Researcher Profile

Researcher Profile

Susan Hafenstein, PhD

Susan Hafenstein, PhD

Associate Professor, Department of Medicine
Associate Professor, Biochemistry & Molecular Biology
Associate Professor, Department of Microbiology and Immunology
Center for Infectious Disease Dynamics
Cancer Institute, Next-Generation Therapies
Scientific Program:Mechanisms of Carcinogenesis
suh21@psu.edu

Research Interests

  • Capsid
  • Viruses
  • Enterovirus
  • Genome
  • Cryoelectron Microscopy
  • Parvovirus
  • Canine Parvovirus
  • Mutation
  • Virion
  • Antibodies
  • Proteins
  • Infections

Recent Publications

2021

Chen, YC, Dinavahi, SS, Feng, Q, Gowda, R, Ramisetti, S, Xia, X, LaPenna, KB, Chirasani, VR, Cho, SH, Hafenstein, SL, Battu, MB, Berg, A, Sharma, AK, Kirchhausen, T, Dokholyan, NV, Amin, S, He, P & Robertson, GP 2021, 'Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis', Cancer Letters, vol. 506, pp. 107-119. https://doi.org/10.1016/j.canlet.2021.01.004
Goetschius, DJ, Hartmann, SR, Subramanian, S, Bator, CM, Christensen, ND & Hafenstein, SL 2021, 'High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility', Scientific reports, vol. 11, no. 1, 3498. https://doi.org/10.1038/s41598-021-83076-5

2020

Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Perederina, A, Li, D, Lee, H, Bator, C, Berezin, I, Hafenstein, SL & Krasilnikov, AS 2020, 'Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP', Nature communications, vol. 11, no. 1, 3474. https://doi.org/10.1038/s41467-020-17308-z
DiNunno, NM, Goetschius, DJ, Narayanan, A, Majowicz, SA, Moustafa, I, Bator, CM, Hafenstein, SL & Jose, J 2020, 'Identification of a pocket factor that is critical to Zika virus assembly', Nature communications, vol. 11, no. 1, 4953. https://doi.org/10.1038/s41467-020-18747-4
Voorhees, IEH, Lee, H, Allison, AB, Lopez-Astacio, R, Goodman, LB, Oyesola, OO, Omobowale, O, Fagbohun, O, Dubovi, EJ, Hafenstein, SL, Holmes, EC & Parrish, CR 2020, 'Limited intrahost diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spread', Journal of virology, vol. 94, no. 1, e01162-19. https://doi.org/10.1128/JVI.01162-19
Martínez-Gualda, B, Sun, L, Martí-Marí, O, Noppen, S, Abdelnabi, R, Bator, CM, Quesada, E, Delang, L, Mirabelli, C, Lee, H, Schols, D, Neyts, J, Hafenstein, S, Camarasa, MJ, Gago, F & San-Félix, A 2020, 'Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors', Journal of Medicinal Chemistry, vol. 63, no. 1, pp. 349-368. https://doi.org/10.1021/acs.jmedchem.9b01737

2019

Goetschius, DJ, Parrish, CR & Hafenstein, S 2019, 'Asymmetry in icosahedral viruses', Current Opinion in Virology, vol. 36, pp. 67-73. https://doi.org/10.1016/j.coviro.2019.05.006
Goetschius, DJ, Lee, H & Hafenstein, S 2019, CryoEM reconstruction approaches to resolve asymmetric features. in FA Rey (ed.), Advances in Virus Research. Advances in Virus Research, vol. 105, Academic Press Inc., pp. 73-91. https://doi.org/10.1016/bs.aivir.2019.07.007
Callaway, HM, Subramanian, S, Urbina, CA, Barnard, KN, Dick, RA, Bator, CM, Hafenstein, SL, Gifford, RJ & Parrish, CR 2019, 'Examination and reconstruction of three ancient endogenous parvovirus capsid protein gene remnants found in rodent genomes', Journal of virology, vol. 93, no. 6, e01542-18. https://doi.org/10.1128/JVI.01542-18
Subramanian, S, Maurer, AC, Bator, CM, Makhov, AM, Conway, JF, Turner, KB, Marden, JH, Vandenberghe, LH & Hafenstein, SL 2019, 'Filling Adeno-Associated Virus Capsids: Estimating Success by Cryo-Electron Microscopy', Human Gene Therapy, vol. 30, no. 12, pp. 1449-1460. https://doi.org/10.1089/hum.2019.041
Caliaro, O, Marti, A, Ruprecht, N, Leisi, R, Subramanian, S, Hafenstein, S & Ros, C 2019, 'Parvovirus B19 uncoating occurs in the cytoplasm without capsid disassembly and it is facilitated by depletion of capsid-associated divalent cations', Viruses, vol. 11, no. 5, 430. https://doi.org/10.3390/v11050430
Lee, H, Callaway, HM, Cifuente, JO, Bator, CM, Parrish, CR & Hafenstein, SL 2019, 'Transferrin receptor binds virus capsid with dynamic motion', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 41, pp. 20462-20471. https://doi.org/10.1073/pnas.1904918116
Sun, L, Lee, H, Thibaut, HJ, Lanko, K, Rivero-Buceta, E, Bator, C, Martinez-Gualda, B, Dallmeier, K, Delang, L, Leyssen, P, Gago, F, San-Felix, A, Hafenstein, S, Mirabelli, C & Neyts, J 2019, 'Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus - A 71 capsid', PLoS pathogens, vol. 15, no. 5, e1007760. https://doi.org/10.1371/journal.ppat.1007760

2018

Callaway, HM, Welsch, K, Weichert, W, Allison, AB, Hafenstein, SL, Huang, K, Iketani, S & Parrish, CR 2018, 'Complex and dynamic interactions between parvovirus capsids, transferrin receptors, and antibodies control cell infection and host range', Journal of virology, vol. 92, no. 13, e00460-18. https://doi.org/10.1128/JVI.00460-18
Minns, AM, Hart, KJ, Subramanian, S, Hafenstein, S & Lindner, SE 2018, 'Nuclear, cytosolic, and surface-localized poly(A)-binding proteins of Plasmodium yoelii', mSphere, vol. 3, no. 1, e00435-17. https://doi.org/10.1128/mSphere.00435-17

2017

Subramanian, S, Organtini, LJ, Grossman, A, Domeier, PP, Cifuente, JO, Makhov, AM, Conway, JF, D'Abramo, A, Cotmore, SF, Tattersall, P & Hafenstein, S 2017, 'Cryo-EM maps reveal five-fold channel structures and their modification by gatekeeper mutations in the parvovirus minute virus of mice (MVM) capsid', Virology, vol. 510, pp. 216-223. https://doi.org/10.1016/j.virol.2017.07.015
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, ND & Hafenstein, S 2017, 'Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site', Structure, vol. 25, no. 2, pp. 253-263. https://doi.org/10.1016/j.str.2016.12.001
Hackenbrack, N, Rogers, MB, Ashley, RE, Keel, MK, Kubiski, SV, Bryan, JA, Ghedin, E, Holmes, EC, Hafenstein, SL & Allison, AB 2017, 'Evolution and cryo-electron microscopy capsid structure of a north american bat adenovirus and its relationship to other mastadenoviruses', Journal of virology, vol. 91, no. 2, e01504-16. https://doi.org/10.1128/JVI.01504-16
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, ND & Hafenstein, S 2017, 'High-resolution structure analysis of antibody V5 and U4 conformational epitopes on human papillomavirus 16', Viruses, vol. 9, no. 12, 374. https://doi.org/10.3390/v9120374
Organtini, LJ, Shingler, KL, Ashley, RE, Capaldi, EA, Durrani, K, Dryden, KA, Makhov, AM, Conway, JF, Pizzorno, MC & Hafenstein, S 2017, 'Honey bee deformed wing virus structures reveal that conformational changes accompany genome release', Journal of virology, vol. 91, no. 2, e01795-16. https://doi.org/10.1128/JVI.01795-16
Carson, SD, Hafenstein, S & Lee, H 2017, 'MOPS and coxsackievirus B3 stability', Virology, vol. 501, pp. 183-187. https://doi.org/10.1016/j.virol.2016.12.002
Callaway, HM, Feng, KH, Lee, DW, Allison, AB, Pinard, M, McKenna, R, Agbandje-McKenna, M, Hafenstein, S & Parrish, CR 2017, 'Parvovirus capsid structures required for infection: Mutations controlling receptor recognition and protease cleavages', Journal of virology, vol. 91, no. 2, e01871-16. https://doi.org/10.1128/JVI.01871-16

Clinical Trials Search


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