Nelson Shu-Sang Yee, MD, PhD, RPh - Penn State Cancer Institute
Researcher Profile
Nelson Shu-Sang Yee, MD, PhD, RPh
Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Cancer Institute, Gastrointestinal Cancer Team
Cancer Institute, Liver, Pancreas and Foregut Cancer Team
Cancer Institute, Liver, Pancreas and Foregut Cancer Team
Clinical Trials
A Pilot Study to Evaluate the Feasibility, Safety, and Efficacy of Cannabigerol/Cannabidiol Oil for Chemotherapy-Induced Peripheral Neuropathy
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US) (NRG-GI008)
A Multicenter, Randomized, Open-Label, Phase 3 Trial of Trastuzumab Deruxtecan (Enhertu®) Plus Chemotherapy Plus or Minus Pembrolizumab versus Chemotherapy Plus Trastuzumab Plus or Minus Pembrolizumab as First-line Treatment in Subjects with Unresectable, Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction (GEJ) Cancer.
Micro/nano technology for extracellular vesicle isolation and towards non-invasive pancreatic cancer diagnosis
Cancer biobank for developing novel diagnostic biomarkers and therapeutic targets
Antibiotics use and chemotherapy in colon cancer
Recent Publications
2025
Mareboina, M, Bakhl, K, Agioti, S, Yee, NS, Georgakopoulos-Soares, I & Zaravinos, A 2025, 'Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers', Biomedicines, vol. 13, no. 2, 408. https://doi.org/10.3390/biomedicines13020408
Young, NA, Prosperi, JR, Freud, AG, Yee, NS & Petricoin, EF 2025, 'Editorial: Clinical implementation of precision oncology data to direct individualized and immunotherapy-based treatment strategies', Frontiers in immunology, vol. 16, 1631591. https://doi.org/10.3389/fimmu.2025.1631591
Yu, T, Wang, J, Wang, H, Lin, M, Liu, H, Yee, NS & Ma, F 2025, Towards Collaborative Fairness in Federated Learning Under Imbalanced Covariate Shift. in KDD 2025 - Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining. Proceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, vol. 2, Association for Computing Machinery, pp. 3645-3656, 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining, KDD 2025, Toronto, Canada, 8/3/25. https://doi.org/10.1145/3711896.3737161
2024
Mareboina, M, Deng, E, Mouratidis, I, Yee, NS, Pitteloud, N, Georgakopoulos-Soares, I & Chartoumpekis, DV 2024, 'A review on cell-free RNA profiling: Insights into metabolic diseases and predictive value for bariatric surgery outcomes', Molecular Metabolism, vol. 87, 101987. https://doi.org/10.1016/j.molmet.2024.101987
McGillen, KL, Pryor, WW, Yee, NS, Zhu, J, Krok, KL & Waybill, PN 2024, 'Accuracy of Contrast-Enhanced Ultrasound for Hepatocellular Carcinoma Post-Transcatheter Arterial Embolization', Journal of Clinical Medicine, vol. 13, no. 24, 7720. https://doi.org/10.3390/jcm13247720
Burke, CE, Eng, NL, Yee, NS & Peng, JS 2024, 'Complete response to chemotherapy in a 6-year survivor of metastatic pancreatic cancer', BMJ case reports, vol. 17, no. 7, e261008. https://doi.org/10.1136/bcr-2024-261008
Tsiatsianis, GC, Chan, CSY, Mouratidis, I, Chantzi, N, Tsiatsiani, AM, Yee, NS, Zaravinos, A, Kantere, V & Georgakopoulos-Soares, I 2024, 'Peptide absent sequences emerging in human cancers', European Journal of Cancer, vol. 196, 113421. https://doi.org/10.1016/j.ejca.2023.113421
Montgomery, A, Tsiatsianis, GC, Mouratidis, I, Chan, CSY, Athanasiou, M, Papanastasiou, AD, Kantere, V, Syrigos, N, Vathiotis, I, Syrigos, K, Yee, NS & Georgakopoulos-Soares, I 2024, 'Utilizing nullomers in cell-free RNA for early cancer detection', Cancer gene therapy, vol. 31, no. 6, pp. 861-870. https://doi.org/10.1038/s41417-024-00741-3
2023
Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114. https://doi.org/10.3390/jpm13071114
Linscott, MP, Markus, H, Sennett, M, Abendroth, C & Yee, NS 2023, 'Nab-Paclitaxel and Gemcitabine as First-Line Treatment of Metastatic Ampullary Adenocarcinoma with a Novel R-Spondin2 RNA Fusion and NTRK3 Mutation', Biomedicines, vol. 11, no. 8, 2326. https://doi.org/10.3390/biomedicines11082326
2022
Kumar, R, Tchelebi, L, Anker, CJ, Sharma, N, Bianchi, NA, Dragovic, J, Goodman, KA, Herman, JM, Jiang, Y, Jones, WE, Kennedy, TJ, Lee, P, Kundranda, M, Russo, S, Small, W, Suh, WW, Yee, N & Jabbour, SK 2022, 'American Radium Society (ARS) Appropriate Use Criteria (AUC) for Locoregional Gastric Adenocarcinoma: Systematic Review and Guidelines', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 9, pp. 391-402. https://doi.org/10.1097/COC.0000000000000930