Researcher Profile

Researcher Profile

Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and Penn State IFC/Panhellenic Dance Marathon Chair for Pediatric Cancer Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
vss5090@psu.edu

Research Interests

  • Messenger RNA
  • Neoplasms
  • Melanoma
  • Carrier Proteins
  • Growth
  • Catenins
  • Ubiquitin-Protein Ligases
  • Genes
  • Proteins
  • Carcinogenesis
  • Skin
  • Colorectal Neoplasms

Recent Publications

2020

Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16. https://doi.org/10.3390/cancers12071739
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25. https://doi.org/10.1074/jbc.ac120.013646

2019

Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, VS 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622. https://doi.org/10.1016/j.tiv.2019.104622
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, IA, Liu, Z, Abraham, T & Spiegelman, VS 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196. https://doi.org/10.1038/s41388-019-0797-3
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, VS, Robertson, GP & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219. https://doi.org/10.1097/CMR.0000000000000545
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363. https://doi.org/10.1038/s41375-019-0656-9

2018

Noubissi, FK, Yedjou, CG, Spiegelman, VS & Tchounwou, PB 2018, 'Cross-talk between Wnt and Hh signaling pathways in the pathology of basal cell carcinoma', International journal of environmental research and public health, vol. 15, no. 7, 1442. https://doi.org/10.3390/ijerph15071442
Chamcheu, JC, Rady, I, Chamcheu, RCN, Siddique, AB, Bloch, MB, Mbeumi, SB, Babatunde, AS, Uddin, MB, Noubissi, FK, Jurutka, PW, Liu, YY, Spiegelman, VS, Whitfield, GK & El Sayed, KA 2018, 'Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling', International journal of molecular sciences, vol. 19, no. 6, 1791. https://doi.org/10.3390/ijms19061791
Kim, TW, Havighurst, T, Kim, KM, Albertini, M, Xu, YG & Spiegelman, VS 2018, 'Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAFV600E inhibitors', Molecular Carcinogenesis, vol. 57, no. 5, pp. 678-683. https://doi.org/10.1002/mc.22786
Poenitzsch Strong, AM, Berry, SM, Beebe, DJ, Li, JL & Spiegelman, V 2018, 'miFAST: A novel and rapid microRNA target capture method', Molecular Carcinogenesis, vol. 57, no. 4, pp. 559-566. https://doi.org/10.1002/mc.22780

2017

Spiegelman, VS & Elcheva, IA 2017, 'Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo', Journal of Investigative Dermatology, vol. 137, no. 9, pp. 1828-1830. https://doi.org/10.1016/j.jid.2017.06.012
Kim, TW, Havighurst, T, Kim, KM, Hebbring, SJ, Ye, Z, Aylward, J, Keles, S, Xu, YG & Spiegelman, VS 2017, 'RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma', Journal of Investigative Dermatology, vol. 137, no. 3, pp. 772-775. https://doi.org/10.1016/j.jid.2016.10.042

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)