Researcher Profile

Researcher Profile

Joshua Warrick, MD

Joshua Warrick, MD

Associate Professor, Department of Pathology and Laboratory Medicine
Division of Anatomic Pathology
Associate Professor, Department of Surgery
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Carcinoma
  • Urinary Bladder Neoplasms
  • Mutation
  • Thyroid Neoplasms
  • Survival
  • Neoplasm Metastasis
  • Hyperplasia
  • Recurrence
  • Biomarkers
  • Urinary Bladder
  • Histology

Clinical Trials

NRG-GU005 Phase III IGRT and SBRT VS IGRT and hypofractionated IMRT for localized intermediate risk prostate cancer
Exon Sequencing of Cancer Associated Genes in Endometrial Hyperplasia
Observational Study to Determine the Differences in Molecular Characterization between Smokers vs. Non-smokers in Patients with Stage IV Bladder Cancer and their Correlation with Clinical Outcome

Recent Publications


Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439.
Moynihan, MJ, Sullivan, TB, Burks, E, Schober, J, Calabrese, M, Fredrick, A, Kalantzakos, T, Warrick, J, Canes, D, Raman, JD & Rieger-Christ, K 2020, 'MicroRNA profile in stage I clear cell renal cell carcinoma predicts progression to metastatic disease', Urologic Oncology: Seminars and Original Investigations.
Russo, M, Newell, JM, Budurlean, L, Houser, KR, Sheldon, K, Kesterson, J, Phaeton, R, Hossler, C, Rosenberg, J, DeGraff, D, Shuman, L, Broach, JR & Warrick, JI 2020, 'Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma', Cancer, vol. 126, no. 12, pp. 2775-2783.
Warrick, JI, Knowles, MA, Yves, A, Van Der Kwast, T, Grignon, DJ, Kristiansen, G, Egevad, L, Hartmann, A & Cheng, L 2020, 'Report from the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges', American Journal of Surgical Pathology.


Donaldson, K, Buchanich, JM, Grigson, PS, Deneke, E, Vrana, KE, Sacks, DB, Kuehn, GJ, Cardamone, D, Pesce, A, Smiley, S, Nickley, J, Krock, K, Thomas, R, Wilkerson, ML, Farag, HA, Challa, SR, Tice, AM, Wolk, DM, Prichard, J, Grant, ML, Regmi, S, Kerbacher, B, Quinton, LE, Tice, AM, Olson, J, Haynes, A, Yu, E, McCully, KS, Assi, J, Wong, M, Zarrin-Khameh, N, Nifong, TP, Hawker, CD, Carlton, GT, Rivera, JM, Foulis, PR, Zuraw, A, Morlote, D, Peker, D, Reddy, V, Harada, S, Crutchfield, C, Zander, D, Barbhuiya, MA, Pederson, EC, Straub, ML, Scott, SC, Neibauer, TL, Salter, WF, Creer, MH, Zhu, Y, Bornhorst, JA, Theobald, JP, Algeciras-Schimnich, A, Cao, L, Knox, J, Hardy, R, Texas, HJ, McGuire, MF, Hunter, RL, Brown, RE, Hicks, J, Cai, Z, Brown, RE, Ali, Y, Cheng, KC, Katz, SR, Ding, Y, Vanselow, DJ, Yakovlev, MA, Lin, AY, Clark, DP, Vargas, P, Xin, X, Copper, JE, Canfield, VA, Ang, KC, Wang, Y, Xiao, X, De Carlo, F, van Rossum, DB, La Rivière, PJ, Newell, J, Hossler, C, Roche, M, Warrick, J, Phaeton, R, Kesterson, J, Myers, C, Barrios, R, Mintz, P, Robyak, K, Hamilton, C, McGhee, P, Pederson, C, Straub, M, Scott, S, Neibauer, T, Salter, W, Robyak, K, Singh, N, Morlote, D, Vnencak-Jones, C, Yemelyanova, A, Harada, S, Shah, M, Moghadamtousi, SZ, Lan, C, Duose, D, Hu, P, Esquenazi, Y, Luthra, R, Ballester, LY, Koenig, AN, Liu, CG, Zhang, J, Kalia, A, Al-Habib, A, Van Arsdall, M, Dhingra, S, Patel, K & Tatevian, N 2019, 'Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019', Annals of clinical and laboratory science, vol. 49, no. 3, pp. 403-416.
Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, JI, Wu, XR, Kaag, M, Raman, JD & Degraff, DJ 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599.
Kim, YS, Gupta Vallur, P, Jones, VM, Worley, BL, Shimko, S, Shin, DH, Crawford, LTC, Chen, CW, Aird, KM, Abraham, T, Shepherd, TG, Warrick, JI, Lee, NY, Phaeton, R, Mythreye, K & Hempel, N 2020, 'Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells', Oncogene, vol. 39, no. 8, pp. 1619-1633.
Kocher, NJ, Loloi, J, Warrick, J, Burns, AS & Decter, RM 2019, 'Ectopic ACTH-secreting neuroendocrine tumor: a rare etiology of a pediatric solid renal mass', The Canadian journal of urology, vol. 26, no. 5, pp. 9956-9959.
Bann, DV, Jin, Q, Sheldon, KE, Houser, KR, Nguyen, L, Warrick, JI, Baker, MJ, Broach, JR, Gerhard, GS & Goldenberg, D 2019, 'Genetic variants implicate dual oxidase-2 in familial and sporadic nonmedullary thyroid cancer', Cancer Research, vol. 79, no. 21, pp. 5490-5499.
Cimino, PJ, Yoda, RA, Wirsching, HG, Warrick, JI, Dorschner, MO & Ferreira, M 2019, 'Genomic profiling of anaplastic meningioma identifies recurrent genetic alterations with relevance to lower-grade meningioma', Neuropathology and Applied Neurobiology, vol. 45, no. 2, pp. 179-182.
Osei-Amponsa, V, Buckwalter, JM, Shuman, L, Zheng, Z, Yamashita, H, Walter, V, Wildermuth, T, Ellis-Mohl, J, Liu, C, Warrick, JI, Shantz, LM, Feehan, RP, Al-Ahmadie, H, Mendelsohn, C, Raman, JD, Kaestner, KH, Wu, XR & DeGraff, DJ 2020, 'Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer', Oncogene, vol. 39, no. 6, pp. 1302-1317.
Yee, CH, Zheng, Z, Shuman, L, Yamashita, H, Warrick, J, Wu, XR, Raman, J & Degraff, D 2019, 'Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS', Scientific reports, vol. 9, no. 1, 270.
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282.
Pool, C, Walter, V, Bann, D, Goldenberg, D, Broach, J, Hennessy, M, Cottrill, E, Washburn, E, Williams, N, Crist, H, Imamura, Y & Warrick, JI 2019, 'Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)', Virchows Archiv, vol. 474, no. 3, pp. 341-351.
Jiang, Z, Albanese, J, Kesterson, J, Warrick, J, Karabakhtsian, R, Dadachova, E & Phaëton, R 2019, 'Monoclonal Antibodies Against Human Papillomavirus E6 and E7 Oncoproteins Inhibit Tumor Growth in Experimental Cervical Cancer', Translational Oncology, vol. 12, no. 10, pp. 1289-1295.
Joshi, M, Warrick, JI, Yin, M, Holder, SL & Drabick, JJ 2019, 'Need for a personalized approach for muscle invasive bladder cancer: Role of tumor biology in response to neoadjuvant chemotherapy', Translational Andrology and Urology, vol. 8, pp. S99-S103.
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69.
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8.
Warrick, J & Lengerich, E 2019, 'Thyroid cancer overdiagnosis and malpractice climate', Archives of Pathology and Laboratory Medicine, vol. 143, no. 4, pp. 414-415.


Crist, H, Hennessy, M, Hodos, J, McGinn, J, White, B, Payne, S & Warrick, JI 2019, 'Acute Invasive Fungal Rhinosinusitis: Frozen Section Histomorphology and Diagnosis with PAS Stain', Head and Neck Pathology, vol. 13, no. 3, pp. 318-326.
Labarge, B, Walter, V, Lengerich, EJ, Crist, H, Karamchandani, D, Williams, N, Goldenberg, D, Bann, DV & Warrick, JI 2018, 'Evidence of a positive association between malpractice climate and thyroid cancer incidence in the United States', PloS one, vol. 13, no. 7, e0199862.
Pharaon, M, Warrick, J & Lynch, MC 2018, 'Fibroepithelial Stromal Polyp of the Vulva: Case Report and Review of Potential Histologic Mimickers', International Journal of Gynecological Pathology, vol. 37, no. 4, pp. e1-e5.
Hennessy, M, McGinn, J, White, B, Payne, S, Warrick, J & Crist, H 2018, 'Frozen Section as a Rapid and Accurate Method for Diagnosing Acute Invasive Fungal Rhinosinusitis', Otolaryngology - Head and Neck Surgery (United States), vol. 159, no. 3, pp. 576-580.
Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, JI, Timmins, PF, Kesterson, JP, Phaëton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, KM & Hempel, N 2019, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology, vol. 25, 101051.
Warrick, JI, Sjödahl, G, Kaag, M, Raman, JD, Merrill, S, Shuman, L, Chen, G, Walter, V & DeGraff, DJ 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22.
Browne, BM, Stensland, KD, Patel, CK, Sullivan, T, Burks, EJ, Canes, D, Raman, JD, Warrick, J & Reiger-Christ, KM 2019, 'MicroRNA Expression Profiles in Upper Tract Urothelial Carcinoma Differentiate Tumor Grade, Stage, and Survival: Implications for Clinical Decision-Making', Urology, vol. 123, pp. 93-100.
Lehman, HL, Kidacki, M, Warrick, JI & Stairs, DB 2018, 'NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation', Oncotarget, vol. 9, no. 13, pp. 11180-11196.


Goldenberg, D, Russo, M, Houser, K, Crist, H, Derr, JB, Walter, V, Warrick, JI, Sheldon, KE, Broach, J & Bann, DV 2017, 'Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident', Laryngoscope, vol. 127, pp. S1-S9.
Clark, CM, Payne, SJ, Warrick, JI & Goldenberg, D 2017, 'Atypical parathyroid adenoma with diffuse fibrosis', Ear, Nose and Throat Journal, vol. 96, no. 2, pp. 57-58.
Warrick, JI 2017, 'Clinical significance of histologic variants of bladder cancer', JNCCN Journal of the National Comprehensive Cancer Network, vol. 15, no. 10, pp. 1268-1274.
Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96.
Russo, M, Broach, J, Sheldon, K, Houser, KR, Liu, DJ, Kesterson, J, Phaeton, R, Hossler, C, Hempel, N, Baker, M, Newell, JM, Zaino, R & Warrick, JI 2017, 'Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma', Human Pathology, vol. 67, pp. 69-77.
Warrick, JI, Kaag, M, Raman, JD, Chan, W, Tran, T, Kunchala, S, Shuman, L, DeGraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345.
Kidacki, M, Lehman, HL, Green, MV, Warrick, JI & Stairs, DB 2017, 'p120-catenin downregulation and PIK3CA mutations cooperate to induce invasion through MMP1 in HNSCC', Molecular Cancer Research, vol. 15, no. 10, pp. 1398-1409.


Raman, JD, Warrick, JI, Caruso, C, Yang, Z, Shuman, L, Bruggeman, RD, Shariat, S, Karam, JA, Wood, C, Weizer, AZ, Remzi, M, Haitel, A, Bensalah, K, Rioux-Leclerq, N, Bolenz, C, Roscigno, M, Krabbe, LM, Kapur, P, Lotan, Y, Margulis, V & DeGraff, DJ 2016, 'Altered Expression of the Transcription Factor Forkhead Box A1 (FOXA1) Is Associated With Poor Prognosis in Urothelial Carcinoma of the Upper Urinary Tract', Urology, vol. 94, pp. 314.e1-314.e7.
Goldenberg, M, Warrick, J, Russo, M & Bann, DV 2016, 'Breast cancer metastasis to the thyroid gland', Ear, nose, & throat journal, vol. 95, no. 10-11, pp. 444-451.
Warrick, JI, Raman, JD, Kaag, M, Bruggeman, T, Cates, J, Clark, P & DeGraff, DJ 2016, 'Enhancer of zeste homolog 2 (EZH2) expression in bladder cancer', Urologic Oncology: Seminars and Original Investigations, vol. 34, no. 6, pp. 258.e1-258.e6.
Warrick, JI, Walter, V, Yamashita, H, Chung, E, Shuman, L, Amponsa, VO, Zheng, Z, Chan, W, Whitcomb, TL, Yue, F, Iyyanki, T, Kawasawa, YI, Kaag, M, Guo, W, Raman, JD, Park, JS & Degraff, DJ 2016, 'FOXA1, GATA3 and PPARIγ Cooperate to drive luminal subtype in bladder cancer: A molecular analysis of established human cell lines', Scientific reports, vol. 6, 38531.
Cimino, PJ, Kung, Y, Warrick, J, Chang, SH & Keene, CD 2016, 'Mutational status of IDH1 in uveal melanoma', Experimental and Molecular Pathology, vol. 100, no. 3, pp. 476-481.
Yamashita, H, Amponsa, VO, Warrick, JI, Zheng, Z, Clark, PE, Raman, JD, Wu, XR, Mendelsohn, C & Degraff, DJ 2017, 'On a FOX hunt: Functions of FOX transcriptional regulators in bladder cancer', Nature Reviews Urology, vol. 14, no. 2, pp. 98-106.
DiSalvo, DS, Oberman, BS, Warrick, JI & Goldenberg, D 2016, 'Pharyngeal Presentation of Goltz Syndrome: A Case Report with Review of the Literature', Head and Neck Pathology, vol. 10, no. 2, pp. 188-191.
Joshi, M, Vasekar, M, Grivas, P, Emamekhoo, H, Hsu, JA, Miller, VA, Stephens, PJ, Ali, SM, Ross, JS, Zhu, J, Warrick, J, Drabick, JJ, Holder, SL, Kaag, M, Li, M & Pal, SK 2016, 'Relationship of smoking status to genomic profile, chemotherapy response and clinical outcome in patients with advanced urothelial carcinoma', Oncotarget, vol. 7, no. 32, pp. 52442-52449.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)