William Evan Higgins, PhD - Penn State Cancer Institute
Researcher Profile
William Evan Higgins, PhD
Distinguished Professor, Electrical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Bronchoscopy
- Thorax
- Lung Neoplasms
- Physicians
- Tomography
- Lymph Nodes
- Bronchoscopes
- Biopsy
- Lung
- Three-Dimensional Imaging
- Multidetector Computed Tomography
- Blood Vessels
Clinical Trials
Piloting a Virtual Navigation (VN) System for Bronchoscopic Tissue Sampling
Recent Publications
2023
Chang, Q, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, ESFPNet: Efficient deep learning architecture for real-time lesion segmentation in autofluorescence bronchoscopic video. in BS Gimi & A Krol (eds), Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging., 1246803, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12468, SPIE, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647897
He, Y & Higgins, WE 2023, Extemporaneous Airway Route Computation During Live Bronchoscopic Procedures. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling., 1246602, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12466, SPIE, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647901
Zhao, W, Kuhlengel, T, Chang, Q, Daneshpajooh, V, Schaer, T, Brewer, L, Hilliard, R, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, Image-Guided Radial-Probe EBUS Bronchoscopy System: Live Study Validation. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling., 124661O, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12466, SPIE, Medical Imaging 2023: Image-Guided Procedures, Robotic Interventions, and Modeling, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2648637
Daneshpajooh, V, Dumas, C, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, Vascular pattern recognition for narrow-band imaging bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging., 124680L, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12468, SPIE, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 2/19/23. https://doi.org/10.1117/12.2647150
2022
Zhao, W, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2023, 'Endobronchial Ultrasound Image Simulation for Image-Guided Bronchoscopy', IEEE Transactions on Biomedical Engineering, vol. 70, no. 1, pp. 318-330. https://doi.org/10.1109/TBME.2022.3190165
Zhao, W, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2022, Image-Guided System for Radial-Probe Endobronchial Ultrasound Bronchoscopy. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling., 120340B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12034, SPIE, Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2612104
Kuhlengel, TK, Bascom, R & Higgins, WE 2022, Image-guided bronchoscopy for comprehensive lymph node staging. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling., 120342U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12034, SPIE, Medical Imaging 2022: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2612203
Zang, X, Zhao, W, Toth, J, Bascom, R & Higgins, W 2022, 'Multimodal Registration for Image-Guided EBUS Bronchoscopy', Journal of Imaging, vol. 8, no. 7, 189. https://doi.org/10.3390/jimaging8070189
Daneshpajooh, V, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2022, Video Analysis Framework for Lesion Detection in Narrow Band Imaging Bronchoscopy. in BS Gimi & A Krol (eds), Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging., 120360M, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12036, SPIE, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, Virtual, Online, 3/21/22. https://doi.org/10.1117/12.2606054
2021
Vasyliev, V, Toth, J, Bascom, R & Higgins, WE 2021, Autonomous planning and guidance for convex-probe endobronchial ultrasound bronchoscopy. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling., 115980T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11598, SPIE, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 2/15/21. https://doi.org/10.1117/12.2580180
Bandyopadhyay, S, Daneshpajooh, V, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2021, Blood vessel segmentation in narrow band imaging bronchoscopic video. in BS Gimi & A Krol (eds), Medical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging., 116001P, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11600, SPIE, Medical Imaging 2021: Biomedical Applications in Molecular, Structural, and Functional Imaging, Virtual, Online, United States, 2/15/21. https://doi.org/10.1117/12.2579930
Chang, Q, Byrnes, PD, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2021, Bronchoscopic video synchronization for interactive multimodal inspection of bronchial lesions. in CA Linte & JH Siewerdsen (eds), Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling., 115981V, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11598, SPIE, Medical Imaging 2021: Image-Guided Procedures, Robotic Interventions, and Modeling, Virtual, Online, 2/15/21. https://doi.org/10.1117/12.2579931
Zang, X, Cheirsilp, R, Byrnes, PD, Kuhlengel, TK, Abendroth, C, Allen, T, Mahraj, R, Toth, J, Bascom, R & Higgins, WE 2021, 'Image-guided EBUS bronchoscopy system for lung-cancer staging', Informatics in Medicine Unlocked, vol. 25, 100665. https://doi.org/10.1016/j.imu.2021.100665
Daneshpajooh, V, Bandyopadhyay, S, Ahmad, D, Toth, J, Bascom, R & Higgins, WE 2021, Super-resolution and deblurring enhancement for narrow band imaging bronchoscopy. in I Isgum & BA Landman (eds), Medical Imaging 2021: Image Processing., 1159625, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11596, SPIE, Medical Imaging 2021: Image Processing, Virtual, Online, United States, 2/15/21. https://doi.org/10.1117/12.2579922
2020
Chang, Q, Bascom, R, Toth, J, Ahmad, D & Higgins, WE 2020, Autofluorescence Bronchoscopy Video Analysis for Lesion Frame Detection. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9176007, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, Institute of Electrical and Electronics Engineers Inc., pp. 1556-1559, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Canada, 7/20/20. https://doi.org/10.1109/EMBC44109.2020.9176007
Byrnes, PD & Higgins, WE 2020, MULTI-FRAME CT-VIDEO REGISTRATION for 3D AIRWAY-WALL ANALYSIS. in ISBI 2020 - 2020 IEEE International Symposium on Biomedical Imaging., 9098472, Proceedings - International Symposium on Biomedical Imaging, vol. 2020-April, IEEE Computer Society, pp. 1638-1641, 17th IEEE International Symposium on Biomedical Imaging, ISBI 2020, Iowa City, United States, 4/3/20. https://doi.org/10.1109/ISBI45749.2020.9098472
Kuhlengel, TK & Higgins, WE 2020, Multi-destination procedure planning for comprehensive lymph node staging bronchoscopy. in B Fei & CA Linte (eds), Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling., 113151T, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11315, SPIE, Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling, Houston, United States, 2/16/20. https://doi.org/10.1117/12.2542851
Zhao, W, Bascom, R, Toth, J & Higgins, WE 2020, Virtual radial-probe endobronchial ultrasound for image-guided bronchoscopy. in B Fei & CA Linte (eds), Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling., 113151U, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11315, SPIE, Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling, Houston, United States, 2/16/20. https://doi.org/10.1117/12.2543063