Researcher Profile

Researcher Profile

Sinisa Dovat, PhD, MD

Sinisa Dovat, PhD, MD

Professor and Vice Chair of Basic Science Research, Department of Pediatrics
Professor, Department of Biochemistry and Molecular Biology
Professor, Department of Pharmacology
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Pediatric Cancer
sxd30@psu.edu

Research Interests

  • Leukemia
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Neoplasms
  • Genes
  • Casein Kinase II
  • Therapeutics
  • B-Lymphocytes
  • Mutation
  • Cell Proliferation
  • DNA
  • Phosphorylation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Clinical Trials

A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients

Recent Publications

2019

Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries' Journal of visualized experiments : JoVE, no. 145. https://doi.org/10.3791/59382
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia. https://doi.org/10.1038/s41375-019-0474-0
Nicolae, C, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, G-L 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540. https://doi.org/10.1038/s41388-019-0810-x

2018

Ge, Z, Han, Q, Gu, Y, Ge, Q, Ma, J, Sloane, J, Gao, G, Payne, KJ, Szekely, L, Song, C & Dovat, S 2018, 'Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia', Oncogenesis, vol. 7, no. 11, 84. https://doi.org/10.1038/s41389-018-0095-x
Tong, YQ, Zhao, ZJ, Liu, B, Bao, AY, Zheng, HY, Gu, J, Xia, Y, McGrath, M, Dovat, S, Song, C & Li, Y 2018, 'New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time', Leukemia Research, vol. 69, pp. 47-53. https://doi.org/10.1016/j.leukres.2018.04.001
Ge, Z, Gu, Y, Han, Q, Sloane, J, Ge, Q, Gao, G, Ma, J, Song, H, Hu, J, Chen, B, Dovat, S & Song, C 2018, 'Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia', Epigenomics, vol. 10, no. 1, pp. 59-69. https://doi.org/10.2217/epi-2017-0092

2017

Pandey, MK, Gowda, K, Sung, S, Abraham, T, Budak-Alpdogan, T, Talamo, G, Dovat, S & Amin, S 2017, 'A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis', Experimental Hematology, vol. 53, pp. 31-42. https://doi.org/10.1016/j.exphem.2017.06.003
Gowda, C, Soliman, M, Kapadia, M, Ding, Y, Payne, K & Dovat, S 2017, 'Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia', Advances in Biological Regulation, vol. 65, pp. 16-25. https://doi.org/10.1016/j.jbior.2017.06.001
Gowda, C, Sachdev, M, Muthusami, S, Kapadia, M, Petrovic-Dovat, L, Hartman, M, Ding, Y, Song, C, Payne, JL, Tan, B & Dovat, S 2017, 'Casein kinase II (CK2) as a therapeutic target for hematological malignancies', Current Pharmaceutical Design, vol. 23, no. 1, pp. 95-107. https://doi.org/10.2174/1381612822666161006154311
Yoshida, N, Sakaguchi, H, Muramatsu, H, Okuno, Y, Song, C, Dovat, S, Shimada, A, Ozeki, M, Ohnishi, H, Teramoto, T, Fukao, T, Kondo, N, Takahashi, Y, Matsumoto, K, Kato, K & Kojima, S 2017, 'Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia', Leukemia, vol. 31, no. 5, pp. 1221-1223. https://doi.org/10.1038/leu.2017.25
Ge, Z, Zhou, X, Gu, Y, Han, Q, Li, J, Chen, B, Ge, Q, Dovat, E, Payne, JL, Sun, T, Song, C & Dovat, S 2017, 'Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia', Oncotarget, vol. 8, no. 5, pp. 8022-8034. https://doi.org/10.18632/oncotarget.14038
Dovat, S & Payne, KJ 2017, 'STAT5 alters the state of transcriptional networks, driving aggressive leukemia', Nature Immunology, vol. 18, no. 6, pp. 597-598. https://doi.org/10.1038/ni.3747

2016

Francis, OL, Milford, TAM, Martinez, SR, Baez, I, Coats, JS, Mayagoitia, K, Concepcion, KR, Ginelli, E, Beldiman, C, Benitez, A, Weldon, AJ, Arogyaswamy, K, Shiraz, P, Fisher, R, Morris, CL, Zhang, XB, Filippov, V, van Handel, B, Ge, Z, Song, C, Dovat, S, Su, RJ & Payne, KJ 2016, 'A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis', Haematologica, vol. 101, no. 4, pp. 417-426. https://doi.org/10.3324/haematol.2015.125336
Xiang, M, Su, H, Shu, G, Wan, D, He, F, Loaec, M, Ding, Y, Li, J, Dovat, S, Yang, G & Song, C 2016, 'Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer', Oncotarget, vol. 7, no. 14, pp. 18521-18530. https://doi.org/10.18632/oncotarget.7848
Ge, Z, Gu, Y, Xiao, L, Han, Q, Li, J, Chen, B, Yu, J, Imamura, Y, Payne, KJ, Dovat, S & Song, C 2016, 'Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction', Oncotarget, vol. 7, no. 29, pp. 46014-46027. https://doi.org/10.18632/oncotarget.10014
Bao, L, Chen, S, Conrad, K, Keefer, K, Abraham, T, Lee, JP, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Wang, H-G, Dovat, S, Gans, B, Madesh, M, Cheung, JY & Miller, B 2016, 'Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species and bioenergetics', Journal of Biological Chemistry, vol. 291, no. 47, pp. 24449-24464. https://doi.org/10.1074/jbc.M116.747147
Song, C, Pan, X, Ge, Z, Gowda, C, Ding, Y, Li, H, Li, Z, Yochum, G, Muschen, M, Li, Q, Payne, KJ & Dovat, S 2016, 'Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia', Leukemia, vol. 30, no. 6, pp. 1436-1440. https://doi.org/10.1038/leu.2015.331
Ge, Z, Gu, Y, Zhao, G, Li, J, Chen, B, Han, Q, Guo, X, Liu, J, Li, H, Yu, MD, Olson, J, Steffens, S, Payne, KJ, Song, C & Dovat, S 2016, 'High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement', Oncotarget, vol. 7, no. 31, pp. 49722-49732. https://doi.org/10.18632/oncotarget.10437
Ge, Z, Li, M, Zhao, G, Xiao, L, Gu, Y, Zhou, X, Yu, MD, Li, J, Dovat, S & Song, C 2016, 'Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia', Oncology Letters, vol. 12, no. 4, pp. 2746-2751. https://doi.org/10.3892/ol.2016.4993
Gowda, C, Song, C, Ding, Y, Kapadia, M & Dovat, S 2016, 'Protein signaling and regulation of gene transcription in leukemia: Role of the Casein Kinase II-Ikaros axis', Journal of Investigative Medicine, vol. 64, no. 3, pp. 735-739. https://doi.org/10.1136/jim-2016-000075
Gowda, C, Song, C, Kapadia, M, Payne, JL, Hu, T, Ding, Y & Dovat, S 2017, 'Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros', Advances in Biological Regulation, vol. 63, pp. 71-80. https://doi.org/10.1016/j.jbior.2016.09.003
Milford, TAM, Su, RJ, Francis, OL, Baez, I, Martinez, SR, Coats, JS, Weldon, AJ, Calderon, MN, Nwosu, MC, Botimer, AR, Suterwala, BT, Zhang, XB, Morris, CL, Weldon, DJ, Dovat, S & Payne, KJ 2016, 'TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis', European Journal of Immunology, vol. 46, no. 9, pp. 2155-2161. https://doi.org/10.1002/eji.201646307
Ge, Z, Gu, Y, Han, Q, Zhao, G, Li, M, Li, J, Chen, B, Sun, T, Dovat, S, Gale, RP & Song, C 2016, 'Targeting high dynamin-2 (DNM2) expression by restoring ikaros function in acute lymphoblastic leukemia', Scientific reports, vol. 6, 38004. https://doi.org/10.1038/srep38004
Wang, H, Song, C, Ding, Y, Pan, X, Ge, Z, Tan, B, Gowda, C, Sachdev, M, Muthusami, S, Ouyang, H, Lai, L, Francis, OL, Morris, CL, Abdel-Azim, H, Dorsam, G, Xiang, M, Payne, KJ & Dovat, S 2016, 'Transcriptional regulation of JARID1B/KDM5B histone demethylase by ikaros, histone deacetylase 1 (HDAC1), and casein kinase 2 (CK2) in B-cell acute lymphoblastic leukemia', Journal of Biological Chemistry, vol. 291, no. 8, pp. 4004-4018. https://doi.org/10.1074/jbc.M115.679332
Ge, Z, Song, EJ, Imamura, Y, Li, J, Dovat, S & Song, C 2016, 'WDR5 high expression and its effect on tumorigenesis in leukemia', Oncotarget, vol. 7, no. 25, pp. 37740-37754. https://doi.org/10.18632/oncotarget.9312

2015

Hu, RM, Tan, B, Tester, DJ, Song, C, He, Y, Dovat, S, Peterson, B, Ackerman, MJ & Makielski, JC 2015, 'Arrhythmogenic biophysical phenotype for SCN5A mutation S1787N depends upon splice variant background and intracellular acidosis' PloS one, vol. 10, no. 4, e0124921. https://doi.org/10.1371/journal.pone.0124921
Guo, X, Zhang, R, Liu, J, Li, M, Song, C, Dovat, S, Li, J & Ge, Z 2015, 'Characterization of LEF1 high expression and novel mutations in adult acute lymphoblastic leukemia', PloS one, vol. 10, no. 5, e0125429. https://doi.org/10.1371/journal.pone.0125429
Ge, Z, Guo, X, Li, J, Hartman, M, Imamura, Y, Dovat, S & Song, C 2015, 'Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia', Oncotarget, vol. 6, no. 39, pp. 42300-42311. https://doi.org/10.18632/oncotarget.5982
Song, C, Gowda, C, Pan, X, Ding, Y, Tong, Y, Tan, B, Wang, H, Muthusami, S, Ge, Z, Sachdev, M, Amin, S, Desai, D, Gowda, K, Gowda, R, Robertson, G, Schjerven, H, Muschen, M, Payne, KJ & Dovat, S 2015, 'Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia', Blood, vol. 126, no. 15, pp. 1813-1822. https://doi.org/10.1182/blood-2015-06-651505
Payne, KJ, Benitez, A & Dovat, S 2015, 'Translating basic science discoveries to clinical practice-Let us not repeat the naiveté of the pre-omics era' Annals of Translational Medicine, vol. 3, no. 4, 46. https://doi.org/10.3978/j.issn.2305-5839.2015.01.39

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)