Researcher Profile

Researcher Profile

Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control

Research Interests

  • Nicotine
  • Fear
  • Conditioning (Psychology)
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Psychological Extinction
  • Inhibition (Psychology)
  • Ethanol
  • Inbred F344 Rats

Recent Publications


Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127.
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234.


Cole, RD, Zimmerman, M, Matchanova, A, Kutlu, MG, Gould, TJ & Parikh, V 2020, 'Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal', Neuropsychopharmacology, vol. 45, no. 5, pp. 866-876.
Goldberg, LR, Zeid, D, Kutlu, MG, Cole, RD, Lallai, V, Sebastian, A, Albert, I, Fowler, CD, Parikh, V & Gould, TJ 2021, 'Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring', Addiction Biology, vol. 26, no. 1, e12859.
Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2020, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology, vol. 25, no. 3, e12769.


Cole, RD, Wolsh, C, Zimmerman, M, Harrington, E, Gould, TJ & Parikh, V 2019, 'Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice', Behavioural Brain Research, vol. 359, pp. 836-844.
on behalf of the Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT) 2018, 'Basic science and public policy: Informed regulation for nicotine and tobacco products', Nicotine and Tobacco Research, vol. 20, no. 7, pp. 789-799.
Gitik, M, Holliday, ED, Leung, M, Yuan, Q, Logue, SF, Tikkanen, R, Goldman, D & Gould, TJ 2018, 'Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure', Neurobiology of Learning and Memory, vol. 155, pp. 239-248.
Tumolo, JM, Kutlu, MG & Gould, TJ 2018, 'Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice', Behavioural Brain Research, vol. 341, pp. 176-180.
Zeid, D & Gould, TJ 2018, 'Chronic nicotine exposure in preadolescence enhances later spontaneous recovery of fear memory', Behavioral Neuroscience, vol. 132, no. 4, pp. 240-246.
Zeid, D, Kutlu, MG & Gould, TJ 2018, 'Differential effects of nicotine exposure on the hippocampus across lifespan', Current Neuropharmacology, vol. 16, no. 4, pp. 388-402.
Kutlu, MG, Tumolo, JM, Cann, C & Gould, TJ 2018, 'Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice', Psychopharmacology, vol. 235, no. 4, pp. 1211-1219.
Payne, P, Fiering, S, Zava, D, Gould, TJ, Brown, A, Hage, P, Gaudet, C & Crane-Godreau, M 2018, 'Digital delivery of meditative movement training improved health of cigarette-smoke-exposed subjects', Frontiers in Public Health, vol. 6, 282.
Goldberg, LR & Gould, TJ 2019, 'Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function', European Journal of Neuroscience, vol. 50, no. 3, pp. 2453-2466.
Zhou, L, Fisher, ML, Cole, RD, Gould, TJ, Parikh, V, Ortinski, PI & Turner, JR 2018, 'Neuregulin 3 Signaling Mediates Nicotine-Dependent Synaptic Plasticity in the Orbitofrontal Cortex and Cognition', Neuropsychopharmacology, vol. 43, no. 6, pp. 1343-1354.
Kutlu, MG, Marin, MF, Tumolo, JM, Kaur, N, VanElzakker, MB, Shin, LM & Gould, TJ 2018, 'Nicotine exposure leads to deficits in differential cued fear conditioning in mice and humans: A potential role of the anterior cingulate cortex', Neuroscience letters, vol. 673, pp. 142-149.
Kutlu, MG, Connor, DA, Tumolo, JM, Cann, C, Garret, B & Gould, TJ 2018, 'Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function', Neuropharmacology, vol. 141, pp. 192-200.
Oliver, CF, Kutlu, MG, Zeid, D & Gould, TJ 2018, 'Sex differences in the effects of nicotine on contextual fear extinction', Pharmacology Biochemistry and Behavior, vol. 165, pp. 25-28.
Mooney-Leber, SM & Gould, TJ 2018, 'The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse', Learning and Memory, vol. 25, no. 9, pp. 481-491.
Kutlu, MG, Cole, RD, Connor, DA, Natwora, B & Gould, TJ 2018, 'Tyrosine receptor kinase B receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction', Journal of Psychopharmacology, vol. 32, no. 3, pp. 367-372.


Kutlu, MG, Garrett, B, Gadiwalla, S, Tumolo, JM & Gould, TJ 2017, 'Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity', Neurobiology of Learning and Memory, vol. 145, pp. 143-150.
Connor, DA & Gould, TJ 2017, 'Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning', Neuropharmacology, vol. 125, pp. 272-283.
Holliday, ED & Gould, TJ 2017, 'Chronic nicotine treatment during adolescence attenuates the effects of acute nicotine in adult contextual fear learning', Nicotine and Tobacco Research, vol. 19, no. 1, pp. 87-93.
England, LJ, Aagaard, K, Bloch, M, Conway, K, Cosgrove, K, Grana, R, Gould, TJ, Hatsukami, D, Jensen, F, Kandel, D, Lanphear, B, Leslie, F, Pauly, JR, Neiderhiser, J, Rubinstein, M, Slotkin, TA, Spindel, E, Stroud, L & Wakschlag, L 2017, 'Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products', Neuroscience and Biobehavioral Reviews, vol. 72, pp. 176-189.
Kutlu, MG, Holliday, E & Gould, TJ 2017, Genetic, Developmental, and Receptor-Level Influences on Nicotine Withdrawal-Associated Deficits in Learning. in Negative Affective States and Cognitive Impairments in Nicotine Dependence. Elsevier Inc., pp. 53-70.
Connor, DA, Kutlu, MG & Gould, TJ 2017, 'Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus', Journal of Psychopharmacology, vol. 31, no. 7, pp. 934-944.
Kutlu, MG, Zeid, D, Tumolo, JM & Gould, TJ 2018, 'Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery', Brain Research Bulletin, vol. 138, pp. 50-55.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)