Researcher Profile

Researcher Profile

Sang Lee, MS, PhD

Sang Lee, MS, PhD

Associate Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies

Research Interests

  • Genes
  • Iron
  • Neoplasms
  • Alzheimer Disease
  • Mutation
  • Neuroblastoma
  • Cell Line
  • Hemochromatosis
  • Oxidative Stress
  • Phosphorylation
  • Amyotrophic Lateral Sclerosis
  • Temozolomide

Recent Publications


Howarth, A, Simms, C, Kerai, N, Allen, O, Mihajluk, K, Madureira, PA, Sokratous, G, Cragg, S, Lee, SY, Morley, AD, Keyoumars, A, Cox, PA, Pilkington, GJ & Hill, R 2019, 'DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas', Translational Oncology, vol. 12, no. 10, pp. 1375-1385.
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475.
Mairuae, N, Connor, JR, Buranrat, B & Lee, SY 2019, 'Oroxylum indicum (L.) extract protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell injury', Molecular medicine reports, vol. 20, no. 2, pp. 1933-1942.


Lee, S 2018, 'Current Knowledge for the Western Blot Normalization', Journal of Medical Oncology and Therapeutics, vol. 3, no. 1, pp. 3-9.
Kwak, HS, An, H, Alam, MB, Choi, WS, Lee, S & Lee, SH 2018, 'Inhibition of migration and invasion in melanoma cells by β-escin via the ERK/NF-κB signaling pathway', Biological and Pharmaceutical Bulletin, vol. 41, no. 10, pp. 1606-1610.


Lee, SY, Zhu, J, Salzberg, AC, Zhang, B, Liu, DJ, Muscat, JE, Langan, ST & Connor, JR 2017, 'Analysis of single nucleotide variants of HFE gene and association to survival in the Cancer Genome Atlas GBM data', PloS one, vol. 12, no. 3, e0174778.
Ramisetti, SR, Pandey, MK, Lee, S, Karelia, D, Narayan, S, Amin, S & Sharma, A 2018, 'Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells', European Journal of Medicinal Chemistry, vol. 143, pp. 1919-1930.
Mrowczynski, OD, Madhankumar, AB, Slagle-Webb, B, Lee, SY, Zacharia, BE & Connor, JR 2017, 'HFE genotype affects exosome phenotype in cancer', Biochimica et Biophysica Acta - General Subjects, vol. 1861, no. 8, pp. 1921-1928.


Lee, S 2016, 'Temozolomide resistance in glioblastoma multiforme', Genes and Diseases, vol. 3, no. 3, pp. 198-210.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)