Researcher Profile

Researcher Profile

Michael Glantz, MD, PhD

Michael Glantz, MD, PhD

Professor, Department of Neurosurgery
Professor, Department of Medicine
Disease Teams:
Central Nervous System Cancer
mjg37@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Cerebrospinal Fluid
  • Brain Neoplasms
  • Meningitis
  • Drug Therapy
  • Radiotherapy
  • Glioblastoma
  • Brain
  • Survival
  • Neoplasm Metastasis
  • Glioma

Clinical Trials

NeMeRe, a Multi-Institutional Retrospective and Prospective Registry of Neoplastic Meningitis in Adults
Maintenance Obinutuzumab for primary central nervous system lymphoma complete responders
A Phase 1b/2 study to assess the safety, tolerability and efficacy of BGB-290 in combination with radiation therapy and/or temozolomide in subjects with first-line or recurrent/refractory glioblastoma
Molecular Genetic, Host-Derived and Clinical Determinants of Long-Term Survival in Glioblastoma
A biospecimen collection study to evaluate the pharmacokinetic,pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
Risk Factors for CIPN Following an Oxaliplatin-Containing Chemotherapy Regimen in Colorectal Cancer Patients
A Multicenter Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor in Patients With Newly Diagnosed or Recurrent Malignant Gliomas: A Safety, Histopathology, and Correlative Biomarker Study

Recent Publications

2019

Boire, A, Brandsma, D, Brastianos, PK, Le Rhun, E, Ahluwalia, M, Junck, L, Glantz, M, Groves, MD, Lee, EQ, Lin, N, Raizer, J, Rudà, R, Weller, M, Van Den Bent, MJ, Vogelbaum, MA, Chang, S, Wen, PY & Soffietti, R 2019, 'Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications', Neuro-oncology, vol. 21, no. 5, pp. 571-583. https://doi.org/10.1093/neuonc/noz012

2018

Sieg, EP, Schlauderaff, AC, Payne, RA, Glantz, M & Simon, S 2018, 'Impact of an External Ventricular Drain Placement and Handling Protocol on Infection Rates: A Meta-Analysis and Single Institution Experience' World neurosurgery, vol. 115, pp. e53-e58. https://doi.org/10.1016/j.wneu.2018.03.160
Brennan, M, Brown, T, Koller, K, Vasekar, M, Cygan, P, Ali, A, Sivik, J & Glantz, M 2018, 'Target wise and pound foolish: A simple technique to evaluate the trade-off between clinical benefit and economic burden of monoclonal antibodies', Journal of Cancer Policy, vol. 18, pp. 11-19. https://doi.org/10.1016/j.jcpo.2018.10.002
Zoccoli, C, Li, CF, Black, D, Smith, DB, Sheehan, J, Harbaugh, R & Glantz, M 2019, 'The Honest Palm Sign: Detecting Incomplete Effort on Physical Examination' World neurosurgery, vol. 122, pp. e1354-e1358. https://doi.org/10.1016/j.wneu.2018.11.047

2017

Baum, GR, Hooten, KG, Lockney, DT, Fargen, KM, Turan, N, Pradilla, G, Murad, GJA, Harbaugh, R & Glantz, M 2017, 'External ventricular drain practice variations: Results from a nationwide survey', Journal of neurosurgery, vol. 127, no. 5, pp. 1190-1197. https://doi.org/10.3171/2016.9.JNS16367
Madhankumar, A, Mrowczynski, OD, Patel, SR, Weston, CL, Zacharia, B, Glantz, M, Siedlecki, C, Xu, L & Connor, J 2017, 'Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles', Acta Biomaterialia, vol. 58, pp. 205-213. https://doi.org/10.1016/j.actbio.2017.06.002
Church, EW, Gundersen, A, Glantz, M & Simon, S 2017, 'Number needed to treat for stroke thrombectomy based on a systematic review and meta-analysis' Clinical Neurology and Neurosurgery, vol. 156, pp. 83-88. https://doi.org/10.1016/j.clineuro.2017.03.005
Payne, R, Nasralah, Z, Sieg, E, Rizk, E, Glantz, M & Harbaugh, K 2017, 'The angular course of the median nerve in the distal forearm and its anatomical importance in preventing nerve injury in a modern era of carpal tunnel release', Journal of Neurosurgery, vol. 126, no. 3, pp. 979-984. https://doi.org/10.3171/2016.4.JNS152672

2016

Baker, M, Goldstein, AM, Gordon, P, Harbaugh, K, Mackley, H, Glantz, M & Drabick, J 2016, 'An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies', Journal of medical genetics, vol. 53, no. 11, pp. 721-727. https://doi.org/10.1136/jmedgenet-2015-103446
Brown, TJ, Brennan, MC, Li, M, Church, EW, Brandmeir, NJ, Rakszawski, KL, Patel, AS, Rizk, E, Suki, D, Sawaya, R & Glantz, M 2016, 'Association of the extent of resection with survival in glioblastoma a systematic review and meta-Analysis', JAMA Oncology, vol. 2, no. 11, pp. 1460-1469. https://doi.org/10.1001/jamaoncol.2016.1373
Korfel, A, Nowosielski, M, Pardo-Moreno, J, Penalver, FJ, Buda, G, Bennani, H, Costopoulos, M, Le Garff-Tavernier, M, Soussain, C, Schmid, M, Orfao, JA & Glantz, M 2016, 'How to facilitate early diagnosis of CNS involvement in malignant lymphoma', Expert Review of Hematology, vol. 9, no. 11, pp. 1081-1091. https://doi.org/10.1080/17474086.2016.1242405
Walbert, T, Glantz, M, Schultz, L & Puduvalli, VK 2016, 'Impact of provider level, training and gender on the utilization of palliative care and hospice in neuro-oncology: A North-American survey', Journal of neuro-oncology, vol. 126, no. 2, pp. 337-345. https://doi.org/10.1007/s11060-015-1973-0
Brown, TJ & Glantz, M 2016, 'InReply' JAMA oncology, vol. 2, no. 11, pp. 1509-1510. https://doi.org/10.1001/jamaoncol.2016.3812
Varlotto, J, DiMaio, C, Grassberger, C, Tangel, M, Mackley, H, Pavelic, M, Specht, C, Sogge, S, Nguyen, DT, Glantz, M, Saw, C, Upadhyay, U, Moser, R, Yunus, S, Rava, P, Fitzgerald, T, Glanzman, J & Sheehan, J 2016, 'Multi-modality management of craniopharyngioma: A review of various treatments and their outcomes', Neuro-Oncology Practice, vol. 3, no. 3, pp. 173-187. https://doi.org/10.1093/nop/npv029
Xiu, J, Piccioni, D, Juarez, T, Pingle, SC, Hu, J, Rudnick, J, Fink, K, Spetzler, DB, Maney, T, Ghazalpour, A, Bender, R, Gatalica, Z, Reddy, S, Sanai, N, Idbaih, A, Glantz, M & Kesari, S 2016, 'Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies', Oncotarget, vol. 7, no. 16, pp. 21556-21569. https://doi.org/10.18632/oncotarget.7722
Yin, M, Joshi, M, Meijer, RP, Glantz, M, Holder, S, Harvey, H, Kaag, MG, Van De Putte, EEF, Horenblas, S & Drabick, J 2016, 'Neoadjuvant chemotherapy for muscle-invasive bladder cancer: A systematic review and two-step meta-analysis', Oncologist, vol. 21, no. 6, pp. 708-715. https://doi.org/10.1634/theoncologist.2015-0440
Schiff, D, Desjardins, A, Cloughesy, T, Mikkelsen, T, Glantz, M, Chamberlain, MC, Reardon, DA & Wen, PY 2016, 'Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas', Cancer, vol. 122, no. 4, pp. 582-587. https://doi.org/10.1002/cncr.29798
Kalinina, J, Ahn, J, Devi, NS, Wang, L, Li, Y, Olson, JJ, Glantz, M, Smith, T, Kim, EL, Giese, A, Jensen, RL, Chen, CC, Carter, BS, Mao, H, He, M & Van Meir, EG 2016, 'Selective detection of the D-enantiomer of 2-hydroxyglutarate in the CSF of glioma patients with mutated isocitrate dehydrogenase', Clinical Cancer Research, vol. 22, no. 24, pp. 6256-6265. https://doi.org/10.1158/1078-0432.CCR-15-2965
Korfel, A, Chamberlain, M, Neuwelt, E, Thiel, E, Doolittle, N, Schlegel, U, Dreyling, M, Rubenstein, J, Fischer, L, Björkholm, M, Martus, P, Weller, M & Glantz, M 2016, 'Therapy for secondary CNS involvement inmalignant lymphomas: No standard yet!', Journal of Clinical Oncology, vol. 34, no. 15, pp. 1829-1830. https://doi.org/10.1200/JCO.2015.65.0879

2015

Varlotto, JM, Flickinger, J, Pavelic, MT, Specht, C, Sheehan, JM, Timek, DT, Glantz, M, Sogge, S, Dimaio, C, Moser, R, Yunus, S, Fitzgerald, TJ, Upadhyay, U, Rava, P, Tangel, M, Yao, A & Kanekar, S 2015, 'Distinguishing grade I meningioma from higher grade meningiomas without biopsy', Oncotarget, vol. 6, no. 35, pp. 38421-38428. https://doi.org/10.18632/oncotarget.5376
Lee, S, Slagle-Webb, B, Sheehan, JM, Zhu, J, Muscat, J, Glantz, M & Connor, J 2015, 'HFE polymorphisms affect survival of brain tumor patients' Journal of neuro-oncology, vol. 122, no. 1, pp. 97-104. https://doi.org/10.1007/s11060-014-1681-1
Elinzano, H, Glantz, M, Mrugala, M, Kesari, S, Piccioni, DE, Kim, L, Pan, E, Yunus, S, Coyle, T, Timothy, K, Evans, D, Mantripragada, K, Boxerman, J, DiPetrillo, T, Donahue, JE, Hebda, N, Mitchell, KM, Rosati, KL & Safran, H 2018, 'PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation: A Randomized Phase II Study: BrUOG 244', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 2, pp. 159-162. https://doi.org/10.1097/COC.0000000000000247

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)