Researcher Profile

Researcher Profile

Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control

Research Interests

  • Nicotine
  • Fear
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Ethanol
  • Psychological Extinction
  • Psychological Inhibition
  • Inbred F344 Rats
  • Cognition

Recent Publications


Goldberg, LR & Gould, TJ 2022, 'Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies', Brain Research Bulletin, vol. 187, pp. 24-38.


Kamens, HM, Miller, CN, Caulfield, JI, Zeid, D, Horton, WJ, Silva, CP, Sebastian, A, Albert, I, Gould, TJ, Fishbein, D, Grigson, PS & Cavigelli, SA 2021, 'Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice', Frontiers in Behavioral Neuroscience, vol. 15, 678102.
Seemiller, LR & Gould, TJ 2021, 'Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment', Behavioural Brain Research, vol. 410, 113351.
Gould, TJ & Goldberg, LR 2021, Genes and behavior: Animal models. in Encyclopedia of Behavioral Neuroscience: Second Edition. vol. 1-3, Elsevier, pp. 255-262.
Mooney-Leber, SM, Zeid, D, Garcia-Trevizo, P, Seemiller, LR, Bogue, MA, Grubb, SC, Peltz, G & Gould, TJ 2021, 'Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains', Frontiers in Psychiatry, vol. 12, 737897.
Seemiller, LR, Mooney-Leber, SM, Henry, E, McGarvey, A, Druffner, A, Peltz, G & Gould, TJ 2021, 'Genetic background determines behavioral responses during fear conditioning', Neurobiology of Learning and Memory, vol. 184, 107501.
Zeid, D, Goldberg, LR, Seemiller, LR, Mooney-Leber, S, Smith, PB & Gould, TJ 2021, 'Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner', Neurotoxicology and Teratology, vol. 85, 106972.
Goldberg, LR, Kutlu, MG, Zeid, D, Seemiller, LR & Gould, TJ 2021, 'Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning', Genes, Brain and Behavior.
Zeid, D, Mooney-Leber, S, Seemiller, LR, Goldberg, LR & Gould, TJ 2021, 'Terc gene cluster variants predict liver telomere length in mice', Cells, vol. 10, no. 10, 2623.
Mooney-Leber, SM, Caruso, MJ, Gould, TJ, Cavigelli, SA & Kamens, HM 2022, 'The impact of adolescent stress on nicotine use and affective disorders in rodent models', European Journal of Neuroscience, vol. 55, no. 9-10, pp. 2196-2215.
Worrell, SD & Gould, TJ 2021, 'Therapeutic potential of ketamine for alcohol use disorder', Neuroscience and Biobehavioral Reviews, vol. 126, pp. 573-589.


Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127.
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234.


Cole, RD, Zimmerman, M, Matchanova, A, Kutlu, MG, Gould, TJ & Parikh, V 2020, 'Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal', Neuropsychopharmacology, vol. 45, no. 5, pp. 866-876.
Goldberg, LR, Zeid, D, Kutlu, MG, Cole, RD, Lallai, V, Sebastian, A, Albert, I, Fowler, CD, Parikh, V & Gould, TJ 2021, 'Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring', Addiction Biology, vol. 26, no. 1, e12859.
Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2020, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology, vol. 25, no. 3, e12769.


Cole, RD, Wolsh, C, Zimmerman, M, Harrington, E, Gould, TJ & Parikh, V 2019, 'Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice', Behavioural Brain Research, vol. 359, pp. 836-844.
on behalf of the Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT) 2018, 'Basic science and public policy: Informed regulation for nicotine and tobacco products', Nicotine and Tobacco Research, vol. 20, no. 7, pp. 789-799.
Gitik, M, Holliday, ED, Leung, M, Yuan, Q, Logue, SF, Tikkanen, R, Goldman, D & Gould, TJ 2018, 'Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure', Neurobiology of Learning and Memory, vol. 155, pp. 239-248.
Tumolo, JM, Kutlu, MG & Gould, TJ 2018, 'Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice', Behavioural Brain Research, vol. 341, pp. 176-180.
Zeid, D & Gould, TJ 2018, 'Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory', Behavioral Neuroscience, vol. 132, no. 4, pp. 240-246.
Zeid, D, Kutlu, MG & Gould, TJ 2018, 'Differential effects of nicotine exposure on the hippocampus across lifespan', Current Neuropharmacology, vol. 16, no. 4, pp. 388-402.
Kutlu, MG, Tumolo, JM, Cann, C & Gould, TJ 2018, 'Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice', Psychopharmacology, vol. 235, no. 4, pp. 1211-1219.
Payne, P, Fiering, S, Zava, D, Gould, TJ, Brown, A, Hage, P, Gaudet, C & Crane-Godreau, M 2018, 'Digital delivery of meditative movement training improved health of cigarette-smoke-exposed subjects', Frontiers in Public Health, vol. 6, 282.
Goldberg, LR & Gould, TJ 2019, 'Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function', European Journal of Neuroscience, vol. 50, no. 3, pp. 2453-2466.
Zhou, L, Fisher, ML, Cole, RD, Gould, TJ, Parikh, V, Ortinski, PI & Turner, JR 2018, 'Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition', Neuropsychopharmacology, vol. 43, no. 6, pp. 1343-1354.
Kutlu, MG, Marin, MF, Tumolo, JM, Kaur, N, VanElzakker, MB, Shin, LM & Gould, TJ 2018, 'Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex', Neuroscience letters, vol. 673, pp. 142-149.
Kutlu, MG, Connor, DA, Tumolo, JM, Cann, C, Garret, B & Gould, TJ 2018, 'Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function', Neuropharmacology, vol. 141, pp. 192-200.
Oliver, CF, Kutlu, MG, Zeid, D & Gould, TJ 2018, 'Sex differences in the effects of nicotine on contextual fear extinction', Pharmacology Biochemistry and Behavior, vol. 165, pp. 25-28.
Mooney-Leber, SM & Gould, TJ 2018, 'The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse', Learning and Memory, vol. 25, no. 9, pp. 481-491.
Kutlu, MG, Cole, RD, Connor, DA, Natwora, B & Gould, TJ 2018, 'Tyrosine receptor kinase B receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction', Journal of Psychopharmacology, vol. 32, no. 3, pp. 367-372.

Clinical Trials Search

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Adults (age >= 18 years)