Researcher Profile

Researcher Profile

Thomas J. Gould, PhD

Thomas J. Gould, PhD

Jean Phillips Shibley Professor and Department Head, Biobehavioral Health
Jean Phillips Shibley Professor, Biobehavioral Health
Penn State Neuroscience Institute
Scientific Program:Cancer Control
tug70@psu.edu

Research Interests

  • Nicotine
  • Fear
  • Learning
  • Inbred C57BL Mouse
  • Hippocampus
  • Nicotinic Receptors
  • Memory
  • Ethanol
  • Psychological Extinction
  • Psychological Inhibition
  • Inbred F344 Rats
  • Substance-Related Disorders

Recent Publications

2022

Cohen, JE, Krishnan-Sarin, S, Eissenberg, T, Gould, TJ, Berman, ML, Bhatnagar, A, Barnett, TE, Soule, E, Popova, L, Tan, ASL, Blank, MD, Ling, PM & O'Connor, R 2022, 'Balancing Risks and Benefits of E-Cigarettes in the Real World', American journal of public health, vol. 112, no. 2, pp. E1-E2. https://doi.org/10.2105/AJPH.2021.306607
Seemiller, LR, Goldberg, LR, Smith, PB, Dennis, J, Patterson, AD & Gould, TJ 2022, 'Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains', Neuropharmacology, vol. 221, 109279. https://doi.org/10.1016/j.neuropharm.2022.109279
Goldberg, LR & Gould, TJ 2022, 'Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies', Brain Research Bulletin, vol. 187, pp. 24-38. https://doi.org/10.1016/j.brainresbull.2022.06.007
Seemiller, LR, Logue, SF & Gould, TJ 2022, 'Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood', Pharmacology Biochemistry and Behavior, vol. 218, 173429. https://doi.org/10.1016/j.pbb.2022.173429
Palmisano, AN, Gould, TJ & Astur, RS 2022, 'The Effect of Acute Nicotine Administration on Human Delay Cued and Context Fear Conditioning', Experimental and clinical psychopharmacology. https://doi.org/10.1037/pha0000592

2021

Kamens, HM, Miller, CN, Caulfield, JI, Zeid, D, Horton, WJ, Silva, CP, Sebastian, A, Albert, I, Gould, TJ, Fishbein, D, Grigson, PS & Cavigelli, SA 2021, 'Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice', Frontiers in Behavioral Neuroscience, vol. 15, 678102. https://doi.org/10.3389/fnbeh.2021.678102
Seemiller, LR & Gould, TJ 2021, 'Adult and adolescent C57BL/6J and DBA/2J mice are differentially susceptible to fear learning deficits after acute ethanol or MK-801 treatment', Behavioural Brain Research, vol. 410, 113351. https://doi.org/10.1016/j.bbr.2021.113351
Gould, TJ & Goldberg, LR 2021, Genes and behavior: Animal models. in Encyclopedia of Behavioral Neuroscience: Second Edition. vol. 1-3, Elsevier, pp. 255-262. https://doi.org/10.1016/B978-0-12-819641-0.00092-X
Mooney-Leber, SM, Zeid, D, Garcia-Trevizo, P, Seemiller, LR, Bogue, MA, Grubb, SC, Peltz, G & Gould, TJ 2021, 'Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains', Frontiers in Psychiatry, vol. 12, 737897. https://doi.org/10.3389/fpsyt.2021.737897
Seemiller, LR, Mooney-Leber, SM, Henry, E, McGarvey, A, Druffner, A, Peltz, G & Gould, TJ 2021, 'Genetic background determines behavioral responses during fear conditioning', Neurobiology of Learning and Memory, vol. 184, 107501. https://doi.org/10.1016/j.nlm.2021.107501
Zeid, D, Goldberg, LR, Seemiller, LR, Mooney-Leber, S, Smith, PB & Gould, TJ 2021, 'Multigenerational nicotine exposure affects offspring nicotine metabolism, nicotine-induced hypothermia, and basal corticosterone in a sex-dependent manner', Neurotoxicology and Teratology, vol. 85, 106972. https://doi.org/10.1016/j.ntt.2021.106972
Goldberg, LR, Kutlu, MG, Zeid, D, Seemiller, LR & Gould, TJ 2021, 'Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning', Genes, Brain and Behavior. https://doi.org/10.1111/gbb.12734
Zeid, D, Mooney-Leber, S, Seemiller, LR, Goldberg, LR & Gould, TJ 2021, 'Terc gene cluster variants predict liver telomere length in mice', Cells, vol. 10, no. 10, 2623. https://doi.org/10.3390/cells10102623
Mooney-Leber, SM, Caruso, MJ, Gould, TJ, Cavigelli, SA & Kamens, HM 2022, 'The impact of adolescent stress on nicotine use and affective disorders in rodent models', European Journal of Neuroscience, vol. 55, no. 9-10, pp. 2196-2215. https://doi.org/10.1111/ejn.15421
Worrell, SD & Gould, TJ 2021, 'Therapeutic potential of ketamine for alcohol use disorder', Neuroscience and Biobehavioral Reviews, vol. 126, pp. 573-589. https://doi.org/10.1016/j.neubiorev.2021.05.006

2020

Zeid, D & Gould, TJ 2020, 'Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome', Neuropharmacology, vol. 173, 108127. https://doi.org/10.1016/j.neuropharm.2020.108127
Seemiller, LR & Gould, TJ 2020, 'The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents', Neurobiology of Learning and Memory, vol. 172, 107234. https://doi.org/10.1016/j.nlm.2020.107234

2019

Cole, RD, Zimmerman, M, Matchanova, A, Kutlu, MG, Gould, TJ & Parikh, V 2020, 'Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal', Neuropsychopharmacology, vol. 45, no. 5, pp. 866-876. https://doi.org/10.1038/s41386-019-0574-6
Goldberg, LR, Zeid, D, Kutlu, MG, Cole, RD, Lallai, V, Sebastian, A, Albert, I, Fowler, CD, Parikh, V & Gould, TJ 2021, 'Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring', Addiction Biology, vol. 26, no. 1, e12859. https://doi.org/10.1111/adb.12859
Holliday, ED, Logue, SF, Oliver, C, Bangasser, DA & Gould, TJ 2020, 'Stress and nicotine during adolescence disrupts adult hippocampal-dependent learning and alters stress reactivity', Addiction Biology, vol. 25, no. 3, e12769. https://doi.org/10.1111/adb.12769

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)