Researcher Profile

Researcher Profile

Robert Paulson, PhD

Robert Paulson, PhD

Professor of Veterinary Science, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
rfp5@psu.edu

Research Interests

  • Erythropoiesis
  • Spleen
  • Friend murine leukemia virus
  • Mutation
  • Receptor Protein-Tyrosine Kinases
  • Leukemia
  • Anemia
  • Erythrocytes
  • Genes
  • Leukemia, Erythroblastic, Acute
  • Selenium
  • Proteins

Recent Publications

2022

Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R

2021

Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR

2020

Hengst, JA, Hegde, S, Paulson, RF & Yun, JK 2020, 'Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization', Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 20, 127453. https://doi.org/10.1016/j.bmcl.2020.127453
Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246. https://doi.org/10.1182/blood.2019003480
Paulson, RF, Ruan, B, Hao, S & Chen, Y 2020, 'Stress Erythropoiesis is a Key Inflammatory Response', Cells, vol. 9, no. 3. https://doi.org/10.3390/cells9030634

2019

Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Matsui, Y, Zhang, Y, Paulson, RF & Lai, ZC 2019, 'Dual role of a C-terminally truncated isoform of large tumor suppressor kinase 1 in the regulation of hippo signaling and tissue growth', DNA and Cell Biology, vol. 38, no. 1, pp. 91-106. https://doi.org/10.1089/dna.2018.4340
Paulson, RF 2019, 'Epo receptor marks the spot', Blood, vol. 134, no. 5, pp. 413-414. https://doi.org/10.1182/blood.2019001581
Hao, S, Xiang, J, Wu, DC, Fraser, JW, Ruan, B, Cai, J, Patterson, AD, Lai, ZC & Paulson, RF 2019, 'Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche', Blood Advances, vol. 3, no. 14, pp. 2205-2217. https://doi.org/10.1182/bloodadvances.2019000375
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336. https://doi.org/10.1126/scisignal.aap7336
Hao, S, Matsui, Y, Lai, ZC & Paulson, RF 2019, 'Yap1 promotes proliferation of transiently amplifying stress erythroid progenitors during erythroid regeneration', Experimental Hematology, vol. 80, pp. 42-54.e4. https://doi.org/10.1016/j.exphem.2019.11.002

2018

Bresnick, EH, Hewitt, KJ, Mehta, C, Keles, S, Paulson, RF & Johnson, KD 2018, 'Mechanisms of erythrocyte development and regeneration: Implications for regenerative medicine and beyond', Development (Cambridge), vol. 145, no. 1, dev151423. https://doi.org/10.1242/dev.151423
Liao, C, Sandeep Prabhu, K & Paulson, RF 2018, 'Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia', Blood, vol. 132, no. 24, pp. 2580-2593. https://doi.org/10.1182/blood-2018-06-856831
Rothberg, JLM, Maganti, HB, Jrade, H, Porter, CJ, Palidwor, GA, Cafariello, C, Battaion, HL, Khan, ST, Perkins, TJ, Paulson, RF, Ito, CY & Stanford, WL 2018, 'Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis', Cell Discovery, vol. 4, no. 1, 21. https://doi.org/10.1038/s41421-018-0022-5
Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Liao, C, Hardison, RC, Kennett, MJ, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis', Blood, vol. 131, no. 23, pp. 2568-2580. https://doi.org/10.1182/blood-2017-08-800607
Bennett, LF, Liao, C & Paulson, RF 2018, Stress erythropoiesis model systems. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1698, Humana Press Inc., pp. 91-102. https://doi.org/10.1007/978-1-4939-7428-3_5
Liao, C, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'The intricate role of selenium and selenoproteins in erythropoiesis', Free Radical Biology and Medicine, vol. 127, pp. 165-171. https://doi.org/10.1016/j.freeradbiomed.2018.04.578

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)