Nelson Shu-Sang Yee, MD, PhD, RPh - Penn State Cancer Institute
Researcher Profile
Nelson Shu-Sang Yee, MD, PhD, RPh
Associate Professor, Department of Medicine
Division of Hematology and Oncology
Assistant Professor, Department of Medicine
Division of Hematology and Oncology
Assistant Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Gastrointestinal Cancer Team
Cancer Institute, Liver, Pancreas and Foregut Cancer Team
Cancer Institute, Liver, Pancreas and Foregut Cancer Team
Research Interests
- Therapeutics
- Neoplasms
- Pancreatic Neoplasms
- Adenocarcinoma
- Zebrafish
- Biomarkers
- Ion Channels
- Carcinoma
- Growth
- Mast Cells
- Exocrine Pancreas
- Hepatocellular Carcinoma
Clinical Trials
A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in combination with GC4711 in the Treatment of Unresectable or Borderline Resectable, Nonmetastatic Pancreatic Cancer
A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid Tumors
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US) (NRG-GI008)
CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts: a prospective, randomized, double-blind, multi-center clinical trial
A Pilot Study to Evaluate the Response and Tolerability of Verzenio (Abemaciclib) in Patients with Advanced Biliary Tract Carcinoma
A Phase I/II Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C mutation (MRT849-001)
Micro/nano technology for extracellular vesicle isolation and towards non-invasive pancreatic cancer diagnosis
Phase 1/2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
EA2197: Optimal Perioperative Therapy For Incidental Gallbladder Cancer (OPT-IN): A Randomized Phase II/III Trial
Recent Publications
2022
Kumar, R, Tchelebi, L, Anker, CJ, Sharma, N, Bianchi, NA, Dragovic, J, Goodman, KA, Herman, JM, Jiang, Y, Jones, WE, Kennedy, TJ, Lee, P, Kundranda, M, Russo, S, Small, W, Suh, WW, Yee, N & Jabbour, SK 2022, 'American Radium Society (ARS) Appropriate Use Criteria (AUC) for Locoregional Gastric Adenocarcinoma: Systematic Review and Guidelines', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 9, pp. 391-402. https://doi.org/10.1097/COC.0000000000000930
2021
Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13. https://doi.org/10.3390/biomedicines9030259
2020
Wheelden, M & Yee, NS 2020, 'Clinical evaluation of the safety and efficacy of trifluridine/tipiracil in the treatment of advanced gastric/gastroesophageal junction adenocarcinoma: Evidence to date', OncoTargets and Therapy, vol. 13, pp. 7459-7465. https://doi.org/10.2147/OTT.S216598
Yee, NS, Zhang, S, He, HZ & Zheng, SY 2020, 'Extracellular vesicles as potential biomarkers for early detection and diagnosis of pancreatic cancer', Biomedicines, vol. 8, no. 12, 581, pp. 1-20. https://doi.org/10.3390/biomedicines8120581
Yee, NS 2020, 'Liquid biopsy: A biomarker-driven tool towards precision oncology', Journal of Clinical Medicine, vol. 9, no. 8, 2556, pp. 1-3. https://doi.org/10.3390/jcm9082556
Schmitz, KH, Potiaumpai, M, Schleicher, EA, Wolf, LJ, Doerksen, SE, Drabick, JJ, Yee, NS, Truica, CI, Mohamed, AA, Shaw, BW & Farley, DC 2021, 'The exercise in all chemotherapy trial', Cancer, vol. 127, no. 9, pp. 1507-1516. https://doi.org/10.1002/cncr.33390
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698. https://doi.org/10.1038/s41598-020-78569-8
2019
Willumsen, N, Ali, SM, Leitzel, K, Drabick, JJ, Yee, N, Polimera, HV, Nagabhairu, V, Krecko, L, Ali, A, Maddukuri, A, Moku, P, Ali, A, Poulose, J, Menon, H, Pancholy, N, Costa, L, Karsdal, MA & Lipton, A 2019, 'Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer', Scientific reports, vol. 9, no. 1, 19761. https://doi.org/10.1038/s41598-019-56268-3
on behalf of the RELIVE Investigators 2019, 'Correction to (The Lancet Gastroenterology & Hepatology (2019) 4(6) (454–465), (S2468125319300408), (10.1016/S2468-1253(19)30040-8))', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. e6. https://doi.org/10.1016/S2468-1253(19)30152-9
Merle, P, Blanc, JF, Phelip, JM, Pelletier, G, Bronowicki, JP, Touchefeu, Y, Pageaux, G, Gerolami, R, Habersetzer, F, Nguyen-Khac, E, Casadei-Gardini, A, Borbath, I, Tran, A, Wege, H, Saad, AS, Colombo, M, Abergel, A, Richou, C, Waked, I, Yee, NS, Molé, A, Attali, P, Le Boulicaut, J, Vasseur, B, Moussata, D, Grangé, JD, Ratziu, V, Khemissa-Akouz, F, Regnault, H, Dauvois, B, Zarski, JP, Ollivier-Hourmand, I, Manfredi, S, Debette-Gratien, M, Gangloff, A, Fontanges, T, Baron, A, Bouattour, M, Vincent, J, Sieghart, W, Maieron, A, Peeters, M, Delwaide, J, Lasser, L, Berg, T, Schultheiß, M, Zipprich, A, Trojan, J, Ehmer, U, Luppi, G, Luca, G, Tamberi, S, Amoroso, D, Alabiso, O, Buonadonna, A, Toniutto, P, Tamburini, E, Cubillo, A, Muñoz, A, Guillén, C, Sánchez, G, Manzano, H, Navarro, V, Ales, I, Massuti, B, Dank, M, Bodoky, G, Kahan, Z, Horváth, Z, Gabrail, N, Ozer, H, Galanopoulos, C, Hauke, R, Raj, M, Harputluoglu, H, Sevinc, A, Goker, E, Coker, A, Yalcin, S, Ali, M, Ata, O, Tugba, I, ElKassas, M, Abdel, A, Wakid, I, Shamaa, S, El, N, Kohail, H, Makarem, J, Chehade, I, Farhat, F, López, C & Marín, M 2019, 'Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial', The Lancet Gastroenterology and Hepatology, vol. 4, no. 6, pp. 454-465. https://doi.org/10.1016/S2468-1253(19)30040-8
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Zhang, WL, Hao, SJ, Yee, NS & Zheng, SY 2019, Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice. in 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII., 8808761, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Institute of Electrical and Electronics Engineers Inc., pp. 273-276, 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Berlin, Germany, 6/23/19. https://doi.org/10.1109/TRANSDUCERS.2019.8808761
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Hao, SJ, Zhang, WL, Yee, NS & Zheng, SY 2019, 'Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica', Lab on a Chip, vol. 19, no. 14, pp. 2346-2355. https://doi.org/10.1039/c8lc01359d
Yee, NS & Lee, NP 2019, 'Special issue: Cancer biomarkers and targets in digestive organs', Biomedicines, vol. 7, no. 1, 3. https://doi.org/10.3390/biomedicines7010003