Researcher Profile

Researcher Profile

Shantu Amin, PhD

Shantu Amin, PhD

Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
sga3@psu.edu

Research Interests

Dr. Shantu Amin is director of the Organic Synthesis Core of Penn State Cancer Institute. His laboratory is nationally recognized for developing synthetic strategies for novel small drug-like molecules for cancer prevention and therapy.

The major focus of Dr. Amin’s research is the synthesis of anti-cancer agents, elucidating their efficacy and investigating their drug metabolism. He has also been involved in structure-activity studies with mutagenic and carcinogenic compounds and using this knowledge to develop appropriate chemopreventive agents.

These studies have resulted in the development of several chemopreventive/ chemotherapeutic agents and an understanding of their mechanisms of action. 

  • Neoplasms
  • Epoxy Compounds
  • DNA
  • Lung
  • Carcinogens
  • DNA Adducts
  • Benzo(a)pyrene
  • Carcinogenesis
  • Tobacco
  • Polycyclic Aromatic Hydrocarbons
  • Liver
  • Skin

Recent Publications

2019

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Alcolea, V, Karelia, DN, Pandey, MK, Plano, D, Singh, P, Palop, JA, Amin, S, Sanmartín, C & Sharma, A 2019, 'Identification of a novel quinoxaline-isoselenourea targeting the STAT3 pathway as a potential melanoma therapeutic' International journal of molecular sciences, vol. 20, no. 3, 521. https://doi.org/10.3390/ijms20030521
Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors' Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803. https://doi.org/10.1016/j.bmc.2019.03.026
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2018

Chen, K-M, Sun, Y-W, Cooper, TK, Benitez, G, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2018, 'Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary', Chemical Research in Toxicology, vol. 31, no. 11, pp. 1111-1118. https://doi.org/10.1021/acs.chemrestox.8b00152
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Dyba, M, Da Silva, B, Coia, H, Hou, Y, Noguchi, S, Pan, J, Berry, D, Creswell, K, Krzeminski, J, Desai, D, Amin, S, Yang, D & Chung, FL 2018, 'Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids', Chemical research in toxicology, vol. 31, no. 8, pp. 772-783. https://doi.org/10.1021/acs.chemrestox.8b00111
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2017

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Ramisetti, SR, Oña-Ruales, JO, Wise, SA, Amin, S & Sharma, A 2017, 'An Efficient Synthesis of Dibenzo[a,l]tetracene and Dibenzo[a,j]tetracene and Their Identification in a Coal Tar Extract' Polycyclic Aromatic Compounds, pp. 1-11. https://doi.org/10.1080/10406638.2017.1362013
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Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models' Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.

2016

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2015

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Van Den Bogaard, EH, Podolsky, MA, Smits, JP, Cui, X, John, C, Gowda, K, Desai, D, Amin, S, Schalkwijk, J, Perdew, GH & Glick, AB 2015, 'Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation', Journal of Investigative Dermatology, vol. 135, no. 5, pp. 1320-1328. https://doi.org/10.1038/jid.2015.6
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Kale, VP, Amin, S & Pandey, MK 2015, 'Targeting ion channels for cancer therapy by repurposing the approved drugs', Biochimica et Biophysica Acta - Biomembranes, vol. 1848, no. 10, 81871, pp. 2747-2755. https://doi.org/10.1016/j.bbamem.2015.03.034
Dick, TE, Hengst, J, Fox, TE, Colledge, AL, Kale, VP, Sung, S, Sharma, A, Amin, S, Loughran, TP, Kester, M, Wang, H-G & Yun, J 2015, 'The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines', Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 3, pp. 494-508. https://doi.org/10.1124/jpet.114.219659
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Sun, Y-W, El-Bayoumy, K, Aliaga, C, Awad, A, Gowda, K, Amin, S & Chen, K-M 2015, 'Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice' Chemical Research in Toxicology, vol. 28, no. 7, pp. 1427-1433. https://doi.org/10.1021/acs.chemrestox.5b00097

Clinical Trials Search


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