Researcher Profile

Researcher Profile

Lorraine C. Santy, PhD

Lorraine C. Santy, PhD

Associate Professor, Biochemistry & Molecular Biology
Scientific Program:Experimental Therapeutics

Research Interests

  • Proteins
  • cytohesin-2
  • GTP Phosphohydrolases
  • Cell Movement
  • Guanine Nucleotide Exchange Factors
  • Epithelial Cells
  • Recycling
  • Membranes
  • Hepatocyte Growth Factor
  • Insulin
  • ADP-Ribosylation Factors
  • Cell Membrane

Recent Publications


Zhang, Y, Shi, X, Zhao, T, Huang, C, Wei, Q, Tang, X, Santy, LC, Saif, MTA & Zhang, S 2019, 'A traction force threshold signifies metastatic phenotypic change in multicellular epithelia', Soft Matter, vol. 15, no. 36, pp. 7203-7210.
Sztul, E, Chen, PW, Casanova, JE, Cherfils, J, Dacks, JB, Lambright, DG, Lee, FJS, Randazzo, PA, Santy, LC, Sch├╝rmann, A, Wilhelmi, I, Yohe, ME & Kahn, RA 2019, 'Arf GTPases and their GEFs and GAPS: Concepts and challenges', Molecular biology of the cell, vol. 30, no. 11, pp. 1249-1271.


Koubek, EJ & Santy, LC 2018, 'ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation', Small GTPases, vol. 9, no. 3, pp. 242-259.


Salem, JC, Reviriego-Mendoza, MM & Santy, LC 2015, 'ARF-GEF cytohesin-2/ARNO regulates R-Ras and ╬▒5-integrin recycling through an EHD1-positive compartment', Molecular biology of the cell, vol. 26, no. 23, pp. 4265-4279.
Reviriego-Mendoza, MM & Santy, LC 2015, 'The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice', Physiological reports, vol. 3, no. 6, e12442.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)