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Sri-Rajasekhar Kothapalli, PhD

Sri-Rajasekhar Kothapalli, PhD

Associate Professor, Biomedical Engineering
Assistant Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
SZK416@psu.edu

Research Interests

  • Transducers
  • Light
  • Microscopy
  • Molecular Imaging
  • Equipment and Supplies
  • Optical Imaging
  • Ultrasonography
  • Tomography
  • Lasers
  • Acoustics
  • Optical Tomography
  • Ultrasonics

Recent Publications

2023

Huang, C, Khandare, SP, Kothapalli, SR & Tadigadapa, S 2023, 'Characterization of Curved Piezoelectric Micromachined Ultrasound Transducers Fabricated by Chip-Scale Glass Blowing Technique', IEEE Sensors Letters, vol. 7, no. 10, 2503304. https://doi.org/10.1109/LSENS.2023.3308112
Mitra, M, Kumar, A, Khandare, S, Gaddale, P, Anandan, Y, Pedibhotla, S, Roy, K, Chen, H, Pratap, R & Kothapalli, SR 2023, 'Low-Cost Scalable PCB-Based 2D Transducer Arrays for Volumetric Photoacoustic Imaging', IEEE Sensors Journal, pp. 1. https://doi.org/10.1109/JSEN.2023.3344824
Lee, K, Davis, B, Wang, X, Mirg, S, Wen, C, Abune, L, Peterson, BE, Han, L, Chen, H, Wang, H, Szczesny, SE, Lei, Y, Kothapalli, SR & Wang, Y 2023, 'Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation', Angewandte Chemie - International Edition, vol. 62, no. 31, e202306583. https://doi.org/10.1002/anie.202306583
Jo, J, Salfi, E, Folz, J, Udager, AM, Keller, E, Kopelman, R, Kothapalli, SR, Xu, G & Wang, X 2023, 'Photoacoustic Spectral Analysis for Evaluating the Aggressiveness of Prostate Cancer Labeled by Methylene Blue Polyacrylamide Nanoparticles', Biosensors, vol. 13, no. 3, 403. https://doi.org/10.3390/bios13030403

2022

Osman, M, Chen, H, Creamer, K, Minotto, J, Liu, J, Mirg, S, Christian, J, Bai, X, Agrawal, S & Kothapalli, SR 2022, 'A Novel Matching Layer Design for Improving the Performance of Transparent Ultrasound Transducers', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, pp. 1. https://doi.org/10.1109/TUFFC.2022.3195998
Chen, H, Agrawal, S, Osman, M, Minotto, J, Mirg, S, Liu, J, Dangi, A, Tran, Q, Jackson, T & Kothapalli, SR 2022, 'A Transparent Ultrasound Array for Real-Time Optical, Ultrasound, and Photoacoustic Imaging', BME Frontiers, vol. 2022, 9871098. https://doi.org/10.34133/2022/9871098
Osman, M, Creamer, K, Chen, H, Minotto, J, Liu, J, Agrawal, S & Kothapalli, SR 2022, A novel translucent ultrasound transducer approach for dual-modality ultrasound and photoacosutic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119601A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610187
Chen, H, Zhu, N, Biskowitz, R, Liu, J, Deng, C, Wong, PK & Kothapalli, SR 2022, A transparent ultrasound on-chip platform enables high-throughput cell stimulation and simultaneous high-resolution optical imaging. in A Tarnok & JP Houston (eds), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX., 119640C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11964, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610058
Liu, J, Chen, H, Agrawal, S, Zhang, N, Gluckman, B & Kothapalli, SR 2022, An optimized geometry for simultaneous functional ultrasound and photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610443
Mirg, S, Chen, H, Turner, KL, Gheres, KW, Liu, J, Gluckman, BJ, Drew, PJ & Kothapalli, SR 2022, 'Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window', Optics Letters, vol. 47, no. 5, pp. 1121-1124. https://doi.org/10.1364/OL.450648
Cheng, C, Peters, T, Dangi, A, Agrawal, S, Chen, H, Kothapalli, SR & Trolier-McKinstry, S 2022, 'Improving PMUT Receive Sensitivity via DC Bias and Piezoelectric Composition', Sensors, vol. 22, no. 15, 5614. https://doi.org/10.3390/s22155614
Mirg, S, Chen, H, Khandare, S, Osman, M & Kothapalli, SR 2022, Noise considerations in piezoelectric transparent ultrasound transducers for photoacoustic imaging applications. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2022., 119600S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11960, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2022, Virtual, Online, 2/20/22. https://doi.org/10.1117/12.2610342
Mirg, S, Turner, KL, Chen, H, Drew, PJ & Kothapalli, SR 2022, 'Photoacoustic imaging for microcirculation', Microcirculation, vol. 29, no. 6-7, e12776. https://doi.org/10.1111/micc.12776

2021

Chen, H, Mirg, S, Osman, M, Agrawal, S, Cai, J, Biskowitz, R, Minotto, J & Kothapalli, SR 2021, 'A High Sensitivity Transparent Ultrasound Transducer Based on PMN-PT for Ultrasound and Photoacoustic Imaging', IEEE Sensors Letters, vol. 5, no. 11. https://doi.org/10.1109/LSENS.2021.3122097
Chen, H, Zhu, N, Osman, M, Biskowitz, R, Liu, J, Khandare, S, Butler, P, Wong, PK & Kothapalli, SR 2021, 'A transparent low intensity pulsed ultrasound (LIPUS) chip for high-throughput cell stimulation', Lab on a Chip, vol. 21, no. 24, pp. 4734-4742. https://doi.org/10.1039/d1lc00667c
Lweesy, K, Fora, M, El-Khalil, H, Kothapalli, SR & Dangi, A 2021, 'Design and evaluation of a transrectal phased piezoelectric micromachined ultrasound transducer (pmut) array for thermal treatment of prostate cancer', Journal of Engineering Science and Technology, vol. 16, no. 2, pp. 1386-1401.
Liu, T, Dangi, A, Kim, JN, Kothapalli, SR, Choi, K, Trolier-Mckinstry, S & Jackson, T 2021, 'Flexible thin-film PZT ultrasonic transducers on polyimide substrates', Sensors (Switzerland), vol. 21, no. 3, 1014, pp. 1-9. https://doi.org/10.3390/s21031014
Agrawal, S, Johnstonbaugh, K, Suresh, T, Garikipati, A, Kuniyil Ajith Singh, M, Karri, SPK & Kothapalli, SR 2021, In vivo demonstration of reflection artifact reduction in LED-based photoacoustic imaging using deep learning. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2021., 116421K, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11642, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2579082
Agrawal, S, Gaddale, P, Karri, SPK & Kothapalli, SR 2021, 'Learning Optical Scattering through Symmetrical Orthogonality Enforced Independent Components for Unmixing Deep Tissue Photoacoustic Signals', IEEE Sensors Letters, vol. 5, no. 5, 9409614. https://doi.org/10.1109/LSENS.2021.3073927
Agrawal, S, Suresh, T, Garikipati, A, Dangi, A & Kothapalli, SR 2021, 'Modeling combined ultrasound and photoacoustic imaging: Simulations aiding device development and artificial intelligence', Photoacoustics, vol. 24, 100304. https://doi.org/10.1016/j.pacs.2021.100304
Agrawal, S, Singh, MKA, Johnstonbaugh, K, Han, DC, Pameijer, CR & Kothapalli, SR 2021, 'Photoacoustic imaging of human vasculature using LED versus laser illumination: A comparison study on tissue phantoms and in vivo humans', Sensors (Switzerland), vol. 21, no. 2, 424, pp. 1-18. https://doi.org/10.3390/s21020424
Yazdani, A, Agrawal, S, Johnstonbaugh, K, Kothapalli, SR & Monga, V 2021, 'Simultaneous Denoising and Localization Network for Photoacoustic Target Localization', IEEE transactions on medical imaging, vol. 40, no. 9, 9420752, pp. 2367-2379. https://doi.org/10.1109/TMI.2021.3077187
Chen, H, Osman, M, Mirg, S, Agrawal, S, Cai, J, Dangi, A & Kothapalli, SR 2021, Transparent ultrasound transducers for multiscale photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2021., 1164220, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11642, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2021, Virtual, Online, United States, 3/6/21. https://doi.org/10.1117/12.2579056

2020

Johnstonbaugh, K, Agrawal, S, Durairaj, DA, Fadden, C, Dangi, A, Karri, SPK & Kothapalli, SR 2020, 'A Deep Learning Approach to Photoacoustic Wavefront Localization in Deep-Tissue Medium', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 12, 8951262, pp. 2649-2659. https://doi.org/10.1109/TUFFC.2020.2964698
Dangi, A, Cheng, CY, Agrawal, S, Tiwari, S, Datta, GR, Benoit, RR, Pratap, R, Trolier-Mckinstry, S & Kothapalli, SR 2020, 'A Photoacoustic Imaging Device Using Piezoelectric Micromachined Ultrasound Transducers (PMUTs)', IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 67, no. 4, 8915732, pp. 801-809. https://doi.org/10.1109/TUFFC.2019.2956463
Dangi, A, Roy, K, Agrawal, S, Chen, H, Ashok, A, Wible, C, Osman, M, Pratap, R & Kothapalli, SR 2020, A modular approach to neonatal whole-brain photoacoustic imaging. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124057, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546854
Roy, K, Agrawal, S, Dangi, A, Liu, T, Chen, H, Jackson, TN, Pratap, R & Kothapalli, SR 2020, Body conformal linear ultrasound array for combined ultrasound and photoacoustic imaging. in IUS 2020 - International Ultrasonics Symposium, Proceedings., 9251458, IEEE International Ultrasonics Symposium, IUS, vol. 2020-September, IEEE Computer Society, 2020 IEEE International Ultrasonics Symposium, IUS 2020, Las Vegas, United States, 9/7/20. https://doi.org/10.1109/IUS46767.2020.9251458
Agrawal, S, Johnstonbaugh, K, Clark, JY, Raman, JD, Wang, X & Kothapalli, SR 2020, 'Design, development, and multi-characterization of an integrated clinical transrectal ultrasound and photoacoustic device for human prostate imaging', Diagnostics, vol. 10, no. 8, 566. https://doi.org/10.3390/diagnostics10080566
Agrawal, S & Kothapalli, SR 2020, Functional and Molecular Photoacoustic Computed Tomography Using Light Emitting Diodes. in Progress in Optical Science and Photonics. Progress in Optical Science and Photonics, vol. 7, Springer, pp. 267-302. https://doi.org/10.1007/978-981-15-3984-8_11
Agrawal, S, Singh, MKA, Yang, X, Albahrani, H, Dangi, A & Kothapalli, SR 2020, Functional, molecular and structural imaging using LED-based photoacoustic and ultrasound imaging system. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 112405A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2547048
Agrawal, S, Yang, X, Albahrani, H, Fadden, C, Dangi, A, Singh, MKA & Kothapalli, SR 2020, Low-cost photoacoustic computed tomography system using light-emitting-diodes. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124058, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546993
Agrawal, S, Singh, MKA, Yang, X, Albahrani, H, Dangi, A & Kothapalli, SR 2020, Photoacoustic imaging capabilities of light emitting diodes (LED) and laser sources: A comparison study. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 1124059, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2547012
Jo, J, Siddiqui, J, Zhu, Y, Ni, L, Kothapalli, SR, Tomlins, SA, Wei, JT, Keller, ET, Udager, AM, Wang, X & Xu, G 2020, 'Photoacoustic spectral analysis at ultraviolet wavelengths for characterizing the Gleason grades of prostate cancer', Optics Letters, vol. 45, no. 21, pp. 6042-6045. https://doi.org/10.1364/OL.409249
Cui, L, Vivona, S, Smith, BR, Kothapalli, SR, Liu, J, Ma, X, Chen, Z, Taylor, M, Kierstead, PH, Fréchet, JMJ, Gambhir, SS & Rao, J 2020, 'Reduction Triggered in Situ Polymerization in Living Mice', Journal of the American Chemical Society, vol. 142, no. 36, pp. 15575-15584. https://doi.org/10.1021/jacs.0c07594
Fadden, C, Thamburaj, K, Dias, M & Kothapalli, SR 2020, Thermoacoustic combined tomography of abusive head trauma. in BC Byram & NV Ruiter (eds), Medical Imaging 2020: Ultrasonic Imaging and Tomography., 1131903, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11319, SPIE, Medical Imaging 2020: Ultrasonic Imaging and Tomography, Houston, United States, 2/16/20. https://doi.org/10.1117/12.2549567
Dangi, A, Agrawal, S, Datta, GR, Srinivasan, V & Kothapalli, SR 2020, 'Towards a Low-Cost and Portable Photoacoustic Microscope for Point-of-Care and Wearable Applications', IEEE Sensors Journal, vol. 20, no. 13, 8801865, pp. 6881-6888. https://doi.org/10.1109/JSEN.2019.2935684
Durairaj, DA, Agrawal, S, Johnstonbaugh, K, Chen, H, Karri, SPK & Kothapalli, SR 2020, Unsupervised deep learning approach for photoacoustic spectral unmixing. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2020., 112403H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11240, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2020, San Francisco, United States, 2/2/20. https://doi.org/10.1117/12.2546964