Researcher Profile

Researcher Profile

Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control
tug70@psu.edu

Research Interests

  • Nicotine
  • Fear
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Ethanol
  • Psychological Extinction
  • Psychological Inhibition
  • Inbred F344 Rats
  • Cognition

Recent Publications

2021

Kamens, HM, Miller, CN, Caulfield, JI, Zeid, D, Horton, WJ, Silva, CP, Sebastian, A, Albert, I, Gould, TJ, Fishbein, D, Grigson, PS & Cavigelli, SA 2021, 'Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice', Frontiers in Behavioral Neuroscience, vol. 15, 678102. https://doi.org/10.3389/fnbeh.2021.678102
Seemiller, LR & Gould, TJ 2021, 'Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment', Behavioural Brain Research, vol. 410, 113351. https://doi.org/10.1016/j.bbr.2021.113351
Zeid, D, Goldberg, LR, Seemiller, LR, Mooney-Leber, S, Smith, PB & Gould, TJ 2021, 'Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner', Neurotoxicology and Teratology, vol. 85, 106972. https://doi.org/10.1016/j.ntt.2021.106972
Goldberg, LR, Kutlu, MG, Zeid, D, Seemiller, LR & Gould, TJ 2021, 'Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning', Genes, Brain and Behavior. https://doi.org/10.1111/gbb.12734
Worrell, SD & Gould, TJ 2021, 'Therapeutic potential of ketamine for alcohol use disorder', Neuroscience and Biobehavioral Reviews, vol. 126, pp. 573-589. https://doi.org/10.1016/j.neubiorev.2021.05.006

2020

Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127. https://doi.org/10.1016/j.neuropharm.2020.108127
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234. https://doi.org/10.1016/j.nlm.2020.107234

2019

Cole, RD, Zimmerman, M, Matchanova, A, Kutlu, MG, Gould, TJ & Parikh, V 2020, 'Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal', Neuropsychopharmacology, vol. 45, no. 5, pp. 866-876. https://doi.org/10.1038/s41386-019-0574-6
Goldberg, LR, Zeid, D, Kutlu, MG, Cole, RD, Lallai, V, Sebastian, A, Albert, I, Fowler, CD, Parikh, V & Gould, TJ 2021, 'Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring', Addiction Biology, vol. 26, no. 1, e12859. https://doi.org/10.1111/adb.12859
Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2020, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology, vol. 25, no. 3, e12769. https://doi.org/10.1111/adb.12769

2018

Cole, RD, Wolsh, C, Zimmerman, M, Harrington, E, Gould, TJ & Parikh, V 2019, 'Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice', Behavioural Brain Research, vol. 359, pp. 836-844. https://doi.org/10.1016/j.bbr.2018.07.019
on behalf of the Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT) 2018, 'Basic science and public policy: Informed regulation for nicotine and tobacco products', Nicotine and Tobacco Research, vol. 20, no. 7, pp. 789-799. https://doi.org/10.1093/ntr/ntx175
Gitik, M, Holliday, ED, Leung, M, Yuan, Q, Logue, SF, Tikkanen, R, Goldman, D & Gould, TJ 2018, 'Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure', Neurobiology of Learning and Memory, vol. 155, pp. 239-248. https://doi.org/10.1016/j.nlm.2018.08.009
Tumolo, JM, Kutlu, MG & Gould, TJ 2018, 'Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice', Behavioural Brain Research, vol. 341, pp. 176-180. https://doi.org/10.1016/j.bbr.2018.01.002
Zeid, D & Gould, TJ 2018, 'Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory', Behavioral Neuroscience, vol. 132, no. 4, pp. 240-246. https://doi.org/10.1037/bne0000247
Zeid, D, Kutlu, MG & Gould, TJ 2018, 'Differential effects of nicotine exposure on the hippocampus across lifespan', Current Neuropharmacology, vol. 16, no. 4, pp. 388-402. https://doi.org/10.2174/1570159X15666170714092436
Kutlu, MG, Tumolo, JM, Cann, C & Gould, TJ 2018, 'Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice', Psychopharmacology, vol. 235, no. 4, pp. 1211-1219. https://doi.org/10.1007/s00213-018-4837-4
Payne, P, Fiering, S, Zava, D, Gould, TJ, Brown, A, Hage, P, Gaudet, C & Crane-Godreau, M 2018, 'Digital delivery of meditative movement training improved health of cigarette-smoke-exposed subjects', Frontiers in Public Health, vol. 6, 282. https://doi.org/10.3389/fpubh.2018.00282
Goldberg, LR & Gould, TJ 2019, 'Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function', European Journal of Neuroscience, vol. 50, no. 3, pp. 2453-2466. https://doi.org/10.1111/ejn.14060
Zhou, L, Fisher, ML, Cole, RD, Gould, TJ, Parikh, V, Ortinski, PI & Turner, JR 2018, 'Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition', Neuropsychopharmacology, vol. 43, no. 6, pp. 1343-1354. https://doi.org/10.1038/npp.2017.278
Kutlu, MG, Marin, MF, Tumolo, JM, Kaur, N, VanElzakker, MB, Shin, LM & Gould, TJ 2018, 'Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex', Neuroscience letters, vol. 673, pp. 142-149. https://doi.org/10.1016/j.neulet.2018.03.002
Kutlu, MG, Connor, DA, Tumolo, JM, Cann, C, Garret, B & Gould, TJ 2018, 'Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function', Neuropharmacology, vol. 141, pp. 192-200. https://doi.org/10.1016/j.neuropharm.2018.08.019
Oliver, CF, Kutlu, MG, Zeid, D & Gould, TJ 2018, 'Sex differences in the effects of nicotine on contextual fear extinction', Pharmacology Biochemistry and Behavior, vol. 165, pp. 25-28. https://doi.org/10.1016/j.pbb.2017.12.005
Mooney-Leber, SM & Gould, TJ 2018, 'The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse', Learning and Memory, vol. 25, no. 9, pp. 481-491. https://doi.org/10.1101/lm.046672.117
Kutlu, MG, Cole, RD, Connor, DA, Natwora, B & Gould, TJ 2018, 'Tyrosine receptor kinase B receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction', Journal of Psychopharmacology, vol. 32, no. 3, pp. 367-372. https://doi.org/10.1177/0269881118758305

2017

Kutlu, MG, Garrett, B, Gadiwalla, S, Tumolo, JM & Gould, TJ 2017, 'Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity', Neurobiology of Learning and Memory, vol. 145, pp. 143-150. https://doi.org/10.1016/j.nlm.2017.10.002
Connor, DA & Gould, TJ 2017, 'Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning', Neuropharmacology, vol. 125, pp. 272-283. https://doi.org/10.1016/j.neuropharm.2017.07.033
Holliday, ED & Gould, TJ 2017, 'Chronic nicotine treatment during adolescence attenuates the effects of acute nicotine in adult contextual fear learning', Nicotine and Tobacco Research, vol. 19, no. 1, pp. 87-93. https://doi.org/10.1093/ntr/ntw176
England, LJ, Aagaard, K, Bloch, M, Conway, K, Cosgrove, K, Grana, R, Gould, TJ, Hatsukami, D, Jensen, F, Kandel, D, Lanphear, B, Leslie, F, Pauly, JR, Neiderhiser, J, Rubinstein, M, Slotkin, TA, Spindel, E, Stroud, L & Wakschlag, L 2017, 'Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products', Neuroscience and Biobehavioral Reviews, vol. 72, pp. 176-189. https://doi.org/10.1016/j.neubiorev.2016.11.013
Kutlu, MG, Holliday, E & Gould, TJ 2017, Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning. in Negative Affective States and Cognitive Impairments in Nicotine Dependence. Elsevier Inc., pp. 53-70. https://doi.org/10.1016/B978-0-12-802574-1.00004-1
Connor, DA, Kutlu, MG & Gould, TJ 2017, 'Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus', Journal of Psychopharmacology, vol. 31, no. 7, pp. 934-944. https://doi.org/10.1177/0269881117695861
Kutlu, MG, Zeid, D, Tumolo, JM & Gould, TJ 2018, 'Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery', Brain Research Bulletin, vol. 138, pp. 50-55. https://doi.org/10.1016/j.brainresbull.2017.06.010

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)