Researcher Profile

Researcher Profile

Pak Kin Wong, PhD

Pak Kin Wong, PhD

Professor, Biomedical Engineering
Professor, Department of Surgery
Scientific Program:Next-Generation Therapies
pxw28@psu.edu

Research Interests

  • Biosensing Techniques
  • Microfluidics
  • Endothelial Cells
  • Cell Movement
  • Neoplasms
  • Urinary Tract Infections
  • Proteins
  • NF-E2-Related Factor 2
  • Urine
  • Gene Expression
  • Growth
  • Equipment and Supplies

Recent Publications

2020

Chow, EKH, Wong, PK & Ding, X 2020, 'Advances in Technology to Address COVID-19', SLAS Technology, vol. 25, no. 6, pp. 511-512. https://doi.org/10.1177/2472630320969634
Zhu, N & Wong, PK 2020, 'Advances in Viral Diagnostic Technologies for Combating COVID-19 and Future Pandemics', SLAS Technology, vol. 25, no. 6, pp. 513-521. https://doi.org/10.1177/2472630320953798
Li, H, Torab, P & Wong, PK 2020, 'Detection of bacterial infection via a fidget spinner', Nature Biomedical Engineering, vol. 4, no. 6, pp. 577-578. https://doi.org/10.1038/s41551-020-0571-4
Li1, H, Shkolyar2, E, Wang3, J, Wang3, J, Conti2, S, Conti2, S, Pao5, AC, Pao5, AC, Liao2, JC, Liao2, JC, Wong1, TS, Wong1, TS, Wong1, TS, Wong1, TS, Wong1, PK, Wong1, PK & Wong1, PK 2020, 'SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease', Science Advances, vol. 6, no. 21, EABA8535. https://doi.org/10.1126/sciadv.aba8535
Torab, P, Yan, Y, Yamashita, H, Warrick, JI, Raman, JD, Degraff, DJ & Wong, PK 2020, 'Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer', Analytical Chemistry, vol. 92, no. 13, pp. 8768-8775. https://doi.org/10.1021/acs.analchem.0c00057

2019

Li, H, Garner, T, Diaz, F & Wong, PK 2019, 'A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents', Small, vol. 15, no. 28, 1901910. https://doi.org/10.1002/smll.201901910
Lu, Y & Wong, PK 2019, A single molecule barcode nanobiosensor for dynamic multigene analysis in live cells during tissue morphogenesis and wound healing. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, Chemical and Biological Microsystems Society, pp. 338-339, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, Basel, Switzerland, 10/27/19.
Li, H, Torab, P, Mach, KE, Surrette, C, England, MR, Craft, DW, Thomas, NJ, Liao, JC, Puleo, C & Wong, PK 2019, 'Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 21, pp. 10270-10279. https://doi.org/10.1073/pnas.1819569116
Xiao, Y, Riahi, R, Torab, P, Zhang, DD & Wong, PK 2019, 'Collective Cell Migration in 3D Epithelial Wound Healing', ACS nano. https://doi.org/10.1021/acsnano.8b06305
Tao, S, Wang, S, Moghaddam, SJ, Ooi, A, Chapman, E, Wong, PK & Zhang, DD 2019, 'Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)', Cancer Research, vol. 79, no. 5, pp. 1015. https://doi.org/10.1158/0008-5472.CAN-19-0070
Wan, Y, Zhu, N, Lu, Y & Wong, PK 2019, 'DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells', Analytical Chemistry, vol. 91, no. 4, pp. 2626-2633. https://doi.org/10.1021/acs.analchem.8b02826
Dean, ZS, Jamilpour, N, Slepian, MJ & Wong, PK 2019, 'Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration', ACS Biomaterials Science and Engineering, vol. 5, no. 8, pp. 3864-3875. https://doi.org/10.1021/acsbiomaterials.8b01222
Bocci, F, Tripathi, SC, Vilchez Mercedes, SA, George, JT, Casabar, JP, Wong, PK, Hanash, SM, Levine, H, Onuchic, JN & Jolly, MK 2019, 'NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype', Integrative biology : quantitative biosciences from nano to macro, vol. 11, no. 6, pp. 251-263. https://doi.org/10.1093/intbio/zyz021
Gao, J, Li, H, Torab, P, Mach, KE, Craft, DW, Thomas, NJ, Puleo, CM, Liao, JC, Wang, TH & Wong, PK 2019, 'Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 246-253. https://doi.org/10.1016/j.nano.2019.01.015
Mach, KE, Kaushik, AM, Hsieh, K, Wong, PK, Wang, TH & Liao, JC 2019, 'Optimizing peptide nucleic acid probes for hybridization-based detection and identification of bacterial pathogens', Analyst, vol. 144, no. 5, pp. 1565-1574. https://doi.org/10.1039/c8an02194e
Jamilpour, N, Nam, KH, Gregorio, CC & Wong, PK 2019, 'Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates', ACS Biomaterials Science and Engineering, vol. 5, no. 8, pp. 3808-3816. https://doi.org/10.1021/acsbiomaterials.8b00815
Li, H, Morowitz, M, Thomas, N & Wong, PK 2019, 'Rapid Single-Cell Microbiological Analysis: Toward Precision Management of Infections and Dysbiosis', SLAS Technology, vol. 24, no. 6, pp. 603-605. https://doi.org/10.1177/2472630319858922
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARĪ³ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Wang, J, Wang, L, Sun, N, Tierney, R, Li, H, Corsetti, M, Williams, L, Wong, PK & Wong, TS 2019, 'Viscoelastic solid-repellent coatings for extreme water saving and global sanitation', Nature Sustainability, vol. 2, no. 12, pp. 1097-1105. https://doi.org/10.1038/s41893-019-0421-0

2018

Wang, S, Xiao, Y, Zhang, DD & Wong, PK 2018, 'A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells', Biomaterials, vol. 156, pp. 56-64. https://doi.org/10.1016/j.biomaterials.2017.11.026
Torab, P, Yan, Y & Wong, PK 2018, A single cell biosensor for probing bladder cancer heterogeneity. in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, vol. 1, Chemical and Biological Microsystems Society, pp. 285-286, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, Taiwan, Province of China, 11/11/18.
Liu, T, Lu, Y, Sun, Y & Wong, PK 2018, An electrokinetic PCR chip with in situ electrochemical amplicon detection for comprehensive microbiological analysis of hospital acquired infections. in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, vol. 1, Chemical and Biological Microsystems Society, pp. 63-65, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, Taiwan, Province of China, 11/11/18.
Lu, Y, Torab, P & Wong, PK 2018, An electrothermal bioprocessor with centimeter-scale fluid motion for acute bacterial infection diagnostics in resource-limited settings. in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, vol. 3, Chemical and Biological Microsystems Society, pp. 1775-1777, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, Taiwan, Province of China, 11/11/18.
Li, H, Lu, Y & Wong, PK 2018, 'Diffusion-reaction kinetics of microfluidic amperometric biosensors', Lab on a Chip, vol. 18, no. 20, pp. 3086-3089. https://doi.org/10.1039/c8lc00794b
Sun, Y, Kim, DH & Wong, PK 2018, 'Guest Editorial Advancing Mechanobiology by Micro/Nanosystems', IEEE Transactions on Nanotechnology, vol. 17, no. 3, pp. 371-372. https://doi.org/10.1109/TNANO.2018.2830458
Chu, M, Novak, SM, Cover, C, Wang, AA, Chinyere, IR, Juneman, EB, Zarnescu, DC, Wong, PK & Gregorio, CC 2018, 'Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1', Circulation, vol. 137, no. 6, pp. 605-618. https://doi.org/10.1161/CIRCULATIONAHA.117.028976
Dodson, M, Liu, P, Jiang, T, Ambrose, AJ, Luo, G, de la Vega, MR, Cholanians, AB, Wong, PK, Chapman, E & Zhang, DD 2018, 'Increased O-GlcNAcylation of SNAP29 drives arsenicinduced autophagic dysfunction', Molecular and cellular biology, vol. 38, no. 11, e00595-17. https://doi.org/10.1128/MCB.00595-17
Dodson, M, de la Vega, MR, Harder, B, Castro-Portuguez, R, Rodrigues, SD, Wong, PK, Chapman, E & Zhang, DD 2018, 'Low-level arsenic causes proteotoxic stress and not oxidative stress', Toxicology and Applied Pharmacology, vol. 341, pp. 106-113. https://doi.org/10.1016/j.taap.2018.01.014
Surrette, C, Scherer, B, Corwin, A, Grossmann, G, Kaushik, AM, Hsieh, K, Zhang, P, Liao, JC, Wong, PK, Wang, TH & Puleo, CM 2018, 'Rapid Microbiology Screening in Pharmaceutical Workflows', SLAS Technology, vol. 23, no. 4, pp. 387-394. https://doi.org/10.1177/2472630318779758

2017

Gao, J, Jeffries, L, Mach, KE, Craft, DW, Thomas, NJ, Gau, V, Liao, JC & Wong, PK 2017, 'A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis', SLAS Technology, vol. 22, no. 4, pp. 466-474. https://doi.org/10.1177/2211068216651232
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, ZC, Halstead, ES & Thomas, NJ 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625. https://doi.org/10.1177/2472630317727704
Altobelli, E, Mohan, R, Mach, KE, Sin, MLY, Liao, JC, Buscarini, M, Wong, PK, Gau, V, Banaei, N & Liao, JC 2017, 'Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing', European Urology Focus, vol. 3, no. 2-3, pp. 293-299. https://doi.org/10.1016/j.euf.2015.12.010
Wang, S, Sun, J, Xiao, Y, Lu, Y, Zhang, DD & Wong, PK 2017, 'Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling', Advanced Biosystems, vol. 1, no. 1-2, 1600019. https://doi.org/10.1002/adbi.201600019

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