Yoshinori Takahashi, MS, PhD - Penn State Cancer Institute
Researcher Profile
Yoshinori Takahashi, MS, PhD
Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Associate Professor, Department of Cell and Biological Systems
Division of Hematology and Oncology
Associate Professor, Department of Cell and Biological Systems
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Takahashi, Y, Opozda, DM & Wang, HG 2026, 'Cutting edge: ESCRT-mediated phagophore closure in mammals', Biochemical Journal, vol. 483, no. 5, pp. 741-759. https://doi.org/10.1042/BCJ20250148
Zhang, R, Chen, L, Liang, X, Zhang, J, Hamamoto, K, Hattori, T, Vangala, V, Schell, TD, Saulnier Sholler, G, Takahashi, Y & Wang, H-G 2026, 'Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth', Oncogene. https://doi.org/10.1038/s41388-026-03800-1
2025
Bui, V, Liang, X, Ye, Y, Giang, W, Tian, F, Takahashi, Y & Wang, HG 2025, 'Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation', Autophagy, vol. 21, no. 5, pp. 1059-1074. https://doi.org/10.1080/15548627.2024.2443300
Fundora, KA, Zhuang, Y, Hamamoto, K, Wang, G, Chen, L, Hattori, T, Liang, X, Bao, L, Vangala, V, Tian, F, Takahashi, Y & Wang, HG 2025, 'DBeQ derivative targets vacuolar protein sorting 4 functions in cancer cells and suppresses tumor growth in mice', Journal of Pharmacology and Experimental Therapeutics, vol. 392, no. 4, 103524. https://doi.org/10.1016/j.jpet.2025.103524
Hamamoto, K, Liang, X, Opozda, DM, Wang, HG & Takahashi, Y 2025, 'Physiological insights into ESCRT-mediated phagophore closure: potential cytoprotective roles for ATG8ylated membranes', Autophagy, vol. 21, no. 6, pp. 1387-1389. https://doi.org/10.1080/15548627.2025.2468907
2024
Ye, Y, Liang, X, Wang, G, Bewley, MC, Hamamoto, K, Liu, X, Flanagan, J, Wang, H-G, Takahashi, Y & Tian, F 2024, 'Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure', Communications Biology, vol. 7, no. 1, 334. https://doi.org/10.1038/s42003-024-06026-7
Hamamoto, K, Liang, X, Ito, A, Lanza, M, Bui, V, Zhang, J, Opozda, DM, Hattori, T, Chen, L, Haddock, D, Imamura, F, Wang, HG & Takahashi, Y 2024, 'Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain', Cell Reports, vol. 43, no. 12, 115016. https://doi.org/10.1016/j.celrep.2024.115016
2023
Hattori, T, Fundora, KA, Hamamoto, K, Opozda, DM, Liang, X, Liu, X, Zhang, J, Uzun, Y, Takahashi, Y & Wang, HG 2024, 'ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis', Autophagy, vol. 20, no. 2, pp. 349-364. https://doi.org/10.1080/15548627.2023.2258701
2022
Kim, J, Li, Y, Cheng, Y, Ren, X, Zhang, Y, Ji, C, Zhu, H, Takahashi, Y, Xiong, X, Gu, L, Ngule, C, Xiong, X, Song, J, Liu, X & Yang, JM 2022, 'Identification of elongation factor-2 as a novel regulator of mitochondrial fission', Natural Sciences, vol. 2, no. 3, e20220011. https://doi.org/10.1002/ntls.20220011