Researcher Profile

Researcher Profile

Matthew G. Kaag, MD

Matthew G. Kaag, MD

Associate Professor, Department of Surgery
Division of Urology
Scientific Program:Cancer Control
Disease Teams:
Genitourinary Cancer
mgk112@psu.edu

Research Interests

  • Neoplasms
  • Urinary Bladder Neoplasms
  • Carcinoma
  • Kidney
  • Renal Cell Carcinoma
  • Therapeutics
  • Nephrectomy
  • Drug Therapy
  • Recurrence
  • Survival
  • Cystectomy
  • Muscles

Clinical Trials

Enhancing Patient Resilience During Multimodal Therapy for Bladder Cancer
Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens
Complications in Patients Undergoing Radical Cystectomy for Bladder Cancer
Observational Study to Determine the Differences in Molecular Characterization between Smokers vs. Non-smokers in Patients with Stage IV Bladder Cancer and their Correlation with Clinical Outcome

Recent Publications

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, J, Wu, XR, Kaag, MG, Raman, J & Degraff, D 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Kaag, MG 2019, 'Editorial Comment', Journal of Urology, vol. 202, no. 1. https://doi.org/10.1097/01.JU.0000557734.15067.14
Zaleski, M, Gogoj, A, Walter, V, Raman, J, Kaag, MG, Merrill, S, Drabick, J, Joshi, M, Holder, S, Degraff, D & Warrick, J 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system' Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Bodo, S, Campagne, C, Thin, TH, Higginson, DS, Vargas, HA, Hua, G, Fuller, JD, Ackerstaff, E, Russell, J, Zhang, Z, Klingler, S, Cho, HJ, Kaag, MG, Mazaheri, Y, Rimner, A, Manova-Todorova, K, Epel, B, Zatcky, J, Cleary, CR, Rao, SS, Yamada, Y, Zelefsky, MJ, Halpern, HJ, Koutcher, JA, Cordon-Cardo, C, Greco, C, Haimovitz-Friedman, A, Sala, E, Powell, SN, Kolesnick, R & Fuks, Z 2019, 'Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury', Journal of Clinical Investigation, vol. 129, no. 2, pp. 786-801. https://doi.org/10.1172/JCI97631

2018

Merrill, S, Sohl, BS, Hamirani, A, Lehman, EB, Lehman, KK, Kaag, MG & Raman, J 2019, 'Capturing Renal Cell Carcinoma Recurrences When Asymptomatic Improves Patient Survival', Clinical Genitourinary Cancer, vol. 17, no. 2, pp. 132-138. https://doi.org/10.1016/j.clgc.2018.11.009
Blair, BM, Robyak, H, Clark, JY, Kaag, MG, Lehman, EB & Raman, J 2018, 'Impact of United States Preventive Services Task Force recommendations on prostate biopsy characteristics and disease presentation at a tertiary-care medical center', Prostate International, vol. 6, no. 3, pp. 110-114. https://doi.org/10.1016/j.prnil.2018.03.001
Warrick, J, Sjödahl, G, Kaag, MG, Raman, J, Merrill, S, Shuman, L, Chen, G, Walter, V & Degraff, D 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22. https://doi.org/10.1016/j.eururo.2018.09.003
Blair, BM, Lehman, EB, Jafri, SM, Kaag, MG & Raman, J 2018, 'Predicted versus observed 30-day perioperative outcomes using the ACS NSQIP surgical risk calculator in patients undergoing partial nephrectomy for renal cell carcinoma' International Urology and Nephrology, vol. 50, no. 7, pp. 1249-1256. https://doi.org/10.1007/s11255-018-1898-6
Kaag, MG & Raman, J 2018, 'Sarcopenia is a reliable predictor of outcomes following radical cystectomy for bladder cancer', Translational Andrology and Urology, vol. 7, pp. S732-S734. https://doi.org/10.21037/tau.2018.09.03
Park, R, Gyorfi, J, Dewan, K, Kirimanjeswara, GS, Clark, JY, Kaag, MG, Lehman, K & Raman, J 2018, 'Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice', International Urology and Nephrology, vol. 50, no. 9, pp. 1563-1568. https://doi.org/10.1007/s11255-018-1937-3

2017

Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96. https://doi.org/10.1016/j.humpath.2016.10.021
Harshman, LC, Tripathi, A, Kaag, MG, Efstathiou, JA, Apolo, AB, Hoffman-Censits, JH, Stadler, WM, Yu, EY, Bochner, BH, Skinner, EC, Downs, T, Kiltie, AE, Bajorin, DF, Guru, K, Shipley, WU, Steinberg, GD, Hahn, NM & Sridhar, SS 2018, 'Contemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer', Clinical Genitourinary Cancer, vol. 16, no. 3, pp. 213-218. https://doi.org/10.1016/j.clgc.2017.11.004
Warrick, J, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345. https://doi.org/10.1007/s00428-017-2190-3

2016

Kaag, MG & Raman, J 2016, 'Clinical guidelines: Clearing murky water-a guideline-based approach to haematuria' Nature Reviews Urology, vol. 13, no. 5, pp. 243-244. https://doi.org/10.1038/nrurol.2016.72
Al-Marrawi, MY, Mackley, H, Ali, S, Wagner Jr., H, Joshi, M, Holder, S, Kaag, MG, Mallon, C, Talamo, G & Drabick, J 2016, 'Consolidation With Radiation or Concurrent Chemo-Radiation After Chemotherapy Results in Durable Complete Remissions of Isolated Nodal Recurrences of Urothelial Cancer: A Case Series and Review', Clinical Genitourinary Cancer, vol. 14, no. 4, pp. e393-e399. https://doi.org/10.1016/j.clgc.2016.01.004
Warrick, J, Raman, J, Kaag, MG, Bruggeman, T, Cates, J, Clark, P & Degraff, D 2016, 'Enhancer of zeste homolog 2 (EZH2) expression in bladder cancer', Urologic Oncology: Seminars and Original Investigations, vol. 34, no. 6, pp. 258.e1-258.e6. https://doi.org/10.1016/j.urolonc.2016.02.011
Warrick, J, Walter, V, Yamashita, H, Chung, E, Shuman, L, Amponsa, VO, Zheng, Z, Chan, W, Whitcomb, T, Yue, F, Iyyanki, T, Imamura, Y, Kaag, MG, Guo, W, Raman, J, Park, JS & Degraff, D 2016, 'FOXA1, GATA3 and PPARIγ Cooperate to drive luminal subtype in bladder cancer: A molecular analysis of established human cell lines', Scientific reports, vol. 6, 38531. https://doi.org/10.1038/srep38531
Yin, M, Joshi, M, Meijer, RP, Glantz, M, Holder, S, Harvey, H, Kaag, MG, Van De Putte, EEF, Horenblas, S & Drabick, J 2016, 'Neoadjuvant chemotherapy for muscle-invasive bladder cancer: A systematic review and two-step meta-analysis', Oncologist, vol. 21, no. 6, pp. 708-715. https://doi.org/10.1634/theoncologist.2015-0440
Joshi, M, Vasekar, M, Grivas, P, Emamekhoo, H, Hsu, JA, Miller, VA, Stephens, PJ, Ali, SM, Ross, JS, Zhu, J, Warrick, J, Drabick, J, Holder, S, Kaag, MG, Li, M & Pal, SK 2016, 'Relationship of smoking status to genomic profile, chemotherapy response and clinical outcome in patients with advanced urothelial carcinoma', Oncotarget, vol. 7, no. 32, pp. 52442-52449. https://doi.org/10.18632/oncotarget.9449
Yin, M, Wang, W, Rosenberg, J, Kaag, MG, Joshi, M, Holder, S, Tuanquin, L & Drabick, J 2016, 'Targeted Therapy in Collecting Duct Carcinoma of the Kidney: A Case Report and Literature Review', Clinical Genitourinary Cancer, vol. 14, no. 2, pp. e203-e206. https://doi.org/10.1016/j.clgc.2015.11.008

2015

Eggener, SE, Clark, MA, Shikanov, S, Smith, B, Kaag, MG, Russo, P, Wheat, JC, Wolf, JS, Matin, SF, Huang, WC, Harel, M, Cambio, J, Shalhav, AL & Raman, J 2015, 'Impact of warm versus cold ischemia on renal function following partial nephrectomy', World Journal of Urology, vol. 33, no. 3, pp. 351-357. https://doi.org/10.1007/s00345-014-1315-4
Warrick, J, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Degraff, D & Chen, G 2015, 'Squamous Dysplasia of the Urinary Bladder', International Journal of Surgical Pathology, vol. 24, no. 4, pp. 306-314. https://doi.org/10.1177/1066896916629783
Apolo, AB, Hoffman, V, Kaag, MG, Latini, DM, Lee, CT, Rosenberg, JE, Knowles, M, Theodorescu, D, Czerniak, BA, Efstathiou, JA, Albert, ML, Sridhar, SS, Margulis, V, Matin, SF, Galsky, MD, Hansel, D, Kamat, AM, Flaig, TW, Smith, AB, Messing, E, Zipursky Quale, D & Lotan, Y 2015, 'Summary of the 8th Annual Bladder Cancer Think Tank: Collaborating to move research forward', Urologic Oncology: Seminars and Original Investigations, vol. 33, no. 2, pp. 53-64. https://doi.org/10.1016/j.urolonc.2014.06.013
Wang, W, Cheng, J, Mallon, C, Al-Marrawi, MY, Holder, S, Joshi, M, Kaag, MG, Talamo, G & Drabick, J 2015, 'Symptomatic secondary polycythemia induced by anti-VEGF therapy for the treatment of metastatic renal cell carcinoma: A case series and review' Clinical Genitourinary Cancer, vol. 13, no. 6, pp. e391-e395. https://doi.org/10.1016/j.clgc.2015.07.003
Lipkin, JS, Rizvi, SM, Gatalica, Z, Sarwani, N, Holder, S, Kaag, MG, Drabick, J & Joshi, M 2015, 'Therapeutic approach guided by genetic alteration: use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression', Cancer biology & therapy, vol. 16, no. 1, pp. 28-33. https://doi.org/10.4161/15384047.2014.972843

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