Researcher Profile

Researcher Profile

Vladimir Spiegelman, MD, PhD

Vladimir Spiegelman, MD, PhD

Professor and Penn State IFC/Panhellenic Dance Marathon Chair for Pediatric Cancer Research, Department of Pediatrics
Professor, Department of Pharmacology
Division of Hematology and Oncology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Messenger RNA
  • Melanoma
  • Growth
  • Carrier Proteins
  • Catenins
  • Ubiquitin-Protein Ligases
  • Carcinogenesis
  • Proteins
  • MicroRNAs
  • Skin
  • Genes

Recent Publications


Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, V 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622.
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, I, Liu, Z, Abraham, T & Spiegelman, V 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196.
Disano, JA, Huffnagle, I, Gowda, R, Spiegelman, V, Robertson, G & Pameijer, CR 2019, 'Loss of miR-155 upregulates WEE1 in metastatic melanoma', Melanoma Research, vol. 29, no. 2, pp. 216-219.


Kim, TW, Havighurst, T, Kim, KM, Albertini, M, Xu, YG & Spiegelman, V 2018, ' Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAF V600E inhibitors ', Molecular Carcinogenesis, vol. 57, no. 5, pp. 678-683.
Noubissi, FK, Yedjou, CG, Spiegelman, V & Tchounwou, PB 2018, 'Cross-talk between Wnt and Hh signaling pathways in the pathology of basal cell carcinoma', International journal of environmental research and public health, vol. 15, no. 7, 1442.
Chamcheu, JC, Rady, I, Chamcheu, RCN, Siddique, AB, Bloch, MB, Mbeumi, SB, Babatunde, AS, Uddin, MB, Noubissi, FK, Jurutka, PW, Liu, YY, Spiegelman, V, Whitfield, GK & El Sayed, KA 2018, 'Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling', International journal of molecular sciences, vol. 19, no. 6, 1791.
Poenitzsch Strong, AM, Berry, SM, Beebe, DJ, Li, JL & Spiegelman, V 2018, 'miFAST: A novel and rapid microRNA target capture method', Molecular Carcinogenesis, vol. 57, no. 4, pp. 559-566.


Spiegelman, V & Elcheva, I 2017, 'Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo', Journal of Investigative Dermatology, vol. 137, no. 9, pp. 1828-1830.
Kim, TW, Havighurst, T, Kim, KM, Hebbring, SJ, Ye, Z, Aylward, J, Keles, S, Xu, YG & Spiegelman, V 2017, 'RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma', Journal of Investigative Dermatology, vol. 137, no. 3, pp. 772-775.


Hamilton, KE, Chatterji, P, Lundsmith, ET, Andres, SF, Giroux, V, Hicks, PD, Noubissi, FK, Spiegelman, V & Rustgi, AK 2015, 'Loss of stromal IMP1 promotes a tumorigenic microenvironment in the colon', Molecular Cancer Research, vol. 13, no. 11, pp. 1478-1486.
Goswami, S, Tarapore, RS, Strong, AMP, TeSlaa, JJ, Grinblat, Y, Setaluri, V & Spiegelman, V 2015, 'MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP)', Journal of Biological Chemistry, vol. 290, no. 1, pp. 384-395.
Fakhraldeen, SA, Clark, RJ, Roopra, A, Chin, EN, Huang, W, Castorino, J, Wisinski, KB, Kim, TW, Spiegelman, V & Alexander, CM 2015, 'Two isoforms of the RNA binding protein, coding region determinant-binding protein (CRD-BP/IGF2BP1), are expressed in breast epithelium and support clonogenic growth of breast tumor cells', Journal of Biological Chemistry, vol. 290, no. 21, pp. 13386-13400.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)