Researcher Profile

Researcher Profile

Pak Kin Wong, PhD

Pak Kin Wong, PhD

Professor, Biomedical Engineering
Professor, Department of Surgery
Scientific Program:Experimental Therapeutics
pxw28@psu.edu

Research Interests

  • Biosensing Techniques
  • Microfluidics
  • Endothelial Cells
  • Cell Movement
  • Neoplasms
  • Urinary Tract Infections
  • Urine
  • Proteins
  • NF-E2-Related Factor 2
  • Gene Expression
  • Growth
  • Equipment and Supplies

Recent Publications

2019

Li, H, Garner, T, Diaz, F & Wong, PK 2019, 'A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents', Small, vol. 15, no. 28, 1901910. https://doi.org/10.1002/smll.201901910
Li, H, Torab, P, Mach, KE, Surrette, C, England, MR, Craft, D, Thomas, N, Liao, JC, Puleo, C & Wong, PK 2019, 'Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 21, pp. 10270-10279. https://doi.org/10.1073/pnas.1819569116
Xiao, Y, Riahi, R, Torab, P, Zhang, DD & Wong, PK 2019, 'Collective Cell Migration in 3D Epithelial Wound Healing' ACS nano. https://doi.org/10.1021/acsnano.8b06305
Tao, S, Wang, S, Moghaddam, SJ, Ooi, A, Chapman, E, Wong, PK & Zhang, DD 2019, 'Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)' Cancer Research, vol. 79, no. 5. https://doi.org/10.1158/0008-5472.CAN-19-0070
Wan, Y, Zhu, N, Lu, Y & Wong, PK 2019, 'DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells', Analytical Chemistry, vol. 91, no. 4, pp. 2626-2633. https://doi.org/10.1021/acs.analchem.8b02826
Dean, ZS, Jamilpour, N, Slepian, MJ & Wong, PK 2019, 'Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration' ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.8b01222
Gao, J, Li, H, Torab, P, Mach, KE, Craft, D, Thomas, N, Puleo, CM, Liao, JC, Wang, TH & Wong, PK 2019, 'Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 246-253. https://doi.org/10.1016/j.nano.2019.01.015
Jamilpour, N, Nam, KH, Gregorio, CC & Wong, PK 2019, 'Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates' ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.8b00815

2018

Wang, S, Xiao, Y, Zhang, DD & Wong, PK 2018, 'A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells', Biomaterials, vol. 156, pp. 56-64. https://doi.org/10.1016/j.biomaterials.2017.11.026
Li, H, Lu, Y & Wong, PK 2018, 'Diffusion-reaction kinetics of microfluidic amperometric biosensors', Lab on a Chip, vol. 18, no. 20, pp. 3086-3089. https://doi.org/10.1039/c8lc00794b
Sun, Y, Kim, DH & Wong, PK 2018, 'Guest Editorial Advancing Mechanobiology by Micro/Nanosystems' IEEE Transactions on Nanotechnology, vol. 17, no. 3, pp. 371-372. https://doi.org/10.1109/TNANO.2018.2830458
Chu, M, Novak, SM, Cover, C, Wang, AA, Chinyere, IR, Juneman, EB, Zarnescu, DC, Wong, PK & Gregorio, CC 2018, 'Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1', Circulation, vol. 137, no. 6, pp. 605-618. https://doi.org/10.1161/CIRCULATIONAHA.117.028976
Dodson, M, Liu, P, Jiang, T, Ambrose, AJ, Luo, G, de la Vega, MR, Cholanians, AB, Wong, PK, Chapman, E & Zhang, DD 2018, 'Increased O-GlcNAcylation of SNAP29 drives arsenicinduced autophagic dysfunction' Molecular and cellular biology, vol. 38, no. 11, e00595-17. https://doi.org/10.1128/MCB.00595-17
Dodson, M, de la Vega, MR, Harder, B, Castro-Portuguez, R, Rodrigues, SD, Wong, PK, Chapman, E & Zhang, DD 2018, 'Low-level arsenic causes proteotoxic stress and not oxidative stress', Toxicology and Applied Pharmacology, vol. 341, pp. 106-113. https://doi.org/10.1016/j.taap.2018.01.014
Surrette, C, Scherer, B, Corwin, A, Grossmann, G, Kaushik, AM, Hsieh, K, Zhang, P, Liao, JC, Wong, PK, Wang, TH & Puleo, CM 2018, 'Rapid Microbiology Screening in Pharmaceutical Workflows', SLAS Technology, vol. 23, no. 4, pp. 387-394. https://doi.org/10.1177/2472630318779758

2017

Gao, J, Jeffries, L, Mach, KE, Craft, D, Thomas, N, Gau, V, Liao, JC & Wong, PK 2017, 'A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis', SLAS Technology, vol. 22, no. 4, pp. 466-474. https://doi.org/10.1177/2211068216651232
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, Z, Halstead, ES & Thomas, N 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625. https://doi.org/10.1177/2472630317727704
Altobelli, E, Mohan, R, Mach, KE, Sin, MLY, Liao, JC, Buscarini, M, Wong, PK, Gau, V, Banaei, N & Liao, JC 2017, 'Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing', European Urology Focus, vol. 3, no. 2-3, pp. 293-299. https://doi.org/10.1016/j.euf.2015.12.010
Wang, S, Sun, J, Xiao, Y, Lu, Y, Zhang, DD & Wong, PK 2017, 'Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling', Advanced Biosystems, vol. 1, no. 1-2, 1600019. https://doi.org/10.1002/adbi.201600019

2016

Xiao, Y, Lu, Y, Hsieh, M, Liao, J & Wong, PK 2016, 'A microfiltration device for urogenital schistosomiasis diagnostics', PloS one, vol. 11, no. 4, e0154640. https://doi.org/10.1371/journal.pone.0154640
Wang, S, Sun, J, Zhang, DD & Wong, PK 2016, 'A nanobiosensor for dynamic single cell analysis during microvascular self-organization', Nanoscale, vol. 8, no. 38, pp. 16894-16901. https://doi.org/10.1039/c6nr03907c
Long, M, De La Vega, MR, Wen, Q, Bharara, M, Jiang, T, Zhang, R, Zhou, S, Wong, PK, Wondrak, GT, Zheng, H & Zhang, DD 2016, 'An essential role of NRF2 in diabetic wound healing', Diabetes, vol. 65, no. 3, pp. 780-793. https://doi.org/10.2337/db15-0564
Sun, J, Hoying, JB, Deymier, PA, Zhang, DD & Wong, PK 2016, 'Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility', PLoS computational biology, vol. 12, no. 5, e1004955. https://doi.org/10.1371/journal.pcbi.1004955
Dean, Z, Utzinger, U & Wong, PK 2016, Dynamic characterization of invasive leader cells during 3D collective cancer invasion. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 459-460, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 10/9/16.
Lu, Y, Ren, Q, Liu, T, Leung, SL, Gau, V, Liao, JC, Chan, CL & Wong, PK 2016, 'Long-range electrothermal fluid motion in microfluidic systems', International Journal of Heat and Mass Transfer, vol. 98, pp. 341-349. https://doi.org/10.1016/j.ijheatmasstransfer.2016.03.034
Tang, Q, Liang, M, Lu, Y, Wong, PK, Wilmink, GJ, Zhang, D & Xin, H 2016, 'Microfluidic devices for terahertz spectroscopy of live cells toward lab-on-a-chip applications', Sensors (Switzerland), vol. 16, no. 4, 476. https://doi.org/10.3390/s16040476
Dean, ZS, Elias, P, Jamilpour, N, Utzinger, U & Wong, PK 2016, 'Probing 3D collective cancer invasion using double-stranded locked nucleic acid biosensors', Analytical Chemistry, vol. 88, no. 17, pp. 8902-8907. https://doi.org/10.1021/acs.analchem.6b02608
Yang, Y, Jamilpour, N, Yao, B, Dean, ZS, Riahi, R & Wong, PK 2016, 'Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement', Scientific reports, vol. 6, 22707. https://doi.org/10.1038/srep22707

2015

Shen, T, Jiang, T, Long, M, Chen, J, Ren, DM, Wong, PK, Chapman, E, Zhou, B & Zhang, DD 2015, 'A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response', Antioxidants and Redox Signaling, vol. 23, no. 8, pp. 651-664. https://doi.org/10.1089/ars.2014.6074
Lu, Y, Macias, D, Dean, ZS, Kreger, NR & Wong, PK 2015, 'A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications', IEEE Transactions on Nanobioscience, vol. 14, no. 8, 7328305, pp. 811-817. https://doi.org/10.1109/TNB.2015.2478481
Lu, Y, Liu, T, Lamanda, AC, Sin, MLY, Gau, V, Liao, JC & Wong, PK 2015, 'AC Electrokinetics of Physiological Fluids for Biomedical Applications' Journal of Laboratory Automation, vol. 20, no. 6, pp. 611-620. https://doi.org/10.1177/2211068214560904
Sun, J, Xiao, Y, Wang, S, Slepian, MJ & Wong, PK 2015, 'Advances in Techniques for Probing Mechanoregulation of Tissue Morphogenesis' Journal of Laboratory Automation, vol. 20, no. 2, pp. 127-137. https://doi.org/10.1177/2211068214554802
Lamanda, A, Lu, Y, Gill, N & Wong, PK 2015, An electrokinetic microdevice for isolation and quantification of circulating cell-free DNA from physiological samples. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7180981, Institute of Electrical and Electronics Engineers Inc., pp. 544-547, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7180981
Ammann, KR, DeCook, KJ, Tran, PL, Merkle, VM, Wong, PK & Slepian, MJ 2015, 'Collective cell migration of smooth muscle and endothelial cells: Impact of injury versus non-injury stimuli' Journal of Biological Engineering, vol. 9, no. 1. https://doi.org/10.1186/s13036-015-0015-y
Mach, KE, Mohan, R, Patel, S, Wong, PK, Hsieh, M & Liao, JC 2015, 'Development of a biosensor-based rapid urine test for detection of urogenital schistosomiasis', PLoS neglected tropical diseases, vol. 9, no. 7, A002, pp. 1-7. https://doi.org/10.1371/journal.pntd.0003845
Pappas, CT, Mayfield, RM, Henderson, C, Jamilpour, N, Cover, C, Hernandez, Z, Hutchinson, KR, Chu, M, Nam, KH, Valdez, JM, Wong, PK, Granzier, HL & Gregorio, CC 2015, 'Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 44, pp. 13573-13578. https://doi.org/10.1073/pnas.1508273112
DeVittorio, M, Dong, L, Li, J, Martinez, A, Costin, A, Chen, SC, Krishna Ghatkesar, M, Saif Islam, M, Li, X, Panoiu, NC, Pierantoni, L, Pontarelli, S, Samugawa, S, Seshia, AA, Suganuma, K, Teuscher, C, Villanueva, LG, Wong, PK, Wong, TS, Haixia Zhang, A, Zhong, Z & Lombardi, F 2015, 'Message from the Editor-In-Chief', IEEE Transactions on Nanotechnology, vol. 14, no. 2, 7055959, pp. 203-204. https://doi.org/10.1109/TNANO.2015.2399773
Riahi, R, Sun, J, Wang, S, Long, M, Zhang, DD & Wong, PK 2015, 'Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration', Nature communications, vol. 6, 6556. https://doi.org/10.1038/ncomms7556
Wu, T, Harder, BG, Wong, PK, Lang, JE & Zhang, DD 2015, 'Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?', Molecular Carcinogenesis, vol. 54, no. 11, pp. 1494-1502. https://doi.org/10.1002/mc.22202
Jiang, T, Harder, B, Rojo De La Vega, M, Wong, PK, Chapman, E & Zhang, DD 2015, 'P62 links autophagy and Nrf2 signaling', Free Radical Biology and Medicine, vol. 88, no. Part B, pp. 199-204. https://doi.org/10.1016/j.freeradbiomed.2015.06.014
Wang, S, Riahi, R, Li, N, Zhang, DD & Wong, PK 2015, 'Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments', Advanced Materials, vol. 27, no. 39, pp. 6034-6038. https://doi.org/10.1002/adma.201502814
Dean, ZS, Riahi, R & Wong, PK 2015, 'Spatiotemporal dynamics of microRNA during epithelial collective cell migration' Biomaterials, vol. 37, pp. 156-163. https://doi.org/10.1016/j.biomaterials.2014.10.022

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)