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Nelson Shu-Sang Yee, MD, PhD, RPh

Nelson Shu-Sang Yee, MD, PhD, RPh

Associate Professor, Department of Medicine
Professor, Department of Medicine
Division of Hematology and Oncology
Assistant Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Gastrointestinal Cancer Team
Cancer Institute, Liver, Pancreas and Foregut Cancer Team

Research Interests

  • Therapeutics
  • Neoplasms
  • Pancreatic Neoplasms
  • Adenocarcinoma
  • Zebrafish
  • Biomarkers
  • Ion Channels
  • Carcinoma
  • Growth
  • Mast Cells
  • Exocrine Pancreas
  • Hepatocellular Carcinoma

Clinical Trials

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US) (NRG-GI008)
A Phase I/II Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C mutation (MRT849-001)
Micro/nano technology for extracellular vesicle isolation and towards non-invasive pancreatic cancer diagnosis
The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing The Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients With Locally Advanced Rectal Cancer
Phase 1/2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
EA2197: Optimal Perioperative Therapy For Incidental Gallbladder Cancer (OPT-IN): A Randomized Phase II/III Trial

Recent Publications


Tsiatsianis, GC, Chan, CSY, Mouratidis, I, Chantzi, N, Tsiatsiani, AM, Yee, NS, Zaravinos, A, Kantere, V & Georgakopoulos-Soares, I 2024, 'Peptide absent sequences emerging in human cancers', European Journal of Cancer, vol. 196, 113421.
Montgomery, A, Tsiatsianis, GC, Mouratidis, I, Chan, CSY, Athanasiou, M, Papanastasiou, AD, Kantere, V, Syrigos, N, Vathiotis, I, Syrigos, K, Yee, NS & Georgakopoulos-Soares, I 2024, 'Utilizing nullomers in cell-free RNA for early cancer detection', Cancer gene therapy.


Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114.
Linscott, MP, Markus, H, Sennett, M, Abendroth, C & Yee, NS 2023, 'Nab-Paclitaxel and Gemcitabine as First-Line Treatment of Metastatic Ampullary Adenocarcinoma with a Novel R-Spondin2 RNA Fusion and NTRK3 Mutation', Biomedicines, vol. 11, no. 8, 2326.


Kumar, R, Tchelebi, L, Anker, CJ, Sharma, N, Bianchi, NA, Dragovic, J, Goodman, KA, Herman, JM, Jiang, Y, Jones, WE, Kennedy, TJ, Lee, P, Kundranda, M, Russo, S, Small, W, Suh, WW, Yee, N & Jabbour, SK 2022, 'American Radium Society (ARS) Appropriate Use Criteria (AUC) for Locoregional Gastric Adenocarcinoma: Systematic Review and Guidelines', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 9, pp. 391-402.


Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13.


Wheelden, M & Yee, NS 2020, 'Clinical evaluation of the safety and efficacy of trifluridine/tipiracil in the treatment of advanced gastric/gastroesophageal junction adenocarcinoma: Evidence to date', OncoTargets and Therapy, vol. 13, pp. 7459-7465.
Yee, NS, Zhang, S, He, HZ & Zheng, SY 2020, 'Extracellular vesicles as potential biomarkers for early detection and diagnosis of pancreatic cancer', Biomedicines, vol. 8, no. 12, 581, pp. 1-20.
Yee, NS 2020, 'Liquid biopsy: A biomarker-driven tool towards precision oncology', Journal of Clinical Medicine, vol. 9, no. 8, 2556, pp. 1-3.
Schmitz, KH, Potiaumpai, M, Schleicher, EA, Wolf, LJ, Doerksen, SE, Drabick, JJ, Yee, NS, Truica, CI, Mohamed, AA, Shaw, BW & Farley, DC 2021, 'The exercise in all chemotherapy trial', Cancer, vol. 127, no. 9, pp. 1507-1516.
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698.