Robert Paulson, PhD - Penn State Cancer Institute
Researcher Profile
Robert Paulson, PhD
Professor of Veterinary Science, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Erythropoiesis
- Spleen
- Friend murine leukemia virus
- Mutation
- Receptor Protein-Tyrosine Kinases
- Erythrocytes
- Leukemia
- Anemia
- Genes
- Leukemia, Erythroblastic, Acute
- Selenium
- Proteins
Recent Publications
2023
Qian, F, Nettleford, SK, Zhou, J, Arner, BE, Hall, MA, Sharma, A, Annageldiyev, C, Rossi, RM, Tukaramrao, DB, Sarkar, D, Hegde, S, Gandhi, UH, Finch, ER, Goodfield, L, Quickel, MD, Claxton, DF, Paulson, RF & Prabhu, KS 2023, 'Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells', Cell Reports, vol. 42, no. 7, 112794. https://doi.org/10.1016/j.celrep.2023.112794
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Maria, NI, Papoin, J, Raparia, C, Sun, Z, Josselsohn, R, Lu, A, Katerji, H, Syeda, MM, Polsky, D, Paulson, R, Kalfa, T, Barnes, BJ, Zhang, W, Blanc, L & Davidson, A 2023, 'Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice', Life Science Alliance, vol. 6, no. 10, e202302241. https://doi.org/10.26508/lsa.202302241
Qian, F, Arner, BE, Nettleford, SK, Paulson, RF & Prabhu, KS 2023, 'Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice', Journal of Visualized Experiments, vol. 2023, no. 191, e64834. https://doi.org/10.3791/64834
Ruan, B & Paulson, RF 2023, 'Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms', Frontiers in Physiology, vol. 13, 1063294. https://doi.org/10.3389/fphys.2022.1063294
2022
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
2020
Hengst, JA, Hegde, S, Paulson, RF & Yun, JK 2020, 'Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization', Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 20, 127453. https://doi.org/10.1016/j.bmcl.2020.127453
Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246. https://doi.org/10.1182/blood.2019003480
Paulson, RF, Ruan, B, Hao, S & Chen, Y 2020, 'Stress Erythropoiesis is a Key Inflammatory Response', Cells, vol. 9, no. 3, 1894. https://doi.org/10.3390/cells9030634