Hiroko Shike, MD, MS - Penn State Cancer Institute
Researcher Profile
Hiroko Shike, MD, MS
Associate Professor, Department of Pathology and Laboratory Medicine
Division of Clinical Pathology
Division of Clinical Pathology
Scientific Program:Next-Generation Therapies
Research Interests
- Mucocutaneous Lymph Node Syndrome
- Child
- Transplants
- Genes
- Alleles
- Tissue Donors
- Gene Expression
- Peptides
- T-Lymphocytes
- Infections
- Polymerase Chain Reaction
- Mutation
Recent Publications
2024
Brow, D, Shike, H, Kendrick, J, Pettersson, L, Mineishi, S, Claxton, DF, Wirk, B, Cioccio, J, Greiner, RJ, Viswanatha, D, Kharfan-Dabaja, MA, Li, Z, Tyler, J & Elrefaei, M 2024, 'Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods', Human Immunology, vol. 85, no. 3, 110794. https://doi.org/10.1016/j.humimm.2024.110794
Zhang, A, Macecevic, S, Thomas, D, Allen, J, Mandley, S, Kawczak, P, Jurcago, R, Tyler, J, Casey, H, Bosler, D, Sobecks, R, Hamilton, B, Sauter, C, Mineishi, S, Claxton, D & Shike, H 2024, 'Engraftment and Measurable Residual Disease Monitoring after Hematopoietic Stem Cell Transplantation: Comparison of Two Chimerism Test Strategies, Next-Generation Sequencing versus a Combination of Short-Tandem Repeats and Quantitative PCR', Journal of Molecular Diagnostics, vol. 26, no. 4, pp. 233-244. https://doi.org/10.1016/j.jmoldx.2024.01.007
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
2023
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Kessler, N, Casey, H, Tyler, J, Mowery, C & Shike, H 2023, 'HLA-C*07:985:01:02Q, a novel allele with an acceptor splice site mutation', HLA, vol. 102, no. 2, pp. 243-245. https://doi.org/10.1111/tan.15086
2022
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Hsieh, LE, Grifoni, A, Sidney, J, Shimizu, C, Shike, H, Ramchandar, N, Moreno, E, Tremoulet, AH, Burns, JC & Franco, A 2022, 'Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children', European Journal of Immunology, vol. 52, no. 1, pp. 123-137. https://doi.org/10.1002/eji.202149556
Casey, H, Tyler, J, Fisher, C, Mowery, C & Shike, H 2021, 'HLA-DQA1*03:03:01:16Q, a novel allele with an acceptor splice site mutation', HLA, vol. 98, no. 5, pp. 490-492. https://doi.org/10.1111/tan.14417
Jain, A, Daoud, D, Kees-Folts, D, Freeman, MA, Butt, F, Abendroth, CS, Shike, H & Kadry, Z 2022, 'Steroid-free maintenance immunosuppression using alemtuzumab in pediatric kidney transplantation: Long-term longitudinal follow-up', Pediatric Transplantation, vol. 26, no. 2, e14173. https://doi.org/10.1111/petr.14173
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022
2020
Fisher, C, Casey, H, Kumer, L, Tyler, J & Shike, H 2020, 'A novel null allele, HLA-DPA1*01:35N in a European American Male from Pennsylvania, USA', HLA, vol. 96, no. 3, pp. 378-379. https://doi.org/10.1111/tan.13944