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Researcher Profile

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Matthew G. Kaag, MD

Matthew G. Kaag, MD

Associate Professor, Department of Urology
Associate Professor, Department of Surgery
Scientific Program:Cancer Control
Disease Teams:
Cancer Institute, Genitourinary Cancer Team
MGK112@psu.edu

Research Interests

  • Neoplasms
  • Urinary Bladder Neoplasms
  • Carcinoma
  • Kidney
  • Nephrectomy
  • Therapeutics
  • Renal Cell Carcinoma
  • Drug Therapy
  • Survival
  • Nephroureterectomy
  • Recurrence
  • Cystectomy

Clinical Trials

A Phase III Randomized, Open-Label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab in Combination With Tremelimumab and Enfortumab Vedotin or Durvalumab in Combination With Enfortumab Vedotin for Perioperative Treatment in Patients Ineligible for Cisplatin Undergoing Radical Cystectomy for Muscle Invasive Bladder Cancer (VOLGA)
Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens
Phase III Randomized Trial Of Concurrent Chemoradiotherapy With or Without Atezoluzumab in Localized Muscle Invasive Bladder Cancer
Phase 2 Study of Bladder-SparIng ChemoradiatioN with CIPosItive bladdeR cancEr (INSPIRE)EA8185
Angelica Herbal Supplement AGN-CognI.Q Acute Dose Safety and Pharmacokinetics (PK) Dose-Response in Prostate Cancer Patients (PK Dose Trial)
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
Complications in Patients Undergoing Radical Cystectomy for Bladder Cancer

Recent Publications

2023

Joshi, M, Tuanquin, L, Zhu, J, Walter, V, Schell, T, Kaag, M, Kilari, D, Liao, J, Holder, SL, Emamekhoo, H, Sankin, A, Merrill, S, Zheng, H, Warrick, J, Hauke, R, Gartrel, B, Stein, M, Drabick, J, Degraff, DJ & Zakharia, Y 2023, 'Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023', Journal for ImmunoTherapy of Cancer, vol. 11, no. 2, e006551. https://doi.org/10.1136/jitc-2022-006551

2022

Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation (Nature Communications, (2022), 13, 1, (6575), 10.1038/s41467-022-34251-3)', Nature communications, vol. 13, no. 1, 7920. https://doi.org/10.1038/s41467-022-35644-0
Loloi, J, Eccles, JM, Owens, G, Lehman, E, Kaag, MG, Raman, JD & Merrill, SB 2022, 'Diagnostic Imaging in Low-Risk Prostate Cancer: More Harm Than Good?', Urology Practice, vol. 9, no. 2, pp. 135-139. https://doi.org/10.1097/UPJ.0000000000000288
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation', Nature communications, vol. 13, no. 1, 6575. https://doi.org/10.1038/s41467-022-34251-3
Hull, BP, Humphrey, MD, Lehman, KK, Kaag, MG, Merrill, SB & Raman, JD 2022, 'Impact of an inpatient advanced practice provider on hospital length of stay after major urologic oncology procedures', Urologic Oncology: Seminars and Original Investigations, vol. 40, no. 9, pp. 411.e19-411.e25. https://doi.org/10.1016/j.urolonc.2022.06.020
Strausser, SA, Owens, RG, Vu, T, Kwok, E, Schaefer, EW, Boltz, S, Aminsharifi, A, Kaag, M, Raman, JD & Merrill, SB 2022, 'Patient Perceptions Regarding Routine Oncologic Follow-Up for Urologic Malignancies', Clinical Genitourinary Cancer, vol. 20, no. 3, pp. 298-298.e11. https://doi.org/10.1016/j.clgc.2022.01.014

2021

Grant Owens, R, Loloi, J, Lehman, EB, Kaag, MG, Raman, JD & Merrill, SB 2021, 'Is pelvic MRI imaging sufficient cross-sectional imaging for staging intermediate and high-risk prostate cancer?', Urologic Oncology: Seminars and Original Investigations, vol. 39, no. 7, pp. 433.e9-433.e15. https://doi.org/10.1016/j.urolonc.2021.01.029
Ramedani, S, Clark, JY, Knoedler, JJ, MacDonald, S, Kaag, MG, Merrill, SB & Raman, JD 2021, 'Topical antiseptic at time of transrectal ultrasound prostate biopsy is associated with fewer severe clinical infections and improves antibiotic stewardship', Prostate International, vol. 9, no. 4, pp. 185-189. https://doi.org/10.1016/j.prnil.2021.05.003

2020

Fuletra, JG, Watts, A, Kaag, MG, Lehman, E, Raman, JD & Merrill, SB 2020, 'Can preoperative imaging characteristics predict pT3 bladder cancer following cystectomy?', World Journal of Urology. https://doi.org/10.1007/s00345-020-03375-w
Lee, CT, Mohamed, NE, Pisipati, S, Shah, QN, Agarwal, PK, Downs, TM, Droller, M, Gilbert, SM, Goltz, HH, Hall, SJ, Hendawi, M, Hoffman-Censits, J, O'Donnell, M, Kaag, M, Karsh, LI, Kassouf, W, Quale, DZ, Sagalowsky, A, Steinberg, GD & Latini, DM 2020, 'Development and evaluation of a bladder Cancer specific survivorship care plan by patients and clinical care providers: A multi-methods approach', BMC health services research, vol. 20, no. 1, 686. https://doi.org/10.1186/s12913-020-05533-7
Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Durant, AM, Lehman, E, Robyak, H, Merrill, SB, Kaag, MG & Raman, JD 2020, 'Hemostatic agent use during partial nephrectomy: trends, outcomes, and associated costs', International Urology and Nephrology, vol. 52, no. 11, pp. 2073-2078. https://doi.org/10.1007/s11255-020-02538-3
Loloi, J, Allen, JL, Schilling, A, Hollenbeak, C, Merrill, SB, Kaag, MG & Raman, JD 2020, 'In the World of Bladder Tumors: Size Does Matter', Bladder Cancer, vol. 6, no. 2, pp. 195-200. https://doi.org/10.3233/BLC-200273
Kaag, MG 2020, 'Tract urothelial cancers', Translational Andrology and Urology, vol. 9, no. 4, pp. 1881-1890. https://doi.org/10.21037/tau.2020.03.48

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, JI, Wu, XR, Kaag, M, Raman, JD & Degraff, DJ 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Kaag, MG 2019, 'Editorial Comment', Journal of Urology, vol. 202, no. 1, pp. 82. https://doi.org/10.1097/01.JU.0000557734.15067.14
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARĪ³ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Bodo, S, Campagne, C, Thin, TH, Higginson, DS, Vargas, HA, Hua, G, Fuller, JD, Ackerstaff, E, Russell, J, Zhang, Z, Klingler, S, Cho, HJ, Kaag, MG, Mazaheri, Y, Rimner, A, Manova-Todorova, K, Epel, B, Zatcky, J, Cleary, CR, Rao, SS, Yamada, Y, Zelefsky, MJ, Halpern, HJ, Koutcher, JA, Cordon-Cardo, C, Greco, C, Haimovitz-Friedman, A, Sala, E, Powell, SN, Kolesnick, R & Fuks, Z 2019, 'Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury', Journal of Clinical Investigation, vol. 129, no. 2, pp. 786-801. https://doi.org/10.1172/JCI97631