Researcher Profile

Researcher Profile

Shengyu Yang, PhD

Shengyu Yang, PhD

Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
sxy99@psu.edu
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Research Interests

The long-term research interest in Dr. Shengyu Yang’s lab is to understand the mechanisms underlying cancer metastasis and developing novel therapeutic strategies in the prevention and treatment of cancer metastasis.

The research in the lab currently focus on two areas related to mitochondrial signaling and metabolism in cancer metastasis.

The first area of research effort is to understand how the actin cytoskeleton remodeling in lung adenocarcinoma promotes metastatic colonization by controlling mitochondrial DNA homeostasis and augmenting mitochondrial oxidative phosphorylation. The second area of research effort is to understand the role of mitochondrial calcium signaling in the control of metabolic stress resistance by activating the Keap1-Nrf2 antioxidant response program in metastatic pancreatic cancer.

  • Neoplasms
  • Neoplasm Metastasis
  • Adenocarcinoma
  • Cell Movement
  • Proteins
  • Therapeutics
  • Pancreatic Neoplasms
  • Calcium
  • Actins
  • Breast Neoplasms
  • Genes
  • Melanoma

Recent Publications

2019

Lin, S, Huang, C, Gunda, V, Sun, J, Chellappan, SP, Li, Z, Izumi, V, Fang, B, Koomen, J, Singh, PK, Hao, J & Yang, S 2019, 'Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments', Cell Reports, vol. 28, no. 11, pp. 2824-2836.e8. https://doi.org/10.1016/j.celrep.2019.08.011
Alhothali, M, Mathew, M, Iyer, G, Lawrence, HR, Yang, S, Chellappan, S & Padmanabhan, J 2019, 'Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC' International journal of molecular sciences, vol. 20, no. 10. https://doi.org/10.3390/ijms20102423
Lu, F, Sun, J, Zheng, Q, Li, J, Hu, Y, Yu, P, He, H, Zhao, Y, Wang, X, Yang, S & Cheng, H 2019, 'Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors', Journal of Cell Science, vol. 132, no. 6, 224923. https://doi.org/10.1242/jcs.224923
Huang, C, Li, Y, Li, Z, Xu, Y, Li, N, Ge, Y, Dong, J, Chang, A, Zhao, T, Wang, X, Wang, H, Yang, S, Xie, K, Hao, J & Ren, H 2019, 'LIMS1 promotes pancreatic cancer cell survival under oxygen-glucose deprivation conditions by enhancing HIF1A protein translation', Clinical Cancer Research, vol. 25, no. 13, pp. 4091-4103. https://doi.org/10.1158/1078-0432.CCR-18-3533
Keeley, TS, Yang, S & Lau, E 2019, 'The diverse contributions of fucose linkages in cancer', Cancers, vol. 11, no. 9, 1241. https://doi.org/10.3390/cancers11091241
Liu, J, Jiang, W, Zhao, K, Wang, H, Zhou, T, Bai, W, Wang, X, Zhao, T, Huang, C, Gao, S, Qin, T, Yu, W, Yang, B, Li, X, Fu, D, Tan, W, Yang, S, Ren, H & Hao, J 2019, 'Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma' Journal of Experimental Medicine, vol. 216, no. 3, pp. 656-673. https://doi.org/10.1084/jem.20180749

2018

Lu, F, Sun, J, Sun, T, Cheng, H & Yang, S 2018, Fluorescence-Based Measurements of Store-Operated Ca 2+ Entry in Cancer Cells Using Fluo-4 and Confocal Live-Cell Imaging in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1843, Humana Press Inc., pp. 63-68. https://doi.org/10.1007/978-1-4939-8704-7_5
Huang, C, Li, Z, Li, N, Li, Y, Chang, A, Zhao, T, Wang, X, Wang, H, Gao, S, Yang, S, Hao, J & Ren, H 2018, 'Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice', Gastroenterology, vol. 154, no. 3, pp. 675-688. https://doi.org/10.1053/j.gastro.2017.09.039
Keeley, T, Lin, S, Lester, DK, Lau, EK & Yang, S 2018, 'The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells', PloS one, vol. 13, no. 6, e0199128. https://doi.org/10.1371/journal.pone.0199128
Mo, P & Yang, S 2018, 'The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization', Frontiers in Bioscience - Landmark, vol. 23, no. 7, pp. 1241-1256.

2017

Zhao, T, Jiang, W, Wang, X, Wang, H, Zheng, C, Li, Y, Sun, Y, Huang, C, Han, ZB, Yang, S, Jia, Z, Xie, K, Ren, H & Hao, J 2017, 'ESE3 inhibits pancreatic cancer metastasis by upregulating E-cadherin', Cancer Research, vol. 77, no. 4, pp. 874-885. https://doi.org/10.1158/0008-5472.CAN-16-2170
Emmons, MF, Anreddy, N, Cuevas, J, Steinberger, K, Yang, S, McLaughlin, M, Silva, A & Hazlehurst, LA 2017, 'MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma', Scientific Reports, vol. 7, no. 1, 2685. https://doi.org/10.1038/s41598-017-02713-0
Huang, C, Li, N, Li, Z, Chang, A, Chen, Y, Zhao, T, Li, Y, Wang, X, Zhang, W, Wang, Z, Luo, L, Shi, J, Yang, S, Ren, H & Hao, J 2017, 'Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression', Nature communications, vol. 8, 14035. https://doi.org/10.1038/ncomms14035

2016

Lang, M, Wang, X, Wang, H, Dong, J, Lan, C, Hao, J, Huang, C, Li, X, Yu, M, Yang, Y, Yang, S & Ren, H 2016, 'Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma', Cancer Letters, vol. 378, no. 2, pp. 87-96. https://doi.org/10.1016/j.canlet.2016.05.016
Wang, X, Lang, M, Zhao, T, Feng, X, Zheng, C, Huang, C, Hao, J, Dong, J, Luo, L, Li, X, Lan, C, Yu, W, Yu, M, Yang, S & Ren, H 2017, 'Cancer-FOXP3 directly activated CCL5 to recruit FOXP3 + Treg cells in pancreatic ductal adenocarcinoma', Oncogene, vol. 36, no. 21, pp. 3048-3058. https://doi.org/10.1038/onc.2016.458
Wang, X, Dong, J, Jia, L, Zhao, T, Lang, M, Li, Z, Lan, C, Li, X, Hao, J, Wang, H, Qin, T, Huang, C, Yang, S, Yu, M & Ren, H 2017, 'HIF-2-dependent expression of stem cell factor promotes metastasis in hepatocellular carcinoma', Cancer Letters, vol. 393, pp. 113-124. https://doi.org/10.1016/j.canlet.2017.01.032
Sung, H, Kanchi, KL, Wang, X, Hill, KS, Messina, JL, Lee, JH, Kim, Y, Dees, ND, Ding, L, Teer, JK, Yang, S, Sarnaik, AA, Sondak, VK, Mulé, JJ, Wilson, RK, Weber, JS & Kim, M 2016, 'Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation', Oncotarget, vol. 7, no. 17, pp. 23885-23896. https://doi.org/10.18632/oncotarget.8127
Lin, S, Lu, S, Mulaj, M, Fang, B, Keeley, T, Wan, L, Hao, J, Muschol, M, Sun, J & Yang, S 2016, 'Monoubiquitination inhibits the actin bundling activity of fascin', Journal of Biological Chemistry, vol. 291, no. 53, pp. 27323-27333. https://doi.org/10.1074/jbc.M116.767640
Wang, X, Ren, H, Zhao, T, Ma, W, Dong, J, Zhang, S, Xin, W, Yang, S, Jia, L & Hao, J 2016, 'Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes', Oncotarget, vol. 7, no. 12, pp. 13717-13729. https://doi.org/10.18632/oncotarget.7263

2015

Sun, J, Lin, S, Keeley, T & Yang, S 2015, 'Disseminating melanoma cells surf on calcium waves' Molecular and Cellular Oncology, vol. 2, no. 4, e1002714. https://doi.org/10.1080/23723556.2014.1002714
Sun, Y, Sun, J, Lungchukiet, P, Quarni, W, Yang, S, Zhang, X & Bai, W 2015, 'Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation' Scientific reports, vol. 5, 11529. https://doi.org/10.1038/srep11529
Woods, N, Trevino, J, Coppola, D, Chellappan, S, Yang, S & Padmanabhan, J 2015, 'Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling' Oncotarget, vol. 6, no. 34, pp. 35931-35948. https://doi.org/10.18632/oncotarget.5933
Zhao, T, Ren, H, Li, J, Chen, J, Zhang, H, Xin, W, Sun, Y, Sun, L, Yang, Y, Sun, J, Wang, X, Gao, S, Huang, C, Zhang, H, Yang, S & Hao, J 2015, 'LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer', Cancer Research, vol. 75, no. 1, pp. 111-119. https://doi.org/10.1158/0008-5472.CAN-14-2040
Wang, JY, Sun, J, Huang, MY, Wang, YS, Hou, MF, Sun, Y, He, H, Krishna, N, Chiu, SJ, Lin, S, Yang, S & Chang, WC 2015, 'STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression', Oncogene, vol. 34, no. 33, pp. 4358-4367. https://doi.org/10.1038/onc.2014.366

Clinical Trials Search


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