Kun-Ming Chen, PhD, MS - Penn State Cancer Institute
Researcher Profile
Kun-Ming Chen, PhD, MS
Associate Professor, Department of Molecular and Precision Medicine
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Li, Y, Li, Z, Li, Q, Sun, D, Ni, B, Tan, M, Shay, AE, Wang, M, Meng, C, Shen, G, Fu, B, Shan, Y, Zhang, S, Tanshee, RR, Zhou, T, Xie, Y, Chen, KM, Qiao, B, Dang, Y, Kimball, SR, Zhang, G, Rajacharya, GH, Singh, PK, Wang, X, Hao, J & Yang, S 2026, 'Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma', Nature communications, vol. 17, no. 1, 1343. https://doi.org/10.1038/s41467-025-68099-0
Chen, KM, Krebs, NM, Sun, YW, Sun, D, Liao, J, Reinhart, L, Mallery, SR & El-Bayoumy, K 2026, 'The effects of black raspberry lozenges on 4-hydroxy-1-(3-pyridyl)-1-butanone-releasing DNA adducts in buccal cells and urinary levels of N′-nitrosonornicotine and its glucuronide in active smokers', Carcinogenesis, vol. 47, no. 2. https://doi.org/10.1093/carcin/bgag019
2025
Zhao, J, Sun, YW, Chen, KM, Aliaga, C, Bisanz, JE & El-Bayoumy, K 2025, 'Black Raspberry Modulates Cecal and Oral Microbiomes at the Early Stage of a Dibenzo[def,p]chrysene-Induced Murine Oral Cancer Model', Cancer Prevention Research, vol. 18, no. 1, pp. 11-21. https://doi.org/10.1158/1940-6207.CAPR-24-0347
El-Bayoumy, K, Christensen, N, Broach, J, Meyers, C, Stairs, D, Machtay, M, Hu, J, Bitzer, ZT, Schell, TD, Chen, K-M, Sun, Y-W, Desai, D, Walter, V & Zhu, J 2025, 'Current challenges and potential opportunities for interception and prevention of head and neck cancer', Carcinogenesis, vol. 46, no. 2, bgaf025. https://doi.org/10.1093/carcin/bgaf025
Chen, KM, Krebs, NM, Sun, YW, Sun, D, Liao, J, Reinhart, L, Krzeminski, J, Amin, S, Stoner, G, Mallery, SR & El-Bayoumy, K 2025, 'Inhibition of benzo[a]pyrene-induced DNA adduct in buccal cells of smokers by black raspberry lozenges', Carcinogenesis, vol. 46, no. 1, bgae067. https://doi.org/10.1093/carcin/bgae067
Schell, TD, Bitzer, ZT, Chen, KM, Aliaga, C, Sun, YW, Desai, D, Lanza, M, Hu, J, Christensen, N & El-Bayoumy, K 2025, 'The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity', Chemico-Biological Interactions, vol. 420, 111694. https://doi.org/10.1016/j.cbi.2025.111694
2024
Sun, YW, Chen, KM, Aliaga, C & El-Bayoumy, K 2024, 'Metabolic reprogramming in saliva of mice treated with the environmental and tobacco carcinogen dibenzo[def, p]chrysene', Scientific reports, vol. 14, no. 1, 29517. https://doi.org/10.1038/s41598-024-80921-1
Chen, KM, Sun, YW, Krebs, NM, Reinhart, L, Sun, D, Liao, J, Cook, R, Bond, PE, Mallery, SR & El-Bayoumy, K 2024, 'The Effects of Black Raspberry as a Whole Food–Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers', Cancer Prevention Research, vol. 17, no. 4, pp. 157-167. https://doi.org/10.1158/1940-6207.CAPR-23-0153
2023
Manni, A, Sun, YW, Schell, TD, Lutsiv, T, Thompson, H, Chen, KM, Aliaga, C, Zhu, J & El-Bayoumy, K 2023, 'Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model', Pharmaceuticals, vol. 16, no. 10, 1422. https://doi.org/10.3390/ph16101422
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega. https://doi.org/10.1021/acsomega.3c09611
2022
Chen, KM, Sun, YW, Sun, D, Gowda, K, Amin, S & El-Bayoumy, K 2022, 'Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells', Chemical research in toxicology, vol. 35, no. 11, pp. 2152-2159. https://doi.org/10.1021/acs.chemrestox.2c00246
Chen, KM, Sun, YW, Krebs, NM, Sun, D, Krzeminski, J, Reinhart, L, Gowda, K, Amin, S, Mallery, S, Richie, JP & El-Bayoumy, K 2022, 'Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells', Carcinogenesis, vol. 43, no. 8, pp. 746-753. https://doi.org/10.1093/carcin/bgac058
Sales, AH, Kolbanovskiy, M, Geacintov, NE, Chen, KM, Sun, YW & El-Bayoumy, K 2022, 'Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism', Antioxidants, vol. 11, no. 11, 2110. https://doi.org/10.3390/antiox11112110