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Researcher Profile

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Hiroko Shike, MD, MS

Hiroko Shike, MD, MS

Associate Professor, Department of Pathology and Laboratory Medicine
Division of Clinical Pathology
Scientific Program:Next-Generation Therapies
HUS14@psu.edu

Research Interests

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  • Mucocutaneous Lymph Node Syndrome
  • Child
  • Transplants
  • Genes
  • Alleles
  • Tissue Donors
  • Gene Expression
  • Peptides
  • T-Lymphocytes
  • Infections
  • Polymerase Chain Reaction
  • Mutation
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Recent Publications

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2023

Kessler, N, Casey, H, Tyler, J, Mowery, C & Shike, H 2023, 'HLA-C*07:985:01:02Q, a novel allele with an acceptor splice site mutation', HLA. https://doi.org/10.1111/tan.15086

2022

Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4

2021

Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Hsieh, LE, Grifoni, A, Sidney, J, Shimizu, C, Shike, H, Ramchandar, N, Moreno, E, Tremoulet, AH, Burns, JC & Franco, A 2022, 'Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children', European Journal of Immunology, vol. 52, no. 1, pp. 123-137. https://doi.org/10.1002/eji.202149556
Casey, H, Tyler, J, Fisher, C, Mowery, C & Shike, H 2021, 'HLA-DQA1*03:03:01:16Q, a novel allele with an acceptor splice site mutation', HLA, vol. 98, no. 5, pp. 490-492. https://doi.org/10.1111/tan.14417
Jain, A, Daoud, D, Kees-Folts, D, Freeman, MA, Butt, F, Abendroth, CS, Shike, H & Kadry, Z 2022, 'Steroid-free maintenance immunosuppression using alemtuzumab in pediatric kidney transplantation: Long-term longitudinal follow-up', Pediatric Transplantation, vol. 26, no. 2, e14173. https://doi.org/10.1111/petr.14173
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Fisher, C, Casey, H, Kumer, L, Tyler, J & Shike, H 2020, 'A novel null allele, HLA-DPA1*01:35N in a European American Male from Pennsylvania, USA', HLA, vol. 96, no. 3, pp. 378-379. https://doi.org/10.1111/tan.13944

2019

Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Shimizu, C, Kim, J, Eleftherohorinou, H, Wright, VJ, Hoang, LT, Tremoulet, AH, Franco, A, Hibberd, ML, Takahashi, A, Kubo, M, Ito, K, Tanaka, T, Onouchi, Y, Coin, LJM, Levin, M, Burns, JC & Shike, H 2019, 'HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease', Human Immunology, vol. 80, no. 9, pp. 731-738. https://doi.org/10.1016/j.humimm.2019.04.020
Tyler, J, Kumer, L, Fisher, C, Casey, H & Shike, H 2019, 'Personalized Chimerism Test that Uses Selection of Short Tandem Repeat or Quantitative PCR Depending on Patient's Chimerism Status', Journal of Molecular Diagnostics, vol. 21, no. 3, pp. 483-490. https://doi.org/10.1016/j.jmoldx.2019.01.007
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