Patricia McLaughlin, MS, DEd - Penn State Cancer Institute
Researcher Profile
Patricia McLaughlin, MS, DEd
Distinguished Professor, Department of Neural and Behavioral Sciences
Penn State Neuroscience Institute
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Recent Publications
2024
Diaz, D, Sassani, JP, Zagon, IS & McLaughlin, PJ 2024, 'Topical naltrexone increases aquaporin 5 production in the lacrimal gland and restores tear production in diabetic rats', Experimental Biology and Medicine, vol. 249, 10175. https://doi.org/10.3389/ebm.2024.10175
2023
Kumari, R, Kareem, ZY & McLaughlin, PJ 2023, 'Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery Following Hypoxia-Ischemic Stroke in Type-2 Diabetic Mice', Neurochemical Research, vol. 48, no. 9, pp. 2835-2846. https://doi.org/10.1007/s11064-023-03938-4
McLaughlin, PJ, West, EA, Grigson, PS & Hobkirk, AL 2023, 'Addiction III: From mouse to man', Brain Research Bulletin, vol. 193, pp. 22-26. https://doi.org/10.1016/j.brainresbull.2022.12.001
Kareem, ZY, McLaughlin, PJ & Kumari, R 2023, 'Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain', Neuropeptides, vol. 99, 102325. https://doi.org/10.1016/j.npep.2023.102325
McLaughlin, PJ, Sassani, JW & Zagon, IS 2023, 'Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini-pigs', Drug Development Research, vol. 84, no. 6, pp. 1279-1284. https://doi.org/10.1002/ddr.22086
2022
McLaughlin, PJ, Odom, LB, Arnett, PA, Orehek, S, Thomas, GA & Zagon, IS 2022, 'Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic', International Immunopharmacology, vol. 113, 109438. https://doi.org/10.1016/j.intimp.2022.109438
2021
McLaughlin, PJ, Sassani, J, Purushothaman, I & Zagon, IS 2021, 'Naltrexone blockade of OGFr enhances cutaneous wound closure in diabetic rats', Medicine in Drug Discovery, vol. 11, 100098. https://doi.org/10.1016/j.medidd.2021.100098
Purushothaman, I, Zagon, IS, Sassani, JW & McLaughlin, PJ 2021, 'Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin', Biochemical Pharmacology, vol. 192, 114712. https://doi.org/10.1016/j.bcp.2021.114712
Purushothaman, I, Zagon, IS, Sassani, J & McLaughlin, PJ 2021, 'Ocular surface complications result from dysregulation of the OGF-OGFr signaling pathway in female diabetic rats', Experimental and Therapeutic Medicine, vol. 22, no. 1, 687. https://doi.org/10.3892/etm.2021.10119
Purushothaman, I, Zagon, IS, Sassani, JW, Zhou, S & McLaughlin, PJ 2021, 'Sex differences in the magnitude of diabetic ocular surface complications: Role of serum OGF', Physiology and Behavior, vol. 237, 113436. https://doi.org/10.1016/j.physbeh.2021.113436
Patel, C, Zagon, IS, Pearce-Clawson, M & McLaughlin, PJ 2022, 'Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis', Journal of Neuroscience Research, vol. 100, no. 2, pp. 551-563. https://doi.org/10.1002/jnr.24983
Patel, C, Thomas, G, Zomorodi, N, Zagon, IS & McLaughlin, PJ 2021, 'β-endorphin and opioid growth factor as biomarkers of physical ability in multiple sclerosis', Multiple Sclerosis and Related Disorders, vol. 50, 102868. https://doi.org/10.1016/j.msard.2021.102868
2020
Zagon, IS, Sassani, JW, Purushothaman, I & McLaughlin, PJ 2021, 'Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications', Experimental Biology and Medicine, vol. 246, no. 5, pp. 629-636. https://doi.org/10.1177/1535370220972060
Zagon, IS, Sassani, JW, Purushothaman, I & McLaughlin, PJ 2020, 'Dysregulation of the OGF–OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat', Experimental Biology and Medicine, vol. 245, no. 15, pp. 1414-1421. https://doi.org/10.1177/1535370220940273
Patel, C, Meadowcroft, MD, Zagon, IS & McLaughlin, PJ 2020, '[Met5]-enkephalin preserves diffusion metrics in EAE mice', Brain Research Bulletin, vol. 165, pp. 246-252. https://doi.org/10.1016/j.brainresbull.2020.10.015