Researcher Profile

Researcher Profile

Navesh Sharma, DO, PhD, FACRO

Navesh Sharma, DO, PhD, FACRO

Professor, Department of Radiation Oncology
Professor, Department of Radiology
Disease Teams:
General Care
Liver, Pancreas and Foregut Cancer
nxs54@psu.edu

Research Interests

  • Radiotherapy
  • Liver
  • Therapeutics
  • Colorectal Neoplasms
  • Drug Therapy
  • Survival
  • Neoplasms
  • Neoplasm Metastasis
  • Microspheres
  • Radiation
  • Yttrium
  • Pancreatic Neoplasms

Recent Publications

2019

Chuong, MD, Kaiser, A, Khan, F, Parikh, P, Ben-Josef, E, Crane, C, Brunner, T, Okumura, T, Schreuder, N, Bentzen, SM, Gutierrez, A, Romero, AM, Yoon, SM, Sharma, N, Kim, TH, Kishi, K, Moeslein, F, Hoffe, S, Schefter, T, Hanish, S, Scorsetti, M & Apisarnthanarax, S 2019, 'Consensus report from the Miami liver proton therapy conference', Frontiers in Oncology, vol. 9, no. MAY, 00457. https://doi.org/10.3389/fonc.2019.00457
Tchelebi, L & Sharma, N 2019, 'Selective Internal Radiation Therapy in the Multidisciplinary Management of Liver Metastases From Colorectal Carcinoma', Seminars in Nuclear Medicine, vol. 49, no. 3, pp. 182-188. https://doi.org/10.1053/j.semnuclmed.2019.01.002

2018

Badiyan, S, Bhooshan, N, Chuong, MD, Sharma, N, Akhter, N, Etezadi, V, Hausner, P, Kudryasheva, S, Kaiser, A, Becker, S, Guerrero, M & Yi, BY 2018, 'Correlation of radiation dose and activity with clinical outcomes in metastatic colorectal cancer after selective internal radiation therapy using yttrium-90 resin microspheres' Nuclear Medicine Communications, vol. 39, no. 10, pp. 915-920. https://doi.org/10.1097/MNM.0000000000000887
SIRFLOX and FOXFIRE Global Trial Investigators 2018, 'Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies', Clinical Colorectal Cancer, vol. 17, no. 4, pp. e617-e629. https://doi.org/10.1016/j.clcc.2018.06.001

2017

Sharma, RA, Gibbs, P, Sharma, N, Ricke, J, Taieb, J, Moschandreas, J, Virdee, PS, Dutton, P, van Hazel, G & Wasan, HS 2017, 'Adequate SIRT activity dose is as important as adequate chemotherapy dose – Authors' reply' The Lancet Oncology, vol. 18, no. 11, pp. e637. https://doi.org/10.1016/S1470-2045(17)30801-X
Kennedy, AS, Ball, D, Cohen, SJ, Cohn, M, Coldwell, DM, Drooz, A, Ehrenwald, E, Kanani, S, Moeslein, FM, Nutting, CW, Putnam, SG, Rose, SC, Savin, M, Schirm, S, Sharma, N & Wang, E 2017, 'Baseline hemoglobin and liver function predict tolerability and overall survival of patients receiving radioembolization for chemotherapy-refractory metastatic colorectal cancer', Journal of Gastrointestinal Oncology, vol. 8, no. 1, pp. 70-80. https://doi.org/10.21037/jgo.2017.01.03
Hepel, JT, Heron, DE, Mundt, AJ, Yashar, C, Feigenberg, S, Koltis, G, Regine, WF, Prasad, D, Patel, S, Sharma, N, Hebert, M, Wallis, N & Kuettel, M 2017, 'Comparison of onsite versus online chart reviews as part of the American college of radiation oncology accreditation program' Journal of oncology practice, vol. 13, no. 5, pp. e516-e520. https://doi.org/10.1200/JOP.2016.015230
FOXFIRE trial investigators 2017, 'First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials', The Lancet Oncology, vol. 18, no. 9, pp. 1159-1171. https://doi.org/10.1016/S1470-2045(17)30457-6
Narsinh, KH, Van Buskirk, M, Kennedy, AS, Suhail, M, Alsaikhan, N, Hoh, CK, Thurston, K, Minocha, J, Ball, DS, Cohen, SJ, Cohn, M, Coldwell, DM, Drooz, A, Ehrenwald, E, Kanani, S, Nutting, CW, Moeslein, FM, Savin, MA, Schirm, S, Putnam, SG, Sharma, N, Wang, EA & Rose, SC 2017, 'Hepatopulmonary shunting: A prognostic indicator of survival in patients with metastatic colorectal adenocarcinoma treated with 90Y radioembolization', Radiology, vol. 282, no. 1, pp. 281-288. https://doi.org/10.1148/radiol.2016152100

2016

Bhooshan, N, Sharma, N, Badiyan, S, Kaiser, A, Moeslein, FM, Kwok, Y, Amin, PP, Kudryasheva, S & Chuong, MD 2016, 'Pretreatment tumor volume as a prognostic factor in metastatic colorectal cancer treated with selective internal radiation to the liver using yttrium-90 resin microspheres', Journal of Gastrointestinal Oncology, vol. 7, no. 6, pp. 931-937. https://doi.org/10.21037/jgo.2016.06.15
D'Emic, N, Engelman, A, Molitoris, J, Hanlon, A, Sharma, N, Moeslein, FM & Chuong, MD 2016, 'Prognostic significance of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients treated with selective internal radiation therapy', Journal of Gastrointestinal Oncology, vol. 7, no. 2, pp. 269-277. https://doi.org/10.3978/j.issn.2078-6891.2015.108
Van Hazel, GA, Heinemann, V, Sharma, N, Findlay, MPN, Ricke, J, Peeters, M, Perez, D, Robinson, BA, Strickland, AH, Ferguson, T, Rodríguez, J, Kröning, H, Wolf, I, Ganju, V, Walpole, E, Boucher, E, Tichler, T, Shacham-Shmueli, E, Powell, A, Eliadis, P, Isaacs, R, Price, D, Moeslein, F, Taieb, J, Bower, G, Gebski, V, Van Buskirk, M, Cade, DN, Thurston, K & Gibbs, P 2016, 'SIRFLOX: Randomized phase III trial comparing first-line mFOLFOX6 (Plus or Minus Bevacizumab) versus mFOLFOX6 (Plus or Minus Bevacizumab) plus selective internal radiation therapy in patients with metastatic colorectal cancer', Journal of Clinical Oncology, vol. 34, no. 15, pp. 1723-1731. https://doi.org/10.1200/JCO.2015.66.1181
Kennedy, AS, Ball, DS, Cohen, SJ, Cohn, M, Coldwell, D, Drooz, A, Ehrenwald, E, Kanani, S, Rose, SC, Nutting, CW, Moeslein, FM, Savin, MA, Schirm, S, Putnam, SG, Sharma, N & Wang, EA 2016, 'Safety and efficacy of radioembolization in elderly (≥ 70 years) and younger patients with unresectable liver-dominant colorectal cancer', Clinical Colorectal Cancer, vol. 15, no. 2, pp. 141-151.e6. https://doi.org/10.1016/j.clcc.2015.09.001

2015

Kennedy, AS, Ball, D, Cohen, SJ, Cohn, M, Coldwell, DM, Drooz, A, Ehrenwald, E, Kanani, S, Rose, SC, Nutting, CW, Moeslein, FM, Savin, MA, Schirm, S, Putnam, SG, Sharma, N & Wang, EA 2015, ' Multicenter evaluation of the safety and efficacy of radioembolization in patients with unresectable colorectal liver metastases selected as candidates for 90 Y resin microspheres ', Journal of Gastrointestinal Oncology, vol. 6, no. 2, pp. 134-142. https://doi.org/10.3978/j.issn.2078-6891.2014.109
Mattiucci, GC, Falconi, M, Van Stiphout, RGPM, Alfieri, S, Calvo, FA, Herman, JM, Maidment, BW, Miller, RC, Regine, WF, Reni, M, Sharma, N, Partelli, S, Genovesi, D, Balducci, M, Deodato, F, Valentini, V & Morganti, AG 2015, 'Adjuvant chemoradiation in pancreatic cancer: A pooled analysis in elderly (≥75 years) patients', Anticancer Research, vol. 35, no. 6, pp. 3441-3446.
Zhou, J, Yan, Z, Lasio, G, Huang, J, Zhang, B, Sharma, N, Prado, K & D'Souza, W 2015, 'Automated compromised right lung segmentation method using a robust atlas-based active volume model with sparse shape composition prior in CT', Computerized Medical Imaging and Graphics, vol. 46, pp. 47-55. https://doi.org/10.1016/j.compmedimag.2015.07.003
Nguyen, DM, Parekh, PR, Chang, ET, Sharma, N & Carrier, F 2015, 'Contribution of dual oxidase 2 (DUOX2) to hyper-radiosensitivity in human gastric cancer cells' Radiation research, vol. 184, no. 2, pp. 151-160. https://doi.org/10.1667/RR13661.1
Kennedy, AS, Ball, DS, Cohen, SJ, Cohn, M, Coldwell, DM, Drooz, A, Ehrenwald, E, Kanani, S, Nutting, CW, Moeslein, FM, Putnam, SG, Rose, SC, Savin, MA, Schirm, S, Sharma, N & Wang, EA 2015, 'Hepatic imaging response to radioembolization with yttrium-90-labeled resin microspheres for tumor progression during systemic chemotherapy in patients with colorectal liver metastases', Journal of Gastrointestinal Oncology, vol. 6, no. 6, pp. 594-604. https://doi.org/10.3978/j.issn.2078-6891.2015.082
Feigenberg, SJ, Cohen, R, Sharma, N, Husain, Z, Chen, S & Dawson, LA 2015, Stereotactic body radiation therapy. in Principles and Practice of Stereotactic Radiosurgery. Springer New York, pp. 177-208. https://doi.org/10.1007/978-1-4614-8363-2_13

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)