Robert Paulson, PhD - Penn State Cancer Institute
Researcher Profile
Robert Paulson, PhD
Professor of Veterinary Science, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Erythropoiesis
- Spleen
- Friend murine leukemia virus
- Mutation
- Receptor Protein-Tyrosine Kinases
- Erythrocytes
- Leukemia
- Anemia
- Genes
- Leukemia, Erythroblastic, Acute
- Selenium
- Proteins
Recent Publications
2023
Qian, F, Arner, BE, Nettleford, SK, Paulson, RF & Prabhu, KS 2023, 'Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice', Journal of Visualized Experiments, vol. 2023, no. 191, e64834. https://doi.org/10.3791/64834
Ruan, B & Paulson, RF 2023, 'Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms', Frontiers in Physiology, vol. 13, 1063294. https://doi.org/10.3389/fphys.2022.1063294
2022
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
2020
Hengst, JA, Hegde, S, Paulson, RF & Yun, JK 2020, 'Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization', Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 20, 127453. https://doi.org/10.1016/j.bmcl.2020.127453
Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246. https://doi.org/10.1182/blood.2019003480
Paulson, RF, Ruan, B, Hao, S & Chen, Y 2020, 'Stress Erythropoiesis is a Key Inflammatory Response', Cells, vol. 9, no. 3. https://doi.org/10.3390/cells9030634
2019
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Matsui, Y, Zhang, Y, Paulson, RF & Lai, ZC 2019, 'Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth', DNA and Cell Biology, vol. 38, no. 1, pp. 91-106. https://doi.org/10.1089/dna.2018.4340
Paulson, RF 2019, 'Epo receptor marks the spot', Blood, vol. 134, no. 5, pp. 413-414. https://doi.org/10.1182/blood.2019001581
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336. https://doi.org/10.1126/scisignal.aap7336
Hao, S, Matsui, Y, Lai, ZC & Paulson, RF 2019, 'Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration', Experimental Hematology, vol. 80, pp. 42-54.e4. https://doi.org/10.1016/j.exphem.2019.11.002