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Researcher Profile

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Sinisa Dovat, PhD, MD

Sinisa Dovat, PhD, MD

Professor and Vice Chair for Basic Science Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Biochemistry and Molecular Biology
Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Pediatric Cancer Team

Research Interests

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia
  • Therapeutics
  • Neoplasms
  • B-Lymphocytes
  • Genes
  • Casein Kinase II
  • Phosphorylation
  • Mutation
  • DNA
  • Epigenomics
  • Acute Myeloid Leukemia

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications


Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942.
Alkashgari, HR, Ruiz-Jimenez, C, Stoian, C, Coats, JS, Baez, I, Chirshev, E, Martinez, SR, Dovat, S, Francis-Boyle, OL, Casiano, CA & Payne, KJ 2023, 'TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia', International journal of molecular sciences, vol. 24, no. 1, 474.


Dovat, S, Gowda, C, Mailman, RB, Parent, LJ & Huang, X 2022, 'Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding', Advances in Medical Education and Practice, vol. 13, pp. 1039-1050.
Li, J, Han, Q, Huang, Y, Wei, Y, Zi, J, Zhao, L, Cai, Z, Lu, X, Xiao, R, Zhang, Y, Yang, X, Xu, H, Sun, N, Zhuang, W, Wu, Z, Xia, Y, Xu, Y, He, B, Zhu, W, Min, F, Chen, Y, Ding, B, Shi, P, Xie, J, Tang, H, Liu, Z, Li, B, Sun, Y, Qiu, H, Duan, L, Dovat, E, Song, C, SzeKely, L, Dovat, S & Ge, Z 2022, 'High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study', Blood Cancer Journal, vol. 12, no. 10, 145.
Gowda, C, Purandare, A, Mercer, K, Duke, K & Dovat, S 2022, 'Novel Casein Kinase II (CK2) inhibitor BMS-135 shows significant in vivo anti-leukemia effect', European Journal of Cancer, vol. 174, pp. S29.
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398.
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972.


Huang, X, Dovat, S, Mailman, RB, Thiboutot, DM, Berini, D & Parent, LJ 2021, 'Building a System to Engage and Sustain Research Careers for Physicians', Academic Medicine, vol. 96, no. 4, pp. 490-494.
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889.
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278.
Yau, E, Chen, Y, Song, C, Webb, J, Carillo, M, Kawasawa, YI, Tang, Z, Takahashi, Y, Umstead, TM, Dovat, S & Chroneos, ZC 2021, 'Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages', Immunobiology, vol. 226, no. 6, 152150.
Raca, G, Abdel-Azim, H, Yue, F, Broach, J, Payne, JL, Reeves, ME, Gowda, C, Schramm, J, Desai, D, Dovat, E, Hu, T, Berg, AS, Bhojwani, D, Payne, KJ & Dovat, S 2021, 'Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity', Leukemia, vol. 35, no. 8, pp. 2399-2402.


Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133.
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534.
Dhanyamraju, PK, Patel, TN & Dovat, S 2020, 'Medulloblastoma: “Onset of the molecular era”', Molecular Biology Reports, vol. 47, no. 12, pp. 9931-9937.
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718.
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393.
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696.
Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247.


Gowda, C, Song, C, Ding, Y, Iyer, S, Dhanyamraju, PK, McGrath, M, Bamme, Y, Soliman, M, Kane, S, Payne, JL & Dovat, S 2020, 'Cellular signaling and epigenetic regulation of gene expression in leukemia', Advances in Biological Regulation, vol. 75, 100665.
Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries', Journal of visualized experiments : JoVE, no. 145.
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia, vol. 33, no. 11, pp. 2720-2731.
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540.
Han, Q, Ma, J, Gu, Y, Song, H, Kapadia, M, Kawasawa, YI, Dovat, S, Song, C & Ge, Z 2019, 'RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia', Journal of Cancer, vol. 10, no. 16, pp. 3842-3850.
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363.
Cury, NM, Mühlethaler, T, Laranjeira, ABA, Canevarolo, RR, Zenatti, PP, Lucena-Agell, D, Barasoain, I, Song, C, Sun, D, Dovat, S, Yunes, RA, Prota, AE, Steinmetz, MO, Díaz, JF & Yunes, JA 2019, 'Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia', iScience, vol. 21, pp. 95-109.