Researcher Profile

Researcher Profile

Neil Christensen, MSc, PhD

Neil Christensen, MSc, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Immunotherapy
ndc1@psu.edu

Research Interests

  • Rabbits
  • Virion
  • Cottontail rabbit papillomavirus
  • Epitopes
  • Papillomavirus Infections
  • Antibodies
  • Human papillomavirus 16
  • Human papillomavirus 11
  • Monoclonal Antibodies
  • Infection
  • Capsid
  • Papilloma

Recent Publications

2019

Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, de Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2019, 'Author Correction: The wide utility of rabbits as models of human diseases (Experimental & Molecular Medicine, (2018), 50, 5, (66), 10.1038/s12276-018-0094-1)', Experimental and Molecular Medicine, vol. 51, no. 7, 71. https://doi.org/10.1038/s12276-019-0252-0
Cladel, NM, Peng, X, Christensen, N & Hu, J 2019, 'The rabbit papillomavirus model: A valuable tool to study viral-host interactions', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1773, 20180294. https://doi.org/10.1098/rstb.2018.0294

2018

Morse, MA, Balogh, KK, Brendle, SA, Campbell, CA, Chen, MX, Furze, RC, Harada, IL, Holyer, ID, Kumar, U, Lee, K, Prinjha, RK, Rüdiger, M, Seal, JT, Taylor, S, Witherington, J & Christensen, N 2018, 'BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo', Antiviral Research, vol. 154, pp. 158-165. https://doi.org/10.1016/j.antiviral.2018.03.012
Bywaters, SM, Brendle, SA, Biryukov, J, Wang, JW, Walston, J, Milici, J, Roden, RB, Meyers, C & Christensen, N 2018, 'Production and characterization of a novel HPV anti-L2 monoclonal antibody panel' Virology, vol. 524, pp. 106-113. https://doi.org/10.1016/j.virol.2018.08.017
Esteves, PJ, Abrantes, J, Baldauf, HM, BenMohamed, L, Chen, Y, Christensen, N, González-Gallego, J, Giacani, L, Hu, J, Kaplan, G, Keppler, OT, Knight, KL, Kong, XP, Lanning, DK, Le Pendu, J, De Matos, AL, Liu, J, Liu, S, Lopes, AM, Lu, S, Lukehart, S, Manabe, YC, Neves, F, McFadden, G, Pan, R, Peng, X, de Sousa-Pereira, P, Pinheiro, A, Rahman, M, Ruvoën-Clouet, N, Subbian, S, Tuñón, MJ, van der Loo, W, Vaine, M, Via, LE, Wang, S & Mage, R 2018, 'The wide utility of rabbits as models of human diseases', Experimental and Molecular Medicine, vol. 50, no. 5, 66. https://doi.org/10.1038/s12276-018-0094-1

2017

Bywaters, SM, Brendle, SA, Tossi, KP, Biryukov, J, Meyers, C & Christensen, N 2017, 'Antibody competition reveals surface location of HPV L2 minor capsid protein residues 17–36', Viruses, vol. 9, no. 11, 336. https://doi.org/10.3390/v9110336
Huber, B, Schellenbacher, C, Shafti-Keramat, S, Jindra, C, Christensen, N & Kirnbauer, R 2017, 'Chimeric L2-based virus-like particle (VLP) vaccines targeting cutaneous human papillomaviruses (HPV)', PLoS One, vol. 12, no. 1, 0169533. https://doi.org/10.1371/journal.pone.0169533
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2017, 'Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site', Structure, vol. 25, no. 2, pp. 253-263. https://doi.org/10.1016/j.str.2016.12.001
Guan, J, Bywaters, SM, Brendle, SA, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2017, 'High-resolution structure analysis of antibody V5 and U4 conformational epitopes on human papillomavirus 16', Viruses, vol. 9, no. 12, 374. https://doi.org/10.3390/v9120374
Kalnin, K, Chivukula, S, Tibbitts, T, Yan, Y, Stegalkina, S, Shen, L, Cieszynski, J, Costa, V, Sabharwal, R, Anderson, SF, Christensen, N, Jagu, S, Roden, RBS & Kleanthous, H 2017, 'Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes', Vaccine, vol. 35, no. 37, pp. 4942-4951. https://doi.org/10.1016/j.vaccine.2017.07.086
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, TK, Brendle, SA, Christensen, ND, Schell, TD & Hu, J 2017, 'Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer', Scientific reports, vol. 7, no. 1, 16932. https://doi.org/10.1038/s41598-017-17089-4
Cladel, NM, Budgeon, LR, Cooper, TK, Balogh, KK, Christensen, N, Myers, R, Majerciak, V, Gotte, D, Zheng, ZM & Hu, J 2017, 'Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy', Journal of General Virology, vol. 98, no. 10, 000926, pp. 2520-2529. https://doi.org/10.1099/jgv.0.000926
Squiquera, L, Taxman, DJ, Brendle, SA, Torres, R, Sulley, J, Hodge, T, Christensen, N & Sidransky, D 2017, 'Ranpirnase eradicates human papillomavirus in cultured cells and heals anogenital warts in a Phase i study', Antiviral Therapy, vol. 22, no. 3, pp. 247-255. https://doi.org/10.3851/IMP3133
Hu, J, Cladel, NM, Budgeon, LR, Balogh, KK & Christensen, N 2017, 'The mouse papillomavirus infection model', Viruses, vol. 9, no. 9, 246. https://doi.org/10.3390/v9090246

2016

Boxus, M, Fochesato, M, Miseur, A, Mertens, E, Dendouga, N, Brendle, S, Balogh, KK, Christensen, N & Giannini, SL 2016, 'Broad cross-protection is induced in preclinical models by a human papillomavirus vaccine composed of L1/L2 chimeric virus-like particles', Journal of virology, vol. 90, no. 14, pp. 6314-6325. https://doi.org/10.1128/JVI.00449-16
Christensen, N 2016, 'HPV disease transmission protection and control', Microbial Cell, vol. 3, no. 9, pp. 476-490. https://doi.org/10.15698/mic2016.09.530
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, T, Hu, J & Christensen, N 2016, 'Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue', Virology, vol. 488, pp. 73-80. https://doi.org/10.1016/j.virol.2015.10.030
Christensen, N, Budgeon, LR, Cladel, NM & Hu, J 2017, 'Recent advances in preclinical model systems for papillomaviruses', Virus Research, vol. 231, pp. 108-118. https://doi.org/10.1016/j.virusres.2016.12.004

2015

Lee, H, Brendle, SA, Bywaters, SM, Guan, J, Ashley, RE, Yoder, JD, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2015, 'A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment', Journal of virology, vol. 89, no. 2, pp. 1428-1438. https://doi.org/10.1128/JVI.02898-14
Cladel, NM, Budgeon, LR, Balogh, KK, Cooper, T, Hu, J & Christensen, N 2015, 'A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections', PloS one, vol. 10, no. 3, e0120128. https://doi.org/10.1371/journal.pone.0120128
Jagu, S, Karanam, B, Wang, JW, Zayed, H, Weghofer, M, Brendle, SA, Balogh, KK, Tossi, KP, Roden, RBS & Christensen, N 2015, 'Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes', Vaccine, vol. 33, no. 42, pp. 5553-5563. https://doi.org/10.1016/j.vaccine.2015.09.005
Brendle, SA & Christensen, N 2015, 'HPV binding assay to laminin-332/integrin α6β4 on human keratinocytes' Methods in Molecular Biology, vol. 1249, pp. 53-66. https://doi.org/10.1007/978-1-4939-2013-6_4
Peng, X, Roshwalb, S, Cooper, T, Zimmerman, H & Christensen, N 2015, 'High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain', Veterinary Ophthalmology, vol. 18, no. 3, pp. 186-190. https://doi.org/10.1111/vop.12203
Du, P, Camacho, F, McCall-Hosenfeld, J, Lengerich, E, Meyers, C & Christensen, N 2015, 'Human papillomavirus vaccination among adults and children in 5 US states', Journal of Public Health Management and Practice, vol. 21, no. 6, pp. 573-583. https://doi.org/10.1097/PHH.0000000000000271
Cozza, EM, Cooper, T, Budgeon, LR, Christensen, N & Schell, T 2015, 'Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors' Cancer Immunology, Immunotherapy, vol. 64, no. 3, pp. 325-336. https://doi.org/10.1007/s00262-014-1635-7
Yang, L, Carrillo, M, Wu, YM, DiAngelo, SL, Silveyra, P, Umstead, TM, Halstead, ES, Davies, ML, Hu, S, Floros, J, McCormack, FX, Christensen, N & Chroneos, Z 2015, 'SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation', PloS one, vol. 10, no. 5, e0126576. https://doi.org/10.1371/journal.pone.0126576
Guan, J, Bywaters, SM, Brendle, SA, Lee, H, Ashley, RE, Makhov, AM, Conway, JF, Christensen, N & Hafenstein, S 2015, 'Structural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization' Virology, vol. 483, pp. 253-263. https://doi.org/10.1016/j.virol.2015.04.016
Guan, J, Bywaters, SM, Brendle, SA, Lee, H, Ashley, RE, Christensen, N & Hafenstein, S 2015, 'The U4 antibody epitope on human papillomavirus 16 identified by cryo-electron microscopy', Journal of virology, vol. 89, no. 23, pp. 12108-12117. https://doi.org/10.1128/JVI.02020-15
Hu, J, Budgeon, LR, Cladel, NM, Balogh, K, Myers, R, Cooper, T & Christensen, N 2015, 'Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model', Journal of General Virology, vol. 96, no. 12, pp. 3554-3565. https://doi.org/10.1099/jgv.0.000295

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