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Researcher Profile

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Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control

Research Interests

  • Nicotine
  • Fear
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Ethanol
  • Psychological Extinction
  • Psychological Inhibition
  • Inbred F344 Rats
  • Inbred Strains Mice

Recent Publications


Zeid, D & Gould, TJ 2023, 'Chronic nicotine exposure alters sperm small RNA content in C57BL/6J mouse model', Developmental psychobiology, vol. 65, no. 2, e22367.
Gould, TJ 2023, 'Epigenetic and long-term effects of nicotine on biology, behavior, and health', Pharmacological Research, vol. 192, 106741.
Seemiller, LR, Goldberg, LR, Garcia-Trevizo, P & Gould, TJ 2023, 'Interstrain differences in adolescent fear conditioning after acute alcohol exposure', Brain Research Bulletin, vol. 194, pp. 35-44.


Cohen, JE, Krishnan-Sarin, S, Eissenberg, T, Gould, TJ, Berman, ML, Bhatnagar, A, Barnett, TE, Soule, E, Popova, L, Tan, ASL, Blank, MD, Ling, PM & O'Connor, R 2022, 'Balancing Risks and Benefits of E-Cigarettes in the Real World', American journal of public health, vol. 112, no. 2, pp. E1-E2.
Seemiller, LR, Goldberg, LR, Smith, PB, Dennis, J, Patterson, AD & Gould, TJ 2022, 'Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains', Neuropharmacology, vol. 221, 109279.
Goldberg, LR & Gould, TJ 2022, 'Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies', Brain Research Bulletin, vol. 187, pp. 24-38.
Seemiller, LR, Logue, SF & Gould, TJ 2022, 'Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood', Pharmacology Biochemistry and Behavior, vol. 218, 173429.
Palmisano, AN, Gould, TJ & Astur, RS 2022, 'The Effect of Acute Nicotine Administration on Human Delay Cued and Context Fear Conditioning', Experimental and clinical psychopharmacology, vol. 31, no. 2, pp. 464-474.


Kamens, HM, Miller, CN, Caulfield, JI, Zeid, D, Horton, WJ, Silva, CP, Sebastian, A, Albert, I, Gould, TJ, Fishbein, D, Grigson, PS & Cavigelli, SA 2021, 'Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice', Frontiers in Behavioral Neuroscience, vol. 15, 678102.
Seemiller, LR & Gould, TJ 2021, 'Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment', Behavioural Brain Research, vol. 410, 113351.
Gould, TJ & Goldberg, LR 2021, Genes and behavior: Animal models. in Encyclopedia of Behavioral Neuroscience: Second Edition. vol. 1-3, Elsevier, pp. 255-262.
Mooney-Leber, SM, Zeid, D, Garcia-Trevizo, P, Seemiller, LR, Bogue, MA, Grubb, SC, Peltz, G & Gould, TJ 2021, 'Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains', Frontiers in Psychiatry, vol. 12, 737897.
Seemiller, LR, Mooney-Leber, SM, Henry, E, McGarvey, A, Druffner, A, Peltz, G & Gould, TJ 2021, 'Genetic background determines behavioral responses during fear conditioning', Neurobiology of Learning and Memory, vol. 184, 107501.
Zeid, D, Goldberg, LR, Seemiller, LR, Mooney-Leber, S, Smith, PB & Gould, TJ 2021, 'Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner', Neurotoxicology and Teratology, vol. 85, 106972.
Goldberg, LR, Kutlu, MG, Zeid, D, Seemiller, LR & Gould, TJ 2021, 'Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning', Genes, Brain and Behavior.
Zeid, D, Mooney-Leber, S, Seemiller, LR, Goldberg, LR & Gould, TJ 2021, 'Terc gene cluster variants predict liver telomere length in mice', Cells, vol. 10, no. 10, 2623.
Mooney-Leber, SM, Caruso, MJ, Gould, TJ, Cavigelli, SA & Kamens, HM 2022, 'The impact of adolescent stress on nicotine use and affective disorders in rodent models', European Journal of Neuroscience, vol. 55, no. 9-10, pp. 2196-2215.
Worrell, SD & Gould, TJ 2021, 'Therapeutic potential of ketamine for alcohol use disorder', Neuroscience and Biobehavioral Reviews, vol. 126, pp. 573-589.


Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127.
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234.


Cole, RD, Zimmerman, M, Matchanova, A, Kutlu, MG, Gould, TJ & Parikh, V 2020, 'Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal', Neuropsychopharmacology, vol. 45, no. 5, pp. 866-876.
Goldberg, LR, Zeid, D, Kutlu, MG, Cole, RD, Lallai, V, Sebastian, A, Albert, I, Fowler, CD, Parikh, V & Gould, TJ 2021, 'Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring', Addiction Biology, vol. 26, no. 1, e12859.
Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2020, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology, vol. 25, no. 3, e12769.