Researcher Profile

Researcher Profile

Robert Paulson, PhD

Robert Paulson, PhD

Professor of Veterinary Science, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
rfp5@psu.edu

Research Interests

  • Erythropoiesis
  • Spleen
  • Friend murine leukemia virus
  • Mutation
  • Receptor Protein-Tyrosine Kinases
  • Anemia
  • Leukemia, Erythroblastic, Acute
  • Genes
  • Erythroid Precursor Cells
  • Selenium
  • Proteins
  • Erythrocytes

Recent Publications

2019

Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Matsui, Y, Zhang, Y, Paulson, RF & Lai, ZC 2019, 'Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth', DNA and Cell Biology, vol. 38, no. 1, pp. 91-106. https://doi.org/10.1089/dna.2018.4340
Paulson, RF 2019, 'Epo receptor marks the spot', Blood, vol. 134, no. 5, pp. 413-414. https://doi.org/10.1182/blood.2019001581
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336. https://doi.org/10.1126/scisignal.aap7336
Hao, S, Matsui, Y, Lai, ZC & Paulson, RF 2019, 'Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration', Experimental Hematology, vol. 80, pp. 42-54.e4. https://doi.org/10.1016/j.exphem.2019.11.002

2018

Bresnick, EH, Hewitt, KJ, Mehta, C, Keles, S, Paulson, RF & Johnson, KD 2018, 'Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond', Development (Cambridge), vol. 145, no. 1, dev151423. https://doi.org/10.1242/dev.151423
Liao, C, Sandeep Prabhu, K & Paulson, RF 2018, 'Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia', Blood, vol. 132, no. 24, pp. 2580-2593. https://doi.org/10.1182/blood-2018-06-856831
Rothberg, JLM, Maganti, HB, Jrade, H, Porter, CJ, Palidwor, GA, Cafariello, C, Battaion, HL, Khan, ST, Perkins, TJ, Paulson, RF, Ito, CY & Stanford, WL 2018, 'Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis', Cell Discovery, vol. 4, no. 1, 21. https://doi.org/10.1038/s41421-018-0022-5
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Liao, C, Hardison, RC, Kennett, MJ, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis', Blood, vol. 131, no. 23, pp. 2568-2580. https://doi.org/10.1182/blood-2017-08-800607
Bennett, LF, Liao, C & Paulson, R 2018, Stress erythropoiesis model systems. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1698, Humana Press Inc., pp. 91-102. https://doi.org/10.1007/978-1-4939-7428-3_5
Liao, C, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'The intricate role of selenium and selenoproteins in erythropoiesis', Free Radical Biology and Medicine, vol. 127, pp. 165-171. https://doi.org/10.1016/j.freeradbiomed.2018.04.578

2017

Finch, ER, Tukaramrao, DB, Goodfield, LL, Quickel, MD, Paulson, RF & Prabhu, KS 2017, 'Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia', Blood, vol. 129, no. 13, pp. 1802-1810. https://doi.org/10.1182/blood-2016-08-736405
Hewitt, KJ, Katsumura, KR, Matson, DR, Devadas, P, Tanimura, N, Hebert, AS, Coon, JJ, Kim, JS, Dewey, CN, Keles, S, Hao, S, Paulson, RF & Bresnick, EH 2017, 'GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia', Developmental Cell, vol. 42, no. 3, pp. 213-225.e4. https://doi.org/10.1016/j.devcel.2017.07.009
Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models', Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.
Diwakar, BT, Korwar, AM, Paulson, RF & Prabhu, KS 2017, The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. in Advances in Cancer Research. Advances in Cancer Research, vol. 136, Academic Press Inc., pp. 153-172. https://doi.org/10.1016/bs.acr.2017.07.003

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)