Researcher Profile

Researcher Profile

Sergei Grigoryev, MS, PhD

Sergei Grigoryev, MS, PhD

Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Experimental Therapeutics
sag17@psu.edu

Research Interests

  • Chromatin
  • Nucleosomes
  • DNA
  • Histones
  • Heterochromatin
  • Proteins
  • Serpins
  • Genes
  • Erythrocytes
  • Granulocytes
  • Chickens
  • Epigenomics

Recent Publications

2019

Bass, MV, Nikitina, T, Norouzi, D, Zhurkin, VB & Grigoryev, S 2019, 'Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays', Journal of Biological Chemistry, vol. 294, no. 11, pp. 4233-4246. https://doi.org/10.1074/jbc.RA118.006412
Grigoryev, S & Schubert, M 2019, 'Unraveling the multiplex folding of nucleosome chains in higher order chromatin', Essays in biochemistry, vol. 63, no. 1, pp. 109-121. https://doi.org/10.1042/EBC20180066

2018

Grigoryev, S 2018, 'Chromatin Higher-Order Folding: A Perspective with Linker DNA Angles', Biophysical journal, vol. 114, no. 10, pp. 2290-2297. https://doi.org/10.1016/j.bpj.2018.03.009

2017

Nikitina, T, Norouzi, D, Grigoryev, S & Zhurkin, VB 2017, 'DNA topology in chromatin is defined by nucleosome spacing', Science Advances, vol. 3, no. 10, e1700957. https://doi.org/10.1126/sciadv.1700957
Salzberg, AC, Harris-Becker, A, Popova, E, Keasey, N, Loughran, TP, Claxton, D & Grigoryev, S 2017, 'Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability', PLoS One, vol. 12, no. 3, e0173723. https://doi.org/10.1371/journal.pone.0173723
Adkins, NL, Swygert, SG, Kaur, P, Niu, H, Grigoryev, S, Sung, P, Wang, H & Peterson, CL 2017, 'Nucleosome-like, single-stranded DNA (ssDNA)-histone octamer complexes and the implication for DNA double strand break repair', Journal of Biological Chemistry, vol. 292, no. 13, pp. 5271-5281. https://doi.org/10.1074/jbc.M117.776369
Buckwalter, JM, Norouzi, D, Harutyunyan, A, Zhurkin, VB & Grigoryev, S 2017, 'Regulation of chromatin folding by conformational variations of nucleosome linker DNA', Nucleic acids research, vol. 45, no. 16, pp. 9372-9387. https://doi.org/10.1093/nar/gkx562

2016

Grigoryev, S, Bascom, G, Buckwalter, JM, Schubert, MB, Woodcock, CL & Schlick, T 2016, 'Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 5, pp. 1238-1243. https://doi.org/10.1073/pnas.1518280113

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