Researcher Profile

Researcher Profile

Nelson Shu-Sang Yee, MD, PhD, RPh

Nelson Shu-Sang Yee, MD, PhD, RPh

Associate Professor, Department of Medicine
Division of Hematology and Oncology
Assistant Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Gastrointestinal Cancer
Liver, Pancreas and Foregut Cancer
nsy2@psu.edu

Research Interests

  • Therapeutics
  • Pancreatic Neoplasms
  • Neoplasms
  • Adenocarcinoma
  • Zebrafish
  • Ion Channels
  • Biomarkers
  • Mast Cells
  • Growth
  • Exocrine Pancreas
  • Hepatocellular Carcinoma
  • Carcinoma

Clinical Trials

CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts: a prospective, randomized, double-blind, multi-center clinical trial
Risk Factors for CIPN Following an Oxaliplatin-Containing Chemotherapy Regimen in Colorectal Cancer Patients

Recent Publications

2019

Willumsen, N, Ali, SM, Leitzel, K, Drabick, JJ, Yee, N, Polimera, HV, Nagabhairu, V, Krecko, L, Ali, A, Maddukuri, A, Moku, P, Ali, A, Poulose, J, Menon, H, Pancholy, N, Costa, L, Karsdal, MA & Lipton, A 2019, 'Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer', Scientific reports, vol. 9, no. 1, 19761. https://doi.org/10.1038/s41598-019-56268-3
on behalf of the RELIVE Investigators 2019, 'Correction to (The Lancet Gastroenterology & Hepatology (2019) 4(6) (454–465), (S2468125319300408), (10.1016/S2468-1253(19)30040-8))', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. e6. https://doi.org/10.1016/S2468-1253(19)30152-9
Merle, P, Blanc, JF, Phelip, JM, Pelletier, G, Bronowicki, JP, Touchefeu, Y, Pageaux, G, Gerolami, R, Habersetzer, F, Nguyen-Khac, E, Casadei-Gardini, A, Borbath, I, Tran, A, Wege, H, Saad, AS, Colombo, M, Abergel, A, Richou, C, Waked, I, Yee, NS, Molé, A, Attali, P, Le Boulicaut, J, Vasseur, B, Moussata, D, Grangé, JD, Ratziu, V, Khemissa-Akouz, F, Regnault, H, Dauvois, B, Zarski, JP, Ollivier-Hourmand, I, Manfredi, S, Debette-Gratien, M, Gangloff, A, Fontanges, T, Baron, A, Bouattour, M, Vincent, J, Sieghart, W, Maieron, A, Peeters, M, Delwaide, J, Lasser, L, Berg, T, Schultheiß, M, Zipprich, A, Trojan, J, Ehmer, U, Luppi, G, Luca, G, Tamberi, S, Amoroso, D, Alabiso, O, Buonadonna, A, Toniutto, P, Tamburini, E, Cubillo, A, Muñoz, A, Guillén, C, Sánchez, G, Manzano, H, Navarro, V, Ales, I, Massuti, B, Dank, M, Bodoky, G, Kahan, Z, Horváth, Z, Gabrail, N, Ozer, H, Galanopoulos, C, Hauke, R, Raj, M, Harputluoglu, H, Sevinc, A, Goker, E, Coker, A, Yalcin, S, Ali, M, Ata, O, Tugba, I, ElKassas, M, Abdel, A, Wakid, I, Shamaa, S, El, N, Kohail, H, Makarem, J, Chehade, I, Farhat, F, López, C & Marín, M 2019, 'Doxorubicin-loaded nanoparticles for patients with advanced hepatocellular carcinoma after sorafenib treatment failure (RELIVE): a phase 3 randomised controlled trial', The Lancet Gastroenterology and Hepatology, vol. 4, no. 6, pp. 454-465. https://doi.org/10.1016/S2468-1253(19)30040-8
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Zhang, WL, Hao, SJ, Yee, NS & Zheng, SY 2019, Enrichment of Extracellular Vesicles Via Lipid Nanoprobe-Functionalized Nanostructured Silica Microdevice. in 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII., 8808761, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Institute of Electrical and Electronics Engineers Inc., pp. 273-276, 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Berlin, Germany, 6/23/19. https://doi.org/10.1109/TRANSDUCERS.2019.8808761
Wan, Y, Maurer, M, He, HZ, Xia, YQ, Hao, SJ, Zhang, WL, Yee, NS & Zheng, SY 2019, 'Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica', Lab on a Chip, vol. 19, no. 14, pp. 2346-2355. https://doi.org/10.1039/c8lc01359d
Yee, NS & Lee, NP 2019, 'Special issue: Cancer biomarkers and targets in digestive organs', Biomedicines, vol. 7, no. 1, 3. https://doi.org/10.3390/biomedicines7010003

2018

Yee, NS, Lengerich, EJ, Schmitz, KH, Maranki, JL, Gusani, NJ, Tchelebi, L, Mackley, HB, Krok, KL, Baker, MJ, de Boer, C & Yee, JD 2018, 'Frontiers in gastrointestinal oncology: Advances in multi-disciplinary patient care', Biomedicines, vol. 6, no. 2, 64. https://doi.org/10.3390/biomedicines6020064
Fonkoua, LK & Yee, NS 2018, 'Molecular characterization of gastric carcinoma: Therapeutic implications for biomarkers and targets', Biomedicines, vol. 6, no. 1, 32. https://doi.org/10.3390/biomedicines6010032
Posadas, K, Ankola, A, Yang, Z & Yee, NS 2018, 'Tumor molecular profiling for an individualized approach to the treatment of hepatocellular carcinoma: A patient case study', Biomedicines, vol. 6, no. 2, 46. https://doi.org/10.3390/biomedicines6020046
Yee, NS 2018, 'Update in systemic and targeted therapies in gastrointestinal oncology', Biomedicines, vol. 6, no. 1, 34. https://doi.org/10.3390/biomedicines6010034

2017

Balaban, E, Mangu, PB & Yee, NS-S 2017, 'Locally advanced unresectable pancreatic cancer: American Society of clinical oncology clinical practice guideline summary', Journal of Oncology Practice, vol. 13, no. 4, pp. 265-269. https://doi.org/10.1200/JOP.2016.017376
Yee, NS 2017, 'Role of TRPM7 in cancer: Potential as molecular biomarker and therapeutic target', Pharmaceuticals, vol. 10, no. 2, 39. https://doi.org/10.3390/ph10020039

2016

Ang, C, Miura, JT, Clark Gamblin, T, He, R, Xiu, J, Millis, SZ, Gatalica, Z, Reddy, SK, Yee, NS & Abou-Alfa, GK 2016, 'Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options', Journal of Surgical Oncology, vol. 113, no. 1, pp. 55-61. https://doi.org/10.1002/jso.24086
Yee, NS 2016, 'Immunotherapeutic approaches in pancreatic adenocarcinoma: Current status and future perspectives', Current Molecular Pharmacology, vol. 9, no. 3, pp. 231-241. https://doi.org/10.2174/1874467208666150716120810
Balaban, EP, Mangu, PB, Khorana, AA, Shah, MA, Mukherjee, S, Crane, CH, Javle, MM, Eads, JR, Allen, P, Ko, AH, Engebretson, A, Herman, JM, Strickler, JH, Benson, AB, Urba, S & Yee, NS 2016, 'Locally advanced, unresectable pancreatic cancer: American society of clinical oncology clinical practice guideline', Journal of Clinical Oncology, vol. 34, no. 22, pp. 2654-2667. https://doi.org/10.1200/JCO.2016.67.5561
Marks, EI & Yee, NS 2016, 'Molecular genetics and targeted therapeutics in biliary tract carcinoma', World journal of gastroenterology, vol. 22, no. 4, pp. 1335-1347. https://doi.org/10.3748/wjg.v22.i4.1335
Marks, EI & Yee, NS-S 2016, 'Molecular genetics and targeted therapy in hepatocellular carcinoma', Current Cancer Drug Targets, vol. 16, no. 1, pp. 53-70.
Yee, NS 2016, TRPM8 Ion Channels as Potential Cancer Biomarker and Target in Pancreatic Cancer. in R Donev (ed.), Advances in Protein Chemistry and Structural Biology. Advances in Protein Chemistry and Structural Biology, vol. 104, Academic Press Inc., pp. 127-155. https://doi.org/10.1016/bs.apcsb.2016.01.001

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)