Researcher Profile

Researcher Profile

Mohamed Trebak, PhD

Mohamed Trebak, PhD

Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
mzt12@psu.edu

Research Interests

  • Proteins
  • Calcium
  • Vascular Smooth Muscle
  • Cell Membrane
  • Smooth Muscle Myocytes
  • Blood Vessels
  • Stromal Interaction Molecule 1
  • Endoplasmic Reticulum
  • Type C Phospholipases
  • Cations
  • Transient Receptor Potential Channels
  • Smooth Muscle

Recent Publications

2019

Gabani, M, Liu, J, Ait-Aissa, K, Koval, O, Kim, YR, Castañeda, D, Vikram, A, Jacobs, JS, Grumbach, I, Trebak, M, Irani, K & Kassan, M 2019, ' MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure ', Cell Calcium, vol. 80, pp. 18-24. https://doi.org/10.1016/j.ceca.2019.03.006
Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, DL & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971. https://doi.org/10.1038/s41467-019-09593-0
Gautier, M, Trebak, M, Fleig, A, Vandier, C & Ouadid-Ahidouch, H 2019, 'Ca2+ channels in cancer', Cell Calcium, vol. 84, 102083. https://doi.org/10.1016/j.ceca.2019.102083
Gautier, M, Trebak, M, Fleig, A, Vandier, C & Ouadid-Ahidouch, H 2019, 'Ca2+ homeostasis and cancer', Cell Calcium, vol. 84, 102084. https://doi.org/10.1016/j.ceca.2019.102084
Trebak, M & Kinet, JP 2019, 'Calcium signalling in T cells', Nature Reviews Immunology, vol. 19, no. 3, pp. 154-169. https://doi.org/10.1038/s41577-018-0110-7
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, DL & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity', Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332. https://doi.org/10.1074/jbc.RA118.006801
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Cossarizza, A, Chang, HD, Radbruch, A, Acs, A, Adam, D, Adam-Klages, S, Agace, WW, Aghaeepour, N, Akdis, M, Allez, M, Almeida, LN, Alvisi, G, Anderson, G, Andrä, I, Annunziato, F, Anselmo, A, Bacher, P, Baldari, CT, Bari, S, Barnaba, V, Barros-Martins, J, Battistini, L, Bauer, W, Baumgart, S, Baumgarth, N, Baumjohann, D, Baying, B, Bebawy, M, Becher, B, Beisker, W, Benes, V, Beyaert, R, Blanco, A, Boardman, DA, Bogdan, C, Borger, JG, Borsellino, G, Boulais, PE, Bradford, JA, Brenner, D, Brinkman, RR, Brooks, AES, Busch, DH, Büscher, M, Bushnell, TP, Calzetti, F, Cameron, G, Cammarata, I, Cao, X, Cardell, SL, Casola, S, Cassatella, MA, Cavani, A, Celada, A, Chatenoud, L, Chattopadhyay, PK, Chow, S, Christakou, E, Čičin-Šain, L, Clerici, M, Colombo, FS, Cook, L, Cooke, A, Cooper, AM, Corbett, AJ, Cosma, A, Cosmi, L, Coulie, PG, Cumano, A, Cvetkovic, L, Dang, VD, Dang-Heine, C, Davey, MS, Davies, D, De Biasi, S, Del Zotto, G, Dela Cruz, GV, Delacher, M, Della Bella, S, Dellabona, P, Deniz, G, Dessing, M, Di Santo, JP, Diefenbach, A, Dieli, F, Dolf, A, Dörner, T, Dress, RJ, Dudziak, D, Dustin, M, Dutertre, CA, Ebner, F, Eckle, SBG, Edinger, M, Eede, P, Ehrhardt, GRA, Eich, M, Engel, P, Engelhardt, B, Erdei, A, Esser, C, Everts, B, Evrard, M, Falk, CS, Fehniger, TA, Felipo-Benavent, M, Ferry, H, Feuerer, M, Filby, A, Filkor, K, Fillatreau, S, Follo, M, Förster, I, Foster, J, Foulds, GA, Frehse, B, Frenette, PS, Frischbutter, S, Fritzsche, W, Galbraith, DW, Gangaev, A, Garbi, N, Gaudilliere, B, Gazzinelli, RT, Geginat, J, Gerner, W, Gherardin, NA, Ghoreschi, K, Gibellini, L, Ginhoux, F, Goda, K, Godfrey, DI, Goettlinger, C, González-Navajas, JM, Goodyear, CS, Gori, A, Grogan, JL, Grummitt, D, Grützkau, A, Haftmann, C, Hahn, J, Hammad, H, Hämmerling, G, Hansmann, L, Hansson, G, Harpur, CM, Hartmann, S, Hauser, A, Hauser, AE, Haviland, DL, Hedley, D, Hernández, DC, Herrera, G, Herrmann, M, Hess, C, Höfer, T, Hoffmann, P, Hogquist, K, Holland, T, Höllt, T, Holmdahl, R, Hombrink, P, Houston, JP, Hoyer, BF, Huang, B, Huang, FP, Huber, JE, Huehn, J, Hundemer, M, Hunter, CA, Hwang, WYK, Iannone, A, Ingelfinger, F, Ivison, SM, Jäck, HM, Jani, PK, Jávega, B, Jonjic, S, Kaiser, T, Kalina, T, Kamradt, T, Kaufmann, SHE, Keller, B, Ketelaars, SLC, Khalilnezhad, A, Khan, S, Kisielow, J, Klenerman, P, Knopf, J, Koay, HF, Kobow, K, Kolls, JK, Kong, WT, Kopf, M, Korn, T, Kriegsmann, K, Kristyanto, H, Kroneis, T, Krueger, A, Kühne, J, Kukat, C, Kunkel, D, Kunze-Schumacher, H, Kurosaki, T, Kurts, C, Kvistborg, P, Kwok, I, Landry, J, Lantz, O, Lanuti, P, LaRosa, F, Lehuen, A, LeibundGut-Landmann, S, Leipold, MD, Leung, LYT, Levings, MK, Lino, AC, Liotta, F, Litwin, V, Liu, Y, Ljunggren, HG, Lohoff, M, Lombardi, G, Lopez, L, López-Botet, M, Lovett-Racke, AE, Lubberts, E, Luche, H, Ludewig, B, Lugli, E, Lunemann, S, Maecker, HT, Maggi, L, Maguire, O, Mair, F, Mair, KH, Mantovani, A, Manz, RA, Marshall, AJ, Martínez-Romero, A, Martrus, G, Marventano, I, Maslinski, W, Matarese, G, Mattioli, AV, Maueröder, C, Mazzoni, A, McCluskey, J, McGrath, M, McGuire, HM, McInnes, IB, Mei, HE, Melchers, F, Melzer, S, Mielenz, D, Miller, SD, Mills, KHG, Minderman, H, Mjösberg, J, Moore, J, Moran, B, Moretta, L, Mosmann, TR, Müller, S, Multhoff, G, Muñoz, LE, Münz, C, Nakayama, T, Nasi, M, Neumann, K, Ng, LG, Niedobitek, A, Nourshargh, S, Núñez, G, O'Connor, JE, Ochel, A, Oja, A, Ordonez, D, Orfao, A, Orlowski-Oliver, E, Ouyang, W, Oxenius, A, Palankar, R, Panse, I, Pattanapanyasat, K, Paulsen, M, Pavlinic, D, Penter, L, Peterson, P, Peth, C, Petriz, J, Piancone, F, Pickl, WF, Piconese, S, Pinti, M, Pockley, AG, Podolska, MJ, Poon, Z, Pracht, K, Prinz, I, Pucillo, CEM, Quataert, SA, Quatrini, L, Quinn, KM, Radbruch, H, Radstake, TRDJ, Rahmig, S, Rahn, HP, Rajwa, B, Ravichandran, G, Raz, Y, Rebhahn, JA, Recktenwald, D, Reimer, D, Reis e Sousa, C, Remmerswaal, EBM, Richter, L, Rico, LG, Riddell, A, Rieger, AM, Robinson, JP, Romagnani, C, Rubartelli, A, Ruland, J, Saalmüller, A, Saeys, Y, Saito, T, Sakaguchi, S, Sala-de-Oyanguren, F, Samstag, Y, Sanderson, S, Sandrock, I, Santoni, A, Sanz, RB, Saresella, M, Sautes-Fridman, C, Sawitzki, B, Schadt, L, Scheffold, A, Scherer, HU, Schiemann, M, Schildberg, FA, Schimisky, E, Schlitzer, A, Schlosser, J, Schmid, S, Schmitt, S, Schober, K, Schraivogel, D, Schuh, W, Schüler, T, Schulte, R, Schulz, AR, Schulz, SR, Scottá, C, Scott-Algara, D, Sester, DP, Shankey, TV, Silva-Santos, B, Simon, AK, Sitnik, KM, Sozzani, S, Speiser, DE, Spidlen, J, Stahlberg, A, Stall, AM, Stanley, N, Stark, R, Stehle, C, Steinmetz, T, Stockinger, H, Takahama, Y, Takeda, K, Tan, L, Tárnok, A, Tiegs, G, Toldi, G, Tornack, J, Traggiai, E, Trebak, M, Tree, TIM, Trotter, J, Trowsdale, J, Tsoumakidou, M, Ulrich, H, Urbanczyk, S, van de Veen, W, van den Broek, M, van der Pol, E, Van Gassen, S, Van Isterdael, G, van Lier, RAW, Veldhoen, M, Vento-Asturias, S, Vieira, P, Voehringer, D, Volk, HD, von Borstel, A, von Volkmann, K, Waisman, A, Walker, RV, Wallace, PK, Wang, SA, Wang, XM, Ward, MD, Ward-Hartstonge, KA, Warnatz, K, Warnes, G, Warth, S, Waskow, C, Watson, JV, Watzl, C, Wegener, L, Weisenburger, T, Wiedemann, A, Wienands, J, Wilharm, A, Wilkinson, RJ, Willimsky, G, Wing, JB, Winkelmann, R, Winkler, TH, Wirz, OF, Wong, A, Wurst, P, Yang, JHM, Yang, J, Yazdanbakhsh, M, Yu, L, Yue, A, Zhang, H, Zhao, Y, Ziegler, SM, Zielinski, C, Zimmermann, J & Zychlinsky, A 2019, 'Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)', European Journal of Immunology, vol. 49, no. 10, pp. 1457-1973. https://doi.org/10.1002/eji.201970107
Kouba, S, Braire, J, Félix, R, Chantôme, A, Jaffrès, PA, Lebreton, J, Dubreuil, D, Pipelier, M, Zhang, X, Trebak, M, Vandier, C, Mathé-Allainmat, M & Potier-Cartereau, M 2020, 'Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity', European Journal of Medicinal Chemistry, vol. 186, 111854. https://doi.org/10.1016/j.ejmech.2019.111854
Johnson, M & Trebak, M 2019, 'ORAI channels in cellular remodeling of cardiorespiratory disease', Cell Calcium, vol. 79, pp. 1-10. https://doi.org/10.1016/j.ceca.2019.01.005
Xu, M, Almasi, S, Yang, Y, Yan, C, Sterea, AM, Rizvi Syeda, AK, Shen, B, Richard Derek, C, Huang, P, Gujar, S, Wang, J, Zong, WX, Trebak, M, El Hiani, Y & Dong, XP 2019, 'The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways', Cell Calcium, vol. 79, pp. 80-88. https://doi.org/10.1016/j.ceca.2019.02.010
Zhou, Y, Nwokonko, RM, Baraniak, JH, Trebak, M, Lee, KPK & Gill, DL 2019, 'The remote allosteric control of Orai channel gating', PLoS biology, vol. 17, no. 8, e3000413. https://doi.org/10.1371/journal.pbio.3000413

2018

Zhou, Y, Nwokonko, RM, Cai, X, Loktionova, NA, Abdulqadir, R, Xin, P, Niemeyer, BA, Wang, Y, Trebak, M & Gill, DL 2018, 'Cross-linking of Orai1 channels by STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 15, pp. E3398-E3407. https://doi.org/10.1073/pnas.1720810115
Verkhratsky, A, Trebak, M, Perocchi, F, Khananshvili, D & Sekler, I 2018, 'Crosslink between calcium and sodium signalling', Experimental Physiology, vol. 103, no. 2, pp. 157-169. https://doi.org/10.1113/EP086534
Liu, Z, Wei, Y, Zhang, L, Yee, PP, Johnson, M, Zhang, X, Gulley, M, Atkinson, JM, Trebak, M, Wang, H-G & Li, W 2019, 'Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ', Oncogene, vol. 38, no. 1, pp. 120-139. https://doi.org/10.1038/s41388-018-0425-7
Pathak, T & Trebak, M 2018, 'Mitochondrial Ca2+ signaling', Pharmacology and Therapeutics, vol. 192, pp. 112-123. https://doi.org/10.1016/j.pharmthera.2018.07.001
Pierro, C, Zhang, X, Kankeu, C, Trebak, M, Bootman, MD & Roderick, HL 2018, 'Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines', Cell Calcium, vol. 72, pp. 70-80. https://doi.org/10.1016/j.ceca.2018.03.002
Cai, X, Nwokonko, RM, Loktionova, NA, Abdulqadir, R, Baraniak, JH, Wang, Y, Trebak, M, Zhou, Y & Gill, DL 2018, 'Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor', Journal of Biological Chemistry, vol. 293, no. 33, pp. 12962-12974. https://doi.org/10.1074/jbc.RA118.003424
Haouzi, P, Gueguinou, M, Sonobe, T, Judenherc-Haouzi, A, Tubbs, N, Trebak, M, Cheung, J & Bouillaud, F 2018, 'Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication', Clinical Toxicology, vol. 56, no. 9, pp. 828-840. https://doi.org/10.1080/15563650.2018.1429615
Johnson, M & Trebak, M 2018, 'Slow traffic makes for bad circulation: The case of β1 subunit of bk channels in hypertension', Hypertension, vol. 72, no. 3, pp. 585-587. https://doi.org/10.1161/HYPERTENSIONAHA.118.11237
Zhang, X, Spinelli, AM, Zhang, W & Trebak, M 2018, Study of the Endogenous CRAC Channel Using shRNA-Mediated Gene Silencing. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1843, Humana Press Inc., pp. 137-145. https://doi.org/10.1007/978-1-4939-8704-7_12

2017

Tanwar, J, Trebak, M & Motiani, RK 2017, Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 993, Springer New York LLC, pp. 425-452. https://doi.org/10.1007/978-3-319-57732-6_22
Hanes, CM, D'Amico, AE, Ueyama, T, Wong, AC, Zhang, X, Hynes, WF, Barroso, MM, Cady, NC, Trebak, M, Saito, N & Lennartz, MR 2017, 'Golgi-associated protein kinase C-ϵ is delivered to phagocytic cups: Role of phosphatidylinositol 4-phosphate', Journal of Immunology, vol. 199, no. 1, pp. 271-277. https://doi.org/10.4049/jimmunol.1700243
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, DL, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815. https://doi.org/10.15252/embj.201592481
Trebak, M & Putney, JW 2017, 'ORAI calcium channels', Physiology, vol. 32, no. 4, pp. 332-342. https://doi.org/10.1152/physiol.00011.2017
Zhang, X, Gueguinou, M & Trebak, M 2017, Store-independent orai channels regulated by STIM. in Calcium Entry Channels in Non-Excitable Cells. CRC Press, pp. 197-213. https://doi.org/10.1201/9781315152592

2016

Beardslee, LA, Stolwijk, J, Khaladj, DA, Trebak, M, Halman, J, Torrejon, KY, Niamsiri, N & Bergkvist, M 2016, 'A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness', Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 104, no. 6, pp. 1192-1201. https://doi.org/10.1002/jbm.b.33464
Stolwijk, JA, Zhang, X, Gueguinou, M, Zhang, W, Matrougui, K, Renken, C & Trebak, M 2016, 'Calcium signaling is dispensable for receptor regulation of endothelial barrier function', Journal of Biological Chemistry, vol. 291, no. 44, pp. 22894-22912. https://doi.org/10.1074/jbc.M116.756114
Hempel, N & Trebak, M 2017, 'Crosstalk between calcium and reactive oxygen species signaling in cancer', Cell Calcium, vol. 63, pp. 70-96. https://doi.org/10.1016/j.ceca.2017.01.007
Kassan, M, Ait-Aissa, K, Radwan, E, Mali, V, Haddox, S, Gabani, M, Zhang, W, Belmadani, S, Irani, K, Trebak, M & Matrougui, K 2016, 'Essential role of smooth muscle STIM1 in hypertension and cardiovascular dysfunction', Arteriosclerosis, thrombosis, and vascular biology, vol. 36, no. 9, pp. 1900-1909. https://doi.org/10.1161/ATVBAHA.116.307869
Shakerley, NL, Chandrasekaran, A, Trebak, M, Miller, BA & Melendez, JA 2016, 'Francisella tularensis catalase restricts immune function by impairing TRPM2 channel activity', Journal of Biological Chemistry, vol. 291, no. 8, pp. 3871-3881. https://doi.org/10.1074/jbc.M115.706879
Wang, H, Zhang, X, Xue, L, Xing, J, Jouvin, MH, Putney, JW, Anderson, MP, Trebak, M & Kinet, JP 2016, 'Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles', Immunity, vol. 44, no. 4, pp. 782-794. https://doi.org/10.1016/j.immuni.2016.01.015
Spinelli, AM & Trebak, M 2016, 'Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle', American Journal of Physiology - Cell Physiology, vol. 310, no. 6, pp. C402-C413. https://doi.org/10.1152/ajpcell.00355.2015
Cai, X, Zhou, Y, Nwokonko, RM, Loktionova, NA, Wang, X, Xin, P, Trebak, M, Wang, Y & Gill, DL 2016, 'The Orai1 store-operated calcium channel functions as a hexamer', Journal of Biological Chemistry, vol. 291, no. 50, pp. 25764-25775. https://doi.org/10.1074/jbc.M116.758813
Zhou, Y, Cai, X, Loktionova, NA, Wang, X, Nwokonko, RM, Wang, X, Wang, Y, Rothberg, BS, Trebak, M & Gill, DL 2016, 'The STIM1-binding site nexus remotely controls Orai1 channel gating', Nature communications, vol. 7, 13725. https://doi.org/10.1038/ncomms13725
Zhang, X, Spinelli, AM, Masiello, T & Trebak, M 2016, Transient receptor potential canonical 7 (TRPC7), a calcium (Ca2+) permeable non-selective cation channel. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 898, Springer New York LLC, pp. 251-264. https://doi.org/10.1007/978-3-319-26974-0_11

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