Researcher Profile

Researcher Profile

Sergei Grigoryev, MS, PhD

Sergei Grigoryev, MS, PhD

Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Chromatin
  • Nucleosomes
  • DNA
  • Histones
  • Heterochromatin
  • Proteins
  • Genes
  • Serpins
  • Granulocytes
  • Chickens
  • Epigenomics
  • Erythrocytes

Recent Publications


Grigoryev, SA & Popova, EY 2019, 'Attraction of Likenesses: Mechanisms of Self-Association and Compartmentalization of Eukaryotic Chromatin', Molekuliarnaia biologiia, vol. 53, no. 6, pp. 933-953.
Bass, MV, Nikitina, T, Norouzi, D, Zhurkin, VB & Grigoryev, SA 2019, 'Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays', Journal of Biological Chemistry, vol. 294, no. 11, pp. 4233-4246.
Grigoryev, SA & Schubert, M 2019, 'Unraveling the multiplex folding of nucleosome chains in higher order chromatin', Essays in biochemistry, vol. 63, no. 1, pp. 109-121.


Grigoryev, SA 2018, 'Chromatin Higher-Order Folding: A Perspective with Linker DNA Angles', Biophysical journal, vol. 114, no. 10, pp. 2290-2297.


Nikitina, T, Norouzi, D, Grigoryev, SA & Zhurkin, VB 2017, 'DNA topology in chromatin is defined by nucleosome spacing', Science Advances, vol. 3, no. 10, e1700957.
Salzberg, AC, Harris-Becker, A, Popova, EY, Keasey, N, Loughran, TP, Claxton, DF & Grigoryev, SA 2017, 'Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability', PloS one, vol. 12, no. 3, e0173723.
Adkins, NL, Swygert, SG, Kaur, P, Niu, H, Grigoryev, SA, Sung, P, Wang, H & Peterson, CL 2017, 'Nucleosome-like, single-stranded DNA (ssDNA)-histone octamer complexes and the implication for DNA double strand break repair', Journal of Biological Chemistry, vol. 292, no. 13, pp. 5271-5281.
Buckwalter, JM, Norouzi, D, Harutyunyan, A, Zhurkin, VB & Grigoryev, SA 2017, 'Regulation of chromatin folding by conformational variations of nucleosome linker DNA', Nucleic acids research, vol. 45, no. 16, pp. 9372-9387.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)