Shengyu Yang, PhD - Penn State Cancer Institute
Researcher Profile
Shengyu Yang, PhD
Professor, Department of Cell and Biological Systems
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Li, Y, Li, Z, Li, Q, Sun, D, Ni, B, Tan, M, Shay, AE, Wang, M, Meng, C, Shen, G, Fu, B, Shan, Y, Zhang, S, Tanshee, RR, Zhou, T, Xie, Y, Chen, KM, Qiao, B, Dang, Y, Kimball, SR, Zhang, G, Rajacharya, GH, Singh, PK, Wang, X, Hao, J & Yang, S 2026, 'Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma', Nature communications, vol. 17, no. 1, 1343. https://doi.org/10.1038/s41467-025-68099-0
Tan, M, Li, Y, Sang, L, Wang, M, Li, Q, Li, Z, Sun, D, Wang, X & Yang, S 2026, 'Coenzyme A mitigates cystine-deprivation-induced ferroptosis by suppressing the iron-starvation response', FEBS Journal, vol. 293, no. 11, pp. 3288-3302. https://doi.org/10.1111/febs.70411
Li, Y, Li, Q, Tan, M & Yang, S 2026, 'Engineering bacterial biocatalysts via directed evolution to deprive cancer cells of cyst(e)ine', Innovation Life, vol. 4, no. 1, 100189. https://doi.org/10.59717/j.xinn-life.2026.100189
Liu, X, Hu, Y, Wu, L, Zhang, Y, Sang, L, Gao, Y, He, L, Xiong, W, Yang, S & Sun, J 2026, 'FSCN1-mediated hepatic gluconeogenesis is indispensable for neonatal mice survival', Acta Biochimica et Biophysica Sinica, vol. 58, no. 3, pp. 584-594. https://doi.org/10.3724/abbs.2025146
Li, Z, Meng, C, Shen, G, Shan, Y, Wang, J, Abudukeremu, D, Zhao, R, Ni, B, Xu, C, Guo, X, Yu, J, Wang, K, Yang, S, Li, YZ, Xie, Y, Zhou, T, Hao, J & Wang, X 2026, 'Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione-Mediated Stemness Maintenance', Advanced Science, vol. 13, no. 17, e07346. https://doi.org/10.1002/advs.202507346
Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2026, 'Retraction Note: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis(Signal Transduction and Targeted Therapy, 10.1038/s41392-023-01478-5)', Signal Transduction and Targeted Therapy, vol. 11, no. 1, 4. https://doi.org/10.1038/s41392-025-02561-9
2025
Xu, C, Li, Z, Shan, Y, She, C, Yang, Y, Zhou, T, Xie, Y, Ni, B, Meng, C, Shen, G, Fu, B, Sheng, G, Wu, L, Pei, J, Zhao, T, Gao, S, Wang, H, Deng, C, Wang, K, Chang, A, Huang, C, Shi, L, Yang, S, Yu, J, Hao, J & Wang, X 2025, 'CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway', Cancer Biology and Medicine, vol. 22, no. 12. https://doi.org/10.20892/j.issn.2095-3941.2025.0058
Sun, X, Cai, W, Li, H, Gao, C, Ma, X, Guo, Y, Fu, D, Xiao, D, Zhang, Z, Wang, Y, Yang, S, Feng, Y, Zhao, T & Hao, J 2025, 'Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling', Gut, vol. 74, no. 9, pp. 1437-1451. https://doi.org/10.1136/gutjnl-2024-333638
2024
Sun, H, Li, H, Guan, Y, Yuan, Y, Xu, C, Fu, D, Xie, P, Li, J, Zhao, T, Wang, X, Feng, Y, Wang, H, Gao, S, Yang, S, Shi, Y, Liu, J, Chang, A, Huang, C & Hao, J 2024, 'BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism', Science Advances, vol. 10, no. 25, eadj8650. https://doi.org/10.1126/sciadv.adj8650
Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2024, 'Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (271), 10.1038/s41392-023-01478-5)', Signal Transduction and Targeted Therapy, vol. 9, no. 1, 8. https://doi.org/10.1038/s41392-023-01721-z
Javed, Z, Shin, DH, Pan, W, White, SR, Elhaw, AT, Kim, YS, Kamlapurkar, S, Cheng, YY, Benson, JC, Abdelnaby, AE, Phaeton, R, Wang, HG, Yang, S, Sullivan, MLG, St.Croix, CM, Watkins, SC, Mullett, SJ, Gelhaus, SL, Lee, N, Coffman, LG, Aird, K, Trebak, M, Mythreye, K, Walter, V & Hempel, N 2024, 'Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression', EMBO Reports, vol. 25, no. 10, pp. 4281-4310. https://doi.org/10.1038/s44319-024-00232-4
Ling, H, Li, Y, Peng, C, Yang, S & Seto, E 2024, 'HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression', NAR Cancer, vol. 6, no. 2, zcae018. https://doi.org/10.1093/narcan/zcae018
Gao, Y, Dong, R, Yan, J, Chen, H, Sang, L, Yao, X, Fan, D, Wang, X, Zuo, X, Zhang, X, Yang, S, Wu, Z & Sun, J 2024, 'Mitochondrial deoxyguanosine kinase is required for female fertility in mice', Acta Biochimica et Biophysica Sinica, vol. 56, no. 3, pp. 427-439. https://doi.org/10.3724/abbs.2024003
Xie, Y, Zhou, T, Li, X, Zhao, K, Bai, W, Hou, X, Liu, Z, Ni, B, Zhang, Z, Yan, J, Wang, Y, Jiang, W, Wang, H, Chang, A, Gao, S, Zhao, T, Yang, S, Huang, C, Liu, J & Hao, J 2024, 'Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2+ Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy', Gastroenterology, vol. 167, no. 2, pp. 281-297. https://doi.org/10.1053/j.gastro.2024.02.046
Demirsoy, S, Tran, H, Liu, J, Li, Y, Yang, S, Aregawi, D, Glantz, MJ, Jacob, NK, Walter, V, Schell, TD & Olmez, I 2024, 'Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition', Cancers, vol. 16, no. 12, 2253. https://doi.org/10.3390/cancers16122253
Sun, H, Ge, Y, Liu, J, Li, Z, Li, H, Zhao, T, Wang, X, Feng, Y, Wang, H, Gao, S, Shi, L, Yang, S, Sun, P, Chang, A, Hao, J & Huang, C 2024, 'Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma', Oncogene, vol. 43, no. 11, pp. 776-788. https://doi.org/10.1038/s41388-024-02938-0
2023
Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2023, 'BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis', Signal Transduction and Targeted Therapy, vol. 8, no. 1, 271. https://doi.org/10.1038/s41392-023-01478-5
Ruggiero, C, Tamburello, M, Rossini, E, Zini, S, Durand, N, Cantini, G, Cioppi, F, Hantel, C, Kiseljak-Vassiliades, K, Wierman, ME, Landwehr, LS, Weigand, I, Kurlbaum, M, Zizioli, D, Turtoi, A, Yang, S, Berruti, A, Luconi, M, Sigala, S & Lalli, E 2023, 'FSCN1 as a new druggable target in adrenocortical carcinoma', International Journal of Cancer, vol. 153, no. 1, pp. 210-223. https://doi.org/10.1002/ijc.34526
Zhou, T, Xie, Y, Hou, X, Bai, W, Li, X, Liu, Z, Man, Q, Sun, J, Fu, D, Yan, J, Zhang, Z, Wang, Y, Wang, H, Jiang, W, Gao, S, Zhao, T, Chang, A, Wang, X, Sun, H, Zhang, X, Yang, S, Huang, C, Hao, J & Liu, J 2023, 'Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis', Journal of Experimental and Clinical Cancer Research, vol. 42, no. 1, 111. https://doi.org/10.1186/s13046-023-02671-8
Fu, D, Yan, J, Zhang, Z, Liu, Y, Ma, X, Ding, J, Yang, S, Zhao, R, Chang, A, Gao, C, Liu, J, Zhao, T, Wang, X, Huang, C, Gao, S, Ma, Y, Tang, B, Feng, Y, Wang, H & Hao, J 2023, 'Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma', Cancer Biology and Medicine, vol. 20, no. 8, pp. 599-626. https://doi.org/10.20892/j.issn.2095-3941.2023.0039
Qi, YL, Li, YZ, Tan, MJ, Yuan, FF, Murthy, N, Duan, YT, Zhu, HL & Yang, SY 2023, 'Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes', Coordination Chemistry Reviews, vol. 486, 215130. https://doi.org/10.1016/j.ccr.2023.215130
Liu, J, Bai, W, Zhou, T, Xie, Y, Yang, B, Sun, J, Wang, Y, Li, X, Hou, X, Liu, Z, Fu, D, Yan, J, Jiang, W, Zhao, K, Zhou, B, Yuan, S, Guo, Y, Wang, H, Chang, A, Gao, S, Shi, L, Huang, C, Yang, S & Hao, J 2023, 'SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation', Gut, vol. 72, no. 9, pp. 1722-1737. https://doi.org/10.1136/gutjnl-2022-327492
2022
Li, Z, Ge, Y, Dong, J, Wang, H, Zhao, T, Wang, X, Liu, J, Gao, S, Shi, L, Yang, S, Huang, C & Hao, J 2022, 'BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation', Gastroenterology, vol. 162, no. 4, pp. 1256-1271.e14. https://doi.org/10.1053/j.gastro.2021.12.249
Zhao, T, Xiao, D, Jin, F, Sun, X, Yu, J, Wang, H, Liu, J, Cai, W, Huang, C, Wang, X, Gao, S, Liu, Z, Yang, S, Gao, C & Hao, J 2022, 'ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis', British Journal of Cancer, vol. 127, no. 8, pp. 1461-1472. https://doi.org/10.1038/s41416-022-01927-y
Wang, X, Li, Y, Li, Z, Lin, S, Wang, H, Sun, J, Lan, C, Wu, L, Sun, D, Huang, C, Singh, PK, Hempel, N, Trebak, M, DeNicola, GM, Hao, J & Yang, S 2022, 'Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer', Cancer Research, vol. 82, no. 12, pp. 2254-2268. https://doi.org/10.1158/0008-5472.CAN-21-3230
Qi, YL, Wang, HR, Chen, LL, Duan, YT, Yang, SY & Zhu, HL 2022, 'Recent advances in small-molecule fluorescent probes for studying ferroptosis', Chemical Society Reviews, vol. 51, no. 18, pp. 7752-7778. https://doi.org/10.1039/d1cs01167g
Gao, S, Hao, J, Yuan, S, Xu, J, Zhou, B, Zhou, Y, Lang, M, Cao, J, Liu, Z & Yang, S 2022, 'SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC', International Journal of Biological Sciences, vol. 18, no. 3, pp. 911-922. https://doi.org/10.7150/IJBS.64752