Researcher Profile

Researcher Profile

Mohamed Trebak, PhD

Mohamed Trebak, PhD

Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
mzt12@psu.edu

Research Interests

  • Proteins
  • Calcium
  • Vascular Smooth Muscle
  • Smooth Muscle Myocytes
  • Cell Membrane
  • Blood Vessels
  • Endoplasmic Reticulum
  • Stromal Interaction Molecule 1
  • Type C Phospholipases
  • Smooth Muscle
  • Cations
  • Transient Receptor Potential Channels

Recent Publications

2021

Guéguinou, M, Pathak, T, Robert, A, Vandier, C, Trebak, M, Lecomte, T & Raoul, W 2021, 'L'échangeur ionique NCLX: Un rôle ambivalent dans la chronologie du cancer colorectal', Medecine/Sciences, vol. 37, no. 2, pp. 124-126. https://doi.org/10.1051/medsci/2020274
Emrich, SM, Yoast, RE, Xin, P, Arige, V, Wagner, LE, Hempel, N, Gill, DL, Sneyd, J, Yule, DI & Trebak, M 2021, 'Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling', Cell Reports, vol. 34, no. 9, 108760. https://doi.org/10.1016/j.celrep.2021.108760

2020

Azimi, I, Stevenson, RJ, Zhang, X, Meizoso-Huesca, A, Xin, P, Johnson, M, Flanagan, JU, Chalmers, SB, Yoast, RE, Kapure, JS, Ross, BP, Vetter, I, Ashton, MR, Launikonis, BS, Denny, WA, Trebak, M & Monteith, GR 2020, 'A New Selective Pharmacological Enhancer of the Orai1 Ca2+ Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions', ACS Pharmacology and Translational Science, vol. 3, no. 1, pp. 135-147. https://doi.org/10.1021/acsptsci.9b00081
Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41. https://doi.org/10.7554/ELIFE.59686
Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Johnson, MT, Pathak, T, Benson, JC, Azimi, I, Gill, DL, Monteith, GR & Trebak, M 2020, 'Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels', Cell Calcium, vol. 91, 102281. https://doi.org/10.1016/j.ceca.2020.102281
Johnson, MT, Gudlur, A, Zhang, X, Xin, P, Emrich, SM, Yoast, RE, Courjaret, R, Nwokonko, RM, Li, W, Hempel, N, Machaca, K, Gill, DL, Hogan, PG & Trebak, M 2020, 'L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 29, pp. 17369-17380. https://doi.org/10.1073/pnas.2007598117
Delierneux, C, Kouba, S, Shanmughapriya, S, Potier-Cartereau, M, Trebak, M & Hempel, N 2020, 'Mitochondrial Calcium Regulation of Redox Signaling in Cancer', Cells, vol. 9, no. 2. https://doi.org/10.3390/cells9020432
Pathak, T & Trebak, M 2020, 'NCLX pumps up the heat', Cell Calcium, vol. 92, 102280. https://doi.org/10.1016/j.ceca.2020.102280
Yoast, RE, Emrich, SM & Trebak, M 2020, 'The anatomy of native CRAC channel(s)', Current Opinion in Physiology, vol. 17, pp. 89-95. https://doi.org/10.1016/j.cophys.2020.07.012
Yoast, RE, Emrich, SM, Zhang, X, Xin, P, Johnson, MT, Fike, AJ, Walter, V, Hempel, N, Yule, DI, Sneyd, J, Gill, DL & Trebak, M 2020, 'The native ORAI channel trio underlies the diversity of Ca2+ signaling events', Nature communications, vol. 11, no. 1, pp. 2444. https://doi.org/10.1038/s41467-020-16232-6

2019

Gabani, M, Liu, J, Ait-Aissa, K, Koval, O, Kim, YR, Castañeda, D, Vikram, A, Jacobs, JS, Grumbach, I, Trebak, M, Irani, K & Kassan, M 2019, ' MiR-204 regulates type 1 IP 3 R to control vascular smooth muscle cell contractility and blood pressure ', Cell Calcium, vol. 80, pp. 18-24. https://doi.org/10.1016/j.ceca.2019.03.006
Zhang, X, Pathak, T, Yoast, R, Emrich, S, Xin, P, Nwokonko, RM, Johnson, M, Wu, S, Delierneux, C, Gueguinou, M, Hempel, N, Putney, JW, Gill, DL & Trebak, M 2019, 'A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction', Nature communications, vol. 10, no. 1, 1971. https://doi.org/10.1038/s41467-019-09593-0
Gautier, M, Trebak, M, Fleig, A, Vandier, C & Ouadid-Ahidouch, H 2019, 'Ca2+ channels in cancer', Cell Calcium, vol. 84, 102083. https://doi.org/10.1016/j.ceca.2019.102083
Gautier, M, Trebak, M, Fleig, A, Vandier, C & Ouadid-Ahidouch, H 2019, 'Ca2+ homeostasis and cancer', Cell Calcium, vol. 84, 102084. https://doi.org/10.1016/j.ceca.2019.102084
Trebak, M & Kinet, JP 2019, 'Calcium signalling in T cells', Nature Reviews Immunology, vol. 19, no. 3, pp. 154-169. https://doi.org/10.1038/s41577-018-0110-7
Emrich, SM, Yoast, RE, Xin, P, Zhang, X, Pathak, T, Nwokonko, R, Gueguinou, MF, Subedi, KP, Zhou, Y, Ambudkar, IS, Hempel, N, Machaca, K, Gill, DL & Trebak, M 2019, 'Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity', Journal of Biological Chemistry, vol. 294, no. 16, pp. 6318-6332. https://doi.org/10.1074/jbc.RA118.006801
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Cossarizza, A, Chang, HD, Radbruch, A, Acs, A, Adam, D, Adam-Klages, S, Agace, WW, Aghaeepour, N, Akdis, M, Allez, M, Almeida, LN, Alvisi, G, Anderson, G, Andrä, I, Annunziato, F, Anselmo, A, Bacher, P, Baldari, CT, Bari, S, Barnaba, V, Barros-Martins, J, Battistini, L, Bauer, W, Baumgart, S, Baumgarth, N, Baumjohann, D, Baying, B, Bebawy, M, Becher, B, Beisker, W, Benes, V, Beyaert, R, Blanco, A, Boardman, DA, Bogdan, C, Borger, JG, Borsellino, G, Boulais, PE, Bradford, JA, Brenner, D, Brinkman, RR, Brooks, AES, Busch, DH, Büscher, M, Bushnell, TP, Calzetti, F, Cameron, G, Cammarata, I, Cao, X, Cardell, SL, Casola, S, Cassatella, MA, Cavani, A, Celada, A, Chatenoud, L, Chattopadhyay, PK, Chow, S, Christakou, E, Čičin-Šain, L, Clerici, M, Colombo, FS, Cook, L, Cooke, A, Cooper, AM, Corbett, AJ, Cosma, A, Cosmi, L, Coulie, PG, Cumano, A, Cvetkovic, L, Dang, VD, Dang-Heine, C, Davey, MS, Davies, D, De Biasi, S, Del Zotto, G, Dela Cruz, GV, Delacher, M, Della Bella, S, Dellabona, P, Deniz, G, Dessing, M, Di Santo, JP, Diefenbach, A, Dieli, F, Dolf, A, Dörner, T, Dress, RJ, Dudziak, D, Dustin, M, Dutertre, CA, Ebner, F, Eckle, SBG, Edinger, M, Eede, P, Ehrhardt, GRA, Eich, M, Engel, P, Engelhardt, B, Erdei, A, Esser, C, Everts, B, Evrard, M, Falk, CS, Fehniger, TA, Felipo-Benavent, M, Ferry, H, Feuerer, M, Filby, A, Filkor, K, Fillatreau, S, Follo, M, Förster, I, Foster, J, Foulds, GA, Frehse, B, Frenette, PS, Frischbutter, S, Fritzsche, W, Galbraith, DW, Gangaev, A, Garbi, N, Gaudilliere, B, Gazzinelli, RT, Geginat, J, Gerner, W, Gherardin, NA, Ghoreschi, K, Gibellini, L, Ginhoux, F, Goda, K, Godfrey, DI, Goettlinger, C, González-Navajas, JM, Goodyear, CS, Gori, A, Grogan, JL, Grummitt, D, Grützkau, A, Haftmann, C, Hahn, J, Hammad, H, Hämmerling, G, Hansmann, L, Hansson, G, Harpur, CM, Hartmann, S, Hauser, A, Hauser, AE, Haviland, DL, Hedley, D, Hernández, DC, Herrera, G, Herrmann, M, Hess, C, Höfer, T, Hoffmann, P, Hogquist, K, Holland, T, Höllt, T, Holmdahl, R, Hombrink, P, Houston, JP, Hoyer, BF, Huang, B, Huang, FP, Huber, JE, Huehn, J, Hundemer, M, Hunter, CA, Hwang, WYK, Iannone, A, Ingelfinger, F, Ivison, SM, Jäck, HM, Jani, PK, Jávega, B, Jonjic, S, Kaiser, T, Kalina, T, Kamradt, T, Kaufmann, SHE, Keller, B, Ketelaars, SLC, Khalilnezhad, A, Khan, S, Kisielow, J, Klenerman, P, Knopf, J, Koay, HF, Kobow, K, Kolls, JK, Kong, WT, Kopf, M, Korn, T, Kriegsmann, K, Kristyanto, H, Kroneis, T, Krueger, A, Kühne, J, Kukat, C, Kunkel, D, Kunze-Schumacher, H, Kurosaki, T, Kurts, C, Kvistborg, P, Kwok, I, Landry, J, Lantz, O, Lanuti, P, LaRosa, F, Lehuen, A, LeibundGut-Landmann, S, Leipold, MD, Leung, LYT, Levings, MK, Lino, AC, Liotta, F, Litwin, V, Liu, Y, Ljunggren, HG, Lohoff, M, Lombardi, G, Lopez, L, López-Botet, M, Lovett-Racke, AE, Lubberts, E, Luche, H, Ludewig, B, Lugli, E, Lunemann, S, Maecker, HT, Maggi, L, Maguire, O, Mair, F, Mair, KH, Mantovani, A, Manz, RA, Marshall, AJ, Martínez-Romero, A, Martrus, G, Marventano, I, Maslinski, W, Matarese, G, Mattioli, AV, Maueröder, C, Mazzoni, A, McCluskey, J, McGrath, M, McGuire, HM, McInnes, IB, Mei, HE, Melchers, F, Melzer, S, Mielenz, D, Miller, SD, Mills, KHG, Minderman, H, Mjösberg, J, Moore, J, Moran, B, Moretta, L, Mosmann, TR, Müller, S, Multhoff, G, Muñoz, LE, Münz, C, Nakayama, T, Nasi, M, Neumann, K, Ng, LG, Niedobitek, A, Nourshargh, S, Núñez, G, O'Connor, JE, Ochel, A, Oja, A, Ordonez, D, Orfao, A, Orlowski-Oliver, E, Ouyang, W, Oxenius, A, Palankar, R, Panse, I, Pattanapanyasat, K, Paulsen, M, Pavlinic, D, Penter, L, Peterson, P, Peth, C, Petriz, J, Piancone, F, Pickl, WF, Piconese, S, Pinti, M, Pockley, AG, Podolska, MJ, Poon, Z, Pracht, K, Prinz, I, Pucillo, CEM, Quataert, SA, Quatrini, L, Quinn, KM, Radbruch, H, Radstake, TRDJ, Rahmig, S, Rahn, HP, Rajwa, B, Ravichandran, G, Raz, Y, Rebhahn, JA, Recktenwald, D, Reimer, D, Reis e Sousa, C, Remmerswaal, EBM, Richter, L, Rico, LG, Riddell, A, Rieger, AM, Robinson, JP, Romagnani, C, Rubartelli, A, Ruland, J, Saalmüller, A, Saeys, Y, Saito, T, Sakaguchi, S, Sala-de-Oyanguren, F, Samstag, Y, Sanderson, S, Sandrock, I, Santoni, A, Sanz, RB, Saresella, M, Sautes-Fridman, C, Sawitzki, B, Schadt, L, Scheffold, A, Scherer, HU, Schiemann, M, Schildberg, FA, Schimisky, E, Schlitzer, A, Schlosser, J, Schmid, S, Schmitt, S, Schober, K, Schraivogel, D, Schuh, W, Schüler, T, Schulte, R, Schulz, AR, Schulz, SR, Scottá, C, Scott-Algara, D, Sester, DP, Shankey, TV, Silva-Santos, B, Simon, AK, Sitnik, KM, Sozzani, S, Speiser, DE, Spidlen, J, Stahlberg, A, Stall, AM, Stanley, N, Stark, R, Stehle, C, Steinmetz, T, Stockinger, H, Takahama, Y, Takeda, K, Tan, L, Tárnok, A, Tiegs, G, Toldi, G, Tornack, J, Traggiai, E, Trebak, M, Tree, TIM, Trotter, J, Trowsdale, J, Tsoumakidou, M, Ulrich, H, Urbanczyk, S, van de Veen, W, van den Broek, M, van der Pol, E, Van Gassen, S, Van Isterdael, G, van Lier, RAW, Veldhoen, M, Vento-Asturias, S, Vieira, P, Voehringer, D, Volk, HD, von Borstel, A, von Volkmann, K, Waisman, A, Walker, RV, Wallace, PK, Wang, SA, Wang, XM, Ward, MD, Ward-Hartstonge, KA, Warnatz, K, Warnes, G, Warth, S, Waskow, C, Watson, JV, Watzl, C, Wegener, L, Weisenburger, T, Wiedemann, A, Wienands, J, Wilharm, A, Wilkinson, RJ, Willimsky, G, Wing, JB, Winkelmann, R, Winkler, TH, Wirz, OF, Wong, A, Wurst, P, Yang, JHM, Yang, J, Yazdanbakhsh, M, Yu, L, Yue, A, Zhang, H, Zhao, Y, Ziegler, SM, Zielinski, C, Zimmermann, J & Zychlinsky, A 2019, 'Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)', European Journal of Immunology, vol. 49, no. 10, pp. 1457-1973. https://doi.org/10.1002/eji.201970107
Kouba, S, Braire, J, Félix, R, Chantôme, A, Jaffrès, PA, Lebreton, J, Dubreuil, D, Pipelier, M, Zhang, X, Trebak, M, Vandier, C, Mathé-Allainmat, M & Potier-Cartereau, M 2020, 'Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity', European Journal of Medicinal Chemistry, vol. 186, 111854. https://doi.org/10.1016/j.ejmech.2019.111854
Johnson, M & Trebak, M 2019, 'ORAI channels in cellular remodeling of cardiorespiratory disease', Cell Calcium, vol. 79, pp. 1-10. https://doi.org/10.1016/j.ceca.2019.01.005
Xu, M, Almasi, S, Yang, Y, Yan, C, Sterea, AM, Rizvi Syeda, AK, Shen, B, Richard Derek, C, Huang, P, Gujar, S, Wang, J, Zong, WX, Trebak, M, El Hiani, Y & Dong, XP 2019, 'The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways', Cell Calcium, vol. 79, pp. 80-88. https://doi.org/10.1016/j.ceca.2019.02.010
Zhou, Y, Nwokonko, RM, Baraniak, JH, Trebak, M, Lee, KPK & Gill, DL 2019, 'The remote allosteric control of Orai channel gating', PLoS biology, vol. 17, no. 8, e3000413. https://doi.org/10.1371/journal.pbio.3000413

2018

Zhou, Y, Nwokonko, RM, Cai, X, Loktionova, NA, Abdulqadir, R, Xin, P, Niemeyer, BA, Wang, Y, Trebak, M & Gill, DL 2018, 'Cross-linking of Orai1 channels by STIM proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 15, pp. E3398-E3407. https://doi.org/10.1073/pnas.1720810115
Verkhratsky, A, Trebak, M, Perocchi, F, Khananshvili, D & Sekler, I 2018, 'Crosslink between calcium and sodium signalling', Experimental Physiology, vol. 103, no. 2, pp. 157-169. https://doi.org/10.1113/EP086534
Liu, Z, Wei, Y, Zhang, L, Yee, PP, Johnson, M, Zhang, X, Gulley, M, Atkinson, JM, Trebak, M, Wang, H-G & Li, W 2019, 'Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ', Oncogene, vol. 38, no. 1, pp. 120-139. https://doi.org/10.1038/s41388-018-0425-7
Pathak, T & Trebak, M 2018, 'Mitochondrial Ca2+ signaling', Pharmacology and Therapeutics, vol. 192, pp. 112-123. https://doi.org/10.1016/j.pharmthera.2018.07.001
Pierro, C, Zhang, X, Kankeu, C, Trebak, M, Bootman, MD & Roderick, HL 2018, 'Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines', Cell Calcium, vol. 72, pp. 70-80. https://doi.org/10.1016/j.ceca.2018.03.002
Cai, X, Nwokonko, RM, Loktionova, NA, Abdulqadir, R, Baraniak, JH, Wang, Y, Trebak, M, Zhou, Y & Gill, DL 2018, 'Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor', Journal of Biological Chemistry, vol. 293, no. 33, pp. 12962-12974. https://doi.org/10.1074/jbc.RA118.003424
Haouzi, P, Gueguinou, M, Sonobe, T, Judenherc-Haouzi, A, Tubbs, N, Trebak, M, Cheung, J & Bouillaud, F 2018, 'Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication', Clinical Toxicology, vol. 56, no. 9, pp. 828-840. https://doi.org/10.1080/15563650.2018.1429615
Johnson, M & Trebak, M 2018, 'Slow traffic makes for bad circulation: The case of β1 subunit of bk channels in hypertension', Hypertension, vol. 72, no. 3, pp. 585-587. https://doi.org/10.1161/HYPERTENSIONAHA.118.11237
Zhang, X, Spinelli, AM, Zhang, W & Trebak, M 2018, Study of the Endogenous CRAC Channel Using shRNA-Mediated Gene Silencing. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1843, Humana Press Inc., pp. 137-145. https://doi.org/10.1007/978-1-4939-8704-7_12

2017

Tanwar, J, Trebak, M & Motiani, RK 2017, Cardiovascular and hemostatic disorders: Role of STIM and orai proteins in vascular Disorders. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 993, Springer New York LLC, pp. 425-452. https://doi.org/10.1007/978-3-319-57732-6_22
Hanes, CM, D'Amico, AE, Ueyama, T, Wong, AC, Zhang, X, Hynes, WF, Barroso, MM, Cady, NC, Trebak, M, Saito, N & Lennartz, MR 2017, 'Golgi-associated protein kinase C-ϵ is delivered to phagocytic cups: Role of phosphatidylinositol 4-phosphate', Journal of Immunology, vol. 199, no. 1, pp. 271-277. https://doi.org/10.4049/jimmunol.1700243
Ben-Kasus Nissim, T, Zhang, X, Elazar, A, Roy, S, Stolwijk, JA, Zhou, Y, Motiani, RK, Gueguinou, M, Hempel, N, Hershfinkel, M, Gill, DL, Trebak, M & Sekler, I 2017, 'Mitochondria control store-operated Ca2+ entry through Na+ and redox signals', EMBO Journal, vol. 36, no. 6, pp. 797-815. https://doi.org/10.15252/embj.201592481
Trebak, M & Putney, JW 2017, 'ORAI calcium channels', Physiology, vol. 32, no. 4, pp. 332-342. https://doi.org/10.1152/physiol.00011.2017
Zhang, X, Gueguinou, M & Trebak, M 2017, Store-independent orai channels regulated by STIM. in Calcium Entry Channels in Non-Excitable Cells. CRC Press, pp. 197-213. https://doi.org/10.1201/9781315152592

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)