cell carcinoma predicts progression to metastatic disease', Urologic Oncology: Seminars and Original Investigations, vol. 38, no. 10, pp. 799.e11-799.e22. https://doi.org/10.1016/j.urolonc.2020.05.006
Russo, M, Newell, JM, Budurlean, L, Houser, KR, Sheldon, K, Kesterson, J, Phaeton, R, Hossler, C, Rosenberg, J, DeGraff, D, Shuman, L, Broach, JR & Warrick, JI 2020, 'Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma', Cancer, vol. 126, no. 12, pp. 2775-2783. https://doi.org/10.1002/cncr.32822
Warrick, JI, Knowles, MA, Yves, A, Van Der Kwast, T, Grignon, DJ, Kristiansen, G, Egevad, L, Hartmann, A & Cheng, L 2020, 'Report from the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges', American Journal of Surgical Pathology, vol. 44, no. 7, pp. E30-E46. https://doi.org/10.1097/PAS.0000000000001453
Torab, P, Yan, Y, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2020, 'Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer', Analytical Chemistry, vol. 92, no. 13, pp. 8768-8775. https://doi.org/10.1021/acs.analchem.0c00057
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