Valerie Brown, MD, PhD - Penn State Cancer Institute
Researcher Profile
Valerie Brown, MD, PhD
Professor, Department of Pediatrics
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Immunotherapy Team
Cancer Institute, Pediatric Cancer Team
Cancer Institute, Pediatric Cancer Team
Clinical Trials
A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Phase II Trial of Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma BCC022
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
A Phase 1/2, Open-label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects with Advanced or Metastatic Malignancies Harboring ALK, ROS1, or NTRK1-3 Alterations (CARE)
P.E.A.C.H. Protocol Precision mEdicine and Adoptive Cellular tHerapy for the treatment of recurrent neuroblastoma and newly diagnosed diffuse intrinsic pontine glioma (DIPG).
A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
Specimen Banking with Clinical and Genomic Data Registry with the Establishment of Tumor Models for Pediatric Cancers.
A Dose Escalation Study Using Difluoromethylornithine (DFMO) and AMXT-1501 followed by a Randomized Controlled Trial of DFMO with or without AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
PARPAML: A Phase 1 Protocol for Relapsed Pediatric AML to Determine the Safety and Efficacy of the PARP Inhibitor Talazoparib in Combination with Chemotherapy
A Phase II Study of Naxitamab Added to Induction Therapy for Subjects with Newly Diagnosed
High-Risk Neuroblastoma
BCC021 Phase I/II study of Silmitasertib (CX-4945) in combination with chemotherapy in children and young adults with relapsed refractory solid tumors
Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
An Intermediate Expanded Use Trial of DFMO (eflornithine HCl)
Pediatric Acute Leukemia (PedAL) Screening Trial Developing New Therapies for Relapsed Leukemias
Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
A Prospective Phase 3 Study of Patients with Newly Diagnosed Very Low-risk and Low-risk Fusion Negative Rhabdomyosarcoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Phase II Trial of Eflornithine/DFMO as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma
A Phase II pilot trial to estimate survival after a non-total body irradiation (TBI) based conditioning regimen in patients diagnosed with B-acute lymphoblastic leukemia (ALL) who are pre-allogeneic hematopoietic cell transplantation (HCT) next-generation-sequence (NGS) minimal residual disease (MRD) negative
AHOD2131 A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
Recent Publications
2024
Oesterheld, J, Ferguson, W, Kraveka, JM, Bergendahl, G, Clinch, T, Lorenzi, E, Berry, D, Wada, RK, Isakoff, MS, Eslin, DE, Brown, VI, Roberts, W, Zage, P, Harrod, VL, Mitchell, DS, Hanson, D & Saulnier Sholler, GL 2024, 'Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons', Journal of Clinical Oncology, vol. 42, no. 1, pp. 90-102. https://doi.org/10.1200/JCO.22.02875
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Sholler, GLS, Bergendahl, G, Lewis, EC, Kraveka, J, Ferguson, W, Nagulapally, AB, Dykema, K, Brown, VI, Isakoff, MS, Junewick, J, Mitchell, D, Rawwas, J, Roberts, W, Eslin, D, Oesterheld, J, Wada, RK, Pastakia, D, Harrod, V, Ginn, K, Saab, R, Bielamowicz, K, Glover, J, Chang, E, Hanna, GK, Enriquez, D, Izatt, T, Halperin, RF, Moore, A, Byron, SA, Hendricks, WPD & Trent, JM 2024, 'Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial', Genome Medicine, vol. 16, no. 1, 28. https://doi.org/10.1186/s13073-024-01297-5
Tripathi, S, Najem, H, Dussold, C, Pacheco, S, Du, R, Sooreshjani, M, Hurley, L, Chandler, JP, Stupp, R, Sonabend, AM, Horbinski, CM, Lukas, RV, Xiu, J, Lopez, G, Nicolaides, TP, Brown, V, Wadhwani, NR, Lam, SK, James, CD, Rao, G, Castro, MG, Heimberger, AB & DeCuypere, M 2024, 'Pediatric glioma immune profiling identifies TIM3 as a therapeutic target in BRAF fusion pilocytic astrocytoma', Journal of Clinical Investigation, vol. 134, no. 19, e177413. https://doi.org/10.1172/JCI177413
Zhang, R, Shang, Y, Cioccio, J, Rakszawski, K, Nickolich, M, Ehmann, C, Inoue, Y, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Liao, J, Greiner, R, Brown, V, Claxton, D, Ning, J, Zhou, S, Mineishi, S, Minagawa, K & Shike, H 2024, 'Sensitivity and Specificity of Chimerism Tests in Predicting Leukemia Relapse Using Increasing Mixed Chimerism', Journal of Molecular Diagnostics, vol. 26, no. 12, pp. 1159-1170. https://doi.org/10.1016/j.jmoldx.2024.09.003
2023
Eslin, D, Zage, PE, Bergendahl, G, Lewis, E, Roberts, W, Kraveka, J, Mitchell, D, Isakoff, MS, Rawwas, J, Wada, RK, Fluchel, M, Brown, VI, Ginn, K, Higgins, T, BeeravallyNagulapally, A, Dykema, K, Hanna, G, Ferguson, W & Saulnier Sholler, GL 2023, 'A phase II trial of nifurtimox combined with topotecan and cyclophosphamide for refractory or relapsed neuroblastoma and medulloblastoma', International Journal of Cancer, vol. 153, no. 5, pp. 1026-1034. https://doi.org/10.1002/ijc.34569
Murthy, HS, Zhang, MJ, Chen, K, Ahmed, S, Deotare, U, Ganguly, S, Kansagra, A, Michelis, FV, Nishihori, T, Patnaik, M, Abid, MB, Aljurf, M, Arai, Y, Bacher, U, Badar, T, Badawy, SM, Ballen, K, Battiwalla, M, Beitinjaneh, A, Bejanyan, N, Bhatt, VR, Brown, VI, Martino, R, Cahn, JY, Castillo, P, Cerny, J, Chhabra, S, Copelan, E, Daly, A, Dholaria, B, Perez, MAD, Freytes, CO, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Jamy, O, Joseph, J, Kanakry, CG, Khera, N, Krem, MM, Kuwatsuka, Y, Lazarus, HM, Lekakis, LJ, Liu, H, Modi, D, Munshi, PN, Mussetti, A, Palmisiano, N, Patel, SS, Rizzieri, DA, Seo, S, Shah, MV, Sharma, A, Sohl, M, Solomon, SR, Ulrickson, M, Ustun, C, van der Poel, M, Verdonck, LF, Wagner, JL, Wang, T, Wirk, B, Zeidan, A, Litzow, M, Kebriaei, P, Hourigan, CS, Weisdorf, DJ, Saber, W & Kharfan-Dabaja, MA 2023, 'Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis', Blood Advances, vol. 7, no. 22, pp. 7007-7016. https://doi.org/10.1182/bloodadvances.2023011308
Caru, M, Alberts, NM, Freeman, MC, Dandekar, SC, Rao, P, McKeone, DJ, Brown, VI, McGregor, LM & Schmitz, KH 2023, 'Chronic pain in children and adolescents diagnosed with cancer: the challenge of mitigating the pain and the potential of integrating exercise into pain management', Supportive Care in Cancer, vol. 31, no. 4, 228. https://doi.org/10.1007/s00520-023-07695-6
Boyiadzis, M, Zhang, MJ, Chen, K, Abdel-Azim, H, Abid, MB, Aljurf, M, Bacher, U, Badar, T, Badawy, SM, Battiwalla, M, Bejanyan, N, Bhatt, VR, Brown, VI, Castillo, P, Cerny, J, Copelan, EA, Craddock, C, Dholaria, B, Perez, MAD, Ebens, CL, Gale, RP, Ganguly, S, Gowda, L, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Iqbal, M, Jamy, O, Kharfan-Dabaja, MA, Khera, N, Lazarus, HM, Lin, R, Modi, D, Nathan, S, Nishihori, T, Patel, SS, Pawarode, A, Saber, W, Sharma, A, Solh, M, Wagner, JL, Wang, T, Williams, KM, Winestone, LE, Wirk, B, Zeidan, A, Hourigan, CS, Litzow, M, Kebriaei, P, de Lima, M, Page, K & Weisdorf, DJ 2023, 'Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients (Leukemia, (2023), 37, 5, (1006-1017), 10.1038/s41375-022-01738-3)', Leukemia, vol. 37, no. 5, pp. 1173. https://doi.org/10.1038/s41375-023-01814-2
Narayan, R, Niroula, A, Wang, T, Kuxhausen, M, He, M, Meyer, E, Chen, YB, Bhatt, VR, Beitinjaneh, A, Nishihori, T, Sharma, A, Brown, VI, Kamoun, M, Diaz, MA, Abid, MB, Askar, M, Kanakry, CG, Gragert, L, Bolon, YT, Marsh, SGE, Gadalla, SM, Paczesny, S, Spellman, S & Lee, SJ 2023, 'HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia', Transplantation and Cellular Therapy, vol. 29, no. 7, pp. 452.e1-452.e11. https://doi.org/10.1016/j.jtct.2023.03.027
2022
Kraveka, JM, Lewis, EC, Bergendahl, G, Ferguson, W, Oesterheld, J, Kim, E, Nagulapally, AB, Dykema, KJ, Brown, VI, Roberts, WD, Mitchell, D, Eslin, D, Hanson, D, Isakoff, MS, Wada, RK, Harrod, VL, Rawwas, J, Hanna, G, Hendricks, WPD, Byron, SA, Snuderl, M, Serrano, J, Trent, JM & Saulnier Sholler, GL 2022, 'A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma', Cancer Reports, vol. 5, no. 11, e1616. https://doi.org/10.1002/cnr2.1616
Caru, M, Levesque, A, Rao, P, Dandekar, S, Terry, C, Brown, V, McGregor, L & Schmitz, K 2022, 'A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors', Critical Reviews in Oncology/Hematology, vol. 171, 103620. https://doi.org/10.1016/j.critrevonc.2022.103620
Bhatt, NS, Sharma, A, St. Martin, A, Abid, MB, Brown, VI, Diaz Perez, MA, Frangoul, H, Gadalla, SM, Herr, MM, Krem, MM, Lazarus, HM, Martens, MJ, Mehta, PA, Nishihori, T, Prestidge, T, Pulsipher, MA, Rangarajan, HG, Williams, KM, Winestone, LE, Yin, DE, Riches, ML, Dandoy, CE & Auletta, JJ 2022, 'Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study', Transplantation and Cellular Therapy, vol. 28, no. 10, pp. 696.e1-696.e7. https://doi.org/10.1016/j.jtct.2022.06.026
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Boyiadzis, M, Zhang, MJ, Chen, K, Abdel-Azim, H, Abid, MB, Aljurf, M, Bacher, U, Badar, T, Badawy, SM, Battiwalla, M, Bejanyan, N, Bhatt, VR, Brown, VI, Castillo, P, Cerny, J, Copelan, EA, Craddock, C, Dholaria, B, Perez, MAD, Ebens, CL, Gale, RP, Ganguly, S, Gowda, L, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Iqbal, M, Jamy, O, Kharfan-Dabaja, MA, Khera, N, Lazarus, HM, Lin, R, Modi, D, Nathan, S, Nishihori, T, Patel, SS, Pawarode, A, Saber, W, Sharma, A, Solh, M, Wagner, JL, Wang, T, Williams, KM, Winestone, LE, Wirk, B, Zeidan, A, Hourigan, CS, Litzow, M, Kebriaei, P, de Lima, M, Page, K & Weisdorf, DJ 2023, 'Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients', Leukemia, vol. 37, no. 5, pp. 1006-1017. https://doi.org/10.1038/s41375-022-01738-3
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Otegbeye, F, Vina, MAF, Wang, T, Bolon, YT, Lazaryan, A, Beitinjaneh, A, Bhatt, VR, Castillo, P, Marsh, SGE, Hildebrandt, GC, Assal, A, Brown, VI, Hsu, J, Spellman, S, de Lima, M & Lee, SJ 2022, 'Natural Killer Cell Alloreactivity Predicted By Killer Cell Immunoglobulin-Like Receptor Ligand Mismatch Does Not Impact Engraftment in Umbilical Cord Blood and Haploidentical Stem Cell Transplantation', Transplantation and Cellular Therapy, vol. 28, no. 8, pp. 483.e1-483.e7. https://doi.org/10.1016/j.jtct.2022.05.034
2021
Center for International Blood and Marrow Transplant Research Immunobiology Working Committee 2021, 'Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation', Transplantation and Cellular Therapy, vol. 27, no. 7, pp. 591-599. https://doi.org/10.1016/j.jtct.2021.04.003
Byron, SA, Hendricks, WPD, Nagulapally, AB, Kraveka, JM, Ferguson, WS, Brown, VI, Eslin, DE, Mitchell, D, Cornelius, A, Roberts, W, Isakoff, MS, Oesterheld, JE, Wada, RK, Rawwas, J, Neville, K, Zage, PE, Harrod, VL, Bergendahl, G, Vansickle, E, Dykema, K, Bond, J, Chou, HC, Wei, JS, Wen, X, Reardon, HV, Roos, A, Nasser, S, Izatt, T, Enriquez, D, Hegde, AM, Cisneros, F, Christofferson, A, Turner, B, Szelinger, S, Keats, JJ, Halperin, RF, Khan, J, Sholler, GLS & Trent, JM 2021, 'Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion', Cancer Research, vol. 81, no. 23, pp. 5818-5832. https://doi.org/10.1158/0008-5472.CAN-21-1033
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7