Researcher Profile

Researcher Profile

Margherita Teresa-Anna Cantorna, PhD

Margherita Teresa-Anna Cantorna, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Center for Infectious Disease Dynamics
Scientific Program:Mechanisms of Carcinogenesis
mxc69@psu.edu

Research Interests

  • Vitamin D
  • Calcitriol Receptors
  • T-Lymphocytes
  • Calcitriol
  • Infections
  • Inflammatory Bowel Diseases
  • Immune System
  • Knockout Mice
  • Vitamin A
  • Inflammation
  • Multiple Sclerosis
  • Diet

Recent Publications

2022

Davila, ML, Xu, M, Huang, C, Gaddes, ER, Winter, L, Cantorna, MT, Wang, Y & Xiong, N 2022, 'CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues', iScience, vol. 25, no. 6, 104426. https://doi.org/10.1016/j.isci.2022.104426
Arora, J, Wang, J, Weaver, V, Zhang, Y & Cantorna, MT 2022, 'Novel insight into the role of the vitamin D receptor in the development and function of the immune system', Journal of Steroid Biochemistry and Molecular Biology, vol. 219, 106084. https://doi.org/10.1016/j.jsbmb.2022.106084
Chai, Z, Lyu, Y, Chen, Q, Wei, CH, Snyder, LM, Weaver, V, Sebastian, A, Albert, I, Li, Q, Cantorna, MT & Ross, C 2022, 'Transcriptional Profiling of the Small Intestine and the Colon Reveals Modulation of Gut Infection with Citrobacter rodentium According to the Vitamin A Status', Nutrients, vol. 14, no. 8, 1563. https://doi.org/10.3390/nu14081563

2021

Chai, Z, Lyu, Y, Chen, Q, Wei, CH, Snyder, LM, Weaver, V, Sebastian, A, Albert, I, Li, Q, Cantorna, MT & Ross, AC 2021, 'RNAseq studies reveal distinct transcriptional response to vitamin A deficiency in small intestine versus colon, uncovering novel vitamin A-regulated genes', Journal of Nutritional Biochemistry, vol. 98, 108814. https://doi.org/10.1016/j.jnutbio.2021.108814

2020

Fleet, JC, Bernal-Mizrachi, C, Hewison, M, Jorde, R, White, J, Cantorna, M, Schoenmakers, I & Erben, R 2020, 'Highlights from the 22nd workshop on vitamin D in New York City, May 2019', Journal of Steroid Biochemistry and Molecular Biology, vol. 203, 105747. https://doi.org/10.1016/j.jsbmb.2020.105747
Snyder, LM, Arora, J, Kennett, MJ, Weaver, V & Cantorna, MT 2020, 'Retinoid Signaling in Intestinal Epithelial Cells Is Essential for Early Survival From Gastrointestinal Infection', Frontiers in immunology, vol. 11, 559635. https://doi.org/10.3389/fimmu.2020.559635

2019

Cantorna, MT, Rogers, CJ & Arora, J 2019, 'Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity', Trends in Endocrinology and Metabolism, vol. 30, no. 7, pp. 459-466. https://doi.org/10.1016/j.tem.2019.04.005
Tian, Y, Gui, W, Smith, PB, Koo, I, Murray, IA, Cantorna, MT, Perdew, GH & Patterson, AD 2019, 'Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus)', Journal of agricultural and food chemistry, vol. 67, no. 33, pp. 9286-9294. https://doi.org/10.1021/acs.jafc.9b03212
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Catharine Ross, A & Cantorna, MT 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN, 3090. https://doi.org/10.3389/fimmu.2018.03090
Cantorna, MT, Snyder, L & Arora, J 2019, 'Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, no. 2, pp. 184-192. https://doi.org/10.1080/10409238.2019.1611734
Cantorna, MT, Lin, YD, Arora, J, Bora, S, Tian, Y, Nichols, RG & Patterson, AD 2019, 'Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon', Frontiers in immunology, vol. 10, pp. 1772. https://doi.org/10.3389/fimmu.2019.01772
Lin, YD, Arora, J, Diehl, K, Bora, SA & Cantorna, MT 2019, 'Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection', Frontiers in immunology, vol. 10, no. JAN, 1. https://doi.org/10.3389/fimmu.2019.00001

2018

Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, RF, Patterson, A, Cantorna, MT & Hankey-Giblin, PA 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232. https://doi.org/10.1016/j.jff.2018.04.008
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73. https://doi.org/10.1016/j.jnutbio.2018.01.011
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408. https://doi.org/10.3389/fimmu.2018.00408
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2017.10.011

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)