Researcher Profile

Researcher Profile

Todd Schell, PhD

Todd Schell, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Immunotherapy
tds6@psu.edu
View Website

Research Interests

Dr. Todd Schell's research focuses on defining immune-based therapies for cancer. His interests include evaluating approaches to improve the persistence and function of tumor-reactive T lymphocytes within the tumor microenvironment. These studies have defined how tumor-reactive T-cells behave in distinct types of cancer including those that occur in the brain, pancreas, prostate and skin. Emphasis is placed on the use of adoptive T-cell therapies as well as defining how existing immune-based therapies currently used in cancer patients can be further improved.

Recent studies from the Schell laboratory highlight how antibody-based therapies targeting CD40 or PD-1 can be improved through combination with existing approaches such as radiation or common medications such as beta-blockers. Through collaborations with clinical investigators, translational studies focus on identification of patient characteristics that are associated with durable clinical responses to immune-based therapies, particularly for metastatic melanoma.

In addition to his research, Dr. Schell is the faculty director of Penn State College of Medicine's Flow Cytometry Core Facility.

  • T-Lymphocytes
  • Neoplasms
  • Epitopes
  • Transgenic Mice
  • Therapeutics
  • Viral Tumor Antigens
  • Neoplasm Antigens
  • Cytotoxic T-Lymphocytes
  • Immunotherapy
  • Simian virus 40
  • Melanoma
  • Polyomavirus Transforming Antigens

Clinical Trials

General Protocol for the Acquisition of Whole Blood for the Detection and Characterization of Circulating Tumor Cells and/or Tumor Specific Immunity/Immune Cell Activation for any Malignancy at any Stage of Disease
Definition of Somatic Variants Corresponding to Immune Targets in Patients with Metastatic Melanoma
A Retrospective Evaluation to Understand how â-adrenergic Antagonism Impacts the Progression of Melanoma and the Efficacy of Standard Treatments Intended to Eliminate the Cancer

Recent Publications

2019

Jia, B, Zhao, C, Rakszawski, KL, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Wang, M, Shike, H, Bayerl, M, Sivik, JM, Schell, T, Drabick, J, Hohl, R & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Feng, Q, Stork, CJ, Xu, S, Yuan, D, Xia, X, LaPenna, KB, Guo, G, Sun, H, Xu, L, Siedlecki, C, Brundage, KM, Sheaffer, N, Schell, T & He, P 2019, 'Increased circulating microparticles in streptozotocin-induced diabetes propagate inflammation contributing to microvascular dysfunction', Journal of Physiology, vol. 597, no. 3, pp. 781-798. https://doi.org/10.1113/JP277312

2018

Bazewicz, CG, Dinavahi, SS, Schell, T & Robertson, G 2019, 'Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer', Immunology, vol. 156, no. 1, pp. 47-55. https://doi.org/10.1111/imm.13016
Jia, B, Wang, L, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, T, Hohl, R & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Ward-Kavanagh, LK, Kokolus, KM, Cooper, TK, Lukacher, A & Schell, T 2018, 'Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors', Cancer Immunology, Immunotherapy, vol. 67, no. 4, pp. 639-652. https://doi.org/10.1007/s00262-018-2115-2
Li, G, Liu, D, Kimchi, ET, Kaifi, JT, Qi, X, Manjunath, Y, Liu, X, Deering, T, Avella, DM, Fox, T, Rockey, DC, Schell, T, Kester, M & Staveley-O'Carroll, KF 2018, 'Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice', Gastroenterology, vol. 154, no. 4, pp. 1024-1036.e9. https://doi.org/10.1053/j.gastro.2017.10.050
Sinha, R, Sinha, I, Calcagnotto, A, Trushin, N, Haley, JS, Schell, T & Richie, J 2018, 'Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function', European Journal of Clinical Nutrition, vol. 72, no. 1, pp. 105-111. https://doi.org/10.1038/ejcn.2017.132
Haeryfar, SMM & Schell, T 2018, 'PD-1/PD-L1 co-inhibition shapes anticancer T cell immunodominance: facing the consequences of an immunological ménage à trois', Cancer Immunology, Immunotherapy, vol. 67, no. 11, pp. 1669-1672. https://doi.org/10.1007/s00262-018-2231-z
Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, D, Helm, K, Drabick, J, Robertson, G, Neighbors, J, Hohl, R & Schell, T 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614

2017

Kokolus, KM, Zhang, Y, Sivik, JM, Schmeck, C, Zhu, J, Repasky, EA, Drabick, J & Schell, T 2018, 'Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice', OncoImmunology, vol. 7, no. 3, e1405205. https://doi.org/10.1080/2162402X.2017.1405205
Zhu, L, Kong, Y, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, Palmisiano, ND, Wang, M, Jia, B, Bayerl, M, Schell, T, Hohl, R, Zeng, H & Zheng, H 2017, 'Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia', Journal of Hematology and Oncology, vol. 10, no. 1, 124. https://doi.org/10.1186/s13045-017-0486-z
Chen, K-M, Schell, T, Richie, J, Sun, Y-W, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Koller, KM, Mackley, H, Liu, J, Wagner Jr., H, Talamo, G, Schell, T, Pameijer, CR, Neves, R, Anderson, B, Kokolus, KM, Mallon, CA & Drabick, J 2017, 'Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone', Cancer Biology and Therapy, vol. 18, no. 1, pp. 36-42. https://doi.org/10.1080/15384047.2016.1264543
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, TK, Brendle, SA, Christensen, ND, Schell, TD & Hu, J 2017, 'Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer', Scientific reports, vol. 7, no. 1, 16932. https://doi.org/10.1038/s41598-017-17089-4
Memarnejadian, A, Meilleur, CE, Shaler, CR, Khazaie, K, Bennink, JR, Schell, T & Haeryfar, SMM 2017, 'PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination', Journal of Immunology, vol. 199, no. 9, pp. 3348-3359. https://doi.org/10.4049/jimmunol.1700643
Li, G, Liu, D, Cooper, T, Kimchi, ET, Qi, X, Avella, DM, Li, N, Yang, Q, Kester, M, Rountree, CB, Kaifi, JT, Cole, DJ, Rockey, DC, Schell, T & Staveley-O'Carroll, KF 2017, 'Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model', Journal of Hepatology, vol. 66, no. 1, pp. 75-85. https://doi.org/10.1016/j.jhep.2016.07.044
Liu, D, Li, G, Avella, DM, Kimchi, ET, Kaifi, JT, Rubinstein, MP, Camp, ER, Rockey, DC, Schell, T & Staveley-O'Carroll, KF 2017, 'Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer', OncoImmunology. https://doi.org/10.1080/2162402X.2017.1372079
Maru, S, Jin, G, Schell, T & Lukacher, A 2017, 'TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection', PLoS Pathogens, vol. 13, no. 4, e1006318. https://doi.org/10.1371/journal.ppat.1006318

2016

Koller, KM, Wang, W, Schell, T, Cozza, EM, Kokolus, KM, Neves, R, Mackley, H, Pameijer, CR, Leung, A, Anderson, B, Mallon, CA, Robertson, G & Drabick, J 2016, 'Malignant melanoma—The cradle of anti-neoplastic immunotherapy', Critical Reviews in Oncology/Hematology, vol. 106, pp. 25-54. https://doi.org/10.1016/j.critrevonc.2016.04.010
Kong, Y, Zhu, L, Schell, T, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, George, M, Zeng, H & Zheng, H 2016, 'T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8+ T-cell exhaustion and poor clinical outcome in AML patients', Clinical Cancer Research, vol. 22, no. 12, pp. 3057-3066. https://doi.org/10.1158/1078-0432.CCR-15-2626
Schietinger, A, Philip, M, Krisnawan, VE, Chiu, EY, Delrow, JJ, Basom, RS, Lauer, P, Brockstedt, DG, Knoblaugh, SE, Hämmerling, GJ, Schell, T, Garbi, N & Greenberg, PD 2016, 'Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis', Immunity, vol. 45, no. 2, pp. 389-401. https://doi.org/10.1016/j.immuni.2016.07.011

2015

Kong, Y, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, Zhu, L, Zeng, H, Schell, T & Zheng, H 2015, ' PD-1 hi TIM-3 + T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation ', Blood Cancer Journal, vol. 5, no. 7, e330. https://doi.org/10.1038/bcj.2015.58
Schell, T & Tevethia, SS 2015, 'Cytotoxic T lymphocytes in SV40 infections', Methods in Molecular Biology, vol. 165, pp. 243-256.
Wyluda, EJ, Cheng, J, Schell, T, Haley, JS, Mallon, C, Neves, R, Robertson, G, Sivik, J, Mackley, H, Talamo, G & Drabick, J 2015, 'Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy' Cancer Biology and Therapy, vol. 16, no. 5, pp. 662-670. https://doi.org/10.1080/15384047.2015.1026507
Cozza, EM, Cooper, T, Budgeon, LR, Christensen, N & Schell, T 2015, 'Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors' Cancer Immunology, Immunotherapy, vol. 64, no. 3, pp. 325-336. https://doi.org/10.1007/s00262-014-1635-7
Koscsó, B, Gowda, K, Schell, T & Bogunovic, M 2015, 'Purification of dendritic cell and macrophage subsets from the normal mouse small intestine' Journal of Immunological Methods, vol. 421, pp. 1-13. https://doi.org/10.1016/j.jim.2015.02.013
Richie, J, Nichenametla, S, Neidig, W, Calcagnotto, A, Haley, JS, Schell, T & Muscat, J 2015, 'Randomized controlled trial of oral glutathione supplementation on body stores of glutathione', European Journal of Nutrition, vol. 54, no. 2, pp. 251-263. https://doi.org/10.1007/s00394-014-0706-z

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)