Michael Glantz, MD, PhD - Penn State Cancer Institute
Researcher Profile
Michael Glantz, MD, PhD
Professor, Department of Neurosurgery
Professor, Department of Medicine
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Research Interests
- Neoplasms
- Therapeutics
- Cerebrospinal Fluid
- Drug Therapy
- Brain Neoplasms
- Glioblastoma
- Survival
- Glioma
- Radiotherapy
- Meningitis
- Brain
- Neoplasm Metastasis
Clinical Trials
A biospecimen collection study to evaluate the pharmacokinetic,pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1
Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
Molecular Genetic, Host-Derived and Clinical Determinants of Long-Term Survival in Glioblastoma
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete Responders
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)
Recent Publications
2023
Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025. https://doi.org/10.1016/j.xcrm.2023.101025
Darabi, S, Xiu, J, Samec, T, Kesari, S, Carrillo, J, Aulakh, S, Walsh, KM, Sengupta, S, Sumrall, A, Spetzler, D, Glantz, M & Demeure, MJ 2023, 'Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target', Medical Oncology, vol. 40, no. 7, 197. https://doi.org/10.1007/s12032-023-02071-0
Agrawal, P, David, KA, Chen, Z, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Gandhi, MK, Keane, C, Bond, DA, Folstad, M, Chang, J, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Matnani, R, Kumar, P, Ollila, TA, Cai, J, Spurgeon, SE, Sieg, AG, Cleveland, J, Epperla, N, Karmali, R, Naik, S, Smith, SM, Rubenstein, JL, Kahl, BS, Chadburn, A, Evens, AM & Martin, P 2023, 'EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort', Leukemia and Lymphoma, vol. 64, no. 5, pp. 1026-1034. https://doi.org/10.1080/10428194.2023.2191152
David, KA, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Bond, DA, Agrawal, P, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Folstad, M, Kumar, P, Ollila, TA, Cai, J, Spurgeon, S, Sieg, A, Cleveland, J, Chang, J, Epperla, N, Karmali, R, Naik, S, Martin, P, Smith, SM, Rubenstein, J, Kahl, B & Evens, AM 2023, 'Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers', American Journal of Hematology. https://doi.org/10.1002/ajh.26919
2022
Hallan, DR, Nguyen, AM, Liang, M, McNutt, S, Goss, M, Bell, E, Natarajan, S, Nichol, A, Messner, C, Bracken, E & Glantz, M 2022, 'Charting the course from abstract to published article', Journal of neurosurgery, vol. 136, no. 6, pp. 1773-1780. https://doi.org/10.3171/2021.7.JNS2128
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, A 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161. https://doi.org/10.1093/noajnl/vdac161
Le Rhun, E, Devos, P, Winklhofer, S, Lmalem, H, Brandsma, D, Kumthekar, P, Castellano, A, Compter, A, Dhermain, F, Franceschi, E, Forsyth, P, Furtner, J, Galldiks, N, Pérez-Larraya, JG, Gempt, J, Hattingen, E, Hempel, JM, Lukacova, S, Minniti, G, O’Brien, B, Postma, TJ, Roth, P, Rudà, R, Schaefer, N, Schmidt, NO, Snijders, TJ, Thust, S, van den Bent, M, van der Hoorn, A, Vogin, G, Smits, M, Tonn, JC, Jaeckle, KA, Preusser, M, Glantz, M, Wen, PY, Bendszus, M & Weller, M 2022, 'Prospective validation of a new imaging scorecard to p g j and RANO effort', Neuro-oncology, vol. 24, no. 10, pp. 1726-1735. https://doi.org/10.1093/neuonc/noac043
Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649. https://doi.org/10.3389/fonc.2022.993649
2021
Halper-Stromberg, E, McCall, CM, Haley, LM, Lin, MT, Vogt, S, Gocke, CD, Eshleman, JR, Stevens, W, Martinson, NA, Epeldegui, M, Holdhoff, M, Bettegowda, C, Glantz, MJ, Ambinder, RF & Xian, RR 2021, 'CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid Malignancies', Clinical chemistry, vol. 67, no. 11, pp. 1524-1533. https://doi.org/10.1093/clinchem/hvab141
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765. https://doi.org/10.3389/fonc.2021.739765
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102. https://doi.org/10.1016/j.wneu.2021.10.113
Schreck, KC, Morin, A, Zhao, G, Allen, AN, Flannery, P, Glantz, M, Green, AL, Jones, C, Jones, KL, Kilburn, LB, Nazemi, KJ, Samuel, D, Sanford, B, Solomon, DA, Wang, J, Pratilas, CA, Nicolaides, T & Levy, JMM 2021, 'Deconvoluting mechanisms of acquired resistance to RAF inhibitors in BRAFV600E-Mutant Human Glioma', Clinical Cancer Research, vol. 27, no. 22, pp. 6197-6208. https://doi.org/10.1158/1078-0432.CCR-21-2660
2020
Bernstein, A, Mrowczynski, OD, Greene, A, Ryan, S, Chung, C, Zacharia, BE & Glantz, M 2020, 'Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: A case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity', Journal of neurosurgery, vol. 133, no. 6, pp. 1704-1709. https://doi.org/10.3171/2019.8.JNS19643
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424. https://doi.org/10.1038/s41467-020-19193-y
Glantz, M & Brandmeir, N 2020, 'When can we be positive about p values?', Journal of neurosurgery, vol. 132, no. 2, pp. 656-661. https://doi.org/10.3171/2018.10.JNS182494
2019
Wen, PY, Reardon, DA, Armstrong, TS, Phuphanich, S, Aiken, RD, Landolfi, JC, Curry, WT, Zhu, JJ, Glantz, M, Peereboom, DM, Markert, JM, LaRocca, R, O'Rourke, DM, Fink, K, Kim, L, Gruber, M, Lesser, GJ, Pan, E, Kesari, S, Muzikansky, A, Pinilla, C, Santos, RG & Yu, JS 2019, 'A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma', Clinical Cancer Research, vol. 25, no. 19, pp. 5799-5807. https://doi.org/10.1158/1078-0432.CCR-19-0261
Boire, A, Brandsma, D, Brastianos, PK, Le Rhun, E, Ahluwalia, M, Junck, L, Glantz, M, Groves, MD, Lee, EQ, Lin, N, Raizer, J, Rudà, R, Weller, M, Van Den Bent, MJ, Vogelbaum, MA, Chang, S, Wen, PY & Soffietti, R 2019, 'Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications', Neuro-oncology, vol. 21, no. 5, pp. 571-583. https://doi.org/10.1093/neuonc/noz012
Brown, TJ, Bota, DA, Van Den Bent, MJ, Brown, PD, Maher, E, Aregawi, D, Liau, LM, Buckner, JC, Weller, M, Berger, MS & Glantz, M 2019, 'Management of low-grade glioma: A systematic review and meta-Analysis', Neuro-Oncology Practice, vol. 6, no. 4, npy034, pp. 249-258. https://doi.org/10.1093/nop/npy034