Robert Greiner, MD - Penn State Cancer Institute
Researcher Profile
Robert Greiner, MD
Associate Professor, Department of Pediatrics
Division of Hematology and Oncology
Division of Hematology and Oncology
Disease Teams:
Cancer Institute, Pediatric Cancer Team
Research Interests
- Therapeutics
- Pediatrics
- Transplants
- Neoplasms
- Tissue Donors
- Hematopoietic Stem Cell Transplantation
- Child
- Drug Therapy
- Allogeneic Cells
- Stem Cells
- Registries
- Diffuse Intrinsic Pontine Glioma
Clinical Trials
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
A Phase 1/2, Open-label, Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity Study of Repotrectinib in Pediatric and Young Adult Subjects with Advanced or Metastatic Malignancies Harboring ALK, ROS1, or NTRK1-3 Alterations (CARE)
A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Phase II Trial of Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation With Randomization to Either Single Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy With Autologous Hematopoietic Progenitor Cell Rescue
Phase 1/2 Study to Evaluate Palbociclib (Ibrance®) in Combination with Irinotecan and Temozolomide or in Combination with Topotecan and Cyclophosphamide in Pediatric Patients with Recurrent or Refractory Solid Tumors
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
A Phase II pilot trial to estimate survival after a non-total body irradiation (TBI) based conditioning regimen in patients diagnosed with B-acute lymphoblastic leukemia (ALL) who are pre-allogeneic hematopoietic cell transplantation (HCT) next-generation-sequence (NGS) minimal residual disease (MRD) negative
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
Recent Publications
2024
Brow, D, Shike, H, Kendrick, J, Pettersson, L, Mineishi, S, Claxton, DF, Wirk, B, Cioccio, J, Greiner, RJ, Viswanatha, D, Kharfan-Dabaja, MA, Li, Z, Tyler, J & Elrefaei, M 2024, 'Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods', Human Immunology. https://doi.org/10.1016/j.humimm.2024.110794
2022
Lazow, MA, Fuller, C, Dewire, M, Lane, A, Bandopadhayay, P, Bartels, U, Bouffet, E, Cheng, S, Cohen, KJ, Cooney, TM, Coven, SL, Dholaria, H, Diez, B, Dorris, K, El-Ayadi, M, El-Sheikh, A, Fisher, PG, Fonseca, A, Garcia Lombardi, M, Greiner, RJ, Goldman, S, Gottardo, N, Gururangan, S, Hansford, JR, Hassall, T, Hawkins, C, Kilburn, L, Koschmann, C, Leary, SE, Ma, J, Minturn, JE, Monje-Deisseroth, M, Packer, R, Samson, Y, Sandler, ES, Sevlever, G, Tinkle, CL, Tsui, K, Wagner, LM, Zaghloul, M, Ziegler, DS, Chaney, B, Black, K, Asher, A, Drissi, R, Fouladi, M, Jones, BV & Leach, JL 2022, 'Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry', Neuro-oncology, vol. 24, no. 5, pp. 821-833. https://doi.org/10.1093/neuonc/noab245
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Rangarajan, HG, Stanek, JR, Abdel-Azim, H, Modi, A, Haight, A, McKinney, CM, McKeone, DJ, Buchbinder, DK, Katsanis, E, Abusin, GA, Ahmed, I, Law, J, Silva, JG, Mallhi, KK, Burroughs, LM, Shah, N, Shaw, PJ, Greiner, R, Shenoy, S, Pulsipher, MA & Abu-Arja, R 2022, 'Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy Consortium', Transplantation and Cellular Therapy, vol. 28, no. 6, pp. 329.e1-329.e9. https://doi.org/10.1016/j.jtct.2022.03.007
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Lazow, MA, Nievelstein, MT, Lane, A, Bandopadhayhay, P, DeWire-Schottmiller, M, Fouladi, M, Glod, JW, Greiner, RJ, Hoffman, LM, Hummel, TR, Kilburn, L, Leary, S, Minturn, JE, Packer, R, Ziegler, DS, Chaney, B, Black, K, de Blank, P & Leach, JL 2022, 'Volumetric endpoints in diffuse intrinsic pontine glioma: p correlations in the International DIPG/DMG Registry', Neuro-oncology, vol. 24, no. 9, pp. 1598-1608. https://doi.org/10.1093/neuonc/noac037
2021
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Hackett, G, Munir, F, Shapiro, T, Greiner, R, McKeone, DJ & Aluquin, VPR 2021, 'Pulmonary arterial hypertension in pediatric patients undergoing high-dose carboplatin/thiotepa and stem cell transplant', Pulmonary Circulation, vol. 11, no. 4. https://doi.org/10.1177/20458940211050469
2020
Mrowczynski, OD, Lane, JR, Specht, CS, Greiner, RJ, Iantosca, MR & Rizk, EB 2020, 'Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature', Child's Nervous System, vol. 36, no. 11, pp. 2845-2849. https://doi.org/10.1007/s00381-020-04597-4