Researcher Profile

Researcher Profile

Yoshinori Takahashi, MS, PhD

Yoshinori Takahashi, MS, PhD

Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies

Research Interests

  • Autophagy
  • Membranes
  • Proteins
  • Autophagosomes
  • Apoptosis
  • Neoplasms
  • Beclin-1
  • Endosomal Sorting Complexes Required for Transport
  • Phosphotransferases
  • Homeostasis
  • Cell Death
  • Caspase 8

Recent Publications


Flower, TG, Takahashi, Y, Hudait, A, Rose, K, Tjahjono, N, Pak, AJ, Yokom, AL, Liang, X, Wang, HG, Bouamr, F, Voth, GA & Hurley, JH 2020, 'A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission', Nature Structural and Molecular Biology, vol. 27, no. 6, pp. 570-580.
Hattori, T, Takahashi, Y, Chen, L, Tang, Z, Wills, CA, Liang, X & Wang, HG 2021, 'Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes', Cell Death and Differentiation, vol. 28, no. 2, pp. 657-670.


Tang, Z, Takahashi, Y & Wang, HG 2019, 'ATG2 regulation of phagophore expansion at mitochondria-associated ER membranes', Autophagy, vol. 15, no. 12, pp. 2165-2166.
Touyama, K, Khan, M, Aoki, K, Matsuda, M, Hiura, F, Takakura, N, Matsubara, T, Harada, Y, Hirohashi, Y, Tamura, Y, Gao, J, Mori, K, Kokabu, S, Yasuda, H, Fujita, Y, Watanabe, K, Takahashi, Y, Maki, K & Jimi, E 2019, 'Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis', Journal of cellular biochemistry, vol. 120, no. 11, pp. 18793-18804.
Tang, Z, Takahashi, Y, He, H, Hattori, T, Chen, C, Liang, X, Chen, H, Young, MM & Wang, HG 2019, 'TOM40 Targets Atg2 to Mitochondria-Associated ER Membranes for Phagophore Expansion', Cell Reports, vol. 28, no. 7, pp. 1744-1757.e5.
Atkinson, JM, Ye, Y, Gebru, MT, Liu, Q, Zhou, S, Young, MM, Takahashi, Y, Lin, Q, Tian, F & Wang, HG 2019, 'Time-resolved FRET and NMR analyses reveal selective binding of peptides containing the LC3-interacting region to ATG8 family proteins', Journal of Biological Chemistry, vol. 294, no. 38, pp. 14033-14042.
Takahashi, Y, Liang, X, Hattori, T, Tang, Z, He, H, Chen, H, Liu, X, Abraham, T, Imamura-Kawasawa, Y, Buchkovich, NJ, Young, MM & Wang, HG 2019, 'VPS37A directs ESCRT recruitment for phagophore closure', The Journal of cell biology, vol. 218, no. 10, pp. 3336-3354.


Takahashi, Y, He, H, Tang, Z, Hattori, T, Liu, Y, Young, MM, Serfass, JM, Chen, L, Gebru, M, Chen, C, Wills, CA, Atkinson, JM, Chen, H, Abraham, T & Wang, HG 2018, 'An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure', Nature communications, vol. 9, no. 1, 2855.
Tang, Z & Takahashi, Y 2018, Analysis of protein–protein interaction by Co-IP in human cells. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1794, Humana Press Inc., pp. 289-296.
Cheng, Y, Ren, X, Yuan, Y, Shan, Y, Li, L, Chen, X, Zhang, L, Takahashi, Y, Yang, JW, Han, B, Liao, J, Li, Y, Harvey, H, Ryazanov, A, Robertson, GP, Wan, G, Liu, D, Chen, AF, Tao, Y & Yang, JM 2018, 'Correction to: eEF-2 kinase is a critical regulator of Warburg effect through controlling PP2A-A synthesis (Oncogene, (2016), 35, 49, (6293-6308), 10.1038/onc.2016.166)', Oncogene, vol. 37, no. 33, pp. 4633-4634.


Tang, Z, Takahashi, Y, Chen, C, Liu, Y, He, H, Tsotakos, N, Serfass, JM, Gebru, MT, Chen, H, Young, MM & Wang, HG 2017, 'Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis', Cell Death and Differentiation, vol. 24, no. 12, pp. 2127-2138.
Serfass, JM, Takahashi, Y, Zhou, Z, Kawasawa, YI, Liu, Y, Tsotakos, N, Young, MM, Tang, Z, Yang, L, Atkinson, JM, Chroneos, ZC & Wang, HG 2017, 'Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection', Journal of Biological Chemistry, vol. 292, no. 24, pp. 10097-10111.
Fino, KK, Yang, L, Silveyra, P, Hu, S, Umstead, TM, Diangelo, S, Halstead, ES, Cooper, TK, Abraham, T, Takahashi, Y, Zhou, Z, Wang, HG & Chroneos, ZC 2017, 'SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection', Scientific reports, vol. 7, no. 1, 7262.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)