Matthew G. Kaag, MD - Penn State Cancer Institute
Researcher Profile
Matthew G. Kaag, MD
Associate Professor, Department of Urology
Associate Professor, Department of Surgery
Associate Professor, Department of Surgery
Scientific Program:Cancer Control
Disease Teams:
Cancer Institute, Genitourinary Cancer Team
Research Interests
- Neoplasms
- Urinary Bladder Neoplasms
- Carcinoma
- Kidney
- Nephrectomy
- Therapeutics
- Renal Cell Carcinoma
- Drug Therapy
- Survival
- Nephroureterectomy
- Recurrence
- Cystectomy
Clinical Trials
Angelica Herbal Supplement AGN-CognI.Q Acute Dose Safety and Pharmacokinetics (PK) Dose-Response in Prostate Cancer Patients (PK Dose Trial)
Phase III Randomized Trial of Stereotactic ablative radiotherapy (SAbR) for Oligometastatic Advanced Renal Carcinoma (SOAR)
A Phase III Randomized, Open-Label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab in Combination With Tremelimumab and Enfortumab Vedotin or Durvalumab in Combination With Enfortumab Vedotin for Perioperative Treatment in Patients Ineligible for Cisplatin Undergoing Radical Cystectomy for Muscle Invasive Bladder Cancer (VOLGA)
A Phase 1, Open-label, Dose-escalation Study to Investigate the Safety, Tolerability, and Pharmacokinetics of UGN-301 (zalifrelimab) Administered Intravesically as Monotherapy and in Combination with Other Agents in Patients with Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens
A Randomized Phase III Trial of Intravesical BCG veRsus Intravesical Docetaxel and GEmcitabine Treatment in BCG Naïve High Grade Non-Muscle Invasive Bladder Cancer (BRIDGE) EA8212
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
A Phase II/III trial of Durvalumab and Chemotherapy for Patients with High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy EA8192
Complications in Patients Undergoing Radical Cystectomy for Bladder Cancer
Recent Publications
2024
Segel, JE, Wong, WG, Kaag, M, Joshi, M, Warrick, J, Lengerich, EJ & Shen, C 2024, 'Relationship Between Availability of Urologists and Primary Care Providers and Stage of Diagnosis for Invasive Urinary Bladder Cancer', Urology Practice, vol. 11, no. 2, pp. 339-346. https://doi.org/10.1097/UPJ.0000000000000503
2023
Joshi, M, Tuanquin, L, Zhu, J, Walter, V, Schell, T, Kaag, M, Kilari, D, Liao, J, Holder, SL, Emamekhoo, H, Sankin, A, Merrill, S, Zheng, H, Warrick, J, Hauke, R, Gartrel, B, Stein, M, Drabick, J, Degraff, DJ & Zakharia, Y 2023, 'Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: Results from phase II study, BTCRC-GU15-023', Journal for ImmunoTherapy of Cancer, vol. 11, no. 2, e006551. https://doi.org/10.1136/jitc-2022-006551
Fuletra, J, Rjepaj, C, Clark, JY, Knoedler, JJ, MacDonald, SM, Kaag, MG, Merrill, SB & Raman, JD 2023, 'Significant Bleeding Complications Following Transrectal Prostate Needle Biopsy: Incidence, Predictors, and Management', Urology Practice, vol. 10, no. 1, pp. 6-8. https://doi.org/10.1097/UPJ.0000000000000349
2022
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation (Nature Communications, (2022), 13, 1, (6575), 10.1038/s41467-022-34251-3)', Nature communications, vol. 13, no. 1, 7920. https://doi.org/10.1038/s41467-022-35644-0
Loloi, J, Eccles, JM, Owens, G, Lehman, E, Kaag, MG, Raman, JD & Merrill, SB 2022, 'Diagnostic Imaging in Low-Risk Prostate Cancer: More Harm Than Good?', Urology Practice, vol. 9, no. 2, pp. 135-139. https://doi.org/10.1097/UPJ.0000000000000288
Warrick, JI, Hu, W, Yamashita, H, Walter, V, Shuman, L, Craig, JM, Gellert, LL, Castro, MAA, Robertson, AG, Kuo, F, Ostrovnaya, I, Sarungbam, J, Chen, YB, Gopalan, A, Sirintrapun, SJ, Fine, SW, Tickoo, SK, Kim, K, Thomas, J, Karan, N, Gao, SP, Clinton, TN, Lenis, AT, Chan, TA, Chen, Z, Rao, M, Hollman, TJ, Li, Y, Socci, ND, Chavan, S, Viale, A, Mohibullah, N, Bochner, BH, Pietzak, EJ, Teo, MY, Iyer, G, Rosenberg, JE, Bajorin, DF, Kaag, M, Merrill, SB, Joshi, M, Adam, R, Taylor, JA, Clark, PE, Raman, JD, Reuter, VE, Chen, Y, Funt, SA, Solit, DB, DeGraff, DJ & Al-Ahmadie, HA 2022, 'FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation', Nature communications, vol. 13, no. 1, 6575. https://doi.org/10.1038/s41467-022-34251-3
Hull, BP, Humphrey, MD, Lehman, KK, Kaag, MG, Merrill, SB & Raman, JD 2022, 'Impact of an inpatient advanced practice provider on hospital length of stay after major urologic oncology procedures', Urologic Oncology: Seminars and Original Investigations, vol. 40, no. 9, pp. 411.e19-411.e25. https://doi.org/10.1016/j.urolonc.2022.06.020
Strausser, SA, Owens, RG, Vu, T, Kwok, E, Schaefer, EW, Boltz, S, Aminsharifi, A, Kaag, M, Raman, JD & Merrill, SB 2022, 'Patient Perceptions Regarding Routine Oncologic Follow-Up for Urologic Malignancies', Clinical Genitourinary Cancer, vol. 20, no. 3, pp. 298-298.e11. https://doi.org/10.1016/j.clgc.2022.01.014
2021
Grant Owens, R, Loloi, J, Lehman, EB, Kaag, MG, Raman, JD & Merrill, SB 2021, 'Is pelvic MRI imaging sufficient cross-sectional imaging for staging intermediate and high-risk prostate cancer?', Urologic Oncology: Seminars and Original Investigations, vol. 39, no. 7, pp. 433.e9-433.e15. https://doi.org/10.1016/j.urolonc.2021.01.029
Ramedani, S, Clark, JY, Knoedler, JJ, MacDonald, S, Kaag, MG, Merrill, SB & Raman, JD 2021, 'Topical antiseptic at time of transrectal ultrasound prostate biopsy is associated with fewer severe clinical infections and improves antibiotic stewardship', Prostate International, vol. 9, no. 4, pp. 185-189. https://doi.org/10.1016/j.prnil.2021.05.003
2020
Fuletra, JG, Watts, A, Kaag, MG, Lehman, E, Raman, JD & Merrill, SB 2020, 'Can preoperative imaging characteristics predict pT3 bladder cancer following cystectomy?', World Journal of Urology. https://doi.org/10.1007/s00345-020-03375-w
Lee, CT, Mohamed, NE, Pisipati, S, Shah, QN, Agarwal, PK, Downs, TM, Droller, M, Gilbert, SM, Goltz, HH, Hall, SJ, Hendawi, M, Hoffman-Censits, J, O'Donnell, M, Kaag, M, Karsh, LI, Kassouf, W, Quale, DZ, Sagalowsky, A, Steinberg, GD & Latini, DM 2020, 'Development and evaluation of a bladder Cancer specific survivorship care plan by patients and clinical care providers: A multi-methods approach', BMC health services research, vol. 20, no. 1, 686. https://doi.org/10.1186/s12913-020-05533-7
Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Durant, AM, Lehman, E, Robyak, H, Merrill, SB, Kaag, MG & Raman, JD 2020, 'Hemostatic agent use during partial nephrectomy: trends, outcomes, and associated costs', International Urology and Nephrology, vol. 52, no. 11, pp. 2073-2078. https://doi.org/10.1007/s11255-020-02538-3
Loloi, J, Allen, JL, Schilling, A, Hollenbeak, C, Merrill, SB, Kaag, MG & Raman, JD 2020, 'In the World of Bladder Tumors: Size Does Matter', Bladder Cancer, vol. 6, no. 2, pp. 195-200. https://doi.org/10.3233/BLC-200273
Badalato, GM, Kaag, M, Lee, R, Vora, A & Burnett, A 2020, 'Role of Telemedicine in Urology: Contemporary Practice Patterns and Future Directions', Urology Practice, vol. 7, no. 2, pp. 122-126. https://doi.org/10.1097/UPJ.0000000000000094
Kaag, MG 2020, 'Tract urothelial cancers', Translational Andrology and Urology, vol. 9, no. 4, pp. 1881-1890. https://doi.org/10.21037/tau.2020.03.48