Researcher Profile
Researcher Profile
Nicholas Buchkovich, PhD
Assistant Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Endosomal Sorting Complexes Required for Transport
- Cytomegalovirus
- Membranes
- Endoplasmic Reticulum
- Viruses
- Cytomegalovirus Infections
- Virion
- Proteins
- Multivesicular Bodies
- Viral Proteins
- Carrier Proteins
- Virus Assembly
Recent Publications
2019
Desai, D, Lauver, M, Ostman, A, Cruz, L, Ferguson, K, Jin, G, Roper, B, Brosius, D, Lukacher, A, Amin, S & Buchkovich, N 2019, 'Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors' Bioorganic and Medicinal Chemistry, vol. 27, no. 9, pp. 1795-1803. https://doi.org/10.1016/j.bmc.2019.03.026
2018
Streck, NT, Carmichael, J & Buchkovich, N 2018, 'Nonenvelopment role for the ESCRTIII complex during human cytomegalovirus infection', Journal of virology, vol. 92, no. 12, e02096-17. https://doi.org/10.1128/JVI.02096-17
2017
Cruz, L, Streck, NT, Ferguson, K, Desai, T, Desai, D, Amin, S & Buchkovich, N 2017, 'Potent inhibition of human cytomegalovirus by modulation of cellular SNARE syntaxin 5', Journal of virology, vol. 91, no. 1, e01637-16. https://doi.org/10.1128/JVI.01637-16
Cruz, L & Buchkovich, N 2017, 'Rerouting the traffic from a virus perspective', Frontiers in Bioscience - Landmark, vol. 22, no. 11, pp. 1845-1866.
2016
Tang, S, Buchkovich, N, Mike Henne, W, Banjade, S, Kim, YJ & Emr, SD 2016, 'ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis', eLife, vol. 5, no. April 2016, e15507. https://doi.org/10.7554/eLife.15507
2015
Tang, S, Henne, WM, Borbat, PP, Buchkovich, N, Freed, JH, Mao, Y, Fromme, JC & Emr, SD 2015, 'Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments', eLife, vol. 4, no. DECEMBER2015, e12548. https://doi.org/10.7554/eLife.12548