Researcher Profile

Researcher Profile

Pak Kin Wong, PhD

Pak Kin Wong, PhD

Professor, Biomedical Engineering
Professor, Department of Surgery
Scientific Program:Experimental Therapeutics

Research Interests

  • Biosensing Techniques
  • Microfluidics
  • Endothelial Cells
  • Cell Movement
  • Neoplasms
  • Urinary Tract Infections
  • Urine
  • Proteins
  • NF-E2-Related Factor 2
  • Gene Expression
  • Growth
  • Equipment and Supplies

Recent Publications


Li, H, Garner, T, Diaz, F & Wong, PK 2019, 'A Multiwell Microfluidic Device for Analyzing and Screening Nonhormonal Contraceptive Agents', Small, vol. 15, no. 28, 1901910.
Li, H, Torab, P, Mach, KE, Surrette, C, England, MR, Craft, D, Thomas, N, Liao, JC, Puleo, C & Wong, PK 2019, 'Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 21, pp. 10270-10279.
Xiao, Y, Riahi, R, Torab, P, Zhang, DD & Wong, PK 2019, 'Collective Cell Migration in 3D Epithelial Wound Healing' ACS nano.
Tao, S, Wang, S, Moghaddam, SJ, Ooi, A, Chapman, E, Wong, PK & Zhang, DD 2019, 'Correction: Oncogenic KRAS confers chemoresistance by upregulating Nrf2 (Cancer Research (2014) 74 (7430-7441) DOI: 10.1158/0008-5472.CAN-14-1439)' Cancer Research, vol. 79, no. 5.
Wan, Y, Zhu, N, Lu, Y & Wong, PK 2019, 'DNA Transformer for Visualizing Endogenous RNA Dynamics in Live Cells', Analytical Chemistry, vol. 91, no. 4, pp. 2626-2633.
Dean, ZS, Jamilpour, N, Slepian, MJ & Wong, PK 2019, 'Decreasing Wound Edge Stress Enhances Leader Cell Formation during Collective Smooth Muscle Cell Migration' ACS Biomaterials Science and Engineering.
Gao, J, Li, H, Torab, P, Mach, KE, Craft, D, Thomas, N, Puleo, CM, Liao, JC, Wang, TH & Wong, PK 2019, 'Nanotube assisted microwave electroporation for single cell pathogen identification and antimicrobial susceptibility testing', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 246-253.
Jamilpour, N, Nam, KH, Gregorio, CC & Wong, PK 2019, 'Probing Collective Mechanoadaptation in Cardiomyocyte Development by Plasma Lithography Patterned Elastomeric Substrates' ACS Biomaterials Science and Engineering.


Wang, S, Xiao, Y, Zhang, DD & Wong, PK 2018, 'A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells', Biomaterials, vol. 156, pp. 56-64.
Li, H, Lu, Y & Wong, PK 2018, 'Diffusion-reaction kinetics of microfluidic amperometric biosensors', Lab on a Chip, vol. 18, no. 20, pp. 3086-3089.
Sun, Y, Kim, DH & Wong, PK 2018, 'Guest Editorial Advancing Mechanobiology by Micro/Nanosystems' IEEE Transactions on Nanotechnology, vol. 17, no. 3, pp. 371-372.
Chu, M, Novak, SM, Cover, C, Wang, AA, Chinyere, IR, Juneman, EB, Zarnescu, DC, Wong, PK & Gregorio, CC 2018, 'Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1', Circulation, vol. 137, no. 6, pp. 605-618.
Dodson, M, Liu, P, Jiang, T, Ambrose, AJ, Luo, G, de la Vega, MR, Cholanians, AB, Wong, PK, Chapman, E & Zhang, DD 2018, 'Increased O-GlcNAcylation of SNAP29 drives arsenicinduced autophagic dysfunction' Molecular and cellular biology, vol. 38, no. 11, e00595-17.
Dodson, M, de la Vega, MR, Harder, B, Castro-Portuguez, R, Rodrigues, SD, Wong, PK, Chapman, E & Zhang, DD 2018, 'Low-level arsenic causes proteotoxic stress and not oxidative stress', Toxicology and Applied Pharmacology, vol. 341, pp. 106-113.
Surrette, C, Scherer, B, Corwin, A, Grossmann, G, Kaushik, AM, Hsieh, K, Zhang, P, Liao, JC, Wong, PK, Wang, TH & Puleo, CM 2018, 'Rapid Microbiology Screening in Pharmaceutical Workflows', SLAS Technology, vol. 23, no. 4, pp. 387-394.


Gao, J, Jeffries, L, Mach, KE, Craft, D, Thomas, N, Gau, V, Liao, JC & Wong, PK 2017, 'A Multiplex Electrochemical Biosensor for Bloodstream Infection Diagnosis', SLAS Technology, vol. 22, no. 4, pp. 466-474.
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, Z, Halstead, ES & Thomas, N 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625.
Altobelli, E, Mohan, R, Mach, KE, Sin, MLY, Liao, JC, Buscarini, M, Wong, PK, Gau, V, Banaei, N & Liao, JC 2017, 'Integrated Biosensor Assay for Rapid Uropathogen Identification and Phenotypic Antimicrobial Susceptibility Testing', European Urology Focus, vol. 3, no. 2-3, pp. 293-299.
Wang, S, Sun, J, Xiao, Y, Lu, Y, Zhang, DD & Wong, PK 2017, 'Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling', Advanced Biosystems, vol. 1, no. 1-2, 1600019.


Xiao, Y, Lu, Y, Hsieh, M, Liao, J & Wong, PK 2016, 'A microfiltration device for urogenital schistosomiasis diagnostics', PloS one, vol. 11, no. 4, e0154640.
Wang, S, Sun, J, Zhang, DD & Wong, PK 2016, 'A nanobiosensor for dynamic single cell analysis during microvascular self-organization', Nanoscale, vol. 8, no. 38, pp. 16894-16901.
Long, M, De La Vega, MR, Wen, Q, Bharara, M, Jiang, T, Zhang, R, Zhou, S, Wong, PK, Wondrak, GT, Zheng, H & Zhang, DD 2016, 'An essential role of NRF2 in diabetic wound healing', Diabetes, vol. 65, no. 3, pp. 780-793.
Sun, J, Hoying, JB, Deymier, PA, Zhang, DD & Wong, PK 2016, 'Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility', PLoS computational biology, vol. 12, no. 5, e1004955.
Dean, Z, Utzinger, U & Wong, PK 2016, Dynamic characterization of invasive leader cells during 3D collective cancer invasion. in 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. Chemical and Biological Microsystems Society, pp. 459-460, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland, 10/9/16.
Lu, Y, Ren, Q, Liu, T, Leung, SL, Gau, V, Liao, JC, Chan, CL & Wong, PK 2016, 'Long-range electrothermal fluid motion in microfluidic systems', International Journal of Heat and Mass Transfer, vol. 98, pp. 341-349.
Tang, Q, Liang, M, Lu, Y, Wong, PK, Wilmink, GJ, Zhang, D & Xin, H 2016, 'Microfluidic devices for terahertz spectroscopy of live cells toward lab-on-a-chip applications', Sensors (Switzerland), vol. 16, no. 4, 476.
Dean, ZS, Elias, P, Jamilpour, N, Utzinger, U & Wong, PK 2016, 'Probing 3D collective cancer invasion using double-stranded locked nucleic acid biosensors', Analytical Chemistry, vol. 88, no. 17, pp. 8902-8907.
Yang, Y, Jamilpour, N, Yao, B, Dean, ZS, Riahi, R & Wong, PK 2016, 'Probing Leader Cells in Endothelial Collective Migration by Plasma Lithography Geometric Confinement', Scientific reports, vol. 6, 22707.


Shen, T, Jiang, T, Long, M, Chen, J, Ren, DM, Wong, PK, Chapman, E, Zhou, B & Zhang, DD 2015, 'A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response', Antioxidants and Redox Signaling, vol. 23, no. 8, pp. 651-664.
Lu, Y, Macias, D, Dean, ZS, Kreger, NR & Wong, PK 2015, 'A UAV-Mounted Whole Cell Biosensor System for Environmental Monitoring Applications', IEEE Transactions on Nanobioscience, vol. 14, no. 8, 7328305, pp. 811-817.
Lu, Y, Liu, T, Lamanda, AC, Sin, MLY, Gau, V, Liao, JC & Wong, PK 2015, 'AC Electrokinetics of Physiological Fluids for Biomedical Applications' Journal of Laboratory Automation, vol. 20, no. 6, pp. 611-620.
Sun, J, Xiao, Y, Wang, S, Slepian, MJ & Wong, PK 2015, 'Advances in Techniques for Probing Mechanoregulation of Tissue Morphogenesis' Journal of Laboratory Automation, vol. 20, no. 2, pp. 127-137.
Lamanda, A, Lu, Y, Gill, N & Wong, PK 2015, An electrokinetic microdevice for isolation and quantification of circulating cell-free DNA from physiological samples. in 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7180981, Institute of Electrical and Electronics Engineers Inc., pp. 544-547, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, United States, 6/21/15.
Ammann, KR, DeCook, KJ, Tran, PL, Merkle, VM, Wong, PK & Slepian, MJ 2015, 'Collective cell migration of smooth muscle and endothelial cells: Impact of injury versus non-injury stimuli' Journal of Biological Engineering, vol. 9, no. 1.
Mach, KE, Mohan, R, Patel, S, Wong, PK, Hsieh, M & Liao, JC 2015, 'Development of a biosensor-based rapid urine test for detection of urogenital schistosomiasis', PLoS neglected tropical diseases, vol. 9, no. 7, A002, pp. 1-7.
Pappas, CT, Mayfield, RM, Henderson, C, Jamilpour, N, Cover, C, Hernandez, Z, Hutchinson, KR, Chu, M, Nam, KH, Valdez, JM, Wong, PK, Granzier, HL & Gregorio, CC 2015, 'Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 44, pp. 13573-13578.
DeVittorio, M, Dong, L, Li, J, Martinez, A, Costin, A, Chen, SC, Krishna Ghatkesar, M, Saif Islam, M, Li, X, Panoiu, NC, Pierantoni, L, Pontarelli, S, Samugawa, S, Seshia, AA, Suganuma, K, Teuscher, C, Villanueva, LG, Wong, PK, Wong, TS, Haixia Zhang, A, Zhong, Z & Lombardi, F 2015, 'Message from the Editor-In-Chief', IEEE Transactions on Nanotechnology, vol. 14, no. 2, 7055959, pp. 203-204.
Riahi, R, Sun, J, Wang, S, Long, M, Zhang, DD & Wong, PK 2015, 'Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration', Nature communications, vol. 6, 6556.
Wu, T, Harder, BG, Wong, PK, Lang, JE & Zhang, DD 2015, 'Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?', Molecular Carcinogenesis, vol. 54, no. 11, pp. 1494-1502.
Jiang, T, Harder, B, Rojo De La Vega, M, Wong, PK, Chapman, E & Zhang, DD 2015, 'P62 links autophagy and Nrf2 signaling', Free Radical Biology and Medicine, vol. 88, no. Part B, pp. 199-204.
Wang, S, Riahi, R, Li, N, Zhang, DD & Wong, PK 2015, 'Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments', Advanced Materials, vol. 27, no. 39, pp. 6034-6038.
Dean, ZS, Riahi, R & Wong, PK 2015, 'Spatiotemporal dynamics of microRNA during epithelial collective cell migration' Biomaterials, vol. 37, pp. 156-163.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)