Researcher Profile

Researcher Profile

Neil Christensen, MSc, PhD

Neil Christensen, MSc, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:

Research Interests

  • Rabbits
  • Virion
  • Cottontail rabbit papillomavirus
  • Epitopes
  • Papillomavirus Infections
  • Antibodies
  • Human papillomavirus 16
  • Human papillomavirus 11
  • Monoclonal Antibodies
  • Infection
  • Capsid
  • Papilloma

Recent Publications


Cladel, NM, Peng, X, Christensen, N & Hu, J 2019, 'The rabbit papillomavirus model: A valuable tool to study viral-host interactions', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1773, 20180294.


Morse, MA, Balogh, KK, Brendle, SA, Campbell, CA, Chen, MX, Furze, RC, Harada, IL, Holyer, ID, Kumar, U, Lee, K, Prinjha, RK, Rüdiger, M, Seal, JT, Taylor, S, Witherington, J & Christensen, N 2018, 'BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo', Antiviral Research, vol. 154, pp. 158-165.
Bywaters, SM, Brendle, SA, Biryukov, J, Wang, JW, Walston, J, Milici, J, Roden, RB, Meyers, C & Christensen, N 2018, 'Production and characterization of a novel HPV anti-L2 monoclonal antibody panel' Virology, vol. 524, pp. 106-113.
Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, De Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2018, 'The wide utility of rabbits as models of human diseases', Experimental and Molecular Medicine, vol. 50, no. 5, 66.


Bywaters, SM, Brendle, SA, Tossi, KP, Biryukov, J, Meyers, C & Christensen, N 2017, 'Antibody competition reveals surface location of HPV L2 minor capsid protein residues 17–36', Viruses, vol. 9, no. 11, 336.
Huber, B, Schellenbacher, C, Shafti-Keramat, S, Jindra, C, Christensen, N & Kirnbauer, R 2017, 'Chimeric L2-based virus-like particle (VLP) vaccines targeting cutaneous human papillomaviruses (HPV)', PLoS One, vol. 12, no. 1, 0169533.
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2017, 'Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site', Structure, vol. 25, no. 2, pp. 253-263.
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2017, 'High-resolution structure analysis of antibody V5 and U4 conformational epitopes on human papillomavirus 16', Viruses, vol. 9, no. 12, 374.
Kalnin, K, Chivukula, S, Tibbitts, T, Yan, Y, Stegalkina, S, Shen, L, Cieszynski, J, Costa, V, Sabharwal, R, Anderson, SF, Christensen, N, Jagu, S, Roden, RBS & Kleanthous, H 2017, 'Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes', Vaccine, vol. 35, no. 37, pp. 4942-4951.
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, TK, Brendle, SA, Christensen, ND, Schell, TD & Hu, J 2017, 'Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer', Scientific reports, vol. 7, no. 1, 16932.
Cladel, NM, Budgeon, LR, Cooper, TK, Balogh, KK, Christensen, N, Myers, R, Majerciak, V, Gotte, D, Zheng, ZM & Hu, J 2017, 'Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy', Journal of General Virology, vol. 98, no. 10, 000926, pp. 2520-2529.
Squiquera, L, Taxman, DJ, Brendle, SA, Torres, R, Sulley, J, Hodge, T, Christensen, N & Sidransky, D 2017, 'Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase i study', Antiviral Therapy, vol. 22, no. 3, pp. 247-255.
Hu, J, Cladel, NM, Budgeon, LR, Balogh, KK & Christensen, N 2017, 'The mouse papillomavirus infection model', Viruses, vol. 9, no. 9, 246.


Boxus, M, Fochesato, M, Miseur, A, Mertens, E, Dendouga, N, Brendle, S, Balogh, KK, Christensen, N & Giannini, SL 2016, 'Broad cross-protection is induced in preclinical models by a human papillomavirus vaccine composed of L1/L2 chimeric virus-like particles', Journal of Virology, vol. 90, no. 14, pp. 6314-6325.
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, T, Hu, J & Christensen, N 2016, 'Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue', Virology, vol. 488, pp. 73-80.
Christensen, N, Budgeon, LR, Cladel, NM & Hu, J 2017, 'Recent advances in preclinical model systems for papillomaviruses', Virus Research, vol. 231, pp. 108-118.


Lee, H, Brendle, SA, Bywaters, SM, Guan, J, Ashley, RE, Yoder, JD, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2015, 'A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment', Journal of virology, vol. 89, no. 2, pp. 1428-1438.
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, T, Hu, J & Christensen, N 2015, 'A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections', PLoS One, vol. 10, no. 3, e0120128.
Jagu, S, Karanam, B, Wang, JW, Zayed, H, Weghofer, M, Brendle, SA, Balogh, KK, Tossi, KP, Roden, RBS & Christensen, N 2015, 'Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes', Vaccine, vol. 33, no. 42, pp. 5553-5563.
Brendle, SA & Christensen, N 2015, 'HPV binding assay to laminin-332/integrin α6β4 on human keratinocytes' Methods in Molecular Biology, vol. 1249, pp. 53-66.
Peng, X, Roshwalb, S, Cooper, T, Zimmerman, H & Christensen, N 2015, 'High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain', Veterinary Ophthalmology, vol. 18, no. 3, pp. 186-190.
Du, P, Camacho, F, McCall-Hosenfeld, J, Lengerich, E, Meyers, C & Christensen, N 2015, 'Human papillomavirus vaccination among adults and children in 5 US states', Journal of Public Health Management and Practice, vol. 21, no. 6, pp. 573-583.
Cozza, EM, Cooper, T, Budgeon, LR, Christensen, N & Schell, T 2015, 'Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors' Cancer Immunology, Immunotherapy, vol. 64, no. 3, pp. 325-336.
Yang, L, Carrillo, M, Wu, YM, DiAngelo, SL, Silveyra, P, Umstead, TM, Halstead, ES, Davies, ML, Hu, S, Floros, J, McCormack, FX, Christensen, N & Chroneos, Z 2015, 'SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation', PloS one, vol. 10, no. 5, e0126576.
Guan, J, Bywaters, SM, Brendle, SA, Lee, H, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2015, 'Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization' Virology, vol. 483, pp. 253-263.
Guan, J, Bywaters, SM, Brendle, SA, Lee, H, Ashley, RE, Christensen, N & Hafenstein, S 2015, 'The U4 antibody epitope on human papillomavirus 16 identified by cryo-electron microscopy' Journal of virology, vol. 89, no. 23, pp. 12108-12117.
Hu, J, Budgeon, LR, Cladel, NM, Balogh, K, Myers, R, Cooper, T & Christensen, N 2015, 'Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model', Journal of General Virology, vol. 96, no. 12, pp. 3554-3565.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)