Researcher Profile

Researcher Profile

Pak Kin Wong, PhD

Pak Kin Wong, PhD

Professor, Biomedical Engineering
Professor, Department of Surgery
Scientific Program:Next-Generation Therapies

Research Interests

  • Biosensing Techniques
  • Microfluidics
  • Endothelial Cells
  • Cell Movement
  • Neoplasms
  • Urinary Tract Infections
  • Urine
  • Proteins
  • NF-E2-Related Factor 2
  • Anti-Bacterial Agents
  • Gene Expression
  • Growth

Recent Publications


Li, H, Garner, T, Diaz, FJ & Wong, PK 2019, 'A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents', Small, vol. 15, no. 28, 1901910.
Li, H, Torab, P, Mach, KE, Surrette, C, England, MR, Craft, DW, Thomas, NJ, Liao, JC, Puleo, C & Wong, PK 2019, 'Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 21, pp. 10270-10279.
Xiao, Y, Riahi, R, Torab, P, Zhang, DD & Wong, PK 2019, 'Collective Cell Migration in 3D Epithelial Wound Healing', ACS nano.
Tao, S, Wang, S, Moghaddam, SJ, Ooi, A, Chapman, E, Wong, PK & Zhang, DD 2019, 'Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)', Cancer Research, vol. 79, no. 5.
Wan, Y, Zhu, N, Lu, Y & Wong, PK 2019, 'DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells', Analytical chemistry, vol. 91, no. 4, pp. 2626-2633.
Dean, ZS, Jamilpour, N, Slepian, MJ & Wong, PK 2019, 'Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration', ACS Biomaterials Science and Engineering, vol. 5, no. 8, pp. 3864-3875.
Gao, J, Li, H, Torab, P, Mach, KE, Craft, DW, Thomas, NJ, Puleo, CM, Liao, JC, Wang, TH & Wong, PK 2019, 'Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 246-253.
Jamilpour, N, Nam, KH, Gregorio, CC & Wong, PK 2019, 'Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates', ACS Biomaterials Science and Engineering, vol. 5, no. 8, pp. 3808-3816.
Li, H, Morowitz, M, Thomas, N & Wong, PK 2019, 'Rapid Single-Cell Microbiological Analysis: Toward Precision Management of Infections and Dysbiosis', SLAS Technology, vol. 24, no. 6, pp. 603-605.


Wang, S, Xiao, Y, Zhang, DD & Wong, PK 2018, 'A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells', Biomaterials, vol. 156, pp. 56-64.
Li, H, Lu, Y & Wong, PK 2018, 'Diffusion-reaction kinetics of microfluidic amperometric biosensors', Lab on a Chip, vol. 18, no. 20, pp. 3086-3089.
Sun, Y, Kim, DH & Wong, PK 2018, 'Guest Editorial Advancing Mechanobiology by Micro/Nanosystems', IEEE Transactions on Nanotechnology, vol. 17, no. 3, pp. 371-372.
Chu, M, Novak, SM, Cover, C, Wang, AA, Chinyere, IR, Juneman, EB, Zarnescu, DC, Wong, PK & Gregorio, CC 2018, 'Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1', Circulation, vol. 137, no. 6, pp. 605-618.
Dodson, M, Liu, P, Jiang, T, Ambrose, AJ, Luo, G, de la Vega, MR, Cholanians, AB, Wong, PK, Chapman, E & Zhang, DD 2018, 'Increased O-GlcNAcylation of SNAP29 drives arsenicinduced autophagic dysfunction', Molecular and cellular biology, vol. 38, no. 11, e00595-17.
Dodson, M, de la Vega, MR, Harder, B, Castro-Portuguez, R, Rodrigues, SD, Wong, PK, Chapman, E & Zhang, DD 2018, 'Low-level arsenic causes proteotoxic stress and not oxidative stress', Toxicology and Applied Pharmacology, vol. 341, pp. 106-113.
Surrette, C, Scherer, B, Corwin, A, Grossmann, G, Kaushik, AM, Hsieh, K, Zhang, P, Liao, JC, Wong, PK, Wang, TH & Puleo, CM 2018, 'Rapid Microbiology Screening in Pharmaceutical Workflows', SLAS Technology, vol. 23, no. 4, pp. 387-394.


Gao, J, Jeffries, L, Mach, KE, Craft, DW, Thomas, NJ, Gau, V, Liao, JC & Wong, PK 2017, 'A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis', SLAS Technology, vol. 22, no. 4, pp. 466-474.
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, Z, Halstead, ES & Thomas, N 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625.
Altobelli, E, Mohan, R, Mach, KE, Sin, MLY, Liao, JC, Buscarini, M, Wong, PK, Gau, V, Banaei, N & Liao, JC 2017, 'Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing', European Urology Focus, vol. 3, no. 2-3, pp. 293-299.
Wang, S, Sun, J, Xiao, Y, Lu, Y, Zhang, DD & Wong, PK 2017, 'Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling', Advanced Biosystems, vol. 1, no. 1-2, 1600019.


Xiao, Y, Lu, Y, Hsieh, M, Liao, J & Wong, PK 2016, 'A microfiltration device for urogenital schistosomiasis diagnostics', PloS one, vol. 11, no. 4, e0154640.
Wang, S, Sun, J, Zhang, DD & Wong, PK 2016, 'A nanobiosensor for dynamic single cell analysis during microvascular self-organization', Nanoscale, vol. 8, no. 38, pp. 16894-16901.
Long, M, De La Vega, MR, Wen, Q, Bharara, M, Jiang, T, Zhang, R, Zhou, S, Wong, PK, Wondrak, GT, Zheng, H & Zhang, DD 2016, 'An essential role of NRF2 in diabetic wound healing', Diabetes, vol. 65, no. 3, pp. 780-793.
Sun, J, Hoying, JB, Deymier, PA, Zhang, DD & Wong, PK 2016, 'Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility', PLoS computational biology, vol. 12, no. 5, e1004955.
Dean, Z, Utzinger, U & Wong, PK 2016, Dynamic characterization of invasive leader cells during 3D collective cancer invasion. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Chemical and Biological Microsystems Society, pp. 459-460, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 10/9/16.
Lu, Y, Ren, Q, Liu, T, Leung, SL, Gau, V, Liao, JC, Chan, CL & Wong, PK 2016, 'Long-range electrothermal fluid motion in microfluidic systems', International Journal of Heat and Mass Transfer, vol. 98, pp. 341-349.
Tang, Q, Liang, M, Lu, Y, Wong, PK, Wilmink, GJ, Zhang, D & Xin, H 2016, 'Microfluidic devices for terahertz spectroscopy of live cells toward lab-on-a-chip applications', Sensors (Switzerland), vol. 16, no. 4, 476.
Dean, ZS, Elias, P, Jamilpour, N, Utzinger, U & Wong, PK 2016, 'Probing 3D collective cancer invasion using double-stranded locked nucleic acid biosensors', Analytical chemistry, vol. 88, no. 17, pp. 8902-8907.
Yang, Y, Jamilpour, N, Yao, B, Dean, ZS, Riahi, R & Wong, PK 2016, 'Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement', Scientific reports, vol. 6, 22707.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)