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Researcher Profile

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Sinisa Dovat, PhD, MD

Sinisa Dovat, PhD, MD

Professor and Vice Chair for Basic Science Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Biochemistry and Molecular Biology
Professor, Department of Pharmacology
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Pediatric Cancer Team
SXD30@psu.edu

Research Interests

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia
  • Therapeutics
  • Neoplasms
  • B-Lymphocytes
  • Genes
  • Casein Kinase II
  • Phosphorylation
  • Acute Myeloid Leukemia
  • Mutation
  • DNA
  • Proteins

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications

2024

Chen, WA, Williams, TG, So, L, Drew, N, Fang, J, Ochoa, P, Nguyen, N, Jawhar, Y, Otiji, J, Duerksen-Hughes, PJ, Reeves, ME, Casiano, CA, Jin, H, Dovat, S, Yang, J, Boyle, KE & Francis-Boyle, OL 2024, 'Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro', International journal of molecular sciences, vol. 25, no. 8, 4342. https://doi.org/10.3390/ijms25084342
Budurlean, L, Tukaramrao, DB, Zhang, L, Dovat, S & Broach, J 2024, 'Integrating Optical Genome Mapping and Whole Genome Sequencing in Somatic Structural Variant Detection', Journal of Personalized Medicine, vol. 14, no. 3, 291. https://doi.org/10.3390/jpm14030291
Dong, MP, Dharmaraj, N, Kaminagakura, E, Xue, J, Leach, DG, Hartgerink, JD, Zhang, M, Hanks, HJ, Ye, Y, Aouizerat, BE, Vining, K, Thomas, CM, Dovat, S, Young, S & Viet, CT 2024, 'Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma', Biomedicines, vol. 12, no. 4, 920. https://doi.org/10.3390/biomedicines12040920

2023

Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060. https://doi.org/10.3390/ph16081060
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571. https://doi.org/10.1038/s41388-023-02671-0
Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942. https://doi.org/10.1016/j.jbior.2022.100942
Gu, S, Hou, Y, Dovat, K, Dovat, S, Song, C & Ge, Z 2023, 'Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia', Experimental Hematology and Oncology, vol. 12, no. 1, 23. https://doi.org/10.1186/s40164-023-00383-5
Alkashgari, HR, Ruiz-Jimenez, C, Stoian, C, Coats, JS, Baez, I, Chirshev, E, Martinez, SR, Dovat, S, Francis-Boyle, OL, Casiano, CA & Payne, KJ 2023, 'TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia', International journal of molecular sciences, vol. 24, no. 1, 474. https://doi.org/10.3390/ijms24010474

2022

Dovat, S, Gowda, C, Mailman, RB, Parent, LJ & Huang, X 2022, 'Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding', Advances in Medical Education and Practice, vol. 13, pp. 1039-1050. https://doi.org/10.2147/AMEP.S365953
Li, J, Han, Q, Huang, Y, Wei, Y, Zi, J, Zhao, L, Cai, Z, Lu, X, Xiao, R, Zhang, Y, Yang, X, Xu, H, Sun, N, Zhuang, W, Wu, Z, Xia, Y, Xu, Y, He, B, Zhu, W, Min, F, Chen, Y, Ding, B, Shi, P, Xie, J, Tang, H, Liu, Z, Li, B, Sun, Y, Qiu, H, Duan, L, Dovat, E, Song, C, SzeKely, L, Dovat, S & Ge, Z 2022, 'High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study', Blood Cancer Journal, vol. 12, no. 10, 145. https://doi.org/10.1038/s41408-022-00740-3
Gowda, C, Purandare, A, Mercer, K, Duke, K & Dovat, S 2022, 'Novel Casein Kinase II (CK2) inhibitor BMS-135 shows significant in vivo anti-leukemia effect', European Journal of Cancer, vol. 174, pp. S29. https://doi.org/10.1016/S0959-8049(22)00879-6
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398. https://doi.org/10.1038/s41586-022-05365-x
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972

2021

Huang, X, Dovat, S, Mailman, RB, Thiboutot, DM, Berini, D & Parent, LJ 2021, 'Building a System to Engage and Sustain Research Careers for Physicians', Academic Medicine, vol. 96, no. 4, pp. 490-494. https://doi.org/10.1097/ACM.0000000000003886
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889. https://doi.org/10.3390/cancers13194889
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Yau, E, Chen, Y, Song, C, Webb, J, Carillo, M, Kawasawa, YI, Tang, Z, Takahashi, Y, Umstead, TM, Dovat, S & Chroneos, ZC 2021, 'Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages', Immunobiology, vol. 226, no. 6, 152150. https://doi.org/10.1016/j.imbio.2021.152150
Raca, G, Abdel-Azim, H, Yue, F, Broach, J, Payne, JL, Reeves, ME, Gowda, C, Schramm, J, Desai, D, Dovat, E, Hu, T, Berg, AS, Bhojwani, D, Payne, KJ & Dovat, S 2021, 'Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity', Leukemia, vol. 35, no. 8, pp. 2399-2402. https://doi.org/10.1038/s41375-021-01133-4

2020

Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133. https://doi.org/10.1093/nar/gkaa098
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Dhanyamraju, PK, Patel, TN & Dovat, S 2020, 'Medulloblastoma: “Onset of the molecular era”', Molecular Biology Reports, vol. 47, no. 12, pp. 9931-9937. https://doi.org/10.1007/s11033-020-05971-w
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718. https://doi.org/10.3390/ijms21051718
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393. https://doi.org/10.3389/fonc.2020.00393
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696. https://doi.org/10.3324/haematol.2018.212886
Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247. https://doi.org/10.1038/s41419-020-2454-8