Researcher Profile

Researcher Profile

Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and Penn State IFC/Panhellenic Dance Marathon Chair for Pediatric Cancer Research, Department of Pediatrics
Professor, Department of Pharmacology
Division of Hematology and Oncology
Scientific Program:Mechanisms of Carcinogenesis
vss5090@psu.edu

Research Interests

  • Neoplasms
  • Messenger RNA
  • Melanoma
  • Growth
  • Carrier Proteins
  • Catenins
  • Ubiquitin-Protein Ligases
  • Carcinogenesis
  • Proteins
  • MicroRNAs
  • Skin
  • Genes

Recent Publications

2019

Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, V 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622. https://doi.org/10.1016/j.tiv.2019.104622
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, I, Liu, Z, Abraham, T & Spiegelman, V 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196. https://doi.org/10.1038/s41388-019-0797-3
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, V, Robertson, G & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219. https://doi.org/10.1097/CMR.0000000000000545

2018

Kim, TW, Havighurst, T, Kim, KM, Albertini, M, Xu, YG & Spiegelman, V 2018, ' Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAF V600E inhibitors ', Molecular Carcinogenesis, vol. 57, no. 5, pp. 678-683. https://doi.org/10.1002/mc.22786
Noubissi, FK, Yedjou, CG, Spiegelman, V & Tchounwou, PB 2018, 'Cross-talk between Wnt and Hh signaling pathways in the pathology of basal cell carcinoma', International journal of environmental research and public health, vol. 15, no. 7, 1442. https://doi.org/10.3390/ijerph15071442
Chamcheu, JC, Rady, I, Chamcheu, RCN, Siddique, AB, Bloch, MB, Mbeumi, SB, Babatunde, AS, Uddin, MB, Noubissi, FK, Jurutka, PW, Liu, YY, Spiegelman, V, Whitfield, GK & El Sayed, KA 2018, 'Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling', International journal of molecular sciences, vol. 19, no. 6, 1791. https://doi.org/10.3390/ijms19061791
Poenitzsch Strong, AM, Berry, SM, Beebe, DJ, Li, JL & Spiegelman, V 2018, 'miFAST: A novel and rapid microRNA target capture method', Molecular Carcinogenesis, vol. 57, no. 4, pp. 559-566. https://doi.org/10.1002/mc.22780

2017

Spiegelman, V & Elcheva, I 2017, 'Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo', Journal of Investigative Dermatology, vol. 137, no. 9, pp. 1828-1830. https://doi.org/10.1016/j.jid.2017.06.012
Kim, TW, Havighurst, T, Kim, KM, Hebbring, SJ, Ye, Z, Aylward, J, Keles, S, Xu, YG & Spiegelman, V 2017, 'RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma', Journal of Investigative Dermatology, vol. 137, no. 3, pp. 772-775. https://doi.org/10.1016/j.jid.2016.10.042

2015

Hamilton, KE, Chatterji, P, Lundsmith, ET, Andres, SF, Giroux, V, Hicks, PD, Noubissi, FK, Spiegelman, V & Rustgi, AK 2015, 'Loss of stromal IMP1 promotes a tumorigenic microenvironment in the colon', Molecular Cancer Research, vol. 13, no. 11, pp. 1478-1486. https://doi.org/10.1158/1541-7786.MCR-15-0224
Goswami, S, Tarapore, RS, Strong, AMP, TeSlaa, JJ, Grinblat, Y, Setaluri, V & Spiegelman, V 2015, 'MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP)', Journal of Biological Chemistry, vol. 290, no. 1, pp. 384-395. https://doi.org/10.1074/jbc.M114.590158
Fakhraldeen, SA, Clark, RJ, Roopra, A, Chin, EN, Huang, W, Castorino, J, Wisinski, KB, Kim, TW, Spiegelman, V & Alexander, CM 2015, 'Two isoforms of the RNA binding protein, coding region determinant-binding protein (CRD-BP/IGF2BP1), are expressed in breast epithelium and support clonogenic growth of breast tumor cells', Journal of Biological Chemistry, vol. 290, no. 21, pp. 13386-13400. https://doi.org/10.1074/jbc.M115.655175

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)