Researcher Profile

Researcher Profile

Shengyu Yang, PhD

Shengyu Yang, PhD

Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
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Research Interests

The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.

The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.

The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.

  • Neoplasms
  • Neoplasm Metastasis
  • Adenocarcinoma
  • fascin
  • Cell Movement
  • Proteins
  • Pancreatic Neoplasms
  • Calcium
  • Actins
  • Breast Neoplasms
  • Genes
  • Melanoma

Recent Publications


Zhao, T, Jin, F, Xiao, D, Wang, H, Huang, C, Wang, X, Gao, S, Liu, J, Yang, S & Hao, J 2020, 'IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer', Theranostics, vol. 10, no. 9, pp. 4088-4100.
Wang, X, Li, X, Wei, X, Jiang, H, Lan, C, Yang, S, Wang, H, Yang, Y, Tian, C, Xu, Z, Zhang, J, Hao, J & Ren, H 2020, 'PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC', Signal Transduction and Targeted Therapy, vol. 5, no. 1, 38.


Lin, S, Huang, C, Gunda, V, Sun, J, Chellappan, SP, Li, Z, Izumi, V, Fang, B, Koomen, J, Singh, PK, Hao, J & Yang, S 2019, 'Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments', Cell Reports, vol. 28, no. 11, pp. 2824-2836.e8.
Alhothali, M, Mathew, M, Iyer, G, Lawrence, HR, Yang, S, Chellappan, S & Padmanabhan, J 2019, 'Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC', International journal of molecular sciences, vol. 20, no. 10.
Lu, F, Sun, J, Zheng, Q, Li, J, Hu, Y, Yu, P, He, H, Zhao, Y, Wang, X, Yang, S & Cheng, H 2019, 'Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors', Journal of Cell Science, vol. 132, no. 6, 224923.
Huang, C, Li, Y, Li, Z, Xu, Y, Li, N, Ge, Y, Dong, J, Chang, A, Zhao, T, Wang, X, Wang, H, Yang, S, Xie, K, Hao, J & Ren, H 2019, 'LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation', Clinical Cancer Research, vol. 25, no. 13, pp. 4091-4103.
Keeley, TS, Yang, S & Lau, E 2019, 'The diverse contributions of fucose linkages in cancer', Cancers, vol. 11, no. 9, 1241.
Lin, S, Huang, C, Sun, J, Bollt, O, Wang, X, Martine, E, Kang, J, Taylor, MD, Fang, B, Singh, PK, Koomen, J, Hao, J & Yang, S 2019, 'The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma', EMBO Molecular Medicine, vol. 11, no. 12, e10849.
Liu, J, Jiang, W, Zhao, K, Wang, H, Zhou, T, Bai, W, Wang, X, Zhao, T, Huang, C, Gao, S, Qin, T, Yu, W, Yang, B, Li, X, Fu, D, Tan, W, Yang, S, Ren, H & Hao, J 2019, 'Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma', Journal of Experimental Medicine, vol. 216, no. 3, pp. 656-673.


Lu, F, Sun, J, Sun, T, Cheng, H & Yang, S 2018, Fluorescence-Based Measurements of Store-Operated Ca 2+ Entry in Cancer Cells Using Fluo-4 and Confocal Live-Cell Imaging in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1843, Humana Press Inc., pp. 63-68.
Huang, C, Li, Z, Li, N, Li, Y, Chang, A, Zhao, T, Wang, X, Wang, H, Gao, S, Yang, S, Hao, J & Ren, H 2018, 'Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice', Gastroenterology, vol. 154, no. 3, pp. 675-688.
Keeley, T, Lin, S, Lester, DK, Lau, EK & Yang, S 2018, 'The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells', PloS one, vol. 13, no. 6, e0199128.
Mo, P & Yang, S 2018, 'The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization', Frontiers in Bioscience - Landmark, vol. 23, no. 7, pp. 1241-1256.


Zhao, T, Jiang, W, Wang, X, Wang, H, Zheng, C, Li, Y, Sun, Y, Huang, C, Han, ZB, Yang, S, Jia, Z, Xie, K, Ren, H & Hao, J 2017, 'ESE3 inhibits pancreatic cancer metastasis by upregulating E-cadherin', Cancer Research, vol. 77, no. 4, pp. 874-885.
Emmons, MF, Anreddy, N, Cuevas, J, Steinberger, K, Yang, S, McLaughlin, M, Silva, A & Hazlehurst, LA 2017, 'MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma', Scientific reports, vol. 7, no. 1, 2685.
Huang, C, Li, N, Li, Z, Chang, A, Chen, Y, Zhao, T, Li, Y, Wang, X, Zhang, W, Wang, Z, Luo, L, Shi, J, Yang, S, Ren, H & Hao, J 2017, 'Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression', Nature communications, vol. 8, 14035.


Lang, M, Wang, X, Wang, H, Dong, J, Lan, C, Hao, J, Huang, C, Li, X, Yu, M, Yang, Y, Yang, S & Ren, H 2016, 'Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma', Cancer Letters, vol. 378, no. 2, pp. 87-96.
Wang, X, Lang, M, Zhao, T, Feng, X, Zheng, C, Huang, C, Hao, J, Dong, J, Luo, L, Li, X, Lan, C, Yu, W, Yu, M, Yang, S & Ren, H 2017, 'Cancer-FOXP3 directly activated CCL5 to recruit FOXP3 + Treg cells in pancreatic ductal adenocarcinoma', Oncogene, vol. 36, no. 21, pp. 3048-3058.
Wang, X, Dong, J, Jia, L, Zhao, T, Lang, M, Li, Z, Lan, C, Li, X, Hao, J, Wang, H, Qin, T, Huang, C, Yang, S, Yu, M & Ren, H 2017, 'HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma', Cancer Letters, vol. 393, pp. 113-124.
Sung, H, Kanchi, KL, Wang, X, Hill, KS, Messina, JL, Lee, JH, Kim, Y, Dees, ND, Ding, L, Teer, JK, Yang, S, Sarnaik, AA, Sondak, VK, Mulé, JJ, Wilson, RK, Weber, JS & Kim, M 2016, 'Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation', Oncotarget, vol. 7, no. 17, pp. 23885-23896.
Lin, S, Lu, S, Mulaj, M, Fang, B, Keeley, T, Wan, L, Hao, J, Muschol, M, Sun, J & Yang, S 2016, 'Monoubiquitination inhibits the actin bundling activity of fascin', Journal of Biological Chemistry, vol. 291, no. 53, pp. 27323-27333.
Wang, X, Ren, H, Zhao, T, Ma, W, Dong, J, Zhang, S, Xin, W, Yang, S, Jia, L & Hao, J 2016, 'Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes', Oncotarget, vol. 7, no. 12, pp. 13717-13729.

Clinical Trials Search

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