Shengyu Yang, PhD - Penn State Cancer Institute
Researcher Profile
Shengyu Yang, PhD
Professor, Department of Cell and Biological Systems
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Sun, X, Cai, W, Li, H, Gao, C, Ma, X, Guo, Y, Fu, D, Xiao, D, Zhang, Z, Wang, Y, Yang, S, Feng, Y, Zhao, T & Hao, J 2025, 'Endothelial-like cancer-associated fibroblasts facilitate pancreatic cancer metastasis via vasculogenic mimicry and paracrine signalling', Gut. https://doi.org/10.1136/gutjnl-2024-333638
2024
Sun, H, Li, H, Guan, Y, Yuan, Y, Xu, C, Fu, D, Xie, P, Li, J, Zhao, T, Wang, X, Feng, Y, Wang, H, Gao, S, Yang, S, Shi, Y, Liu, J, Chang, A, Huang, C & Hao, J 2024, 'BICC1 drives pancreatic cancer stemness and chemoresistance by facilitating tryptophan metabolism', Science Advances, vol. 10, no. 25, eadj8650. https://doi.org/10.1126/sciadv.adj8650
Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2024, 'Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (271), 10.1038/s41392-023-01478-5)', Signal Transduction and Targeted Therapy, vol. 9, no. 1, 8. https://doi.org/10.1038/s41392-023-01721-z
Javed, Z, Shin, DH, Pan, W, White, SR, Elhaw, AT, Kim, YS, Kamlapurkar, S, Cheng, YY, Benson, JC, Abdelnaby, AE, Phaeton, R, Wang, HG, Yang, S, Sullivan, MLG, St.Croix, CM, Watkins, SC, Mullett, SJ, Gelhaus, SL, Lee, N, Coffman, LG, Aird, K, Trebak, M, Mythreye, K, Walter, V & Hempel, N 2024, 'Drp1 splice variants regulate ovarian cancer mitochondrial dynamics and tumor progression', EMBO Reports, vol. 25, no. 10, pp. 4281-4310. https://doi.org/10.1038/s44319-024-00232-4
Ling, H, Li, Y, Peng, C, Yang, S & Seto, E 2024, 'HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression', NAR Cancer, vol. 6, no. 2, zcae018. https://doi.org/10.1093/narcan/zcae018
Gao, Y, Dong, R, Yan, J, Chen, H, Sang, L, Yao, X, Fan, D, Wang, X, Zuo, X, Zhang, X, Yang, S, Wu, Z & Sun, J 2024, 'Mitochondrial deoxyguanosine kinase is required for female fertility in mice', Acta Biochimica et Biophysica Sinica, vol. 56, no. 3, pp. 427-439. https://doi.org/10.3724/abbs.2024003
Xie, Y, Zhou, T, Li, X, Zhao, K, Bai, W, Hou, X, Liu, Z, Ni, B, Zhang, Z, Yan, J, Wang, Y, Jiang, W, Wang, H, Chang, A, Gao, S, Zhao, T, Yang, S, Huang, C, Liu, J & Hao, J 2024, 'Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2+ Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy', Gastroenterology, vol. 167, no. 2, pp. 281-297. https://doi.org/10.1053/j.gastro.2024.02.046
Demirsoy, S, Tran, H, Liu, J, Li, Y, Yang, S, Aregawi, D, Glantz, MJ, Jacob, NK, Walter, V, Schell, TD & Olmez, I 2024, 'Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition', Cancers, vol. 16, no. 12, 2253. https://doi.org/10.3390/cancers16122253
Sun, H, Ge, Y, Liu, J, Li, Z, Li, H, Zhao, T, Wang, X, Feng, Y, Wang, H, Gao, S, Shi, L, Yang, S, Sun, P, Chang, A, Hao, J & Huang, C 2024, 'Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma', Oncogene, vol. 43, no. 11, pp. 776-788. https://doi.org/10.1038/s41388-024-02938-0
2023
Huang, C, Li, H, Xu, Y, Xu, C, Sun, H, Li, Z, Ge, Y, Wang, H, Zhao, T, Gao, S, Wang, X, Yang, S, Sun, P, Liu, Z, Liu, J, Chang, A & Hao, J 2023, 'BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis', Signal Transduction and Targeted Therapy, vol. 8, no. 1, 271. https://doi.org/10.1038/s41392-023-01478-5
Ruggiero, C, Tamburello, M, Rossini, E, Zini, S, Durand, N, Cantini, G, Cioppi, F, Hantel, C, Kiseljak-Vassiliades, K, Wierman, ME, Landwehr, LS, Weigand, I, Kurlbaum, M, Zizioli, D, Turtoi, A, Yang, S, Berruti, A, Luconi, M, Sigala, S & Lalli, E 2023, 'FSCN1 as a new druggable target in adrenocortical carcinoma', International Journal of Cancer, vol. 153, no. 1, pp. 210-223. https://doi.org/10.1002/ijc.34526
Zhou, T, Xie, Y, Hou, X, Bai, W, Li, X, Liu, Z, Man, Q, Sun, J, Fu, D, Yan, J, Zhang, Z, Wang, Y, Wang, H, Jiang, W, Gao, S, Zhao, T, Chang, A, Wang, X, Sun, H, Zhang, X, Yang, S, Huang, C, Hao, J & Liu, J 2023, 'Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis', Journal of Experimental and Clinical Cancer Research, vol. 42, no. 1, 111. https://doi.org/10.1186/s13046-023-02671-8
Fu, D, Yan, J, Zhang, Z, Liu, Y, Ma, X, Ding, J, Yang, S, Zhao, R, Chang, A, Gao, C, Liu, J, Zhao, T, Wang, X, Huang, C, Gao, S, Ma, Y, Tang, B, Feng, Y, Wang, H & Hao, J 2023, 'Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma', Cancer Biology and Medicine, vol. 20, no. 8, pp. 599-626. https://doi.org/10.20892/j.issn.2095-3941.2023.0039
Qi, YL, Li, YZ, Tan, MJ, Yuan, FF, Murthy, N, Duan, YT, Zhu, HL & Yang, SY 2023, 'Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes', Coordination Chemistry Reviews, vol. 486, 215130. https://doi.org/10.1016/j.ccr.2023.215130
Liu, J, Bai, W, Zhou, T, Xie, Y, Yang, B, Sun, J, Wang, Y, Li, X, Hou, X, Liu, Z, Fu, D, Yan, J, Jiang, W, Zhao, K, Zhou, B, Yuan, S, Guo, Y, Wang, H, Chang, A, Gao, S, Shi, L, Huang, C, Yang, S & Hao, J 2023, 'SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation', Gut, vol. 72, no. 9, pp. 1722-1737. https://doi.org/10.1136/gutjnl-2022-327492
2022
Li, Z, Ge, Y, Dong, J, Wang, H, Zhao, T, Wang, X, Liu, J, Gao, S, Shi, L, Yang, S, Huang, C & Hao, J 2022, 'BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation', Gastroenterology, vol. 162, no. 4, pp. 1256-1271.e14. https://doi.org/10.1053/j.gastro.2021.12.249
Zhao, T, Xiao, D, Jin, F, Sun, X, Yu, J, Wang, H, Liu, J, Cai, W, Huang, C, Wang, X, Gao, S, Liu, Z, Yang, S, Gao, C & Hao, J 2022, 'ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis', British Journal of Cancer, vol. 127, no. 8, pp. 1461-1472. https://doi.org/10.1038/s41416-022-01927-y
Wang, X, Li, Y, Li, Z, Lin, S, Wang, H, Sun, J, Lan, C, Wu, L, Sun, D, Huang, C, Singh, PK, Hempel, N, Trebak, M, DeNicola, GM, Hao, J & Yang, S 2022, 'Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer', Cancer Research, vol. 82, no. 12, pp. 2254-2268. https://doi.org/10.1158/0008-5472.CAN-21-3230
Qi, YL, Wang, HR, Chen, LL, Duan, YT, Yang, SY & Zhu, HL 2022, 'Recent advances in small-molecule fluorescent probes for studying ferroptosis', Chemical Society Reviews, vol. 51, no. 18, pp. 7752-7778. https://doi.org/10.1039/d1cs01167g
Gao, S, Hao, J, Yuan, S, Xu, J, Zhou, B, Zhou, Y, Lang, M, Cao, J, Liu, Z & Yang, S 2022, 'SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC', International Journal of Biological Sciences, vol. 18, no. 3, pp. 911-922. https://doi.org/10.7150/IJBS.64752
2021
Yu, X, Liu, W, Wang, Z, Wang, H, Liu, J, Huang, C, Zhao, T, Wang, X, Gao, S, Ma, Y, Wu, L, Li, X, Yang, S & Hao, J 2021, 'CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms', Cancer Letters, vol. 519, pp. 289-303. https://doi.org/10.1016/j.canlet.2021.07.024
Lin, S, Li, Y, Wang, D, Huang, C, Marino, D, Bollt, O, Wu, C, Taylor, MD, Li, W, DeNicola, GM, Hao, J, Singh, PK & Yang, S 2021, 'Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression', Cancer Letters, vol. 518, pp. 230-242. https://doi.org/10.1016/j.canlet.2021.07.025
Dong, J, Yu, J, Li, Z, Gao, S, Wang, H, Yang, S, Wu, L, Lan, C, Zhao, T, Gao, C, Liu, Z, Wang, X & Hao, J 2021, 'Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting', Journal of Cachexia, Sarcopenia and Muscle, vol. 12, no. 3, pp. 704-716. https://doi.org/10.1002/jcsm.12692
Lu, F, Li, Y, Lin, S, Cheng, H & Yang, S 2021, 'Spatiotemporal regulation of store-operated calcium entry in cancer metastasis', Biochemical Society transactions, vol. 49, no. 6, pp. 2581-2589. https://doi.org/10.1042/BST20210307