Sinisa Dovat, PhD, MD - Penn State Cancer Institute
Researcher Profile
Sinisa Dovat, PhD, MD
Professor and Vice Chair for Basic Science Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Penn State Neuroscience Institute
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Pediatric Cancer Team
Clinical Trials
A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Phase II Trial of Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma BCC022
ACCL1931: A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy
A Dose Escalation Study Using Difluoromethylornithine (DFMO) and AMXT-1501 followed by a Randomized Controlled Trial of DFMO with or without AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas
BCC021 Phase I/II study of Silmitasertib (CX-4945) in combination with chemotherapy in children and young adults with relapsed refractory solid tumors
Pediatric Acute Leukemia (PedAL) Screening Trial Developing New Therapies for Relapsed Leukemias
A Prospective Phase 3 Study of Patients with Newly Diagnosed Very Low-risk and Low-risk Fusion Negative Rhabdomyosarcoma
AHOD2131 A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
Recent Publications
2025
Han, Q, Gu, Y, Xiang, H, Zhang, L, Wang, Y, Yang, C, Li, J, Steiner, C, Lapalombella, R, Woyach, JA, Yang, Y, Dovat, S, Song, C & Ge, Z 2025, 'Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL', Blood, vol. 145, no. 13, pp. 1407-1421. https://doi.org/10.1182/blood.2024024130
2024
Chen, WA, Williams, TG, So, L, Drew, N, Fang, J, Ochoa, P, Nguyen, N, Jawhar, Y, Otiji, J, Duerksen-Hughes, PJ, Reeves, ME, Casiano, CA, Jin, H, Dovat, S, Yang, J, Boyle, KE & Francis-Boyle, OL 2024, 'Duocarmycin SA Reduces Proliferation and Increases Apoptosis in Acute Myeloid Leukemia Cells In Vitro', International journal of molecular sciences, vol. 25, no. 8, 4342. https://doi.org/10.3390/ijms25084342
Golla, U, Patel, S, Shah, N, Talamo, S, Bhalodia, R, Claxton, D, Dovat, S & Sharma, A 2024, 'From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies', Cancers, vol. 16, no. 20, 3454. https://doi.org/10.3390/cancers16203454
Budurlean, L, Tukaramrao, DB, Zhang, L, Dovat, S & Broach, J 2024, 'Integrating Optical Genome Mapping and Whole Genome Sequencing in Somatic Structural Variant Detection', Journal of Personalized Medicine, vol. 14, no. 3, 291. https://doi.org/10.3390/jpm14030291
Dovat, S & Schramm, J 2024, 'New precision medicine weapons for targeted treatment of high-risk B-cell precursor acute lymphoblastic leukemia', Haematologica, vol. 109, no. 12, pp. 3835-3837. https://doi.org/10.3324/haematol.2024.285784
Dong, MP, Dharmaraj, N, Kaminagakura, E, Xue, J, Leach, DG, Hartgerink, JD, Zhang, M, Hanks, HJ, Ye, Y, Aouizerat, BE, Vining, K, Thomas, CM, Dovat, S, Young, S & Viet, CT 2024, 'Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma', Biomedicines, vol. 12, no. 4, 920. https://doi.org/10.3390/biomedicines12040920
G C, B, Hoyt, LJ, Dovat, S & Dong, F 2024, 'Upregulation of nuclear protein Hemgn by transcriptional repressor Gfi1 through repressing PU.1 contributes to the anti-apoptotic activity of Gfi1', Journal of Biological Chemistry, vol. 300, no. 11, 107860. https://doi.org/10.1016/j.jbc.2024.107860
2023
Kale, VP, Hengst, JA, Sharma, AK, Golla, U, Dovat, S, Amin, SG, Yun, JK & Desai, DH 2023, 'Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases', Pharmaceuticals, vol. 16, no. 8, 1060. https://doi.org/10.3390/ph16081060
Elcheva, IA, Gowda, CP, Bogush, D, Gornostaeva, S, Fakhardo, A, Sheth, N, Kokolus, KM, Sharma, A, Dovat, S, Uzun, Y, Schell, TD & Spiegelman, VS 2023, 'IGF2BP family of RNA-binding proteins regulate innate and adaptive immune responses in cancer cells and tumor microenvironment', Frontiers in immunology, vol. 14, 1224516. https://doi.org/10.3389/fimmu.2023.1224516
Dhamdhere, MR, Gowda, CP, Singh, V, Liu, Z, Carruthers, N, Grant, C, Sharma, A, Dovat, S, Sundstrom, JM, Wang, HG & Spiegelman, VS 2023, 'IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis', Oncogene, vol. 42, no. 19, pp. 1558-1571. https://doi.org/10.1038/s41388-023-02671-0
Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942. https://doi.org/10.1016/j.jbior.2022.100942
Gu, S, Hou, Y, Dovat, K, Dovat, S, Song, C & Ge, Z 2023, 'Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia', Experimental Hematology and Oncology, vol. 12, no. 1, 23. https://doi.org/10.1186/s40164-023-00383-5
Alkashgari, HR, Ruiz-Jimenez, C, Stoian, C, Coats, JS, Baez, I, Chirshev, E, Martinez, SR, Dovat, S, Francis-Boyle, OL, Casiano, CA & Payne, KJ 2023, 'TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia', International journal of molecular sciences, vol. 24, no. 1, 474. https://doi.org/10.3390/ijms24010474
2022
Dovat, S, Gowda, C, Mailman, RB, Parent, LJ & Huang, X 2022, 'Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding', Advances in Medical Education and Practice, vol. 13, pp. 1039-1050. https://doi.org/10.2147/AMEP.S365953
Li, J, Han, Q, Huang, Y, Wei, Y, Zi, J, Zhao, L, Cai, Z, Lu, X, Xiao, R, Zhang, Y, Yang, X, Xu, H, Sun, N, Zhuang, W, Wu, Z, Xia, Y, Xu, Y, He, B, Zhu, W, Min, F, Chen, Y, Ding, B, Shi, P, Xie, J, Tang, H, Liu, Z, Li, B, Sun, Y, Qiu, H, Duan, L, Dovat, E, Song, C, SzeKely, L, Dovat, S & Ge, Z 2022, 'High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study', Blood Cancer Journal, vol. 12, no. 10, 145. https://doi.org/10.1038/s41408-022-00740-3
Gowda, C, Purandare, A, Mercer, K, Duke, K & Dovat, S 2022, 'Novel Casein Kinase II (CK2) inhibitor BMS-135 shows significant in vivo anti-leukemia effect', European Journal of Cancer, vol. 174, pp. S29. https://doi.org/10.1016/S0959-8049(22)00879-6
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398. https://doi.org/10.1038/s41586-022-05365-x
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972
2021
Huang, X, Dovat, S, Mailman, RB, Thiboutot, DM, Berini, D & Parent, LJ 2021, 'Building a System to Engage and Sustain Research Careers for Physicians', Academic Medicine, vol. 96, no. 4, pp. 490-494. https://doi.org/10.1097/ACM.0000000000003886
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889. https://doi.org/10.3390/cancers13194889
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Yau, E, Chen, Y, Song, C, Webb, J, Carillo, M, Kawasawa, YI, Tang, Z, Takahashi, Y, Umstead, TM, Dovat, S & Chroneos, ZC 2021, 'Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages', Immunobiology, vol. 226, no. 6, 152150. https://doi.org/10.1016/j.imbio.2021.152150
Raca, G, Abdel-Azim, H, Yue, F, Broach, J, Payne, JL, Reeves, ME, Gowda, C, Schramm, J, Desai, D, Dovat, E, Hu, T, Berg, AS, Bhojwani, D, Payne, KJ & Dovat, S 2021, 'Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity', Leukemia, vol. 35, no. 8, pp. 2399-2402. https://doi.org/10.1038/s41375-021-01133-4