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Researcher Profile

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Sinisa Dovat, PhD, MD

Sinisa Dovat, PhD, MD

Professor and Vice Chair for Basic Science Research, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Biochemistry and Molecular Biology
Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Pediatric Cancer Team
SXD30@psu.edu

Research Interests

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  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia
  • Therapeutics
  • Neoplasms
  • B-Lymphocytes
  • Genes
  • Casein Kinase II
  • Phosphorylation
  • Mutation
  • DNA
  • Epigenomics
  • Acute Myeloid Leukemia
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Clinical Trials

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PSCI-18-004
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
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Recent Publications

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2023

Bogush, D, Schramm, J, Ding, Y, He, B, Singh, C, Sharma, A, Tukaramrao, DB, Iyer, S, Desai, D, Nalesnik, G, Hengst, J, Bhalodia, R, Gowda, C & Dovat, S 2023, 'Signaling pathways and regulation of gene expression in hematopoietic cells', Advances in Biological Regulation, vol. 88, 100942. https://doi.org/10.1016/j.jbior.2022.100942
Alkashgari, HR, Ruiz-Jimenez, C, Stoian, C, Coats, JS, Baez, I, Chirshev, E, Martinez, SR, Dovat, S, Francis-Boyle, OL, Casiano, CA & Payne, KJ 2023, 'TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia', International journal of molecular sciences, vol. 24, no. 1, 474. https://doi.org/10.3390/ijms24010474

2022

Dovat, S, Gowda, C, Mailman, RB, Parent, LJ & Huang, X 2022, 'Clinician-Scientist Faculty Mentoring Program (FAME) – A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding', Advances in Medical Education and Practice, vol. 13, pp. 1039-1050. https://doi.org/10.2147/AMEP.S365953
Li, J, Han, Q, Huang, Y, Wei, Y, Zi, J, Zhao, L, Cai, Z, Lu, X, Xiao, R, Zhang, Y, Yang, X, Xu, H, Sun, N, Zhuang, W, Wu, Z, Xia, Y, Xu, Y, He, B, Zhu, W, Min, F, Chen, Y, Ding, B, Shi, P, Xie, J, Tang, H, Liu, Z, Li, B, Sun, Y, Qiu, H, Duan, L, Dovat, E, Song, C, SzeKely, L, Dovat, S & Ge, Z 2022, 'High efficacy of Azacitidine plus HAG in acute myeloid leukemia: an open-label, single-arm, multi-center, phase 2 study', Blood Cancer Journal, vol. 12, no. 10, 145. https://doi.org/10.1038/s41408-022-00740-3
Gowda, C, Purandare, A, Mercer, K, Duke, K & Dovat, S 2022, 'Novel Casein Kinase II (CK2) inhibitor BMS-135 shows significant in vivo anti-leukemia effect', European Journal of Cancer, vol. 174, pp. S29. https://doi.org/10.1016/S0959-8049(22)00879-6
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398. https://doi.org/10.1038/s41586-022-05365-x
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972

2021

Huang, X, Dovat, S, Mailman, RB, Thiboutot, DM, Berini, D & Parent, LJ 2021, 'Building a System to Engage and Sustain Research Careers for Physicians', Academic Medicine, vol. 96, no. 4, pp. 490-494. https://doi.org/10.1097/ACM.0000000000003886
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889. https://doi.org/10.3390/cancers13194889
Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Yau, E, Chen, Y, Song, C, Webb, J, Carillo, M, Kawasawa, YI, Tang, Z, Takahashi, Y, Umstead, TM, Dovat, S & Chroneos, ZC 2021, 'Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages', Immunobiology, vol. 226, no. 6, 152150. https://doi.org/10.1016/j.imbio.2021.152150
Raca, G, Abdel-Azim, H, Yue, F, Broach, J, Payne, JL, Reeves, ME, Gowda, C, Schramm, J, Desai, D, Dovat, E, Hu, T, Berg, AS, Bhojwani, D, Payne, KJ & Dovat, S 2021, 'Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity', Leukemia, vol. 35, no. 8, pp. 2399-2402. https://doi.org/10.1038/s41375-021-01133-4

2020

Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133. https://doi.org/10.1093/nar/gkaa098
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Dhanyamraju, PK, Patel, TN & Dovat, S 2020, 'Medulloblastoma: “Onset of the molecular era”', Molecular Biology Reports, vol. 47, no. 12, pp. 9931-9937. https://doi.org/10.1007/s11033-020-05971-w
Payne, JL, Song, C, Ding, Y, Dhanyamraju, PK, Bamme, Y, Schramm, JW, Desai, D, Sharma, A, Gowda, C & Dovat, S 2020, 'Regulation of small GTPase Rab20 by ikaros in B-cell acute lymphoblastic leukemia', International journal of molecular sciences, vol. 21, no. 5, 1718. https://doi.org/10.3390/ijms21051718
Annageldiyev, C, Tan, SF, Thakur, S, Dhanyamraju, PK, Ramisetti, SR, Bhadauria, P, Schick, J, Zeng, Z, Sharma, V, Dunton, W, Dovat, S, Desai, D, Zheng, H, Feith, DJ, Loughran, TP, Amin, S, Sharma, AK, Claxton, D & Sharma, A 2020, 'The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia', Frontiers in Oncology, vol. 10, 393. https://doi.org/10.3389/fonc.2020.00393
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696. https://doi.org/10.3324/haematol.2018.212886
Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247. https://doi.org/10.1038/s41419-020-2454-8

2019

Gowda, C, Song, C, Ding, Y, Iyer, S, Dhanyamraju, PK, McGrath, M, Bamme, Y, Soliman, M, Kane, S, Payne, JL & Dovat, S 2020, 'Cellular signaling and epigenetic regulation of gene expression in leukemia', Advances in Biological Regulation, vol. 75, 100665. https://doi.org/10.1016/j.jbior.2019.100665
Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries', Journal of visualized experiments : JoVE, no. 145. https://doi.org/10.3791/59382
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia, vol. 33, no. 11, pp. 2720-2731. https://doi.org/10.1038/s41375-019-0474-0
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540. https://doi.org/10.1038/s41388-019-0810-x
Han, Q, Ma, J, Gu, Y, Song, H, Kapadia, M, Kawasawa, YI, Dovat, S, Song, C & Ge, Z 2019, 'RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia', Journal of Cancer, vol. 10, no. 16, pp. 3842-3850. https://doi.org/10.7150/jca.33989
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363. https://doi.org/10.1038/s41375-019-0656-9
Cury, NM, Mühlethaler, T, Laranjeira, ABA, Canevarolo, RR, Zenatti, PP, Lucena-Agell, D, Barasoain, I, Song, C, Sun, D, Dovat, S, Yunes, RA, Prota, AE, Steinmetz, MO, Díaz, JF & Yunes, JA 2019, 'Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia', iScience, vol. 21, pp. 95-109. https://doi.org/10.1016/j.isci.2019.10.003
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