Researcher Profile

Researcher Profile

Margherita Teresa-Anna Cantorna, PhD

Margherita Teresa-Anna Cantorna, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Pediatric Cancer
mxc69@psu.edu

Research Interests

  • Vitamin D
  • Calcitriol Receptors
  • T-Lymphocytes
  • Calcitriol
  • Inflammatory Bowel Diseases
  • Infection
  • Immune System
  • Knockout Mice
  • Inflammation
  • Diet
  • Multiple Sclerosis
  • Natural Killer T-Cells

Recent Publications

2019

Cantorna, MT-A, Rogers, CJ & Arora, J 2019, 'Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity', Trends in Endocrinology and Metabolism, vol. 30, no. 7, pp. 459-466. https://doi.org/10.1016/j.tem.2019.04.005
Snyder, LM, McDaniel, KL, Tian, Y, Wei, CH, Kennett, MJ, Patterson, AD, Ross, AC & Cantorna, MT-A 2019, 'Retinoic acid mediated clearance of Citrobacter rodentium in vitamin A deficient mice requires CD11b+ and T cells', Frontiers in immunology, vol. 10, no. JAN. https://doi.org/10.3389/fimmu.2018.03090
Cantorna, MT-A, Snyder, L & Arora, J 2019, 'Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, no. 2, pp. 184-192. https://doi.org/10.1080/10409238.2019.1611734
Lin, YD, Arora, J, Diehl, K, Bora, SA & Cantorna, MT-A 2019, 'Vitamin D is required for ILC3 derived IL-22 and protection from Citrobacter rodentium infection', Frontiers in immunology, vol. 10, no. JAN. https://doi.org/10.3389/fimmu.2019.00001

2018

Dey, A, Allen, JN, Fraser, JW, Snyder, LM, Tian, Y, Zhang, L, Paulson, R, Patterson, AD, Cantorna, MT-A & Giblin, PH 2018, 'Neuroprotective role of the ron receptor tyrosine kinase underlying central nervous system inflammation in health and disease', Frontiers in immunology, vol. 9, no. MAR, 513. https://doi.org/10.3389/fimmu.2018.00513
Tian, Y, Nichols, RG, Roy, P, Gui, W, Smith, PB, Zhang, J, Lin, Y, Weaver, V, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice', Journal of Functional Foods, vol. 45, pp. 223-232. https://doi.org/10.1016/j.jff.2018.04.008
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics', Journal of Nutritional Biochemistry, vol. 56, pp. 65-73. https://doi.org/10.1016/j.jnutbio.2018.01.011
Bora, SA, Kennett, MJ, Smith, PB, Patterson, AD & Cantorna, MT-A 2018, 'The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23', Frontiers in immunology, vol. 9, no. MAR, 408. https://doi.org/10.3389/fimmu.2018.00408
Tian, Y, Nichols, RG, Cai, J, Patterson, AD & Cantorna, MT-A 2018, 'Vitamin A deficiency in mice alters host and gut microbial metabolism leading to altered energy homeostasis', Journal of Nutritional Biochemistry, vol. 54, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2017.10.011

2017

Cantorna, MT-A 2017, 'Comment on "diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells"', Journal of Immunology, vol. 198, no. 11. https://doi.org/10.4049/jimmunol.1700411
James, J, Weaver, V & Cantorna, MT-A 2017, 'Control of circulating IgE by the Vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms', Journal of Immunology, vol. 198, no. 3, pp. 1164-1171. https://doi.org/10.4049/jimmunol.16012133
Bora, S & Cantorna, MT-A 2017, 'The role of UVR and Vitamin D on T cells and inflammatory bowel disease', Photochemical and Photobiological Sciences, vol. 16, no. 3, pp. 347-353. https://doi.org/10.1039/c6pp00266h
Cantorna, MT-A & Bruce, D 2017, Vitamin D and Inflammatory Bowel Disease. in Health, Disease and Therapeutics. vol. 2, Elsevier Inc., pp. 1025-1036. https://doi.org/10.1016/B978-0-12-809963-6.00108-5

2016

Cantorna, MT-A 2016, 'IBD: Vitamin D and IBD: Moving towards clinical trials', Nature Reviews Gastroenterology and Hepatology, vol. 13, no. 6, pp. 322-323. https://doi.org/10.1038/nrgastro.2016.72
Cantorna, MT-A 2016, 'Vitamin D and lung infection' Infection and Immunity, vol. 84, no. 11, pp. 3094-3096. https://doi.org/10.1128/IAI.00679-16

2015

Chen, J, Waddell, A, Lin, YD & Cantorna, MT-A 2015, 'Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells', Mucosal Immunology, vol. 8, no. 3, pp. 618-626. https://doi.org/10.1038/mi.2014.94
Waddell, A, Zhao, J & Cantorna, MT-A 2015, 'NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice', International Immunology, vol. 27, no. 5, pp. 237-244. https://doi.org/10.1093/intimm/dxu147
Cantorna, MT-A, Snyder, L, Lin, YD & Yang, L 2015, 'Vitamin D and 1,25(OH)2D regulation of T cells', Nutrients, vol. 7, no. 4, pp. 3011-3021. https://doi.org/10.3390/nu7043011

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)