Researcher Profile

Researcher Profile

Matthew G. Kaag, MD

Matthew G. Kaag, MD

Associate Professor, Department of Surgery
Division of Urology
Scientific Program:Cancer Control
Disease Teams:
Genitourinary Cancer
mgk112@psu.edu

Research Interests

  • Neoplasms
  • Urinary Bladder Neoplasms
  • Carcinoma
  • Kidney
  • Nephrectomy
  • Therapeutics
  • Renal Cell Carcinoma
  • Drug Therapy
  • Nephroureterectomy
  • Survival
  • Cystectomy
  • Recurrence

Clinical Trials

A Phase III Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)
APG-115 - A Phase Ib/II Study of APG-115 in Combination with Pembrolizumab in Patients with Unresectable or Metastatic Melanomas or Advanced Solid Tumors
A Phase 2b, Single- Arm, Multicenter Trial to Evaluate the Effficacy and Safety of UGN-102 as Primary Chemoablative Therapy in Patients with Low Grade (LG) Non-Muscle- Invasive Bladder Cancer (NMIBC) at Intermediate Risk of Recurrance
Phase III Randomized Trial Of Concurrent Chemoradiotherapy With or Without Atezoluzumab in Localized Muscle Invasive Bladder Cancer
Phase 2 Study of Bladder-SparIng ChemoradiatioN with CIPosItive bladdeR cancEr (INSPIRE)EA8185
NRG-GU005 Phase III IGRT and SBRT VS IGRT and hypofractionated IMRT for localized intermediate risk prostate cancer
A study of enfortumab vedotin (ASG-22CE) as monotherapy or in combination with other anticancer therapies for the treatment of urothelial cancer
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
Enhancing Patient Resilience During Multimodal Therapy for Bladder Cancer
Creation of a Clinical and Pathologic Tissue Microarray Registry for Radical Cystectomy Specimens
Complications in Patients Undergoing Radical Cystectomy for Bladder Cancer
Observational Study to Determine the Differences in Molecular Characterization between Smokers vs. Non-smokers in Patients with Stage IV Bladder Cancer and their Correlation with Clinical Outcome

Recent Publications

2021

Grant Owens, R, Loloi, J, Lehman, EB, Kaag, MG, Raman, JD & Merrill, SB 2021, 'Is pelvic MRI imaging sufficient cross-sectional imaging for staging intermediate and high-risk prostate cancer?', Urologic Oncology: Seminars and Original Investigations. https://doi.org/10.1016/j.urolonc.2021.01.029

2020

Fuletra, JG, Watts, A, Kaag, MG, Lehman, E, Raman, JD & Merrill, SB 2020, 'Can preoperative imaging characteristics predict pT3 bladder cancer following cystectomy?', World Journal of Urology. https://doi.org/10.1007/s00345-020-03375-w
Lee, CT, Mohamed, NE, Pisipati, S, Shah, QN, Agarwal, PK, Downs, TM, Droller, M, Gilbert, SM, Goltz, HH, Hall, SJ, Hendawi, M, Hoffman-Censits, J, O'Donnell, M, Kaag, M, Karsh, LI, Kassouf, W, Quale, DZ, Sagalowsky, A, Steinberg, GD & Latini, DM 2020, 'Development and evaluation of a bladder Cancer specific survivorship care plan by patients and clinical care providers: A multi-methods approach', BMC health services research, vol. 20, no. 1, 686. https://doi.org/10.1186/s12913-020-05533-7
Li, H, Zhang, Q, Shuman, L, Kaag, M, Raman, JD, Merrill, S, DeGraff, DJ, Warrick, JI & Chen, G 2020, 'Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes', Scientific reports, vol. 10, no. 1, 1439. https://doi.org/10.1038/s41598-020-58351-6
Durant, AM, Lehman, E, Robyak, H, Merrill, SB, Kaag, MG & Raman, JD 2020, 'Hemostatic agent use during partial nephrectomy: trends, outcomes, and associated costs', International Urology and Nephrology, vol. 52, no. 11, pp. 2073-2078. https://doi.org/10.1007/s11255-020-02538-3
Loloi, J, Allen, JL, Schilling, A, Hollenbeak, C, Merrill, SB, Kaag, MG & Raman, JD 2020, 'In the World of Bladder Tumors: Size Does Matter', Bladder Cancer, vol. 6, no. 2, pp. 195-200. https://doi.org/10.3233/BLC-200273
Kaag, MG 2020, 'Tract urothelial cancers', Translational Andrology and Urology, vol. 9, no. 4, pp. 1881-1890. https://doi.org/10.21037/tau.2020.03.48

2019

Buckwalter, JM, Chan, W, Shuman, L, Wildermuth, T, Ellis-Mohl, J, Walter, V, Warrick, JI, Wu, XR, Kaag, M, Raman, JD & Degraff, DJ 2019, 'Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems', International journal of molecular sciences, vol. 20, no. 10, 2599. https://doi.org/10.3390/ijms20102599
Kaag, MG 2019, 'Editorial Comment', Journal of Urology, vol. 202, no. 1, pp. 82. https://doi.org/10.1097/01.JU.0000557734.15067.14
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Bodo, S, Campagne, C, Thin, TH, Higginson, DS, Vargas, HA, Hua, G, Fuller, JD, Ackerstaff, E, Russell, J, Zhang, Z, Klingler, S, Cho, HJ, Kaag, MG, Mazaheri, Y, Rimner, A, Manova-Todorova, K, Epel, B, Zatcky, J, Cleary, CR, Rao, SS, Yamada, Y, Zelefsky, MJ, Halpern, HJ, Koutcher, JA, Cordon-Cardo, C, Greco, C, Haimovitz-Friedman, A, Sala, E, Powell, SN, Kolesnick, R & Fuks, Z 2019, 'Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury', Journal of Clinical Investigation, vol. 129, no. 2, pp. 786-801. https://doi.org/10.1172/JCI97631

2018

Merrill, SB, Sohl, BS, Hamirani, A, Lehman, EB, Lehman, KK, Kaag, MG & Raman, JD 2019, 'Capturing Renal Cell Carcinoma Recurrences When Asymptomatic Improves Patient Survival', Clinical Genitourinary Cancer, vol. 17, no. 2, pp. 132-138. https://doi.org/10.1016/j.clgc.2018.11.009
Blair, BM, Robyak, H, Clark, JY, Kaag, MG, Lehman, EB & Raman, JD 2018, 'Impact of United States Preventive Services Task Force recommendations on prostate biopsy characteristics and disease presentation at a tertiary-care medical center', Prostate International, vol. 6, no. 3, pp. 110-114. https://doi.org/10.1016/j.prnil.2018.03.001
Warrick, JI, Sjödahl, G, Kaag, M, Raman, JD, Merrill, S, Shuman, L, Chen, G, Walter, V & DeGraff, DJ 2019, 'Intratumoral Heterogeneity of Bladder Cancer by Molecular Subtypes and Histologic Variants [Figure presented]', European Urology, vol. 75, no. 1, pp. 18-22. https://doi.org/10.1016/j.eururo.2018.09.003
Blair, BM, Lehman, EB, Jafri, SM, Kaag, MG & Raman, J 2018, 'Predicted versus observed 30-day perioperative outcomes using the ACS NSQIP surgical risk calculator in patients undergoing partial nephrectomy for renal cell carcinoma', International Urology and Nephrology, vol. 50, no. 7, pp. 1249-1256. https://doi.org/10.1007/s11255-018-1898-6
Kaag, MG & Raman, JD 2018, 'Sarcopenia is a reliable predictor of outcomes following radical cystectomy for bladder cancer', Translational Andrology and Urology, vol. 7, pp. S732-S734. https://doi.org/10.21037/tau.2018.09.03
Park, R, Gyorfi, J, Dewan, K, Kirimanjeswara, G, Clark, JY, Kaag, MG, Lehman, K & Raman, JD 2018, 'Topical rectal antiseptic at time of prostate biopsy: how a resident patient safety project has evolved into institutional practice', International Urology and Nephrology, vol. 50, no. 9, pp. 1563-1568. https://doi.org/10.1007/s11255-018-1937-3

2017

Shah, TS, Kaag, MG, Raman, J, Chan, W, Tran, T, Kunchala, S, Shuman, L, Degraff, D, Chen, G & Warrick, J 2017, 'Clinical significance of prominent retraction clefts in invasive urothelial carcinoma', Human Pathology, vol. 61, pp. 90-96. https://doi.org/10.1016/j.humpath.2016.10.021
Harshman, LC, Tripathi, A, Kaag, M, Efstathiou, JA, Apolo, AB, Hoffman-Censits, JH, Stadler, WM, Yu, EY, Bochner, BH, Skinner, EC, Downs, T, Kiltie, AE, Bajorin, DF, Guru, K, Shipley, WU, Steinberg, GD, Hahn, NM & Sridhar, SS 2018, 'Contemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer', Clinical Genitourinary Cancer, vol. 16, no. 3, pp. 213-218. https://doi.org/10.1016/j.clgc.2017.11.004
Warrick, JI, Kaag, M, Raman, JD, Chan, W, Tran, T, Kunchala, S, Shuman, L, DeGraff, D & Chen, G 2017, 'FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma', Virchows Archiv, vol. 471, no. 3, pp. 337-345. https://doi.org/10.1007/s00428-017-2190-3

Clinical Trials Search


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Adults (age >= 18 years)