Shengyu Yang, PhD - Penn State Cancer Institute
Researcher Profile
Shengyu Yang, PhD
Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.
The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.
The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.
- Neoplasms
- Neoplasm Metastasis
- Adenocarcinoma
- Pancreatic Neoplasms
- fascin
- Cell Movement
- Proteins
- Calcium
- Growth
- Actins
- Genes
- Breast Neoplasms
Recent Publications
2022
Li, Z, Ge, Y, Dong, J, Wang, H, Zhao, T, Wang, X, Liu, J, Gao, S, Shi, L, Yang, S, Huang, C & Hao, J 2022, 'BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation', Gastroenterology, vol. 162, no. 4, pp. 1256-1271.e14. https://doi.org/10.1053/j.gastro.2021.12.249
Zhao, T, Xiao, D, Jin, F, Sun, X, Yu, J, Wang, H, Liu, J, Cai, W, Huang, C, Wang, X, Gao, S, Liu, Z, Yang, S, Gao, C & Hao, J 2022, 'ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis', British Journal of Cancer, vol. 127, no. 8, pp. 1461-1472. https://doi.org/10.1038/s41416-022-01927-y
Wang, X, Li, Y, Li, Z, Lin, S, Wang, H, Sun, J, Lan, C, Wu, L, Sun, D, Huang, C, Singh, PK, Hempel, N, Trebak, M, DeNicola, GM, Hao, J & Yang, S 2022, 'Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer', Cancer Research, vol. 82, no. 12, pp. 2254-2268. https://doi.org/10.1158/0008-5472.CAN-21-3230
Qi, YL, Wang, HR, Chen, LL, Duan, YT, Yang, SY & Zhu, HL 2022, 'Recent advances in small-molecule fluorescent probes for studying ferroptosis', Chemical Society Reviews, vol. 51, no. 18, pp. 7752-7778. https://doi.org/10.1039/d1cs01167g
Gao, S, Hao, J, Yuan, S, Xu, J, Zhou, B, Zhou, Y, Lang, M, Cao, J, Liu, Z & Yang, S 2022, 'SOX8 Affects Tumoral SPARC Expression by Regulating EZH2 to Attenuate Effectiveness of albumin-bound paclitaxel in PDAC', International Journal of Biological Sciences, vol. 18, no. 3, pp. 911-922. https://doi.org/10.7150/IJBS.64752
2021
Yu, X, Liu, W, Wang, Z, Wang, H, Liu, J, Huang, C, Zhao, T, Wang, X, Gao, S, Ma, Y, Wu, L, Li, X, Yang, S & Hao, J 2021, 'CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms', Cancer Letters, vol. 519, pp. 289-303. https://doi.org/10.1016/j.canlet.2021.07.024
Lin, S, Li, Y, Wang, D, Huang, C, Marino, D, Bollt, O, Wu, C, Taylor, MD, Li, W, DeNicola, GM, Hao, J, Singh, PK & Yang, S 2021, 'Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression', Cancer Letters, vol. 518, pp. 230-242. https://doi.org/10.1016/j.canlet.2021.07.025
Dong, J, Yu, J, Li, Z, Gao, S, Wang, H, Yang, S, Wu, L, Lan, C, Zhao, T, Gao, C, Liu, Z, Wang, X & Hao, J 2021, 'Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting', Journal of Cachexia, Sarcopenia and Muscle, vol. 12, no. 3, pp. 704-716. https://doi.org/10.1002/jcsm.12692
Lu, F, Li, Y, Lin, S, Cheng, H & Yang, S 2021, 'Spatiotemporal regulation of store-operated calcium entry in cancer metastasis', Biochemical Society transactions, vol. 49, no. 6, pp. 2581-2589. https://doi.org/10.1042/BST20210307
2020
Zhou, T, Liu, J, Xie, Y, Yuan, S, Guo, Y, Bai, W, Zhao, K, Jiang, W, Wang, H, Wang, H, Zhao, T, Huang, C, Gao, S, Wang, X, Yang, S & Hao, J 2022, 'ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4', Gut, vol. 71, no. 2, pp. 357-371. https://doi.org/10.1136/gutjnl-2020-321952
Lin, S, Taylor, MD, Singh, PK & Yang, S 2021, 'How does fascin promote cancer metastasis?', FEBS Journal, vol. 288, no. 5, pp. 1434-1446. https://doi.org/10.1111/febs.15484
Zhao, T, Jin, F, Xiao, D, Wang, H, Huang, C, Wang, X, Gao, S, Liu, J, Yang, S & Hao, J 2020, 'IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer', Theranostics, vol. 10, no. 9, pp. 4088-4100. https://doi.org/10.7150/thno.42416
Jiao, D & Yang, S 2020, 'Overcoming Resistance to Drugs Targeting KRASG12C Mutation', The Innovation, vol. 1, no. 2, 100035. https://doi.org/10.1016/j.xinn.2020.100035
Wang, X, Li, X, Wei, X, Jiang, H, Lan, C, Yang, S, Wang, H, Yang, Y, Tian, C, Xu, Z, Zhang, J, Hao, J & Ren, H 2020, 'PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC', Signal Transduction and Targeted Therapy, vol. 5, no. 1, 38. https://doi.org/10.1038/s41392-020-0144-8
2019
Lin, S, Huang, C, Gunda, V, Sun, J, Chellappan, SP, Li, Z, Izumi, V, Fang, B, Koomen, J, Singh, PK, Hao, J & Yang, S 2019, 'Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments', Cell Reports, vol. 28, no. 11, pp. 2824-2836.e8. https://doi.org/10.1016/j.celrep.2019.08.011
Alhothali, M, Mathew, M, Iyer, G, Lawrence, HR, Yang, S, Chellappan, S & Padmanabhan, J 2019, 'Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC', International journal of molecular sciences, vol. 20, no. 10. https://doi.org/10.3390/ijms20102423
Lu, F, Sun, J, Zheng, Q, Li, J, Hu, Y, Yu, P, He, H, Zhao, Y, Wang, X, Yang, S & Cheng, H 2019, 'Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors', Journal of Cell Science, vol. 132, no. 6, 224923. https://doi.org/10.1242/jcs.224923
Huang, C, Li, Y, Li, Z, Xu, Y, Li, N, Ge, Y, Dong, J, Chang, A, Zhao, T, Wang, X, Wang, H, Yang, S, Xie, K, Hao, J & Ren, H 2019, 'LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation', Clinical Cancer Research, vol. 25, no. 13, pp. 4091-4103. https://doi.org/10.1158/1078-0432.CCR-18-3533
Keeley, TS, Yang, S & Lau, E 2019, 'The diverse contributions of fucose linkages in cancer', Cancers, vol. 11, no. 9, 1241. https://doi.org/10.3390/cancers11091241
Lin, S, Huang, C, Sun, J, Bollt, O, Wang, X, Martine, E, Kang, J, Taylor, MD, Fang, B, Singh, PK, Koomen, J, Hao, J & Yang, S 2019, 'The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma', EMBO Molecular Medicine, vol. 11, no. 12, e10849. https://doi.org/10.15252/emmm.201910849
Liu, J, Jiang, W, Zhao, K, Wang, H, Zhou, T, Bai, W, Wang, X, Zhao, T, Huang, C, Gao, S, Qin, T, Yu, W, Yang, B, Li, X, Fu, D, Tan, W, Yang, S, Ren, H & Hao, J 2019, 'Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma', Journal of Experimental Medicine, vol. 216, no. 3, pp. 656-673. https://doi.org/10.1084/jem.20180749