Researcher Profile

Researcher Profile

Valerie Brown, MD, PhD

Valerie Brown, MD, PhD

Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Immunotherapy
Pediatric Cancer
vub2@psu.edu

Research Interests

  • Transplants
  • Therapeutics
  • Hematopoietic Stem Cell Transplantation
  • Pediatrics
  • Leukemia
  • Allogeneic Cells
  • Survival
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Child
  • Cell Transplantation
  • Tissue Donors
  • Infections

Clinical Trials

Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
A Phase I/II Study of Neratinib in Pediatric Patients with Relapsed or Refractory Solid Tumors or Hematologic Malignancies
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
A Phase I/II, Multicenter, Open-Label, Multi-Arm Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Activity of Idasanutlin in Combination with either Chemotherapy or Venetoclax in the Treatment of Pediatric and Young Adult Patients with Relapsed/Refractory Acute Leukemias or Solid Tumors
Phase 1 Study To Evaluate the Safety and Pharmacokinetics of Palbociclib (Ibrance®) in Combination with Irinotecan and Temozolomide in Pediatric Patients with Recurrent or Refractory Solid Tumors
A Phase 1/2, Open-label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects with Advanced or Metastatic Malignancies Harboring ALK, ROS1, or NTRK1-3 Alterations
Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
Phase II Trial of Eflornithine/DFMO as Maintenance Therapy for Molecular High Risk/Very High Risk and Relapsed/Refractory Medulloblastoma
Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

Recent Publications

2022

Kraveka, JM, Lewis, EC, Bergendahl, G, Ferguson, W, Oesterheld, J, Kim, E, Nagulapally, AB, Dykema, KJ, Brown, VI, Roberts, WD, Mitchell, D, Eslin, D, Hanson, D, Isakoff, MS, Wada, RK, Harrod, VL, Rawwas, J, Hanna, G, Hendricks, WPD, Byron, SA, Snuderl, M, Serrano, J, Trent, JM & Saulnier Sholler, GL 2022, 'A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma', Cancer Reports, vol. 5, no. 11, e1616. https://doi.org/10.1002/cnr2.1616
Bhatt, NS, Sharma, A, St. Martin, A, Abid, MB, Brown, VI, Diaz Perez, MA, Frangoul, H, Gadalla, SM, Herr, MM, Krem, MM, Lazarus, HM, Martens, MJ, Mehta, PA, Nishihori, T, Prestidge, T, Pulsipher, MA, Rangarajan, HG, Williams, KM, Winestone, LE, Yin, DE, Riches, ML, Dandoy, CE & Auletta, JJ 2022, 'Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study', Transplantation and Cellular Therapy, vol. 28, no. 10, pp. 696.e1-696.e7. https://doi.org/10.1016/j.jtct.2022.06.026
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2022, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology. https://doi.org/10.1007/s00277-022-05077-2
Boyiadzis, M, Zhang, MJ, Chen, K, Abdel-Azim, H, Abid, MB, Aljurf, M, Bacher, U, Badar, T, Badawy, SM, Battiwalla, M, Bejanyan, N, Bhatt, VR, Brown, VI, Castillo, P, Cerny, J, Copelan, EA, Craddock, C, Dholaria, B, Perez, MAD, Ebens, CL, Gale, RP, Ganguly, S, Gowda, L, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Iqbal, M, Jamy, O, Kharfan-Dabaja, MA, Khera, N, Lazarus, HM, Lin, R, Modi, D, Nathan, S, Nishihori, T, Patel, SS, Pawarode, A, Sharma, A, Solh, M, Wagner, JL, Wang, T, Williams, KM, Winestone, LE, Wirk, B, Hourigan, CS, Litzow, M, Kebriaei, P, de Lima, M, Page, K & Weisdorf, DJ 2022, 'Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients', Leukemia. https://doi.org/10.1038/s41375-022-01738-3
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Otegbeye, F, Vina, MAF, Wang, T, Bolon, YT, Lazaryan, A, Beitinjaneh, A, Bhatt, VR, Castillo, P, Marsh, SGE, Hildebrandt, GC, Assal, A, Brown, VI, Hsu, J, Spellman, S, de Lima, M & Lee, SJ 2022, 'Natural Killer Cell Alloreactivity Predicted By Killer Cell Immunoglobulin-Like Receptor Ligand Mismatch Does Not Impact Engraftment in Umbilical Cord Blood and Haploidentical Stem Cell Transplantation', Transplantation and Cellular Therapy, vol. 28, no. 8, pp. 483.e1-483.e7. https://doi.org/10.1016/j.jtct.2022.05.034

2021

Center for International Blood and Marrow Transplant Research Immunobiology Working Committee 2021, 'Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation', Transplantation and Cellular Therapy, vol. 27, no. 7, pp. 591-599. https://doi.org/10.1016/j.jtct.2021.04.003
Byron, SA, Hendricks, WPD, Nagulapally, AB, Kraveka, JM, Ferguson, WS, Brown, VI, Eslin, DE, Mitchell, D, Cornelius, A, Roberts, W, Isakoff, MS, Oesterheld, JE, Wada, RK, Rawwas, J, Neville, K, Zage, PE, Harrod, VL, Bergendahl, G, Vansickle, E, Dykema, K, Bond, J, Chou, HC, Wei, JS, Wen, X, Reardon, HV, Roos, A, Nasser, S, Izatt, T, Enriquez, D, Hegde, AM, Cisneros, F, Christofferson, A, Turner, B, Szelinger, S, Keats, JJ, Halperin, RF, Khan, J, Sholler, GLS & Trent, JM 2021, 'Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion', Cancer Research, vol. 81, no. 23, pp. 5818-5832. https://doi.org/10.1158/0008-5472.CAN-21-1033
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7

2020

Lewis, EC, Kraveka, JM, Ferguson, W, Eslin, D, Brown, VI, Bergendahl, G, Roberts, W, Wada, RK, Oesterheld, J, Mitchell, D, Foley, J, Zage, P, Rawwas, J, Rich, M, Lorenzi, E, Broglio, K, Berry, D & Saulnier Sholler, GL 2020, 'A subset analysis of a phase II trial evaluating the use of DFMO as maintenance therapy for high-risk neuroblastoma', International Journal of Cancer, vol. 147, no. 11, pp. 3152-3159. https://doi.org/10.1002/ijc.33044
Dandoy, CE, Kim, S, Chen, M, Ahn, KW, Ardura, MI, Brown, V, Chhabra, S, Diaz, MA, Dvorak, C, Farhadfar, N, Flagg, A, Ganguly, S, Hale, GA, Hashmi, SK, Hematti, P, Martino, R, Nishihori, T, Nusrat, R, Olsson, RF, Rotz, SJ, Sung, AD, Perales, MA, Lindemans, CA, Komanduri, KV & Riches, ML 2020, 'Incidence, Risk Factors, and Outcomes of Patients Who Develop Mucosal Barrier Injury-Laboratory Confirmed Bloodstream Infections in the First 100 Days After Allogeneic Hematopoietic Stem Cell Transplant', JAMA network open, vol. 3, no. 1, pp. e1918668. https://doi.org/10.1001/jamanetworkopen.2019.18668
Camacho-Bydume, C, Wang, T, Sees, JA, Fernandez-Viña, M, Abid, MB, Askar, M, Beitinjaneh, A, Brown, V, Castillo, P, Chhabra, S, Gadalla, SM, Hsu, JM, Kamoun, M, Lazaryan, A, Nishihori, T, Page, K, Schetelig, J, Fleischhauer, K, Marsh, SGE, Paczesny, S, Spellman, SR, Lee, SJ & Hsu, KC 2020, 'Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes', Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2020.10.010

2019

Papanicolaou, GA, Ustun, C, Young, JAH, Chen, M, Kim, S, Woo Ahn, K, Komanduri, K, Lindemans, C, Auletta, JJ, Riches, ML, Abdel-Azim, H, Ahmed, IA, Aljurf, M, Antin, J, Ballen, KK, Beitinjaneh, A, Brown, VI, Cerny, J, Champlin, R, Chao, N, Chhabra, S, Dahi, PB, Daly, A, Dandoy, C, Dvorak, CC, Forman, S, Ganguly, S, Hashmi, SK, Kharfan-Dabaja, MA, Lazarus, H, Ljungman, P, Malone, AK, Murthy, G, Nishihori, T, Page, K, Pingali, RSR, Reddy, V, Saad, A, Savani, BN, Seftel, M, Szer, J, Vij, R, Weisdorf, D, William, BM, Williams, K, Wirk, B & Yared, J 2019, 'Bloodstream Infection Due to Vancomycin-resistant Enterococcus Is Associated with Increased Mortality after Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome: A Multicenter, Retrospective Cohort Study', Clinical Infectious Diseases, vol. 69, no. 10, pp. 1771-1779. https://doi.org/10.1093/cid/ciz031
Ustun, C, Kim, S, Chen, M, Beitinjaneh, AM, Brown, VI, Dahi, PB, Daly, A, Diaz, MA, Freytes, CO, Ganguly, S, Hashmi, S, Hildebrandt, GC, Lazarus, HM, Nishihori, T, Olsson, RF, Page, KM, Papanicolaou, G, Saad, A, Seo, S, William, BM, Wingard, JR, Wirk, B, Yared, JA, Perales, MA, Auletta, JJ, Komanduri, KV, Lindemans, CA & Riches, ML 2019, 'Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1', Blood Advances, vol. 3, no. 17, pp. 2525-2536. https://doi.org/10.1182/bloodadvances.2019000226
Naik, S, Riches, M, Hari, P, Kim, S, Chen, M, Bachier, C, Shaughnessy, P, Hill, J, Ljungman, P, Battiwalla, M, Chhabra, S, Daly, A, Storek, J, Ustun, C, Diaz, MA, Cerny, J, Beitinjaneh, A, Yared, J, Brown, V, Page, K, Dahi, PB, Ganguly, S, Seo, S, Chao, N, Freytes, CO, Saad, A, Savani, BN, Woo Ahn, K, Boeckh, M, Heslop, HE, Lazarus, HM, Auletta, JJ & Kamble, RT 2019, 'Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study', Transplant Infectious Disease, vol. 21, no. 5, e13145. https://doi.org/10.1111/tid.13145

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)