Researcher Profile

Researcher Profile

Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Scientific Program:Cancer Control
tug70@psu.edu

Research Interests

  • Nicotine
  • Fear
  • Conditioning (Psychology)
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Ethanol
  • Inbred F344 Rats
  • Cognition
  • Aptitude
  • Long-Term Memory

Recent Publications

2019

Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2019, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology. https://doi.org/10.1111/adb.12769

2018

Cole, RD, Wolsh, C, Zimmerman, M, Harrington, E, Gould, TJ & Parikh, V 2019, 'Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice', Behavioural Brain Research, vol. 359, pp. 836-844. https://doi.org/10.1016/j.bbr.2018.07.019
on behalf of the Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT) 2018, 'Basic science and public policy: Informed regulation for nicotine and tobacco products', Nicotine and Tobacco Research, vol. 20, no. 7, pp. 789-799. https://doi.org/10.1093/ntr/ntx175
Gitik, M, Holliday, ED, Leung, M, Yuan, Q, Logue, SF, Tikkanen, R, Goldman, D & Gould, TJ 2018, 'Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure', Neurobiology of Learning and Memory, vol. 155, pp. 239-248. https://doi.org/10.1016/j.nlm.2018.08.009
Tumolo, JM, Kutlu, MG & Gould, TJ 2018, 'Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice', Behavioural Brain Research, vol. 341, pp. 176-180. https://doi.org/10.1016/j.bbr.2018.01.002
Zeid, D & Gould, TJ 2018, 'Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory' Behavioral Neuroscience, vol. 132, no. 4, pp. 240-246. https://doi.org/10.1037/bne0000247
Zeid, D, Kutlu, MG & Gould, TJ 2018, 'Differential effects of nicotine exposure on the hippocampus across lifespan', Current Neuropharmacology, vol. 16, no. 4, pp. 388-402. https://doi.org/10.2174/1570159X15666170714092436
Kutlu, MG, Tumolo, JM, Cann, C & Gould, TJ 2018, 'Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice', Psychopharmacology, vol. 235, no. 4, pp. 1211-1219. https://doi.org/10.1007/s00213-018-4837-4
Goldberg, LR & Gould, TJ 2018, 'Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function', European Journal of Neuroscience. https://doi.org/10.1111/ejn.14060
Zhou, L, Fisher, ML, Cole, RD, Gould, TJ, Parikh, V, Ortinski, PI & Turner, JR 2018, 'Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition', Neuropsychopharmacology, vol. 43, no. 6, pp. 1343-1354. https://doi.org/10.1038/npp.2017.278
Kutlu, MG, Marin, MF, Tumolo, JM, Kaur, N, VanElzakker, MB, Shin, LM & Gould, TJ 2018, 'Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex', Neuroscience letters, vol. 673, pp. 142-149. https://doi.org/10.1016/j.neulet.2018.03.002
Kutlu, MG, Connor, DA, Tumolo, JM, Cann, C, Garret, B & Gould, TJ 2018, 'Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function', Neuropharmacology, vol. 141, pp. 192-200. https://doi.org/10.1016/j.neuropharm.2018.08.019
Oliver, CF, Kutlu, MG, Zeid, D & Gould, TJ 2018, 'Sex differences in the effects of nicotine on contextual fear extinction', Pharmacology Biochemistry and Behavior, vol. 165, pp. 25-28. https://doi.org/10.1016/j.pbb.2017.12.005
Mooney-Leber, SM & Gould, TJ 2018, 'The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse', Learning and Memory, vol. 25, no. 9, pp. 481-491. https://doi.org/10.1101/lm.046672.117
Kutlu, MG, Cole, RD, Connor, DA, Natwora, B & Gould, TJ 2018, 'Tyrosine receptor kinase B receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction' Journal of Psychopharmacology, vol. 32, no. 3, pp. 367-372. https://doi.org/10.1177/0269881118758305

2017

Kutlu, MG, Garrett, B, Gadiwalla, S, Tumolo, JM & Gould, TJ 2017, 'Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity', Neurobiology of Learning and Memory, vol. 145, pp. 143-150. https://doi.org/10.1016/j.nlm.2017.10.002
Connor, DA & Gould, TJ 2017, 'Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning', Neuropharmacology, vol. 125, pp. 272-283. https://doi.org/10.1016/j.neuropharm.2017.07.033
Holliday, ED & Gould, TJ 2017, 'Chronic nicotine treatment during adolescence attenuates the effects of acute nicotine in adult contextual fear learning', Nicotine and Tobacco Research, vol. 19, no. 1, pp. 87-93. https://doi.org/10.1093/ntr/ntw176
England, LJ, Aagaard, K, Bloch, M, Conway, K, Cosgrove, K, Grana, R, Gould, TJ, Hatsukami, D, Jensen, F, Kandel, D, Lanphear, B, Leslie, F, Pauly, JR, Neiderhiser, JM, Rubinstein, M, Slotkin, TA, Spindel, E, Stroud, L & Wakschlag, L 2017, 'Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products', Neuroscience and Biobehavioral Reviews, vol. 72, pp. 176-189. https://doi.org/10.1016/j.neubiorev.2016.11.013
Connor, DA, Kutlu, MG & Gould, TJ 2017, 'Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus', Journal of Psychopharmacology, vol. 31, no. 7, pp. 934-944. https://doi.org/10.1177/0269881117695861
Kutlu, MG, Zeid, D, Tumolo, JM & Gould, TJ 2018, 'Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery', Brain Research Bulletin, vol. 138, pp. 50-55. https://doi.org/10.1016/j.brainresbull.2017.06.010

2016

Kutlu, MG, Tumolo, JM, Holliday, E, Garrett, B & Gould, TJ 2016, 'Acute nicotine enhances spontaneous recovery of contextual fear and changes c-fos early gene expression in infralimbic cortex, hippocampus, and amygdala', Learning and Memory, vol. 23, no. 8, pp. 405-414. https://doi.org/10.1101/lm.042655.116
Kutlu, MG, Braak, DC, Tumolo, JM & Gould, TJ 2016, 'Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults', Brain research, vol. 1642, pp. 445-451. https://doi.org/10.1016/j.brainres.2016.04.023
Leach, PT, Kenney, JW & Gould, TJ 2016, 'C-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning' Neuroscience letters, vol. 627, pp. 61-64. https://doi.org/10.1016/j.neulet.2016.05.048
Parikh, V, Cole, RD, Patel, PJ, Poole, RL & Gould, TJ 2016, 'Cognitive control deficits during mecamylamine-precipitated withdrawal in mice: Possible links to frontostriatal BDNF imbalance', Neurobiology of Learning and Memory, vol. 128, pp. 110-116. https://doi.org/10.1016/j.nlm.2016.01.003
Poole, RL, Braak, D & Gould, TJ 2016, 'Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice', Behavioural Brain Research, vol. 298, pp. 69-77. https://doi.org/10.1016/j.bbr.2015.03.045
Kutlu, MG & Gould, TJ 2016, 'Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: Contributions to development and maintenance of addiction', Learning and Memory, vol. 23, no. 10, pp. 515-533. https://doi.org/10.1101/lm.042192.116
Kutlu, MG, Holliday, E & Gould, TJ 2016, Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning. in Negative Affective States and Cognitive Impairments in Nicotine Dependence. Elsevier Inc., pp. 53-70. https://doi.org/10.1016/B978-0-12-802574-1.00004-1
Kutlu, MG, Holliday, E & Gould, TJ 2016, 'High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction', Neurobiology of Learning and Memory, vol. 128, pp. 17-22. https://doi.org/10.1016/j.nlm.2015.11.021
Kutlu, MG, Oliver, C, Huang, P, Liu-Chen, LY & Gould, TJ 2016, 'Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation', Neuropharmacology, vol. 109, pp. 341-348. https://doi.org/10.1016/j.neuropharm.2016.06.032
Holliday, ED, Nucero, P, Kutlu, MG, Oliver, C, Connelly, KL, Gould, TJ & Unterwald, EM 2016, 'Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure', European Journal of Neuroscience, vol. 44, no. 10, pp. 2818-2828. https://doi.org/10.1111/ejn.13398
Parikh, V, Kutlu, MG & Gould, TJ 2016, 'NAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives', Schizophrenia Research, vol. 171, no. 1-3, pp. 1-15. https://doi.org/10.1016/j.schres.2016.01.020
Holliday, E & Gould, TJ 2016, 'Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse', Neuroscience and Biobehavioral Reviews, vol. 65, pp. 173-184. https://doi.org/10.1016/j.neubiorev.2016.04.003
Kutlu, MG & Gould, TJ 2016, 'Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory', Physiology and Behavior, vol. 155, pp. 162-171. https://doi.org/10.1016/j.physbeh.2015.12.008
Connor, DA & Gould, TJ 2016, 'The role of working memory and declarative memory in trace conditioning', Neurobiology of Learning and Memory, vol. 134, no. Part B, pp. 193-209. https://doi.org/10.1016/j.nlm.2016.07.009

2015

Yildirim, E, Connor, DA & Gould, TJ 2015, 'ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice', Behavioural Pharmacology, vol. 26, no. 3, pp. 241-248. https://doi.org/10.1097/FBP.0000000000000111
Cole, RD, Poole, RL, Guzman, DM, Gould, TJ & Parikh, V 2015, 'Contributions of β2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice' Psychopharmacology, vol. 232, no. 7, pp. 1207-1217. https://doi.org/10.1007/s00213-014-3754-4
Hall, FS, Der-Avakian, A, Gould, TJ, Markou, A, Shoaib, M & Young, JW 2015, 'Negative affective states and cognitive impairments in nicotine dependence', Neuroscience and Biobehavioral Reviews, vol. 58, pp. 168-185. https://doi.org/10.1016/j.neubiorev.2015.06.004
Kutlu, MG, Parikh, V & Gould, TJ 2015, Nicotine Addiction and Psychiatric Disorders. in M De Biasi (ed.), Nicotine Use in Mental Illness and Neurological Disorders, 2015. International Review of Neurobiology, vol. 124, Academic Press Inc., pp. 171-208. https://doi.org/10.1016/bs.irn.2015.08.004
Kutlu, MG & Gould, TJ 2015, 'Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders', Biochemical Pharmacology, vol. 97, no. 4, pp. 498-511. https://doi.org/10.1016/j.bcp.2015.07.029
Kutlu, MG & Gould, TJ 2015, 'Nicotinic receptors, memory, and hippocampus' Current Topics in Behavioral Neurosciences, vol. 23, pp. 137-163. https://doi.org/10.1007/978-3-319-13665-3_6
Kutlu, MG, Ortega, LA & Gould, TJ 2015, 'Strain-dependent performance in nicotine-induced conditioned place preference' Behavioral Neuroscience, vol. 129, no. 1, pp. 37-41. https://doi.org/10.1037/bne0000029
Leach, PT, Kenney, JW & Gould, TJ 2015, 'Stronger learning recruits additional cell-signaling cascades: C-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning', Neurobiology of Learning and Memory, vol. 118, pp. 162-166. https://doi.org/10.1016/j.nlm.2014.12.008
Leach, PT & Gould, TJ 2015, 'Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine' Neuroscience and Biobehavioral Reviews, vol. 57, pp. 252-263. https://doi.org/10.1016/j.neubiorev.2015.09.001
Leach, PT, Kenney, JW, Connor, DA & Gould, TJ 2015, 'Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory' Neuropharmacology, vol. 93, pp. 155-163. https://doi.org/10.1016/j.neuropharm.2015.01.026
Leach, PT, Holliday, E, Kutlu, MG & Gould, TJ 2015, 'Withdrawal from chronic nicotine reduces thyroid hormone levels and levothyroxine treatment ameliorates nicotine withdrawal-induced deficits in hippocampus-dependent learning in C57BL/6J mice' Nicotine and Tobacco Research, vol. 17, no. 6, pp. 690-696. https://doi.org/10.1093/ntr/ntu229

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