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Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and THON Chair for Pediatric Cancer Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
VSS5090@psu.edu

Research Interests

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  • Neoplasms
  • Messenger RNA
  • Melanoma
  • Carrier Proteins
  • Growth
  • Catenins
  • RNA-Binding Proteins
  • Proteins
  • Ubiquitin-Protein Ligases
  • Genes
  • Carcinogenesis
  • Skin
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Recent Publications

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2024

Wills, CA, Liu, X, Chen, L, Zhao, Y, Liu, Z, Spiegelman, VS, Sundstrom, J & Wang, HG 2024, 'Chemotherapy-induced small extracellular vesicles prime the pre-metastatic niche to accelerate neuroblastoma metastasis', Genes and Diseases, vol. 11, no. 4, 101017. https://doi.org/10.1016/j.gendis.2023.05.016
Singh, A, Singh, V, Wallis, N, Abis, G, Oberman, F, Wood, T, Dhamdhere, M, Gershon, T, Ramos, A, Yisraeli, J, Spiegelman, VS & Sharma, AK 2024, 'Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers', European Journal of Medicinal Chemistry, vol. 263, 115940. https://doi.org/10.1016/j.ejmech.2023.115940

2023

Baringer, SL, Lukacher, AS, Palsa, K, Kim, H, Lippmann, ES, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo- and holo-transferrin', Journal of neurochemistry, vol. 167, no. 2, pp. 248-261. https://doi.org/10.1111/jnc.15954
Baringer, SL, Palsa, K, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation', Journal of Biomedical Science, vol. 30, no. 1, 36. https://doi.org/10.1186/s12929-023-00934-2
Palsa, K, Baringer, SL, Shenoy, G, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status', Journal of Biological Chemistry, vol. 299, no. 2, 102868. https://doi.org/10.1016/j.jbc.2022.102868
Dhamdhere, MR, Spiegelman, DV, Schneper, L, Erbe, AK, Sondel, PM & Spiegelman, VS 2023, 'Generation of Novel Immunocompetent Mouse Cell Lines to Model Experimental Metastasis of High-Risk Neuroblastoma', Cancers, vol. 15, no. 19, 4693. https://doi.org/10.3390/cancers15194693
Singh, V, Walter, V, Elcheva, I, Imamura Kawasawa, Y & Spiegelman, VS 2023, 'Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells', Frontiers in Cell and Developmental Biology, vol. 11, 1236356. https://doi.org/10.3389/fcell.2023.1236356
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571. https://doi.org/10.1038/s41388-023-02671-0

2022

Singh, A, Singh, V, Wallis, N, Elimelech, O, Oberman, F, Ramos, A, Yisraeli, J, Spiegelman, V & Sharma, A 2022, 'Development of a Novel IGF2BP1 Inhibitor as Metastasis-Specific Therapeutic Agent', European Journal of Cancer, vol. 174, pp. S104-S105. https://doi.org/10.1016/S0959-8049(22)01078-4
Fakhraldeen, SA, Berry, SM, Beebe, DJ, Roopra, A, Bisbach, CM, Spiegelman, VS, Niemi, NM & Alexander, CM 2022, 'Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells', Journal of Biological Chemistry, vol. 298, no. 3, 101649. https://doi.org/10.1016/j.jbc.2022.101649
Betson, N, Hajahmed, M, Gebretsadek, T, Ndebele, K, Ahmad, HA, Tchounwou, PB, Spiegelman, VS & Noubissi, FK 2022, 'Inhibition of insulin-like growth factor 2 mRNA-binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics', FASEB BioAdvances, vol. 4, no. 12, pp. 816-829. https://doi.org/10.1096/fba.2021-00069
Liu, X, Wills, CA, Chen, L, Zhang, J, Zhao, Y, Zhou, M, Sundstrom, JM, Schell, T, Spiegelman, VS, Young, MM & Wang, HG 2022, 'Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy', Journal for ImmunoTherapy of Cancer, vol. 10, no. 4, e004399. https://doi.org/10.1136/jitc-2021-004399
Grant, CN, Wills, CA, Liu, X, Spiegelman, VS & Wang, HG 2022, 'Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma', In Vivo, vol. 36, no. 1, pp. 49-56. https://doi.org/10.21873/INVIVO.12675

2021

Liu, Z, Spiegelman, VS & Wang, HG 2022, 'Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis', Cancer Reports, vol. 5, no. 10, e1592. https://doi.org/10.1002/cnr2.1592
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation', Data in Brief, vol. 35, 106858. https://doi.org/10.1016/j.dib.2021.106858
Biegel, JM, Dhamdhere, M, Gao, S, Gowda, CP, Kawasawa, YI & Spiegelman, VS 2021, 'Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents', Frontiers in Oncology, vol. 11, 608816. https://doi.org/10.3389/fonc.2021.608816
Liu, Z, Liang, M, Grant, CN, Spiegelman, VS & Wang, HG 2021, 'Interpretable models for high-risk neuroblastoma stratification with multi-cohort copy number profiles', Informatics in Medicine Unlocked, vol. 25, 100701. https://doi.org/10.1016/j.imu.2021.100701
Wallis, N, Oberman, F, Shurrush, K, Germain, N, Greenwald, G, Gershon, T, Pearl, T, Abis, G, Singh, V, Singh, A, Sharma, AK, Barr, HM, Ramos, A, Spiegelman, VS & Yisraeli, JK 2022, 'Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells', RNA Biology, vol. 19, no. 1, pp. 26-43. https://doi.org/10.1080/15476286.2021.2010983
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers', Bioorganic Chemistry, vol. 107, 104595. https://doi.org/10.1016/j.bioorg.2020.104595
Elcheva, IA & Spiegelman, VS 2021, 'Targeting RNA-binding proteins in acute and chronic leukemia', Leukemia, vol. 35, no. 2, pp. 360-376. https://doi.org/10.1038/s41375-020-01066-4

2020

Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16. https://doi.org/10.3390/cancers12071739
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612. https://doi.org/10.1074/jbc.ac120.013646
Elcheva, IA & Spiegelman, VS 2020, 'The role of cis-and trans-acting rna regulatory elements in leukemia', Cancers, vol. 12, no. 12, 3854, pp. 1-30. https://doi.org/10.3390/cancers12123854
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