Researcher Profile

Researcher Profile

Sinisa Dovat, PhD, MD

Sinisa Dovat, PhD, MD

Professor and Vice Chair for Basic Science Research, Department of Pediatrics
Professor, Department of Biochemistry and Molecular Biology
Professor, Department of Pharmacology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Pediatric Cancer

Research Interests

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia
  • Neoplasms
  • Genes
  • B-Lymphocytes
  • Casein Kinase II
  • Phosphorylation
  • Mutation
  • DNA
  • Zinc Fingers
  • Cell Proliferation
  • Epigenomics

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications


Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133.
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718.
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696.


Gowda, C, Song, C, Ding, Y, Iyer, S, Dhanyamraju, PK, McGrath, M, Bamme, Y, Soliman, M, Kane, S, Payne, JL & Dovat, S 2020, 'Cellular signaling and epigenetic regulation of gene expression in leukemia', Advances in Biological Regulation, vol. 75, 100665.
Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries', Journal of visualized experiments : JoVE, no. 145.
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia, vol. 33, no. 11, pp. 2720-2731.
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540.
Han, Q, Ma, J, Gu, Y, Song, H, Kapadia, M, Kawasawa, YI, Dovat, S, Song, C & Ge, Z 2019, 'RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia', Journal of Cancer, vol. 10, no. 16, pp. 3842-3850.
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363.
Cury, NM, Mühlethaler, T, Laranjeira, ABA, Canevarolo, RR, Zenatti, PP, Lucena-Agell, D, Barasoain, I, Song, C, Sun, D, Dovat, S, Yunes, RA, Prota, AE, Steinmetz, MO, Díaz, JF & Yunes, JA 2019, 'Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia', iScience, vol. 21, pp. 95-109.


Ge, Z, Han, Q, Gu, Y, Ge, Q, Ma, J, Sloane, J, Gao, G, Payne, KJ, Szekely, L, Song, C & Dovat, S 2018, 'Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia', Oncogenesis, vol. 7, no. 11, 84.
Tong, YQ, Zhao, ZJ, Liu, B, Bao, AY, Zheng, HY, Gu, J, Xia, Y, McGrath, M, Dovat, S, Song, C & Li, Y 2018, 'New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time', Leukemia Research, vol. 69, pp. 47-53.
Ge, Z, Gu, Y, Han, Q, Sloane, J, Ge, Q, Gao, G, Ma, J, Song, H, Hu, J, Chen, B, Dovat, S & Song, C 2018, 'Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia', Epigenomics, vol. 10, no. 1, pp. 59-69.


Pandey, MK, Gowda, K, Sung, SS, Abraham, T, Budak-Alpdogan, T, Talamo, G, Dovat, S & Amin, S 2017, 'A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis', Experimental Hematology, vol. 53, pp. 31-42.
Gowda, C, Soliman, M, Kapadia, M, Ding, Y, Payne, K & Dovat, S 2017, 'Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia', Advances in Biological Regulation, vol. 65, pp. 16-25.
Gowda, C, Sachdev, M, Muthusami, S, Kapadia, M, Petrovic-Dovat, L, Hartman, M, Ding, Y, Song, C, Payne, JL, Tan, BH & Dovat, S 2017, 'Casein kinase II (CK2) as a therapeutic target for hematological malignancies', Current Pharmaceutical Design, vol. 23, no. 1, pp. 95-107.
Ge, Z, Gu, Y, Han, Q, Zhao, G, Li, M, Li, J, Chen, B, Sun, T, Dovat, S, Gale, RP & Song, C 2017, 'Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia', Scientific reports, vol. 7.
Yoshida, N, Sakaguchi, H, Muramatsu, H, Okuno, Y, Song, C, Dovat, S, Shimada, A, Ozeki, M, Ohnishi, H, Teramoto, T, Fukao, T, Kondo, N, Takahashi, Y, Matsumoto, K, Kato, K & Kojima, S 2017, 'Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia', Leukemia, vol. 31, no. 5, pp. 1221-1223.
Ge, Z, Zhou, X, Gu, Y, Han, Q, Li, J, Chen, B, Ge, Q, Dovat, E, Payne, JL, Sun, T, Song, C & Dovat, S 2017, 'Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia', Oncotarget, vol. 8, no. 5, pp. 8022-8034.
Dovat, S & Payne, KJ 2017, 'STAT5 alters the state of transcriptional networks, driving aggressive leukemia', Nature Immunology, vol. 18, no. 6, pp. 597-598.


Francis, OL, Milford, TAM, Martinez, SR, Baez, I, Coats, JS, Mayagoitia, K, Concepcion, KR, Ginelli, E, Beldiman, C, Benitez, A, Weldon, AJ, Arogyaswamy, K, Shiraz, P, Fisher, R, Morris, CL, Zhang, XB, Filippov, V, van Handel, B, Ge, Z, Song, C, Dovat, S, Su, RJ & Payne, KJ 2016, 'A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis', Haematologica, vol. 101, no. 4, pp. 417-426.
Xiang, M, Su, H, Shu, G, Wan, D, He, F, Loaec, M, Ding, Y, Li, J, Dovat, S, Yang, G & Song, C 2016, 'Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer', Oncotarget, vol. 7, no. 14, pp. 18521-18530.
Ge, Z, Gu, Y, Xiao, L, Han, Q, Li, J, Chen, B, Yu, J, Kawasawa, YI, Payne, KJ, Dovat, S & Song, C 2016, 'Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction', Oncotarget, vol. 7, no. 29, pp. 46014-46027.
Bao, L, Chen, SJ, Conrad, K, Keefer, K, Abraham, T, Lee, JP, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Wang, HG, Dovat, S, Gans, B, Madesh, M, Cheung, JY & Miller, BA 2016, 'Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics', Journal of Biological Chemistry, vol. 291, no. 47, pp. 24449-24464.
Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440.
Ge, Z, Gu, Y, Zhao, G, Li, J, Chen, B, Han, Q, Guo, X, Liu, J, Li, H, Yu, MD, Olson, J, Steffens, S, Payne, KJ, Song, C & Dovat, S 2016, 'High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement', Oncotarget, vol. 7, no. 31, pp. 49722-49732.
Ge, Z, Li, M, Zhao, G, Xiao, L, Gu, Y, Zhou, X, Yu, MD, Li, J, Dovat, S & Song, C 2016, 'Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia', Oncology Letters, vol. 12, no. 4, pp. 2746-2751.
Gowda, C, Song, C, Ding, Y, Kapadia, M & Dovat, S 2016, 'Protein signaling and regulation of gene transcription in leukemia: Role of the Casein Kinase II-Ikaros axis', Journal of Investigative Medicine, vol. 64, no. 3, pp. 735-739.
Gowda, C, Song, C, Kapadia, M, Payne, JL, Hu, T, Ding, Y & Dovat, S 2017, 'Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros', Advances in Biological Regulation, vol. 63, pp. 71-80.
Milford, TAM, Su, RJ, Francis, OL, Baez, I, Martinez, SR, Coats, JS, Weldon, AJ, Calderon, MN, Nwosu, MC, Botimer, AR, Suterwala, BT, Zhang, XB, Morris, CL, Weldon, DJ, Dovat, S & Payne, KJ 2016, 'TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis', European Journal of Immunology, vol. 46, no. 9, pp. 2155-2161.
Ge, Z, Gu, Y, Han, Q, Zhao, G, Li, M, Li, J, Chen, B, Sun, T, Dovat, S, Gale, RP & Song, C 2016, 'Targeting high dynamin-2 (DNM2) expression by restoring ikaros function in acute lymphoblastic leukemia', Scientific reports, vol. 6, 38004.
Wang, H, Song, C, Ding, Y, Pan, X, Ge, Z, Tan, BH, Gowda, C, Sachdev, M, Muthusami, S, Ouyang, H, Lai, L, Francis, OL, Morris, CL, Abdel-Azim, H, Dorsam, G, Xiang, M, Payne, KJ & Dovat, S 2016, 'Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia', Journal of Biological Chemistry, vol. 291, no. 8, pp. 4004-4018.
Ge, Z, Song, EJ, Kawasawa, YI, Li, J, Dovat, S & Song, C 2016, 'WDR5 high expression and its effect on tumorigenesis in leukemia', Oncotarget, vol. 7, no. 25, pp. 37740-37754.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)