Researcher Profile

Researcher Profile

Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and Penn State IFC/Panhellenic Dance Marathon Chair for Pediatric Cancer Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
vss5090@psu.edu

Research Interests

  • Neoplasms
  • Messenger RNA
  • Melanoma
  • Carrier Proteins
  • Growth
  • Catenins
  • RNA-Binding Proteins
  • Ubiquitin-Protein Ligases
  • Proteins
  • Genes
  • Carcinogenesis
  • Skin

Recent Publications

2022

Singh, A, Singh, V, Wallis, N, Elimelech, O, Oberman, F, Ramos, A, Yisraeli, J, Spiegelman, V & Sharma, A 2022, 'Development of a Novel IGF2BP1 Inhibitor as Metastasis-Specific Therapeutic Agent', European Journal of Cancer, vol. 174, pp. S104-S105. https://doi.org/10.1016/S0959-8049(22)01078-4
Fakhraldeen, SA, Berry, SM, Beebe, DJ, Roopra, A, Bisbach, CM, Spiegelman, VS, Niemi, NM & Alexander, CM 2022, 'Enhanced immunoprecipitation techniques for the identification of RNA-binding protein partners: IGF2BP1 interactions in mammary epithelial cells', Journal of Biological Chemistry, vol. 298, no. 3, 101649. https://doi.org/10.1016/j.jbc.2022.101649
Betson, N, Hajahmed, M, Gebretsadek, T, Ndebele, K, Ahmad, HA, Tchounwou, PB, Spiegelman, VS & Noubissi, FK 2022, 'Inhibition of insulin-like growth factor 2 mRNA-binding protein 1 sensitizes colorectal cancer cells to chemotherapeutics', FASEB BioAdvances, vol. 4, no. 12, pp. 816-829. https://doi.org/10.1096/fba.2021-00069
Liu, X, Wills, CA, Chen, L, Zhang, J, Zhao, Y, Zhou, M, Sundstrom, JM, Schell, T, Spiegelman, VS, Young, MM & Wang, HG 2022, 'Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy', Journal for ImmunoTherapy of Cancer, vol. 10, no. 4, e004399. https://doi.org/10.1136/jitc-2021-004399
Grant, CN, Wills, CA, Liu, X, Spiegelman, VS & Wang, HG 2022, 'Thoracic Neuroblastoma: A Novel Surgical Model for the Study of Extra-adrenal Neuroblastoma', In Vivo, vol. 36, no. 1, pp. 49-56. https://doi.org/10.21873/INVIVO.12675

2021

Liu, Z, Spiegelman, VS & Wang, HG 2022, 'Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis', Cancer Reports, vol. 5, no. 10, e1592. https://doi.org/10.1002/cnr2.1592
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation', Data in Brief, vol. 35, 106858. https://doi.org/10.1016/j.dib.2021.106858
Biegel, JM, Dhamdhere, M, Gao, S, Gowda, CP, Kawasawa, YI & Spiegelman, VS 2021, 'Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents', Frontiers in Oncology, vol. 11, 608816. https://doi.org/10.3389/fonc.2021.608816
Liu, Z, Liang, M, Grant, CN, Spiegelman, VS & Wang, HG 2021, 'Interpretable models for high-risk neuroblastoma stratification with multi-cohort copy number profiles', Informatics in Medicine Unlocked, vol. 25, 100701. https://doi.org/10.1016/j.imu.2021.100701
Wallis, N, Oberman, F, Shurrush, K, Germain, N, Greenwald, G, Gershon, T, Pearl, T, Abis, G, Singh, V, Singh, A, Sharma, AK, Barr, HM, Ramos, A, Spiegelman, VS & Yisraeli, JK 2022, 'Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells', RNA Biology, vol. 19, no. 1, pp. 26-43. https://doi.org/10.1080/15476286.2021.2010983
Roy, T, Boateng, ST, Banang-Mbeumi, S, Singh, PK, Basnet, P, Chamcheu, RCN, Ladu, F, Chauvin, I, Spiegelman, VS, Hill, RA, Kousoulas, KG, Nagalo, BM, Walker, AL, Fotie, J, Murru, S, Sechi, M & Chamcheu, JC 2021, 'Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers', Bioorganic Chemistry, vol. 107, 104595. https://doi.org/10.1016/j.bioorg.2020.104595
Elcheva, IA & Spiegelman, VS 2021, 'Targeting RNA-binding proteins in acute and chronic leukemia', Leukemia, vol. 35, no. 2, pp. 360-376. https://doi.org/10.1038/s41375-020-01066-4

2020

Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16. https://doi.org/10.3390/cancers12071739
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612. https://doi.org/10.1074/jbc.ac120.013646
Elcheva, IA & Spiegelman, VS 2020, 'The role of cis-and trans-acting rna regulatory elements in leukemia', Cancers, vol. 12, no. 12, 3854, pp. 1-30. https://doi.org/10.3390/cancers12123854

2019

Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, VS 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622. https://doi.org/10.1016/j.tiv.2019.104622
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, IA, Liu, Z, Abraham, T & Spiegelman, VS 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196. https://doi.org/10.1038/s41388-019-0797-3
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, VS, Robertson, GP & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219. https://doi.org/10.1097/CMR.0000000000000545
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363. https://doi.org/10.1038/s41375-019-0656-9

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)