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Researcher Profile

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Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and THON Chair for Pediatric Cancer Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Messenger RNA
  • Melanoma
  • Carrier Proteins
  • Growth
  • Catenins
  • RNA-Binding Proteins
  • Proteins
  • Ubiquitin-Protein Ligases
  • Genes
  • Carcinogenesis
  • Skin

Recent Publications


Baringer, SL, Palsa, K, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation', Journal of Biomedical Science, vol. 30, no. 1, 36.
Palsa, K, Baringer, SL, Shenoy, G, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status', Journal of Biological Chemistry, vol. 299, no. 2, 102868.
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516.
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, CN, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571.


Singh, A, Singh, V, Wallis, N, Elimelech, O, Oberman, F, Ramos, A, Yisraeli, J, Spiegelman, V & Sharma, A 2022, 'Development of a Novel IGF2BP1 Inhibitor as Metastasis-Specific Therapeutic Agent', European Journal of Cancer, vol. 174, pp. S104-S105.
Fakhraldeen, SA, Berry, SM, Beebe, DJ, Roopra, A, Bisbach, CM, Spiegelman, VS, Niemi, NM & Alexander, CM 2022, 'Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells', Journal of Biological Chemistry, vol. 298, no. 3, 101649.
Betson, N, Hajahmed, M, Gebretsadek, T, Ndebele, K, Ahmad, HA, Tchounwou, PB, Spiegelman, VS & Noubissi, FK 2022, 'Inhibition of insulin-like growth factor 2 mRNA-binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics', FASEB BioAdvances, vol. 4, no. 12, pp. 816-829.
Liu, X, Wills, CA, Chen, L, Zhang, J, Zhao, Y, Zhou, M, Sundstrom, JM, Schell, T, Spiegelman, VS, Young, MM & Wang, HG 2022, 'Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy', Journal for ImmunoTherapy of Cancer, vol. 10, no. 4, e004399.
Grant, CN, Wills, CA, Liu, X, Spiegelman, VS & Wang, HG 2022, 'Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma', In Vivo, vol. 36, no. 1, pp. 49-56.


Liu, Z, Spiegelman, VS & Wang, HG 2022, 'Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis', Cancer Reports, vol. 5, no. 10, e1592.
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278.
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation', Data in Brief, vol. 35, 106858.
Biegel, JM, Dhamdhere, M, Gao, S, Gowda, CP, Kawasawa, YI & Spiegelman, VS 2021, 'Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents', Frontiers in Oncology, vol. 11, 608816.
Liu, Z, Liang, M, Grant, CN, Spiegelman, VS & Wang, HG 2021, 'Interpretable models for high-risk neuroblastoma stratification with multi-cohort copy number profiles', Informatics in Medicine Unlocked, vol. 25, 100701.
Wallis, N, Oberman, F, Shurrush, K, Germain, N, Greenwald, G, Gershon, T, Pearl, T, Abis, G, Singh, V, Singh, A, Sharma, AK, Barr, HM, Ramos, A, Spiegelman, VS & Yisraeli, JK 2022, 'Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells', RNA Biology, vol. 19, no. 1, pp. 26-43.
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers', Bioorganic Chemistry, vol. 107, 104595.
Elcheva, IA & Spiegelman, VS 2021, 'Targeting RNA-binding proteins in acute and chronic leukemia', Leukemia, vol. 35, no. 2, pp. 360-376.


Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16.
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534.
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612.
Elcheva, IA & Spiegelman, VS 2020, 'The role of cis-and trans-acting rna regulatory elements in leukemia', Cancers, vol. 12, no. 12, 3854, pp. 1-30.


Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, VS 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622.
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, IA, Liu, Z, Abraham, T & Spiegelman, VS 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196.
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, VS, Robertson, GP & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219.
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363.