Researcher Profile

Researcher Profile

Matthew Moyer, MS, MD

Matthew Moyer, MS, MD

Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Next-Generation Therapies
Disease Teams:
Gastrointestinal Cancer
View Website

Research Interests

Dr. Matthew Moyer's research interests primarily focus on interventional endoscopy and cancerous/pre-cancerous conditions in gastroenterology. His current research projects include EUS-guided ablation of premalignant pancreatic cysts (including the NIH funded CHARM II multi-center randomized clinical trial), Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Natural Orifice Transluminal Endoscopic Surgery (NOTES) and innovative endoscopic techniques for patients with inflammatory bowel disease. 

Dr Moyer also leads several intellectual property and endoscopic technology projects. These projects include the Chimera Project which is a joint project with Penn State University Bioengineering to develop an endoscopic ultrasound (EUS)-guided device which uses the twin modalities of radiofrequency ablation and targeted external beam radiation to treat solid abdominal mass lesions. Additional projects include the Quic-fuse Project in cooperation with IDE Inc. of Sydney Australia to develop a purpose-made chemoinfusion gun to enable safer and more standardized EUS-guided chemoablation of mucinous type pancreatic cysts.

  • Natural Orifice Endoscopic Surgery
  • Polyps
  • Animals
  • Stomach
  • Pancreatic Cyst
  • Endoscopic Mucosal Resection
  • Swine
  • Surgical Instruments
  • Neoplasms
  • Equipment and Supplies
  • Hemorrhage
  • Endoscopy

Clinical Trials

CHARM II: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts: a prospective, randomized, double-blind, multi-center clinical trial

Recent Publications


Large Polyp Study Group Consortium 2022, 'Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results From a Randomized Trial', Clinical Gastroenterology and Hepatology, vol. 20, no. 8, pp. 1757-1765.e4.
Motchum, L, Levenick, JM, Djinbachian, R, Moyer, MT, Bouchard, S, Taghiakbari, M, Repici, A, Deslandres, É & von Renteln, D 2022, 'EMR combined with hybrid argon plasma coagulation to prevent recurrence of large nonpedunculated colorectal polyps (with videos)', Gastrointestinal Endoscopy, vol. 96, no. 5, pp. 840-848.e2.


Hartz, KM, Lee, RY, Walsh, LT, Dixon, MEB & Moyer, MT 2021, 'Endoscopic hemostatic spray for uncontrolled bleeding after complicated endoscopic mucosal resection or endoscopic submucosal dissection: a report of 2 cases', VideoGIE, vol. 6, no. 10, pp. 481-483.
Syed, N & Moyer, MT 2021, 'Endoscopic resection of large Paris 0-Ip pedunculated polyps: video demonstration of recent U.S. Multi-Society Task Force recommendations on resection and removal for general endoscopists', VideoGIE, vol. 6, no. 9, pp. 395-397.
Ortiz, O, Rex, DK, Grimm, IS, Moyer, MT, Hasan, MK, Pleskow, D, Elmunzer, BJ, Khashab, MA, Sanaei, O, Al-Kawas, FH, Gordon, SR, Mathew, A, Levenick, JM, Aslanian, HR, Antaki, F, Von Renteln, D, Crockett, SD, Rastogi, A, Gill, JA, Law, R, Wallace, MB, Elias, PA, Mackenzie, TA, Pohl, H & Pellisé, M 2021, 'Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps', Endoscopy, vol. 53, no. 11, pp. 1150-1159.
Motz, VL, Lester, C, Moyer, MT, Maranki, JL & Levenick, JM 2022, 'Hybrid argon plasma coagulation-assisted endoscopic mucosal resection for large sessile colon polyps to reduce local recurrence: A prospective pilot study', Endoscopy, vol. 54, no. 6, pp. 580-584.
Lester, C, Walsh, L, Hartz, KM, Mathew, A, Levenick, JM, Headlee, BD, Heisey, HD, Birkholz, JH, Dixon, M, Maranki, JL, Gusani, NJ, Dye, CE & Moyer, MT 2022, 'The Durability of EUS-Guided Chemoablation of Mucinous Pancreatic Cysts: A Long-Term Follow-Up of the CHARM trial', Clinical Gastroenterology and Hepatology, vol. 20, no. 2, pp. e326-e329.


Clarke, K, Kang, M, Gorrepati, VS, Stine, JG, Tinsley, A, Williams, E, Moyer, M & Coates, M 2020, 'Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study', International Journal of Colorectal Disease, vol. 35, no. 12, pp. 2301-2307.
Pohl, H, Grimm, IS, Moyer, MT, Hasan, MK, Pleskow, D, Elmunzer, BJ, Khashab, MA, Sanaei, O, Al-Kawas, FH, Gordon, SR, Mathew, A, Levenick, JM, Aslanian, HR, Antaki, F, von Renteln, D, Crockett, SD, Rastogi, A, Gill, JA, Law, RJ, Elias, PA, Pellise, M, Mackenzie, TA & Rex, DK 2020, 'Effects of Blended (Yellow) vs Forced Coagulation (Blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial', Gastroenterology, vol. 159, no. 1, pp. 119-128.e2.
Walsh, LT, Groff, A, Mathew, A & Moyer, MT 2020, 'Endoscopic management of large peripancreatic fluid collections in two pediatric patients by endoscopic ultrasound-guided transmural drainage', Pediatric Gastroenterology, Hepatology and Nutrition, vol. 23, no. 1, pp. 105-109.
Hartz, KM, Dixon, MEB, Levenick, J & Moyer, MT 2020, 'High-risk main-duct intraductal papillary mucinous neoplasm successfully treated with EUS-guided chemoablation', VideoGIE, vol. 5, no. 12, pp. 679-680.


Gaballa, D, Abendroth, C & Moyer, M 2019, 'Case Report: Alcohol-Free Chemoablation of Multifocal Pancreatic Insulinoma', Endoscopy International Open, vol. 2019, no. 7, E186-E188. <>
Pohl, H, Grimm, IS, Moyer, MT, Hasan, MK, Pleskow, D, Elmunzer, BJ, Khashab, MA, Sanaei, O, Al-Kawas, FH, Gordon, SR, Mathew, A, Levenick, JM, Aslanian, HR, Antaki, F, von Renteln, D, Crockett, SD, Rastogi, A, Gill, JA, Law, RJ, Elias, PA, Pellise, M, Wallace, MB, Mackenzie, TA & Rex, DK 2019, 'Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial', Gastroenterology, vol. 157, no. 4, pp. 977-984.e3.
Moyer, MT, Maranki, JL & DeWitt, JM 2019, 'EUS-Guided Pancreatic Cyst Ablation: a Clinical and Technical Review', Current gastroenterology reports, vol. 21, no. 5, 19.
Moyer, MT, Walsh, LT, Manzo, CE, Loloi, J, Burdette, A & Mathew, A 2019, 'Percutaneous debridement and washout of walled-off abdominal abscess and necrosis by the use of flexible endoscopy: an attractive clinical option when transluminal approaches are unsafe or not possible', VideoGIE, vol. 4, no. 8, pp. 389-393.
Yuen-Bun Teoh, A, Wan Seo, D, Brugge, W, DeWitt, JM, Kongkam, P, Linghu, E, Moyer, M, Ryu, JK & Ho, KY 2019, 'Position statement on EUS-guided ablation of pancreatic cystic neoplasms from an international expert panel', Endoscopy International Open, vol. 2019, no. 9, E1094.
Walsh, LT, Loloi, J, Manzo, CE, Mathew, A, Maranki, J, Dye, CE, Levenick, JM, Taylor, MD & Moyer, MT 2019, 'Successful treatment of large cavity esophageal disruptions with transluminal washout and endoscopic vacuum therapy: a report of two cases', Therapeutic Advances in Gastrointestinal Endoscopy, vol. 12.
Walsh, LT & Moyer, MT 2019, 'The importance of 2 views in the combined antegrade-retrograde dilation procedure', VideoGIE, vol. 4, no. 12, pp. 584.
Walsh, LT, Mitchell, L, Johri, A, Matone, N, Frecker, MI & Moyer, M 2019, 'When high viscosity of pancreatic cysts precludes effective EUS-FNA: A benchtop comparison of negative pressure devices', Endoscopy International Open, vol. 2019, no. 4. <>

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)