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Wei Li, PhD

Wei Li, PhD

Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Associate Professor, Department of Biochemistry and Molecular Biology
Penn State Neuroscience Institute
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Dr. Wei Li’s laboratory is interested in studying intercellular interactions during tissue homeostasis and determining how de-regulated interactions among cells promote cell transformation and tumor progression. His research integrates molecular, cellular and biochemical approaches in combination with mouse tumorigenesis models. Currently, Dr. Li’s laboratory focuses on elucidating the regulation and function of the Hippo tumor suppressor pathway in brain tumors. The goal of Dr. Li’s research is to find molecular targets and biomarkers for cancer therapy.

  • Neoplasms
  • Neurofibromin 2
  • Carcinogenesis
  • Genes
  • Growth
  • Glioblastoma
  • Ubiquitin-Protein Ligases
  • Proteins
  • Necrosis
  • Mutation
  • Cadaver
  • Neurofibromatosis 2

Recent Publications


Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649.


Wei, Y & Li, W 2021, 'Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation', Frontiers in Cell and Developmental Biology, vol. 9, 694828.
Lin, S, Li, Y, Wang, D, Huang, C, Marino, D, Bollt, O, Wu, C, Taylor, MD, Li, W, DeNicola, GM, Hao, J, Singh, PK & Yang, S 2021, 'Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression', Cancer Letters, vol. 518, pp. 230-242.
Wei, Y, Luo, H, Yee, PP, Zhang, L, Liu, Z, Zheng, H, Zhang, L, Anderson, B, Tang, M, Huang, S & Li, W 2021, 'Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program', Advanced Science, vol. 8, no. 24, 2102653.
Yee, PP & Li, W 2021, 'Tumor necrosis: A synergistic consequence of metabolic stress and inflammation', BioEssays, vol. 43, no. 7, 2100029.


Johnson, MT, Gudlur, A, Zhang, X, Xin, P, Emrich, SM, Yoast, RE, Courjaret, R, Nwokonko, RM, Li, W, Hempel, N, Machaca, K, Gill, DL, Hogan, PG & Trebak, M 2020, 'L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 29, pp. 17369-17380.
Wei, Y, Yee, PP, Liu, Z, Zhang, L, Guo, H, Zheng, H, Anderson, B, Gulley, M & Li, W 2020, 'NEDD4L-mediated Merlin ubiquitination facilitates Hippo pathway activation', EMBO Reports, vol. 21, no. 12, e50642.
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424.