Navigation Menu

Clinical Trial External Search


Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Sri-Rajasekhar Kothapalli, PhD

Sri-Rajasekhar Kothapalli, PhD

Associate Professor, Biomedical Engineering
Assistant Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
SZK416@psu.edu

Research Interests

View Details
  • Transducers
  • Light
  • Microscopy
  • Molecular Imaging
  • Equipment and Supplies
  • Optical Imaging
  • Ultrasonography
  • Tomography
  • Lasers
  • Acoustics
  • Optical Tomography
  • Ultrasonics
View Details

Recent Publications

View Details

2024

Khandare, SP, Huang, C, Kothapalli, SR & Tadigadapa, SA 2024, Performance of Aluminum Nitride Curved PMUT Arrays Fabricated Using Glass Blowing Technique. in IEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 198-201, 37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024, Austin, United States, 1/21/24. https://doi.org/10.1109/MEMS58180.2024.10439406

2023

Huang, C, Khandare, SP, Kothapalli, SR & Tadigadapa, S 2023, 'Characterization of Curved Piezoelectric Micromachined Ultrasound Transducers Fabricated by Chip-Scale Glass Blowing Technique', IEEE Sensors Letters, vol. 7, no. 10, 2503304. https://doi.org/10.1109/LSENS.2023.3308112
Mitra, M, Kumar, A, Khandare, S, Gaddale, P, Anandan, Y, Pedibhotla, S, Roy, K, Chen, H, Pratap, R & Kothapalli, SR 2024, 'Low-Cost Scalable PCB-Based 2-D Transducer Arrays for Volumetric Photoacoustic Imaging', IEEE Sensors Journal, vol. 24, no. 4, pp. 4380-4386. https://doi.org/10.1109/JSEN.2023.3344824
Lee, K, Davis, B, Wang, X, Mirg, S, Wen, C, Abune, L, Peterson, BE, Han, L, Chen, H, Wang, H, Szczesny, SE, Lei, Y, Kothapalli, SR & Wang, Y 2023, 'Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation', Angewandte Chemie - International Edition, vol. 62, no. 31, e202306583. https://doi.org/10.1002/anie.202306583
Jo, J, Salfi, E, Folz, J, Udager, AM, Keller, E, Kopelman, R, Kothapalli, SR, Xu, G & Wang, X 2023, 'Photoacoustic Spectral Analysis for Evaluating the Aggressiveness of Prostate Cancer Labeled by Methylene Blue Polyacrylamide Nanoparticles', Biosensors, vol. 13, no. 3, 403. https://doi.org/10.3390/bios13030403
Pashaei, V, Huan, J, Chen, H, Osman, MSEA, Kothapalli, SR, Majerus, SJA & Mandal, S 2023, Wearable Ultrasound Probe for Nerve Localization and Stimulation. in BioCAS 2023 - 2023 IEEE Biomedical Circuits and Systems Conference, Conference Proceedings. BioCAS 2023 - 2023 IEEE Biomedical Circuits and Systems Conference, Conference Proceedings, Institute of Electrical and Electronics Engineers Inc., 2023 IEEE Biomedical Circuits and Systems Conference, BioCAS 2023, Toronto, Canada, 10/19/23. https://doi.org/10.1109/BioCAS58349.2023.10388793

2022

Osman, M, Chen, H, Creamer, K, Minotto, J, Liu, J, Mirg, S, Christian, J, Bai, X, Agrawal, S & Kothapalli, SR 2022, 'A Novel Matching Layer Design for Improving the Performance of Transparent Ultrasound Transducers', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, pp. 1. https://doi.org/10.1109/TUFFC.2022.3195998
Chen, H, Agrawal, S, Osman, M, Minotto, J, Mirg, S, Liu, J, Dangi, A, Tran, Q, Jackson, T & Kothapalli, SR 2022, 'A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging', BME Frontiers, vol. 2022, 9871098. https://doi.org/10.34133/2022/9871098
Osman, M, Creamer, K, Chen, H, Minotto, J, Liu, J, Agrawal, S & Kothapalli, SR 2022, A novel translucent ultrasound transducer approach for dual-modality ultrasound and photoacosutic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119601A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610187
Chen, H, Zhu, N, Biskowitz, R, Liu, J, Deng, C, Wong, PK & Kothapalli, SR 2022, A transparent ultrasound on-chip platform enables high-throughput cell stimulation and simultaneous high-resolution optical imaging. in A Tarnok & JP Houston (eds), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX., 119640C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11964, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610058
Liu, J, Chen, H, Agrawal, S, Zhang, N, Gluckman, B & Kothapalli, SR 2022, An optimized geometry for simultaneous functional ultrasound and photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610443
Mirg, S, Chen, H, Turner, KL, Gheres, KW, Liu, J, Gluckman, BJ, Drew, PJ & Kothapalli, SR 2022, 'Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window', Optics Letters, vol. 47, no. 5, pp. 1121-1124. https://doi.org/10.1364/OL.450648
Cheng, C, Peters, T, Dangi, A, Agrawal, S, Chen, H, Kothapalli, SR & Trolier-McKinstry, S 2022, 'Improving PMUT Receive Sensitivity via DC Bias and Piezoelectric Composition', Sensors, vol. 22, no. 15, 5614. https://doi.org/10.3390/s22155614
Mirg, S, Chen, H, Khandare, S, Osman, M & Kothapalli, SR 2022, Noise considerations in piezoelectric transparent ultrasound transducers for photoacoustic imaging applications. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610342
Mirg, S, Turner, KL, Chen, H, Drew, PJ & Kothapalli, SR 2022, 'Photoacoustic imaging for microcirculation', Microcirculation, vol. 29, no. 6-7, e12776. https://doi.org/10.1111/micc.12776

2021

Chen, H, Mirg, S, Osman, M, Agrawal, S, Cai, J, Biskowitz, R, Minotto, J & Kothapalli, SR 2021, 'A High Sensitivity Transparent Ultrasound Transducer Based on PMN-PT for Ultrasound and Photoacoustic Imaging', IEEE Sensors Letters, vol. 5, no. 11. https://doi.org/10.1109/LSENS.2021.3122097
Chen, H, Zhu, N, Osman, M, Biskowitz, R, Liu, J, Khandare, S, Butler, P, Wong, PK & Kothapalli, SR 2021, 'A transparent low intensity pulsed ultrasound (LIPUS) chip for high-throughput cell stimulation', Lab on a Chip, vol. 21, no. 24, pp. 4734-4742. https://doi.org/10.1039/d1lc00667c
Lweesy, K, Fora, M, El-Khalil, H, Kothapalli, SR & Dangi, A 2021, 'Design and evaluation of a transrectal phased piezoelectric micromachined ultrasound transducer (pmut) array for thermal treatment of prostate cancer', Journal of Engineering Science and Technology, vol. 16, no. 2, pp. 1386-1401.
Liu, T, Dangi, A, Kim, JN, Kothapalli, SR, Choi, K, Trolier-Mckinstry, S & Jackson, T 2021, 'Flexible thin-film PZT ultrasonic transducers on polyimide substrates', Sensors (Switzerland), vol. 21, no. 3, 1014, pp. 1-9. https://doi.org/10.3390/s21031014
Agrawal, S, Johnstonbaugh, K, Suresh, T, Garikipati, A, Kuniyil Ajith Singh, M, Karri, SPK & Kothapalli, SR 2021, In vivo demonstration of reflection artifact reduction in LED-based photoacoustic imaging using deep learning. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2021., 116421K, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11642, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2579082
Agrawal, S, Gaddale, P, Karri, SPK & Kothapalli, SR 2021, 'Learning Optical Scattering through Symmetrical Orthogonality Enforced Independent Components for Unmixing Deep Tissue Photoacoustic Signals', IEEE Sensors Letters, vol. 5, no. 5, 9409614. https://doi.org/10.1109/LSENS.2021.3073927
Agrawal, S, Suresh, T, Garikipati, A, Dangi, A & Kothapalli, SR 2021, 'Modeling combined ultrasound and photoacoustic imaging: Simulations aiding device development and artificial intelligence', Photoacoustics, vol. 24, 100304. https://doi.org/10.1016/j.pacs.2021.100304
Agrawal, S, Singh, MKA, Johnstonbaugh, K, Han, DC, Pameijer, CR & Kothapalli, SR 2021, 'Photoacoustic imaging of human vasculature using LED versus laser illumination: A comparison study on tissue phantoms and in vivo humans', Sensors (Switzerland), vol. 21, no. 2, 424, pp. 1-18. https://doi.org/10.3390/s21020424
Yazdani, A, Agrawal, S, Johnstonbaugh, K, Kothapalli, SR & Monga, V 2021, 'Simultaneous Denoising and Localization Network for Photoacoustic Target Localization', IEEE transactions on medical imaging, vol. 40, no. 9, 9420752, pp. 2367-2379. https://doi.org/10.1109/TMI.2021.3077187
Chen, H, Osman, M, Mirg, S, Agrawal, S, Cai, J, Dangi, A & Kothapalli, SR 2021, Transparent ultrasound transducers for multiscale photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2021., 1164220, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11642, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2579056

2020

Johnstonbaugh, K, Agrawal, S, Durairaj, DA, Fadden, C, Dangi, A, Karri, SPK & Kothapalli, SR 2020, 'A Deep Learning Approach to Photoacoustic Wavefront Localization in Deep-Tissue Medium', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 12, 8951262, pp. 2649-2659. https://doi.org/10.1109/TUFFC.2020.2964698
Dangi, A, Cheng, CY, Agrawal, S, Tiwari, S, Datta, GR, Benoit, RR, Pratap, R, Trolier-Mckinstry, S & Kothapalli, SR 2020, 'A Photoacoustic Imaging Device Using Piezoelectric Micromachined Ultrasound Transducers (PMUTs)', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 4, 8915732, pp. 801-809. https://doi.org/10.1109/TUFFC.2019.2956463
Dangi, A, Roy, K, Agrawal, S, Chen, H, Ashok, A, Wible, C, Osman, M, Pratap, R & Kothapalli, SR 2020, A modular approach to neonatal whole-brain photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124057, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546854
Roy, K, Agrawal, S, Dangi, A, Liu, T, Chen, H, Jackson, TN, Pratap, R & Kothapalli, SR 2020, Body conformal linear ultrasound array for combined ultrasound and photoacoustic imaging. in IUS 2020 - International Ultrasonics Symposium, Proceedings., 9251458, IEEE International Ultrasonics Symposium, IUS, vol. 2020-September, IEEE Computer Society, 2020 IEEE International Ultrasonics Symposium, IUS 2020, Las Vegas, United States, 9/7/20. https://doi.org/10.1109/IUS46767.2020.9251458
Agrawal, S, Johnstonbaugh, K, Clark, JY, Raman, JD, Wang, X & Kothapalli, SR 2020, 'Design, development, and multi-characterization of an integrated clinical transrectal ultrasound and photoacoustic device for human prostate imaging', Diagnostics, vol. 10, no. 8, 566. https://doi.org/10.3390/diagnostics10080566
Agrawal, S & Kothapalli, SR 2020, Functional and Molecular Photoacoustic Computed Tomography Using Light Emitting Diodes. in Progress in Optical Science and Photonics. Progress in Optical Science and Photonics, vol. 7, Springer, pp. 267-302. https://doi.org/10.1007/978-981-15-3984-8_11
Agrawal, S, Singh, MKA, Yang, X, Albahrani, H, Dangi, A & Kothapalli, SR 2020, Functional, molecular and structural imaging using LED-based photoacoustic and ultrasound imaging system. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 112405A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2547048
Agrawal, S, Yang, X, Albahrani, H, Fadden, C, Dangi, A, Singh, MKA & Kothapalli, SR 2020, Low-cost photoacoustic computed tomography system using light-emitting-diodes. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124058, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546993
Agrawal, S, Singh, MKA, Yang, X, Albahrani, H, Dangi, A & Kothapalli, SR 2020, Photoacoustic imaging capabilities of light emitting diodes (LED) and laser sources: A comparison study. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124059, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2547012
Jo, J, Siddiqui, J, Zhu, Y, Ni, L, Kothapalli, SR, Tomlins, SA, Wei, JT, Keller, ET, Udager, AM, Wang, X & Xu, G 2020, 'Photoacoustic spectral analysis at ultraviolet wavelengths for characterizing the Gleason grades of prostate cancer', Optics Letters, vol. 45, no. 21, pp. 6042-6045. https://doi.org/10.1364/OL.409249
Cui, L, Vivona, S, Smith, BR, Kothapalli, SR, Liu, J, Ma, X, Chen, Z, Taylor, M, Kierstead, PH, Fréchet, JMJ, Gambhir, SS & Rao, J 2020, 'Reduction Triggered in Situ Polymerization in Living Mice', Journal of the American Chemical Society, vol. 142, no. 36, pp. 15575-15584. https://doi.org/10.1021/jacs.0c07594
Fadden, C, Thamburaj, K, Dias, M & Kothapalli, SR 2020, Thermoacoustic combined tomography of abusive head trauma. in BC Byram & NV Ruiter (eds), Medical Imaging 2020: Ultrasonic Imaging and Tomography., 1131903, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11319, SPIE, Medical Imaging 2020: Ultrasonic Imaging and Tomography, Houston, United States, 2/16/20. https://doi.org/10.1117/12.2549567
Dangi, A, Agrawal, S, Datta, GR, Srinivasan, V & Kothapalli, SR 2020, 'Towards a Low-Cost and Portable Photoacoustic Microscope for Point-of-Care and Wearable Applications', IEEE Sensors Journal, vol. 20, no. 13, 8801865, pp. 6881-6888. https://doi.org/10.1109/JSEN.2019.2935684
Durairaj, DA, Agrawal, S, Johnstonbaugh, K, Chen, H, Karri, SPK & Kothapalli, SR 2020, Unsupervised deep learning approach for photoacoustic spectral unmixing. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 112403H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546964
View Details