Researcher Profile
Researcher Profile
Lorraine C. Santy, PhD
Associate Professor, Biochemistry & Molecular Biology
Scientific Program:Experimental Therapeutics
Research Interests
- Proteins
- cytohesin-2
- GTP Phosphohydrolases
- Cell Movement
- Guanine Nucleotide Exchange Factors
- Epithelial Cells
- Recycling
- Membranes
- Hepatocyte Growth Factor
- Insulin
- ADP-Ribosylation Factors
- Cell Membrane
Recent Publications
2019
Zhang, Y, Shi, X, Zhao, T, Huang, C, Wei, Q, Tang, X, Santy, LC, Saif, MTA & Zhang, S 2019, 'A traction force threshold signifies metastatic phenotypic change in multicellular epithelia', Soft Matter, vol. 15, no. 36, pp. 7203-7210. https://doi.org/10.1039/c9sm00733d
Sztul, E, Chen, PW, Casanova, JE, Cherfils, J, Dacks, JB, Lambright, DG, Lee, FJS, Randazzo, PA, Santy, LC, Schürmann, A, Wilhelmi, I, Yohe, ME & Kahn, RA 2019, 'Arf GTPases and their GEFs and GAPS: Concepts and challenges', Molecular biology of the cell, vol. 30, no. 11, pp. 1249-1271. https://doi.org/10.1091/mbc.E18-12-0820
2016
Koubek, EJ & Santy, LC 2018, 'ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation', Small GTPases, vol. 9, no. 3, pp. 242-259. https://doi.org/10.1080/21541248.2016.1219186
2015
Salem, JC, Reviriego-Mendoza, MM & Santy, LC 2015, 'ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment', Molecular biology of the cell, vol. 26, no. 23, pp. 4265-4279. https://doi.org/10.1091/mbc.E15-05-0278
Reviriego-Mendoza, MM & Santy, LC 2015, 'The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice', Physiological reports, vol. 3, no. 6, e12442. https://doi.org/10.14814/phy2.12442