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Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control

Research Interests

  • Nicotine
  • Fear
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Ethanol
  • Psychological Extinction
  • Psychological Inhibition
  • Inbred F344 Rats
  • Inbred Strains Mice

Recent Publications


Seemiller, LR, Garcia-Trevizo, P, Novoa, C, Goldberg, LR, Murray, S & Gould, TJ 2023, 'Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice', Pharmacology Biochemistry and Behavior, vol. 232, 173655.
Zeid, D, Seemiller, LR, Wagstaff, DA & Gould, TJ 2023, 'Behavioral and genetic architecture of fear conditioning and related phenotypes', Neurobiology of Learning and Memory, vol. 205, 107837.
Zeid, D & Gould, TJ 2023, 'Chronic nicotine exposure alters sperm small RNA content in C57BL/6J mouse model', Developmental psychobiology, vol. 65, no. 2, e22367.
Gould, TJ 2023, 'Epigenetic and long-term effects of nicotine on biology, behavior, and health', Pharmacological Research, vol. 192, 106741.
Seemiller, LR, Goldberg, LR, Garcia-Trevizo, P & Gould, TJ 2023, 'Interstrain differences in adolescent fear conditioning after acute alcohol exposure', Brain Research Bulletin, vol. 194, pp. 35-44.


Cohen, JE, Krishnan-Sarin, S, Eissenberg, T, Gould, TJ, Berman, ML, Bhatnagar, A, Barnett, TE, Soule, E, Popova, L, Tan, ASL, Blank, MD, Ling, PM & O'Connor, R 2022, 'Balancing Risks and Benefits of E-Cigarettes in the Real World', American journal of public health, vol. 112, no. 2, pp. E1-E2.
Seemiller, LR, Goldberg, LR, Smith, PB, Dennis, J, Patterson, AD & Gould, TJ 2022, 'Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains', Neuropharmacology, vol. 221, 109279.
Goldberg, LR & Gould, TJ 2022, 'Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies', Brain Research Bulletin, vol. 187, pp. 24-38.
Seemiller, LR, Logue, SF & Gould, TJ 2022, 'Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood', Pharmacology Biochemistry and Behavior, vol. 218, 173429.
Palmisano, AN, Gould, TJ & Astur, RS 2022, 'The Effect of Acute Nicotine Administration on Human Delay Cued and Context Fear Conditioning', Experimental and clinical psychopharmacology, vol. 31, no. 2, pp. 464-474.


Kamens, HM, Miller, CN, Caulfield, JI, Zeid, D, Horton, WJ, Silva, CP, Sebastian, A, Albert, I, Gould, TJ, Fishbein, D, Grigson, PS & Cavigelli, SA 2021, 'Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice', Frontiers in Behavioral Neuroscience, vol. 15, 678102.
Seemiller, LR & Gould, TJ 2021, 'Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment', Behavioural Brain Research, vol. 410, 113351.
Gould, TJ & Goldberg, LR 2021, Genes and behavior: Animal models. in Encyclopedia of Behavioral Neuroscience: Second Edition. vol. 1-3, Elsevier, pp. 255-262.
Mooney-Leber, SM, Zeid, D, Garcia-Trevizo, P, Seemiller, LR, Bogue, MA, Grubb, SC, Peltz, G & Gould, TJ 2021, 'Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains', Frontiers in Psychiatry, vol. 12, 737897.
Seemiller, LR, Mooney-Leber, SM, Henry, E, McGarvey, A, Druffner, A, Peltz, G & Gould, TJ 2021, 'Genetic background determines behavioral responses during fear conditioning', Neurobiology of Learning and Memory, vol. 184, 107501.
Zeid, D, Goldberg, LR, Seemiller, LR, Mooney-Leber, S, Smith, PB & Gould, TJ 2021, 'Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner', Neurotoxicology and Teratology, vol. 85, 106972.
Goldberg, LR, Kutlu, MG, Zeid, D, Seemiller, LR & Gould, TJ 2021, 'Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning', Genes, Brain and Behavior.
Zeid, D, Mooney-Leber, S, Seemiller, LR, Goldberg, LR & Gould, TJ 2021, 'Terc gene cluster variants predict liver telomere length in mice', Cells, vol. 10, no. 10, 2623.
Mooney-Leber, SM, Caruso, MJ, Gould, TJ, Cavigelli, SA & Kamens, HM 2022, 'The impact of adolescent stress on nicotine use and affective disorders in rodent models', European Journal of Neuroscience, vol. 55, no. 9-10, pp. 2196-2215.
Worrell, SD & Gould, TJ 2021, 'Therapeutic potential of ketamine for alcohol use disorder', Neuroscience and Biobehavioral Reviews, vol. 126, pp. 573-589.


Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127.
Gulick, D & Gould, TJ 2020, THE EFFECTS OF ACUTE, CHRONIC AND WITHDRAWAL FROM CHRONIC ETHANOL ON EMOTIONAL LEARNING*. in Encyclopedia of Substance Abuse. Nova Science Publishers, Inc., pp. 557-584.
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234.