Researcher Profile

Researcher Profile

Valerie Brown, MD, PhD

Valerie Brown, MD, PhD

Professor, Department of Pediatrics
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Immunotherapy
Pediatric Cancer
vub2@psu.edu

Research Interests

  • Hematopoietic Stem Cell Transplantation
  • Therapeutics
  • Pediatrics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia
  • Transplants
  • Graft vs Host Disease
  • Survival
  • Sirolimus
  • Bone Marrow
  • Proteins
  • Growth

Clinical Trials

A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant
Risk-based, Response-adapted, Phase II Open-label Trial of Nivolumab + Brentuximab Vedotin (N + Bv) for Children, Adolescents, and Young Adults With Relapsed/Refractory (R/R) CD30 + Classic Hodgkin Lymphoma (cHL) After Failure of First-line Therapy, Followed by Brentuximab + Bendamustine (Bv + B) for Participants With a Suboptimal Response (CheckMate 744: CHECKpoint Pathway and Nivolumab Clinical Trial Evaluation)
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma.
A Phase II Study of Pazopanib (GW786034, NSC# 737754) in Children, Adolescents and Young Adults with Refractory Solid Tumors
A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention Versus No Systemic Anticoagulant Prophylaxis During Induction Chemotherapy in Children With Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B Cell) Treated With Asparaginase
Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.

Recent Publications

2018

Ustun, C, Young, JAH, Papanicolaou, GA, Kim, S, Ahn, KW, Chen, M, Abdel-Azim, H, Aljurf, M, Beitinjaneh, A, Brown, V, Cerny, J, Chhabra, S, Kharfan-Dabaja, MA, Dahi, PB, Daly, A, Dandoy, CE, Dvorak, CC, Freytes, CO, Hashmi, S, Lazarus, H, Ljungman, P, Nishihori, T, Page, K, Pingali, SRK, Saad, A, Savani, BN, Weisdorf, D, Williams, K, Wirk, B, Auletta, JJ, Lindemans, CA, Komanduri, K & Riches, M 2019, 'Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation', Bone Marrow Transplantation, vol. 54, no. 8, pp. 1254-1265. https://doi.org/10.1038/s41409-018-0401-4
Slayton, WB, Schultz, KR, Kairalla, JA, Devidas, M, Mi, X, Pulsipher, MA, Chang, BH, Mullighan, C, Iacobucci, I, Silverman, LB, Borowitz, MJ, Carroll, AJ, Heerema, NA, Gastier-Foster, JM, Wood, BL, Mizrahy, SL, Merchant, T, Brown, V, Sieger, L, Siegel, MJ, Raetz, EA, Winick, NJ, Loh, ML, Carroll, WL & Hunger, SP 2018, 'Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of children’s oncology group trial AALL0622', Journal of Clinical Oncology, vol. 36, no. 22, pp. 2306-2313. https://doi.org/10.1200/JCO.2017.76.7228
Brown, V 2018, Graft-versus-host disease. in The 5-Minute Pediatric Consult, 8th Edition. Wolters Kluwer Health, pp. 402-403.
Sholler, GLS, Ferguson, W, Bergendahl, G, Bond, JP, Neville, K, Eslin, D, Brown, V, Roberts, W, Wada, RK, Oesterheld, J, Mitchell, D, Foley, J, Parikh, NS, Eshun, F, Zage, P, Rawwas, J, Sencer, S, Pankiewicz, D, Quinn, M, Rich, M, Junewick, J & Kraveka, JM 2018, 'Maintenance DFMO Increases Survival in High Risk Neuroblastoma', Scientific reports, vol. 8, no. 1, 14445. https://doi.org/10.1038/s41598-018-32659-w
Lund, TC, Ahn, KW, Tecca, HR, Hilgers, MV, Abdel-Azim, H, Abraham, A, Diaz, MA, Badawy, SM, Broglie, L, Brown, V, Dvorak, CC, Gonzalez-Vicent, M, Hashem, H, Hayashi, RJ, Jacobsohn, DA, Kent, MW, Li, CK, Margossian, SP, Martin, PL, Mehta, P, Myers, K, Olsson, R, Page, K, Pulsipher, MA, Shaw, PJ, Smith, AR, Triplett, BM, Verneris, MR & Eapen, M 2019, 'Outcomes after Second Hematopoietic Cell Transplantation in Children and Young Adults with Relapsed Acute Leukemia' Biology of Blood and Marrow Transplantation, vol. 25, no. 2, pp. 301-306. https://doi.org/10.1016/j.bbmt.2018.09.016

2017

Brown, V 2017, Brief introduction to the basic scientific principles of hematopoietic stem cell transplantation (HSCT). in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 19-53. https://doi.org/10.1007/978-3-319-63146-2_3
Brown, V 2017, Cardiac complications associated with HSCT. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 333-341. https://doi.org/10.1007/978-3-319-63146-2_23
Brown, V 2017, Engraftment and chimerism. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 177-186. https://doi.org/10.1007/978-3-319-63146-2_10
Brown, V 2017, Graft failure. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 187-194. https://doi.org/10.1007/978-3-319-63146-2_11
Eichelberger, C & Brown, V 2017, HSCT recipient pretransplantation evaluation. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 91-96. https://doi.org/10.1007/978-3-319-63146-2_6
Brown, V 2017, HSCT-associated complications of the skin, hair, and nails. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 363-368. https://doi.org/10.1007/978-3-319-63146-2_25
Khandelwal, P, Millard, HR, Thiel, E, Abdel-Azim, H, Abraham, AA, Auletta, JJ, Boulad, F, Brown, V, Camitta, BM, Chan, KW, Chaudhury, S, Cowan, MJ, Angel-Diaz, M, Gadalla, SM, Gale, RP, Hale, G, Kasow, KA, Keating, AK, Kitko, CL, MacMillan, ML, Olsson, RF, Page, KM, Seber, A, Smith, AR, Warwick, AB, Wirk, B & Mehta, PA 2017, 'Hematopoietic Stem Cell Transplantation Activity in Pediatric Cancer between 2008 and 2014 in the United States: A Center for International Blood and Marrow Transplant Research Report', Biology of Blood and Marrow Transplantation, vol. 23, no. 8, pp. 1342-1349. https://doi.org/10.1016/j.bbmt.2017.04.018
Brown, V 2017, Hematopoietic stem cell transplantation for the pediatric hematologist/oncologist. Springer International Publishing. https://doi.org/10.1007/978-3-319-63146-2
Brown, V 2017, Hepatotoxicity in the peri-HSCT period. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 215-233. https://doi.org/10.1007/978-3-319-63146-2_15
Brown, V 2017, Historical overview of pediatric HSCT. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 7-18. https://doi.org/10.1007/978-3-319-63146-2_2
Brown, V 2017, Introduction. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 3-5. https://doi.org/10.1007/978-3-319-63146-2_1
Brown, V 2017, Neurologic and sensory complications associated with HSCT. in Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist. Springer International Publishing, pp. 343-361. https://doi.org/10.1007/978-3-319-63146-2_24
Bitan, M, Ahn, KW, Millard, HR, Pulsipher, MA, Abdel-Azim, H, Auletta, JJ, Brown, V, Chan, KW, Diaz, MA, Dietz, A, Vincent, MG, Guilcher, G, Hale, GA, Hayashi, RJ, Keating, A, Mehta, P, Myers, K, Page, K, Prestidge, T, Shah, NN, Smith, AR, Woolfrey, A, Thiel, E, Davies, SM & Eapen, M 2017, 'Personalized Prognostic Risk Score for Long-Term Survival for Children with Acute Leukemia after Allogeneic Transplantation', Biology of Blood and Marrow Transplantation, vol. 23, no. 9, pp. 1523-1530. https://doi.org/10.1016/j.bbmt.2017.05.011

2015

Burke, MJ, Verneris, MR, Le Rademacher, J, He, W, Abdel-Azim, H, Abraham, AA, Auletta, JJ, Ayas, M, Brown, V, Cairo, MS, Chan, KW, Diaz Perez, MA, Dvorak, CC, Egeler, RM, Eldjerou, L, Frangoul, H, Guilcher, GMT, Hayashi, RJ, Ibrahim, A, Kasow, KA, Leung, WH, Olsson, RF, Pulsipher, MA, Shah, N, Shah, NN, Thiel, E, Talano, JA & Kitko, CL 2015, 'Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research' Biology of Blood and Marrow Transplantation, vol. 21, no. 12, pp. 2154-2159. https://doi.org/10.1016/j.bbmt.2015.08.023

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)