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Researcher Profile

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Lorraine C. Santy, PhD

Lorraine C. Santy, PhD

Associate Professor, Biochemistry & Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Proteins
  • cytohesin-2
  • GTP Phosphohydrolases
  • Cell Movement
  • Guanine Nucleotide Exchange Factors
  • Epithelial Cells
  • Recycling
  • Membranes
  • Hepatocyte Growth Factor
  • ADP-Ribosylation Factors
  • Cell Membrane
  • Integrins

Recent Publications


Koubek, EJ & Santy, LC 2022, 'Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement', Cells, vol. 11, no. 22, 3565.


Zhang, Y, Shi, X, Zhao, T, Huang, C, Wei, Q, Tang, X, Santy, LC, Saif, MTA & Zhang, S 2019, 'A traction force threshold signifies metastatic phenotypic change in multicellular epithelia', Soft matter, vol. 15, no. 36, pp. 7203-7210.
Sztul, E, Chen, PW, Casanova, JE, Cherfils, J, Dacks, JB, Lambright, DG, Lee, FJS, Randazzo, PA, Santy, LC, Schürmann, A, Wilhelmi, I, Yohe, ME & Kahn, RA 2019, 'Arf GTPases and their GEFs and GAPS: Concepts and challenges', Molecular biology of the cell, vol. 30, no. 11, pp. 1249-1271.