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Michael Glantz, MD, PhD

Michael Glantz, MD, PhD

Professor, Department of Neurosurgery
Professor, Department of Medicine
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team

Research Interests

  • Neoplasms
  • Therapeutics
  • Cerebrospinal Fluid
  • Drug Therapy
  • Brain Neoplasms
  • Glioblastoma
  • Survival
  • Glioma
  • Radiotherapy
  • Meningitis
  • Brain
  • Neoplasm Metastasis

Clinical Trials

A biospecimen collection study to evaluate the pharmacokinetic,pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
Molecular Genetic, Host-Derived and Clinical Determinants of Long-Term Survival in Glioblastoma
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)

Recent Publications


Cioffi, G, Waite, KA, Dmukauskas, M, Glantz, M, Aulakh, S, Nicolaides, T, Sengupta, S, Xiu, J & Barnholtz-Sloan, JS 2024, 'Sex differences in glioblastoma response to treatment: Impact of MGMT methylation', Neuro-Oncology Advances, vol. 6, no. 1, vdae031.


Johnson, M, Bell, A, Lauing, KL, Ladomersky, E, Zhai, L, Penco-Campillo, M, Shah, Y, Mauer, E, Xiu, J, Nicolaides, T, Drumm, M, McCortney, K, Elemento, O, Kim, M, Bommi, P, Low, JT, Memon, R, Wu, J, Zhao, J, Mi, X, Glantz, MJ, Sengupta, S, Castro, B, Yamini, B, Horbinski, C, Baker, DJ, Walunas, TL, Schiltz, GE, Lukas, RV & Wainwright, DA 2023, 'Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence', Clinical Cancer Research, vol. 29, no. 23, pp. 4973-4989.
Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025.
Darabi, S, Xiu, J, Samec, T, Kesari, S, Carrillo, J, Aulakh, S, Walsh, KM, Sengupta, S, Sumrall, A, Spetzler, D, Glantz, M & Demeure, MJ 2023, 'Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target', Medical Oncology, vol. 40, no. 7, 197.
Zuccato, JA, Patil, V, Mansouri, S, Voisin, M, Chakravarthy, A, Yi Shen, S, Nassiri, F, Mikolajewicz, N, Trifoi, M, Skakodub, A, Zacharia, B, Glantz, M, De Carvalho, DD, Mansouri, A & Zadeh, G 2023, 'Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification', Neuro-oncology, vol. 25, no. 8, pp. 1452-1460.
Agrawal, P, David, KA, Chen, Z, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Gandhi, MK, Keane, C, Bond, DA, Folstad, M, Chang, J, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Matnani, R, Kumar, P, Ollila, TA, Cai, J, Spurgeon, SE, Sieg, AG, Cleveland, J, Epperla, N, Karmali, R, Naik, S, Smith, SM, Rubenstein, JL, Kahl, BS, Chadburn, A, Evens, AM & Martin, P 2023, 'EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort', Leukemia and Lymphoma, vol. 64, no. 5, pp. 1026-1034.
Hertler, C, Felsberg, J, Gramatzki, D, Le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, AF, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, DA, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, AF, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, CA, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, PY, Reifenberger, G & Weller, M 2023, 'Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)', European Journal of Cancer, vol. 189, 112913.
David, KA, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Bond, DA, Agrawal, P, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Folstad, M, Kumar, P, Ollila, TA, Cai, J, Spurgeon, S, Sieg, A, Cleveland, J, Chang, J, Epperla, N, Karmali, R, Naik, S, Martin, P, Smith, SM, Rubenstein, J, Kahl, B & Evens, AM 2023, 'Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers', American Journal of Hematology, vol. 98, no. 6, pp. 900-912.
Douville, C, Curtis, S, Summers, M, Azad, TD, Rincon-Torroella, J, Wang, Y, Mattox, A, Avigdor, B, Dudley, J, Materi, J, Raj, D, Nair, S, Bhanja, D, Tuohy, K, Dobbyn, L, Popoli, M, Ptak, J, Nehme, N, Silliman, N, Blair, C, Judge, K, Gallia, GL, Groves, M, Jackson, CM, Jackson, EM, Laterra, J, Lim, M, Mukherjee, D, Weingart, J, Naidoo, J, Koschmann, C, Smith, N, Schreck, KC, Pardo, CA, Glantz, M, Holdhoff, M, Kinzler, KW, Papadopoulos, N, Vogelstein, B & Bettegowda, C 2023, 'Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid', Cell Reports Medicine, vol. 4, no. 8, 101148.


Hallan, DR, Nguyen, AM, Liang, M, McNutt, S, Goss, M, Bell, E, Natarajan, S, Nichol, A, Messner, C, Bracken, E & Glantz, M 2022, 'Charting the course from abstract to published article', Journal of neurosurgery, vol. 136, no. 6, pp. 1773-1780.
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, A 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161.
Le Rhun, E, Devos, P, Winklhofer, S, Lmalem, H, Brandsma, D, Kumthekar, P, Castellano, A, Compter, A, Dhermain, F, Franceschi, E, Forsyth, P, Furtner, J, Galldiks, N, Pérez-Larraya, JG, Gempt, J, Hattingen, E, Hempel, JM, Lukacova, S, Minniti, G, O’Brien, B, Postma, TJ, Roth, P, Rudà, R, Schaefer, N, Schmidt, NO, Snijders, TJ, Thust, S, van den Bent, M, van der Hoorn, A, Vogin, G, Smits, M, Tonn, JC, Jaeckle, KA, Preusser, M, Glantz, M, Wen, PY, Bendszus, M & Weller, M 2022, 'Prospective validation of a new imaging scorecard to p g j and RANO effort', Neuro-oncology, vol. 24, no. 10, pp. 1726-1735.
Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649.


Halper-Stromberg, E, McCall, CM, Haley, LM, Lin, MT, Vogt, S, Gocke, CD, Eshleman, JR, Stevens, W, Martinson, NA, Epeldegui, M, Holdhoff, M, Bettegowda, C, Glantz, MJ, Ambinder, RF & Xian, RR 2021, 'CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies', Clinical chemistry, vol. 67, no. 11, pp. 1524-1533.
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765.
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102.
Schreck, KC, Morin, A, Zhao, G, Allen, AN, Flannery, P, Glantz, M, Green, AL, Jones, C, Jones, KL, Kilburn, LB, Nazemi, KJ, Samuel, D, Sanford, B, Solomon, DA, Wang, J, Pratilas, CA, Nicolaides, T & Levy, JMM 2021, 'Deconvoluting mechanisms of acquired resistance to RAF inhibitors in BRAFV600E-Mutant Human Glioma', Clinical Cancer Research, vol. 27, no. 22, pp. 6197-6208.
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492.


Bernstein, A, Mrowczynski, OD, Greene, A, Ryan, S, Chung, C, Zacharia, BE & Glantz, M 2020, 'Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: A case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity', Journal of neurosurgery, vol. 133, no. 6, pp. 1704-1709.
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424.
Glantz, M & Brandmeir, N 2020, 'When can we be positive about p values?', Journal of neurosurgery, vol. 132, no. 2, pp. 656-661.