Researcher Profile

Researcher Profile

Wei Li, PhD

Wei Li, PhD

Assistant Professor, Department of Pediatrics
Division of Hematology and Oncology
Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
wul27@psu.edu

Research Interests

Dr. Wei Li’s laboratory is interested in studying intercellular interactions during tissue homeostasis and determining how de-regulated interactions among cells promote cell transformation and tumor progression. His research integrates molecular, cellular and biochemical approaches in combination with mouse tumorigenesis models. Currently, Dr. Li’s laboratory focuses on elucidating the regulation and function of the Hippo tumor suppressor pathway in brain tumors. The goal of Dr. Li’s research is to find molecular targets and biomarkers for cancer therapy.

  • Neoplasms
  • Neurofibromin 2
  • Carcinogenesis
  • Ubiquitin-Protein Ligases
  • Growth
  • Genes
  • Therapeutics
  • Mutation
  • Neurofibromatosis 2
  • Glioma
  • Drosophila
  • Cell Death

Recent Publications

2019

Liu, Z, Yee, PP, Wei, Y, Liu, Z, Imamura, Y & Li, W 2019, 'Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis', Journal of Cell Science, vol. 132, no. 5, jcs225714. https://doi.org/10.1242/jcs.225714

2018

Fisher, MJ, Belzberg, AJ, de Blank, P, De Raedt, T, Elefteriou, F, Ferner, RE, Giovannini, M, Harris, GJ, Kalamarides, M, Karajannis, MA, Kim, AR, Lázaro, C, Le, LQ, Li, W, Listernick, R, Martin, S, Morrison, H, Pasmant, E, Ratner, N, Schorry, E, Ullrich, NJ, Viskochil, D, Weiss, B, Widemann, BC, Zhu, Y, Bakker, A & Serra, E 2018, '2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis', American Journal of Medical Genetics, Part A, vol. 176, no. 5, pp. 1258-1269. https://doi.org/10.1002/ajmg.a.38675
Liu, Z, Wei, Y, Zhang, L, Yee, PP, Johnson, M, Zhang, X, Gulley, M, Atkinson, JM, Trebak, M, Wang, H-G & Li, W 2019, 'Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ', Oncogene, vol. 38, no. 1, pp. 120-139. https://doi.org/10.1038/s41388-018-0425-7
Zhang, L, Cheng, F, Wei, Y, Zhang, L, Guo, D, Wang, B & Li, W 2019, 'Inhibition of TAZ contributes radiation-induced senescence and growth arrest in glioma cells', Oncogene, vol. 38, no. 15, pp. 2788-2799. https://doi.org/10.1038/s41388-018-0626-0

2016

Chen, YB, Xu, J, Skanderup, AJ, Dong, Y, Brannon, AR, Wang, L, Won, HH, Wang, PI, Nanjangud, GJ, Jungbluth, AA, Li, W, Ojeda, V, Hakimi, AA, Voss, MH, Schultz, N, Motzer, RJ, Russo, P, Cheng, EH, Giancotti, FG, Lee, W, Berger, MF, Tickoo, SK, Reuter, VE & Hsieh, JJ 2016, 'Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets', Nature communications, vol. 7, 13131. https://doi.org/10.1038/ncomms13131

2015

Kale, A, Li, W, Lee, CH & Baker, NE 2015, 'Apoptotic mechanisms during competition of ribosomal protein mutant cells: Roles of the initiator caspases Dronc and Dream/Strica', Cell Death and Differentiation, vol. 22, no. 8, pp. 1300-1312. https://doi.org/10.1038/cdd.2014.218

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)