Researcher Profile

Researcher Profile

Zhonghua Gao, PhD

Zhonghua Gao, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Experimental Therapeutics
zxg12@psu.edu

Research Interests

During mammalian development, hundreds of cell types derived from a single zygote are maintained throughout cell cycles. Deregulation of cell identity is often associated with pathogenesis such as cancer. Despite identical genetic information, cells with distinct identity are controlled by the differential epigenetic landscape. Dr. Zhonghua Gao's research interest is to understand how cell identity is established and maintained via epigenetic mechanisms, particularly how Polycomb group complexes are involved in regulating chromatin structure and gene transcription.

Dr. Gao's lab has established an in vitro neuronal differentiation model using both mouse and human embryonic stem cells. These efforts led to an identification and characterization of novel essential component for a sub-type of PRC1 complex.

The lab is currently continuing to investigate how this regulation controls cell fate determination as well as its involvement in diseases such as cancer and autism.

Dr. Gao is part of the Stem Cell and Regenerative Biology program at Penn State College of Medicine.

 

  • Proteins
  • Ubiquitin
  • Casein Kinase I
  • Neoplasms
  • Peptides
  • Chromatin
  • Autistic Disorder
  • Calcineurin
  • Nicotinamide Phosphoribosyltransferase
  • Ligases
  • Proteomics
  • Genes

Recent Publications

2018

Wang, Q, Geng, Z, Gong, Y, Warren, K, Zheng, H, Imamura, Y & Gao, Z 2018, 'WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells', Stem Cell Research, vol. 33, pp. 206-214. https://doi.org/10.1016/j.scr.2018.10.023

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)