Researcher Profile

Researcher Profile

Neil Christensen, MSc, PhD

Neil Christensen, MSc, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Immunotherapy
ndc1@psu.edu

Research Interests

  • Rabbits
  • Virion
  • Cottontail rabbit papillomavirus
  • Epitopes
  • Antibodies
  • Papillomavirus Infections
  • Human papillomavirus 16
  • Capsid
  • Human papillomavirus 11
  • Monoclonal Antibodies
  • Papilloma
  • Infection

Recent Publications

2020

El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An Integrated Approach for Preventing Oral Cavity and Oropharyngeal Cancers: Two Etiologies with Distinct and Shared Mechanisms of Carcinogenesis', Cancer prevention research (Philadelphia, Pa.), vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Osborne, AJ, Atkins, HM, Balogh, KK, Brendle, SA, Shearer, DA, Hu, J, Sample, CE & Christensen, ND 2020, 'Antibody-Mediated Immune Subset Depletion Modulates the Immune Response in a Rabbit (Oryctolagus cuniculus) Model of Epstein-Barr Virus Infection', Comparative Medicine, vol. 70, no. 5, pp. 312-322. https://doi.org/10.30802/AALAS-CM-20-000019
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321

2019

Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, de Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2019, 'Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)', Experimental and Molecular Medicine, vol. 51, no. 7, 71. https://doi.org/10.1038/s12276-019-0252-0
Cladel, NM, Jiang, P, Li, JJ, Peng, X, Cooper, TK, Majerciak, V, Balogh, KK, Meyer, TJ, Brendle, SA, Budgeon, LR, Shearer, DA, Munden, R, Cam, M, Vallur, R, Christensen, ND, Zheng, ZM & Hu, J 2019, 'Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models', Emerging Microbes and Infections, vol. 8, no. 1, pp. 1108-1121. https://doi.org/10.1080/22221751.2019.1637072
Cladel, NM, Peng, X, Christensen, N & Hu, J 2019, 'The rabbit papillomavirus model: A valuable tool to study viral-host interactions', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1773, 20180294. https://doi.org/10.1098/rstb.2018.0294

2018

Morse, MA, Balogh, KK, Brendle, SA, Campbell, CA, Chen, MX, Furze, RC, Harada, IL, Holyer, ID, Kumar, U, Lee, K, Prinjha, RK, Rüdiger, M, Seal, JT, Taylor, S, Witherington, J & Christensen, ND 2018, 'BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo', Antiviral Research, vol. 154, pp. 158-165. https://doi.org/10.1016/j.antiviral.2018.03.012
Bywaters, SM, Brendle, SA, Biryukov, J, Wang, JW, Walston, J, Milici, J, Roden, RB, Meyers, C & Christensen, ND 2018, 'Production and characterization of a novel HPV anti-L2 monoclonal antibody panel', Virology, vol. 524, pp. 106-113. https://doi.org/10.1016/j.virol.2018.08.017
Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, De Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2018, 'The wide utility of rabbits as models of human diseases', Experimental and Molecular Medicine, vol. 50, no. 5, 66. https://doi.org/10.1038/s12276-018-0094-1

2017

Bywaters, SM, Brendle, SA, Tossi, KP, Biryukov, J, Meyers, C & Christensen, ND 2017, 'Antibody competition reveals surface location of HPV L2 minor capsid protein residues 17–36', Viruses, vol. 9, no. 11, 336. https://doi.org/10.3390/v9110336
Huber, B, Schellenbacher, C, Shafti-Keramat, S, Jindra, C, Christensen, N & Kirnbauer, R 2017, 'Chimeric L2-based virus-like particle (VLP) vaccines targeting cutaneous human papillomaviruses (HPV)', PloS one, vol. 12, no. 1, 0169533. https://doi.org/10.1371/journal.pone.0169533
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, ND & Hafenstein, S 2017, 'Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site', Structure, vol. 25, no. 2, pp. 253-263. https://doi.org/10.1016/j.str.2016.12.001
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, ND & Hafenstein, S 2017, 'High-resolution structure analysis of antibody V5 and U4 conformational epitopes on human papillomavirus 16', Viruses, vol. 9, no. 12, 374. https://doi.org/10.3390/v9120374
Kalnin, K, Chivukula, S, Tibbitts, T, Yan, Y, Stegalkina, S, Shen, L, Cieszynski, J, Costa, V, Sabharwal, R, Anderson, SF, Christensen, N, Jagu, S, Roden, RBS & Kleanthous, H 2017, 'Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes', Vaccine, vol. 35, no. 37, pp. 4942-4951. https://doi.org/10.1016/j.vaccine.2017.07.086
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, TK, Brendle, SA, Christensen, ND, Schell, TD & Hu, J 2017, 'Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer', Scientific reports, vol. 7, no. 1, 16932. https://doi.org/10.1038/s41598-017-17089-4
Cladel, NM, Budgeon, LR, Cooper, TK, Balogh, KK, Christensen, ND, Myers, R, Majerciak, V, Gotte, D, Zheng, ZM & Hu, J 2017, 'Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy', Journal of General Virology, vol. 98, no. 10, 000926, pp. 2520-2529. https://doi.org/10.1099/jgv.0.000926
Squiquera, L, Taxman, DJ, Brendle, SA, Torres, R, Sulley, J, Hodge, T, Christensen, N & Sidransky, D 2017, 'Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase i study', Antiviral Therapy, vol. 22, no. 3, pp. 247-255. https://doi.org/10.3851/IMP3133
Hu, J, Cladel, NM, Budgeon, LR, Balogh, KK & Christensen, ND 2017, 'The mouse papillomavirus infection model', Viruses, vol. 9, no. 9, 246. https://doi.org/10.3390/v9090246

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)