Researcher Profile

Researcher Profile

Nelson Shu-Sang Yee, MD, PhD, RPh

Nelson Shu-Sang Yee, MD, PhD, RPh

Associate Professor, Department of Medicine
Division of Hematology and Oncology
Assistant Professor, Department of Medicine
Scientific Program:Experimental Therapeutics
Disease Teams:
Gastrointestinal Cancer
Liver, Pancreas and Foregut Cancer
nsy2@psu.edu

Research Interests

  • Therapeutics
  • Pancreatic Neoplasms
  • Neoplasms
  • Adenocarcinoma
  • Zebrafish
  • Ion Channels
  • Biomarkers
  • Pancreas
  • Mast Cells
  • Growth
  • Exocrine Pancreas
  • Mutation

Clinical Trials

MATCH Treatment Subprotocol C2: Crizotinib in Patients with Tumors with MET Exon 14 Deletion
MATCH Treatment Subprotocol E: AZD9291 in Patients with Tumors Having EGFR T790M Mutations (Except Non-Small Cell Lung Cancer) or Rare Activating Mutations of EGFR
MATCH Treatment Subprotocol F: Crizotinib in Patients with Tumors (Other Than Adenocarcinoma of Lung or ALCL) with ALK Rearrangements
MATCH Treatment Subprotocol G: Phase II Study of Crizotinib in Patients with ROS1 Translocations (Other Than Patients with Non-Small Cell Lung Cancer)
MATCH Treatment Subprotocol L: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with mTOR Mutations
MATCH Treatment Subprotocol M: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with TSC1 or TSC2 Mutations
MATCH Treatment Subprotocol T: GDC-0449 (vismodegib) in Patients with Tumors (except basal cell skin carcinoma) with Smoothened (SMO) or Patched 1 (PTCH1) Mutations
MATCH Treatment Subprotocol V: Phase II Study of Sunitinib in Patients with Tumors with c-Kit Mutations (Excluding GIST, Renal Cell Carcinoma or Pancreatic Neuroendocrine Tumor).
Extracellular Vesicles as Biomarkers for Early Detection of Recurrent Pancreatic Carcinoma
CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts: a prospective, randomized, double-blind, multi-center clinical trial
Risk Factors for CIPN Following an Oxaliplatin-Containing Chemotherapy Regimen in Colorectal Cancer Patients

Recent Publications

2019

Merle, P, Blanc, JF, Phelip, JM, Pelletier, G, Bronowicki, JP, Touchefeu, Y, Pageaux, G, Gerolami, R, Habersetzer, F, Nguyen-Khac, E, Casadei-Gardini, A, Borbath, I, Tran, A, Wege, H, Saad, AS, Colombo, M, Abergel, A, Richou, C, Waked, I, Yee, NS-S, Molé, A, Attali, P, Le Boulicaut, J, Vasseur, B, Moussata, D, Grangé, JD, Ratziu, V, Khemissa-Akouz, F, Regnault, H, Dauvois, B, Zarski, JP, Ollivier-Hourmand, I, Manfredi, S, Debette-Gratien, M, Gangloff, A, Fontanges, T, Baron, A, Bouattour, M, Vincent, J, Sieghart, W, Maieron, A, Peeters, M, Delwaide, J, Lasser, L, Berg, T, Schultheiß, M, Zipprich, A, Trojan, J, Ehmer, U, Luppi, G, Luca, G, Tamberi, S, Amoroso, D, Alabiso, O, Buonadonna, A, Toniutto, P, Tamburini, E, Cubillo, A, Muñoz, A, Guillén, C, Sánchez, G, Manzano, H, Navarro, V, Ales, I, Massuti, B, Dank, M, Bodoky, G, Kahan, Z, Horváth, Z, Gabrail, N, Ozer, H, Galanopoulos, C, Hauke, R, Raj, M, Harputluoglu, H, Sevinc, A, Goker, E, Coker, A, Yalcin, S, Ali, M, Ata, O, Tugba, I, ElKassas, M, Abdel, A, Wakid, I, Shamaa, S, El, N, Kohail, H, Makarem, J, Chehade, I, Farhat, F, López, C & Marín, M 2019, 'Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial', The Lancet Gastroenterology and Hepatology, vol. 4, no. 6, pp. 454-465. https://doi.org/10.1016/S2468-1253(19)30040-8
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Hao, SJ, Zhang, WL, Yee, NS-S & Zheng, S 2019, 'Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica', Lab on a Chip, vol. 19, no. 14, pp. 2346-2355. https://doi.org/10.1039/c8lc01359d
Yee, NS-S & Lee, NP 2019, 'Special issue: Cancer biomarkers and targets in digestive organs', Biomedicines, vol. 7, no. 1, 3. https://doi.org/10.3390/biomedicines7010003

2018

Yee, NS-S, Lengerich, E, Schmitz, K, Maranki, J, Gusani, NJ, Tchelebi, L, Mackley, H, Krok, K, Baker, M, de Boer, C & Yee, JD 2018, 'Frontiers in gastrointestinal oncology: Advances in multi-disciplinary patient care', Biomedicines, vol. 6, no. 2, 64. https://doi.org/10.3390/biomedicines6020064
Fonkoua, LK & Yee, NS-S 2018, 'Molecular characterization of gastric carcinoma: Therapeutic implications for biomarkers and targets', Biomedicines, vol. 6, no. 1, 32. https://doi.org/10.3390/biomedicines6010032
Posadas, K, Ankola, A, Yang, Z & Yee, NS-S 2018, 'Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study', Biomedicines, vol. 6, no. 2, 46. https://doi.org/10.3390/biomedicines6020046
Yee, NS-S 2018, 'Update in systemic and targeted therapies in gastrointestinal oncology', Biomedicines, vol. 6, no. 1, 34. https://doi.org/10.3390/biomedicines6010034

2017

Balaban, E, Mangu, PB & Yee, NS-S 2017, 'Locally advanced unresectable pancreatic cancer: American Society of clinical oncology clinical practice guideline summary', Journal of Oncology Practice, vol. 13, no. 4, pp. 265-269. https://doi.org/10.1200/JOP.2016.017376
Yee, NS-S 2017, 'Role of TRPM7 in cancer: Potential as molecular biomarker and therapeutic target', Pharmaceuticals, vol. 10, no. 2, 39. https://doi.org/10.3390/ph10020039

2016

Ang, C, Miura, JT, Clark Gamblin, T, He, R, Xiu, J, Millis, SZ, Gatalica, Z, Reddy, SK, Yee, NS-S & Abou-Alfa, GK 2016, 'Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options', Journal of Surgical Oncology, vol. 113, no. 1, pp. 55-61. https://doi.org/10.1002/jso.24086
Yee, NS-S 2016, 'Immunotherapeutic approaches in pancreatic adenocarcinoma: Current status and future perspectives', Current Molecular Pharmacology, vol. 9, no. 3, pp. 231-241. https://doi.org/10.2174/1874467208666150716120810
Balaban, E, Mangu, PB, Khorana, AA, Shah, MA, Mukherjee, S, Crane, CH, Javle, MM, Eads, JR, Allen, P, Ko, AH, Engebretson, A, Herman, JM, Strickler, JH, Benson, AB, Urba, S & Yee, NS-S 2016, 'Locally advanced, unresectable pancreatic cancer: American society of clinical oncology clinical practice guideline', Journal of Clinical Oncology, vol. 34, no. 22, pp. 2654-2667. https://doi.org/10.1200/JCO.2016.67.5561
Marks, EI & Yee, NS-S 2016, 'Molecular genetics and targeted therapeutics in biliary tract carcinoma', World Journal of Gastroenterology, vol. 22, no. 4, pp. 1335-1347. https://doi.org/10.3748/wjg.v22.i4.1335
Marks, EI & Yee, NS-S 2016, 'Molecular genetics and targeted therapy in hepatocellular carcinoma', Current Cancer Drug Targets, vol. 16, no. 1, pp. 53-70.
Yee, NS-S 2016, TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer. in R Donev (ed.), Advances in Protein Chemistry and Structural Biology. Advances in Protein Chemistry and Structural Biology, vol. 104, Academic Press Inc., pp. 127-155. https://doi.org/10.1016/bs.apcsb.2016.01.001

2015

Yee, NS-S, Kazi, A, Li, Q, Yang, Z, Berg, A & Yee, RK 2015, 'Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: Required for cancer cell invasion and implicated in tumor growth and metastasis', Biology Open, vol. 4, no. 4, pp. 507-514. https://doi.org/10.1242/bio.20137088
Yee, NS-S 2015, 'Advances in pharmacological treatment of cancer in digestive organs' Current Clinical Pharmacology, vol. 10, no. 4, pp. 254-255. https://doi.org/10.2174/157488471004151028132440
Yee, NS-S, Kazi, A & Yee, RK 2015, 'Current systemic treatment and emerging therapeutic strategies in pancreatic adenocarcinoma' Current Clinical Pharmacology, vol. 10, no. 4, pp. 256-266. https://doi.org/10.2174/1574884710666151020100640
Fonkoua, LK & Yee, NS-S 2015, 'Immunotherapy in gastric carcinoma: Current status and future perspectives' Clinical Cancer Drugs, vol. 2, no. 2, pp. 91-99.
El-Deiry, WS, Vijayvergia, N, Xiu, J, Scicchitano, A, Lim, B, Yee, NS-S, Harvey, H, Gatalica, Z & Reddy, S 2015, 'Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites', Cancer Biology and Therapy, vol. 16, no. 12, pp. 1726-1737. https://doi.org/10.1080/15384047.2015.1113356
Yee, NS-S 2015, 'Roles of TRPM8 ion channels in cancer: Proliferation, survival, and invasion', Cancers, vol. 7, no. 4, A13, pp. 2134-2146. https://doi.org/10.3390/cancers7040882
Wyluda, E & Yee, NS-S 2015, 'Systemic treatment of advanced biliary tract Carcinoma: Emerging roles of targeted therapy and molecular profiling' Clinical Cancer Drugs, vol. 2, no. 2, pp. 80-86.

Clinical Trials Search


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