Researcher Profile

Researcher Profile

Hiroko Shike, MD, MS

Hiroko Shike, MD, MS

Associate Professor, Department of Pathology and Laboratory Medicine
Division of Clinical Pathology
Scientific Program:Next-Generation Therapies

Research Interests

  • Mucocutaneous Lymph Node Syndrome
  • Child
  • Genes
  • Transplants
  • Gene Expression
  • Alleles
  • Peptides
  • Tissue Donors
  • Infections
  • Polymerase Chain Reaction
  • Acute Disease
  • Bass

Recent Publications


Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437.
Hsieh, LE, Grifoni, A, Sidney, J, Shimizu, C, Shike, H, Ramchandar, N, Moreno, E, Tremoulet, AH, Burns, JC & Franco, A 2022, 'Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children', European Journal of Immunology, vol. 52, no. 1, pp. 123-137.
Casey, H, Tyler, J, Fisher, C, Mowery, C & Shike, H 2021, 'HLA-DQA1*03:03:01:16Q, a novel allele with an acceptor splice site mutation', HLA, vol. 98, no. 5, pp. 490-492.
Jain, A, Daoud, D, Kees-Folts, D, Freeman, MA, Butt, F, Abendroth, CS, Shike, H & Kadry, Z 2022, 'Steroid-free maintenance immunosuppression using alemtuzumab in pediatric kidney transplantation: Long-term longitudinal follow-up', Pediatric Transplantation, vol. 26, no. 2, e14173.
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641.


Fisher, C, Casey, H, Kumer, L, Tyler, J & Shike, H 2020, 'A novel null allele, HLA-DPA1*01:35N in a European American Male from Pennsylvania, USA', HLA, vol. 96, no. 3, pp. 378-379.


Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645.
Shimizu, C, Kim, J, Eleftherohorinou, H, Wright, VJ, Hoang, LT, Tremoulet, AH, Franco, A, Hibberd, ML, Takahashi, A, Kubo, M, Ito, K, Tanaka, T, Onouchi, Y, Coin, LJM, Levin, M, Burns, JC & Shike, H 2019, 'HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease', Human Immunology, vol. 80, no. 9, pp. 731-738.
Tyler, J, Kumer, L, Fisher, C, Casey, H & Shike, H 2019, 'Personalized Chimerism Test that Uses Selection of Short Tandem Repeat or Quantitative PCR Depending on Patient's Chimerism Status', Journal of Molecular Diagnostics, vol. 21, no. 3, pp. 483-490.


Jia, B, Wang, L, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, TD, Hohl, RJ & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34.
Rakszawski, K, Miki, K, Claxton, D, Wagner Jr., H, Shike, H, Mineishi, S & Naik, S 2018, 'Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML', International journal of hematology, vol. 108, no. 3, pp. 348-350.
Shike, H, Kadry, Z, Imamura-Kawasawa, Y, Greene, W, Riley, T, Nathan, HM, Hasz, RD & Jain, A 2018, 'Hepatitis C virus (HCV) RNA level in plasma and kidney tissue in HCV antibody-positive donors: Quantitative comparison', Clinical Transplantation, vol. 32, no. 9, e13358.
Lokhandwala, PM, Shike, H, Wang, M, Domen, RE & George, MR 2018, 'Optimizing donor scheduling before recruitment: An effective approach to increasing apheresis platelet collections', PloS one, vol. 13, no. 5, e0198062.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)