Researcher Profile

Researcher Profile

Yoshinori Takahashi, MS, PhD

Yoshinori Takahashi, MS, PhD

Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
yut4@psu.edu

Research Interests

  • Autophagy
  • Membranes
  • Proteins
  • Autophagosomes
  • Apoptosis
  • Neoplasms
  • Beclin-1
  • Endosomal Sorting Complexes Required for Transport
  • Phosphotransferases
  • Homeostasis
  • Cell Death
  • Caspase 8

Recent Publications

2020

Flower, TG, Takahashi, Y, Hudait, A, Rose, K, Tjahjono, N, Pak, AJ, Yokom, AL, Liang, X, Wang, HG, Bouamr, F, Voth, GA & Hurley, JH 2020, 'A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission', Nature Structural and Molecular Biology, vol. 27, no. 6, pp. 570-580. https://doi.org/10.1038/s41594-020-0426-4
Hattori, T, Takahashi, Y, Chen, L, Tang, Z, Wills, CA, Liang, X & Wang, HG 2021, 'Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes', Cell Death and Differentiation, vol. 28, no. 2, pp. 657-670. https://doi.org/10.1038/s41418-020-00610-0

2019

Tang, Z, Takahashi, Y & Wang, HG 2019, 'ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes', Autophagy, vol. 15, no. 12, pp. 2165-2166. https://doi.org/10.1080/15548627.2019.1666594
Touyama, K, Khan, M, Aoki, K, Matsuda, M, Hiura, F, Takakura, N, Matsubara, T, Harada, Y, Hirohashi, Y, Tamura, Y, Gao, J, Mori, K, Kokabu, S, Yasuda, H, Fujita, Y, Watanabe, K, Takahashi, Y, Maki, K & Jimi, E 2019, 'Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis', Journal of cellular biochemistry, vol. 120, no. 11, pp. 18793-18804. https://doi.org/10.1002/jcb.29193
Tang, Z, Takahashi, Y, He, H, Hattori, T, Chen, C, Liang, X, Chen, H, Young, MM & Wang, HG 2019, 'TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion', Cell Reports, vol. 28, no. 7, pp. 1744-1757.e5. https://doi.org/10.1016/j.celrep.2019.07.036
Atkinson, JM, Ye, Y, Gebru, MT, Liu, Q, Zhou, S, Young, MM, Takahashi, Y, Lin, Q, Tian, F & Wang, HG 2019, 'Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins', Journal of Biological Chemistry, vol. 294, no. 38, pp. 14033-14042. https://doi.org/10.1074/jbc.RA119.008723
Takahashi, Y, Liang, X, Hattori, T, Tang, Z, He, H, Chen, H, Liu, X, Abraham, T, Imamura-Kawasawa, Y, Buchkovich, NJ, Young, MM & Wang, HG 2019, 'VPS37A directs ESCRT recruitment for phagophore closure', The Journal of cell biology, vol. 218, no. 10, pp. 3336-3354. https://doi.org/10.1083/jcb.201902170

2018

Takahashi, Y, He, H, Tang, Z, Hattori, T, Liu, Y, Young, MM, Serfass, JM, Chen, L, Gebru, M, Chen, C, Wills, CA, Atkinson, JM, Chen, H, Abraham, T & Wang, HG 2018, 'An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure', Nature communications, vol. 9, no. 1, 2855. https://doi.org/10.1038/s41467-018-05254-w
Tang, Z & Takahashi, Y 2018, Analysis of protein–protein interaction by Co-IP in human cells. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1794, Humana Press Inc., pp. 289-296. https://doi.org/10.1007/978-1-4939-7871-7_20
Cheng, Y, Ren, X, Yuan, Y, Shan, Y, Li, L, Chen, X, Zhang, L, Takahashi, Y, Yang, JW, Han, B, Liao, J, Li, Y, Harvey, H, Ryazanov, A, Robertson, GP, Wan, G, Liu, D, Chen, AF, Tao, Y & Yang, JM 2018, 'Correction to: eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis (Oncogene, (2016), 35, 49, (6293-6308), 10.1038/onc.2016.166)', Oncogene, vol. 37, no. 33, pp. 4633-4634. https://doi.org/10.1038/s41388-018-0322-0

2017

Tang, Z, Takahashi, Y, Chen, C, Liu, Y, He, H, Tsotakos, N, Serfass, JM, Gebru, MT, Chen, H, Young, MM & Wang, HG 2017, 'Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis', Cell Death and Differentiation, vol. 24, no. 12, pp. 2127-2138. https://doi.org/10.1038/cdd.2017.133
Serfass, JM, Takahashi, Y, Zhou, Z, Kawasawa, YI, Liu, Y, Tsotakos, N, Young, MM, Tang, Z, Yang, L, Atkinson, JM, Chroneos, ZC & Wang, HG 2017, 'Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection', Journal of Biological Chemistry, vol. 292, no. 24, pp. 10097-10111. https://doi.org/10.1074/jbc.M117.792747
Fino, KK, Yang, L, Silveyra, P, Hu, S, Umstead, TM, Diangelo, S, Halstead, ES, Cooper, TK, Abraham, T, Takahashi, Y, Zhou, Z, Wang, HG & Chroneos, ZC 2017, 'SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection', Scientific reports, vol. 7, no. 1, 7262. https://doi.org/10.1038/s41598-017-07724-5

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)