Robert Greiner, MD - Penn State Cancer Institute
Researcher Profile
Robert Greiner, MD
Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Division of Hematology and Oncology
Disease Teams:
Cancer Institute, Pediatric Cancer Team
Clinical Trials
A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
Phase II Trial of Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma BCC022
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
A Phase 1/2, Open-label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects with Advanced or Metastatic Malignancies Harboring ALK, ROS1, or NTRK1-3 Alterations (CARE)
A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
A Dose Escalation Study Using Difluoromethylornithine (DFMO) and AMXT-1501 followed by a Randomized Controlled Trial of DFMO with or without AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Phase II Study of Naxitamab Added to Induction Therapy for Subjects with Newly Diagnosed
High-Risk Neuroblastoma
BCC021 Phase I/II study of Silmitasertib (CX-4945) in combination with chemotherapy in children and young adults with relapsed refractory solid tumors
Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
Pediatric Acute Leukemia (PedAL) Screening Trial Developing New Therapies for Relapsed Leukemias
A Prospective Phase 3 Study of Patients with Newly Diagnosed Very Low-risk and Low-risk Fusion Negative Rhabdomyosarcoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
A Phase II pilot trial to estimate survival after a non-total body irradiation (TBI) based conditioning regimen in patients diagnosed with B-acute lymphoblastic leukemia (ALL) who are pre-allogeneic hematopoietic cell transplantation (HCT) next-generation-sequence (NGS) minimal residual disease (MRD) negative
AHOD2131 A Randomized Phase 3 Interim Response Adapted Trial Comparing Standard Therapy with Immuno-oncology Therapy for Children and Adults with Newly Diagnosed Stage I and II Classic Hodgkin Lymphoma
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
Recent Publications
2024
Brow, D, Shike, H, Kendrick, J, Pettersson, L, Mineishi, S, Claxton, DF, Wirk, B, Cioccio, J, Greiner, RJ, Viswanatha, D, Kharfan-Dabaja, MA, Li, Z, Tyler, J & Elrefaei, M 2024, 'Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods', Human Immunology, vol. 85, no. 3, 110794. https://doi.org/10.1016/j.humimm.2024.110794
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Caru, M, Dandekar, S, Gordon, B, Conroy, DE, Barb, ED, Doerksen, SE, Smink, GM, McKeone, DJ, Shah, NB, Greiner, RJ, Schramm, JW, Rao, P, McGregor, L & Schmitz, KH 2024, 'Implementing a behavioral physical activity program in children and adolescent survivors of childhood cancer: a pilot randomized controlled trial', Journal of Behavioral Medicine, vol. 47, no. 5, pp. 792-803. https://doi.org/10.1007/s10865-024-00497-z
Zhang, R, Shang, Y, Cioccio, J, Rakszawski, K, Nickolich, M, Ehmann, C, Inoue, Y, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Liao, J, Greiner, R, Brown, V, Claxton, D, Ning, J, Zhou, S, Mineishi, S, Minagawa, K & Shike, H 2024, 'Sensitivity and Specificity of Chimerism Tests in Predicting Leukemia Relapse Using Increasing Mixed Chimerism', Journal of Molecular Diagnostics, vol. 26, no. 12, pp. 1159-1170. https://doi.org/10.1016/j.jmoldx.2024.09.003
2022
Lazow, MA, Fuller, C, Dewire, M, Lane, A, Bandopadhayay, P, Bartels, U, Bouffet, E, Cheng, S, Cohen, KJ, Cooney, TM, Coven, SL, Dholaria, H, Diez, B, Dorris, K, El-Ayadi, M, El-Sheikh, A, Fisher, PG, Fonseca, A, Garcia Lombardi, M, Greiner, RJ, Goldman, S, Gottardo, N, Gururangan, S, Hansford, JR, Hassall, T, Hawkins, C, Kilburn, L, Koschmann, C, Leary, SE, Ma, J, Minturn, JE, Monje-Deisseroth, M, Packer, R, Samson, Y, Sandler, ES, Sevlever, G, Tinkle, CL, Tsui, K, Wagner, LM, Zaghloul, M, Ziegler, DS, Chaney, B, Black, K, Asher, A, Drissi, R, Fouladi, M, Jones, BV & Leach, JL 2022, 'Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry', Neuro-oncology, vol. 24, no. 5, pp. 821-833. https://doi.org/10.1093/neuonc/noab245
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Rangarajan, HG, Stanek, JR, Abdel-Azim, H, Modi, A, Haight, A, McKinney, CM, McKeone, DJ, Buchbinder, DK, Katsanis, E, Abusin, GA, Ahmed, I, Law, J, Silva, JG, Mallhi, KK, Burroughs, LM, Shah, N, Shaw, PJ, Greiner, R, Shenoy, S, Pulsipher, MA & Abu-Arja, R 2022, 'Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy Consortium', Transplantation and Cellular Therapy, vol. 28, no. 6, pp. 329.e1-329.e9. https://doi.org/10.1016/j.jtct.2022.03.007
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Lazow, MA, Nievelstein, MT, Lane, A, Bandopadhayhay, P, DeWire-Schottmiller, M, Fouladi, M, Glod, JW, Greiner, RJ, Hoffman, LM, Hummel, TR, Kilburn, L, Leary, S, Minturn, JE, Packer, R, Ziegler, DS, Chaney, B, Black, K, de Blank, P & Leach, JL 2022, 'Volumetric endpoints in diffuse intrinsic pontine glioma: p correlations in the International DIPG/DMG Registry', Neuro-oncology, vol. 24, no. 9, pp. 1598-1608. https://doi.org/10.1093/neuonc/noac037
2021
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Hackett, G, Munir, F, Shapiro, T, Greiner, R, McKeone, DJ & Aluquin, VPR 2021, 'Pulmonary arterial hypertension in pediatric patients undergoing high-dose carboplatin/thiotepa and stem cell transplant', Pulmonary Circulation, vol. 11, no. 4. https://doi.org/10.1177/20458940211050469