Neil Christensen, MSc, PhD - Penn State Cancer Institute
Researcher Profile
Neil Christensen, MSc, PhD
Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Microbiology and Immunology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Division of Experimental Pathology
Professor, Department of Microbiology and Immunology
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Cancer Institute, Immunotherapy Team
Recent Publications
2024
Kumar, R, Maldonado, RK, Christensen, N, Bewley, MC, Flanagan, J, Buchkovich, N & Parent, L 2024, 'ESCRT Protein VPS4A Is Required for the Formation of Replication Centers and Replication of Human Coronavirus 229E (HCoV-229E)', COVID, vol. 4, no. 9, pp. 1338-1354. https://doi.org/10.3390/covid4090095
Momenilandi, M, Lévy, R, Sobrino, S, Li, J, Lagresle-Peyrou, C, Esmaeilzadeh, H, Fayand, A, Le Floc'h, C, Guérin, A, Mina, ED, Shearer, D, Delmonte, OM, Yatim, A, Mulder, K, Mancini, M, Rinchai, D, Denis, A, Neehus, AL, Balogh, K, Brendle, S, Rokni-Zadeh, H, Changi-Ashtiani, M, Seeleuthner, Y, Deswarte, C, Bessot, B, Cremades, C, Materna, M, Cederholm, A, Ogishi, M, Philippot, Q, Beganovic, O, Ackermann, M, Wuyts, M, Khan, T, Fouéré, S, Herms, F, Chanal, J, Palterer, B, Bruneau, J, Molina, TJ, Leclerc-Mercier, S, Prétet, JL, Youssefian, L, Vahidnezhad, H, Parvaneh, N, Claeys, KG, Schrijvers, R, Luka, M, Pérot, P, Fourgeaud, J, Nourrisson, C, Poirier, P, Jouanguy, E, Boisson-Dupuis, S, Bustamante, J, Notarangelo, LD, Christensen, N, Landegren, N, Abel, L, Marr, N, Six, E, Langlais, D, Waterboer, T, Ginhoux, F, Ma, CS, Tangye, SG, Meyts, I, Lachmann, N, Hu, J, Shahrooei, M, Bossuyt, X, Casanova, JL & Béziat, V 2024, 'FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice', Cell, vol. 187, no. 11, pp. 2817-2837.e31. https://doi.org/10.1016/j.cell.2024.04.009
Atkins, H, Uslu, AA, Li, JJ, Shearer, DA, Brendle, SA, Han, C, Kozak, M, Lopez, P, Nayar, D, Balogh, KK, Abendroth, C, Copper, J, Cheng, K, Christensen, N, Zhu, Y, Avril, S, Burgener, AD, Murooka, TT & Hu, J 2024, 'Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening', mBio, vol. 15, no. 8, pp. e0142024. https://doi.org/10.1128/mbio.01420-24
2023
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega. https://doi.org/10.1021/acsomega.3c09611
Brendle, SA, Li, JJ, Walter, V, Schell, T, Kozak, M, Balogh, KK, Lu, S, Christensen, ND, Zhu, Y, El-Bayoumy, K & Hu, J 2023, 'Immune Responses in Oral Papillomavirus Clearance in the MmuPV1 Mouse Model', Pathogens, vol. 12, no. 12, 1452. https://doi.org/10.3390/pathogens12121452
Sharma, N, Jerajani, K, Wan, Y, Kumru, OS, Pullagurla, SR, Ogun, O, Mapari, S, Brendle, S, Christensen, ND, Batwal, S, Mahedvi, M, Rao, H, Dogar, V, Chandrasekharan, R, Shaligram, U, Volkin, DB & Joshi, SB 2023, 'Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies', Journal of Pharmaceutical Sciences, vol. 112, no. 2, pp. 458-470. https://doi.org/10.1016/j.xphs.2022.11.021
2022
Vishweshwaraiah, YL, Hnath, B, Rackley, B, Wang, J, Gontu, A, Chandler, M, Afonin, KA, Kuchipudi, SV, Christensen, N, Yennawar, NH & Dokholyan, NV 2022, 'Adaptation-Proof SARS-CoV-2 Vaccine Design', Advanced Functional Materials, vol. 32, no. 49, 2206055. https://doi.org/10.1002/adfm.202206055
Jerajani, K, Wan, Y, Hickey, JM, Kumru, OS, Sharma, N, Pullagurla, SR, Ogun, O, Mapari, S, Whitaker, N, Brendle, S, Christensen, ND, Batwal, S, Mahedvi, M, Rao, H, Dogar, V, Chandrasekharan, R, Shaligram, U, Joshi, SB & Volkin, DB 2022, 'Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development', Journal of Pharmaceutical Sciences, vol. 111, no. 11, pp. 2983-2997. https://doi.org/10.1016/j.xphs.2022.07.019
Hu, J, Brendle, SA, Li, JJ, Walter, V, Cladel, NM, Cooper, T, Shearer, DA, Balogh, KK & Christensen, ND 2022, 'Depo Medroxyprogesterone (DMPA) Promotes Papillomavirus Infections but Does Not Accelerate Disease Progression in the Anogenital Tract of a Mouse Model', Viruses, vol. 14, no. 5, 980. https://doi.org/10.3390/v14050980
Cladel, NM, Xu, J, Peng, X, Jiang, P, Christensen, ND, Zheng, ZM & Hu, J 2022, 'Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus', Viruses, vol. 14, no. 9, 1964. https://doi.org/10.3390/v14091964
Jerajani, K, Wan, Y, Kumru, OS, Pullagurla, SR, Kumar, P, Sharma, N, Ogun, O, Mapari, S, Brendle, S, Christensen, ND, Batwal, S, Mahedvi, M, Rao, H, Dogar, V, Chandrasekharan, R, Shaligram, U, Joshi, SB & Volkin, DB 2023, 'Multi-Dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I - Screening of Preservative Combinations', Journal of Pharmaceutical Sciences, vol. 112, no. 2, pp. 446-457. https://doi.org/10.1016/j.xphs.2022.09.001
Brendle, SA, Li, J, Cladel, NM, Balogh, KK, Booth, J, Shearer, DA, Walter, V, Lu, S, Christensen, ND, Covington, D, DeBroff, J, Milici, J, Zhu, Y, Viscidi, R & Hu, J 2022, 'Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections', Journal of virology, vol. 96, no. 16. https://doi.org/10.1128/jvi.00703-22
Olczak, P, Matsui, K, Wong, M, Alvarez, J, Lambert, P, Christensen, ND, Hu, J, Huber, B, Kirnbauer, R, Wang, JW & Roden, RBS 2022, 'RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer', Journal of virology, vol. 96, no. 13. https://doi.org/10.1128/jvi.00566-22
2021
Brendle, S, Cladel, N, Balogh, K, Alam, S, Christensen, N, Meyers, C & Hu, J 2021, 'A comparative study on delivery of externally attached dna by papillomavirus vlps and pseudoviruses', Vaccines, vol. 9, no. 12, 1501. https://doi.org/10.3390/vaccines9121501
Hartmann, SR, Goetschius, DJ, Hu, J, Graff, JJ, Bator, CM, Christensen, ND & Hafenstein, SL 2021, 'Cryo em analysis reveals inherent flexibility of authentic murine papillomavirus capsids', Viruses, vol. 13, no. 10, 2023. https://doi.org/10.3390/v13102023
Xu, J, Zhang, J, Yang, D, Song, J, Pallas, B, Zhang, C, Hu, J, Peng, X, Christensen, ND, Han, R & Chen, YE 2021, 'Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research', Frontiers in Genetics, vol. 12, 642444. https://doi.org/10.3389/fgene.2021.642444
Goetschius, DJ, Hartmann, SR, Subramanian, S, Bator, CM, Christensen, ND & Hafenstein, SL 2021, 'High resolution cryo EM analysis of HPV16 identifies minor structural protein L2 and describes capsid flexibility', Scientific reports, vol. 11, no. 1, 3498. https://doi.org/10.1038/s41598-021-83076-5
Béziat, V, Rapaport, F, Hu, J, Titeux, M, Bonnet des Claustres, M, Bourgey, M, Griffin, H, Bandet, É, Ma, CS, Sherkat, R, Rokni-Zadeh, H, Louis, DM, Changi-Ashtiani, M, Delmonte, OM, Fukushima, T, Habib, T, Guennoun, A, Khan, T, Bender, N, Rahman, M, About, F, Yang, R, Rao, G, Rouzaud, C, Li, J, Shearer, D, Balogh, K, Al Ali, F, Ata, M, Dabiri, S, Momenilandi, M, Nammour, J, Alyanakian, MA, Leruez-Ville, M, Guenat, D, Materna, M, Marcot, L, Vladikine, N, Soret, C, Vahidnezhad, H, Youssefian, L, Saeidian, AH, Uitto, J, Catherinot, É, Navabi, SS, Zarhrate, M, Woodley, DT, Jeljeli, M, Abraham, T, Belkaya, S, Lorenzo, L, Rosain, J, Bayat, M, Lanternier, F, Lortholary, O, Zakavi, F, Gros, P, Orth, G, Abel, L, Prétet, JL, Fraitag, S, Jouanguy, E, Davis, MM, Tangye, SG, Notarangelo, LD, Marr, N, Waterboer, T, Langlais, D, Doorbar, J, Hovnanian, A, Christensen, N, Bossuyt, X, Shahrooei, M & Casanova, JL 2021, 'Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy', Cell, vol. 184, no. 14, pp. 3812-3828.e30. https://doi.org/10.1016/j.cell.2021.06.004
Kumar, R, Christensen, ND, Kaddis Maldonado, RJ, Bewley, MC, Ostman, A, Sudol, M, Chen, EC, Buchkovich, NW, Gontu, A, Surendran Nair, M, Nissly, RH, Minns, AM, Kapur, V, Rossi, R, Kuchipudi, SV, Lindner, SE, Parent, LJ, Flanagan, JM & Buchkovich, NJ 2021, 'Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses', Viruses, vol. 13, no. 10, 1899. https://doi.org/10.3390/v13101899
Brendle, S, Li, JJ, Cladel, NM, Shearer, DA, Budgeon, LR, Balogh, KK, Atkins, H, Costa-Fujishima, M, Lopez, P, Christensen, ND, Doorbar, J, Murooka, TT & Hu, J 2021, 'Mouse papillomavirus l1 and l2 are dispensable for viral infection and persistence at both cutaneous and mucosal tissues', Viruses, vol. 13, no. 9, 1824. https://doi.org/10.3390/v13091824
Tschirley, AM, Stockwell, PA, Rodger, EJ, Eltherington, O, Morison, IM, Christensen, N, Chatterjee, A & Hibma, M 2021, 'The mouse papillomavirus epigenetic signature is characterised by dna hypermethylation after lesion regression', Viruses, vol. 13, no. 10, 2045. https://doi.org/10.3390/v13102045
2020
El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Lauver, MD, Goetschius, DJ, Netherby-Winslow, CS, Ayers, KN, Jin, G, Haas, DG, Frost, EL, Cho, SH, Bator, CM, Bywaters, SM, Christensen, ND, Hafenstein, SL & Lukacher, AE 2020, 'Antibody escape by polyomavirus capsid mutation facilitates neurovirulence', eLife, vol. 9, pp. 1-68. https://doi.org/10.7554/ELIFE.61056
Osborne, AJ, Atkins, HM, Balogh, KK, Brendle, SA, Shearer, DA, Hu, J, Sample, CE & Christensen, ND 2020, 'Antibody-mediated immune subset depletion modulates the immune response in a rabbit (Oryctolagus cuniculus) model of Epstein-Barr virus infection', Comparative Medicine, vol. 70, no. 5, pp. 312-322. https://doi.org/10.30802/AALAS-CM-20-000019
Godi, A, Boampong, D, Elegunde, B, Panwar, K, Fleury, M, Li, S, Zhao, Q, Xia, N, Christensen, ND & Beddows, S 2020, 'Comprehensive Assessment of the Antigenic Impact of Human Papillomavirus Lineage Variation on Recognition by Neutralizing Monoclonal Antibodies Raised against Lineage A Major Capsid Proteins of Vaccine-Related Genotypes', Journal of virology, vol. 94, no. 24, e01236-20. https://doi.org/10.1128/JVI.01236-20
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321