Researcher Profile

Researcher Profile

Michael Glantz, MD, PhD

Michael Glantz, MD, PhD

Professor, Department of Neurosurgery
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Brain and Central Nervous System Cancer
mjg37@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Cerebrospinal Fluid
  • Brain Neoplasms
  • Drug Therapy
  • Glioma
  • Radiotherapy
  • Survival
  • Meningitis
  • Glioblastoma
  • Brain
  • Neoplasm Metastasis

Clinical Trials

Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete Responders
Molecular Genetic, Host-Derived and Clinical Determinants of Long-Term Survival in Glioblastoma
A biospecimen collection study to evaluate the pharmacokinetic,pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1
Risk Factors for CIPN Following an Oxaliplatin-Containing Chemotherapy Regimen in Colorectal Cancer Patients

Recent Publications

2022

Hallan, DR, Nguyen, AM, Liang, M, McNutt, S, Goss, M, Bell, E, Natarajan, S, Nichol, A, Messner, C, Bracken, E & Glantz, M 2022, 'Charting the course from abstract to published article', Journal of neurosurgery, vol. 136, no. 6, pp. 1773-1780. https://doi.org/10.3171/2021.7.JNS2128

2021

Halper-Stromberg, E, McCall, CM, Haley, LM, Lin, MT, Vogt, S, Gocke, CD, Eshleman, JR, Stevens, W, Martinson, NA, Epeldegui, M, Holdhoff, M, Bettegowda, C, Glantz, MJ, Ambinder, RF & Xian, RR 2021, 'CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies', Clinical chemistry, vol. 67, no. 11, pp. 1524-1533. https://doi.org/10.1093/clinchem/hvab141
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765. https://doi.org/10.3389/fonc.2021.739765
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102. https://doi.org/10.1016/j.wneu.2021.10.113
Schreck, KC, Morin, A, Zhao, G, Allen, AN, Flannery, P, Glantz, M, Green, AL, Jones, C, Jones, KL, Kilburn, LB, Nazemi, KJ, Samuel, D, Sanford, B, Solomon, DA, Wang, J, Pratilas, CA, Nicolaides, T & Levy, JMM 2021, 'Deconvoluting mechanisms of acquired resistance to RAF inhibitors in BRAFV600E-Mutant Human Glioma', Clinical Cancer Research, vol. 27, no. 22, pp. 6197-6208. https://doi.org/10.1158/1078-0432.CCR-21-2660

2020

Bernstein, A, Mrowczynski, OD, Greene, A, Ryan, S, Chung, C, Zacharia, BE & Glantz, M 2020, 'Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: A case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity', Journal of neurosurgery, vol. 133, no. 6, pp. 1704-1709. https://doi.org/10.3171/2019.8.JNS19643
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424. https://doi.org/10.1038/s41467-020-19193-y
Glantz, M & Brandmeir, N 2020, 'When can we be positive about p values?', Journal of neurosurgery, vol. 132, no. 2, pp. 656-661. https://doi.org/10.3171/2018.10.JNS182494

2019

Wen, PY, Reardon, DA, Armstrong, TS, Phuphanich, S, Aiken, RD, Landolfi, JC, Curry, WT, Zhu, JJ, Glantz, M, Peereboom, DM, Markert, JM, LaRocca, R, O'Rourke, DM, Fink, K, Kim, L, Gruber, M, Lesser, GJ, Pan, E, Kesari, S, Muzikansky, A, Pinilla, C, Santos, RG & Yu, JS 2019, 'A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma', Clinical Cancer Research, vol. 25, no. 19, pp. 5799-5807. https://doi.org/10.1158/1078-0432.CCR-19-0261
Boire, A, Brandsma, D, Brastianos, PK, Le Rhun, E, Ahluwalia, M, Junck, L, Glantz, M, Groves, MD, Lee, EQ, Lin, N, Raizer, J, RudĂ , R, Weller, M, Van Den Bent, MJ, Vogelbaum, MA, Chang, S, Wen, PY & Soffietti, R 2019, 'Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications', Neuro-oncology, vol. 21, no. 5, pp. 571-583. https://doi.org/10.1093/neuonc/noz012
Brown, TJ, Bota, DA, Van Den Bent, MJ, Brown, PD, Maher, E, Aregawi, D, Liau, LM, Buckner, JC, Weller, M, Berger, MS & Glantz, M 2019, 'Management of low-grade glioma: A systematic review and meta-Analysis', Neuro-Oncology Practice, vol. 6, no. 4, npy034, pp. 249-258. https://doi.org/10.1093/nop/npy034

2018

Sieg, EP, Schlauderaff, AC, Payne, RA, Glantz, MJ & Simon, SD 2018, 'Impact of an External Ventricular Drain Placement and Handling Protocol on Infection Rates: A Meta-Analysis and Single Institution Experience', World neurosurgery, vol. 115, pp. e53-e58. https://doi.org/10.1016/j.wneu.2018.03.160
Brennan, M, Brown, T, Koller, K, Vasekar, M, Cygan, P, Ali, A, Sivik, J & Glantz, M 2018, 'Target wise and pound foolish: A simple technique to evaluate the trade-off between clinical benefit and economic burden of monoclonal antibodies', Journal of Cancer Policy, vol. 18, pp. 11-19. https://doi.org/10.1016/j.jcpo.2018.10.002
Zoccoli, C, Li, CF, Black, D, Smith, DB, Sheehan, J, Harbaugh, RE & Glantz, M 2019, 'The Honest Palm Sign: Detecting Incomplete Effort on Physical Examination', World neurosurgery, vol. 122, pp. e1354-e1358. https://doi.org/10.1016/j.wneu.2018.11.047

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)