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Kun-Ming Chen, PhD, MS

Kun-Ming Chen, PhD, MS

Associate Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • dibenzo(a,l)pyrene
  • Tobacco
  • Carcinogens
  • Neoplasms
  • DNA Damage
  • Rubus
  • Carcinogenesis
  • Mouth
  • Smoke
  • DNA Adducts
  • Proteins
  • Environmental Pollutants

Recent Publications


Chen, KM, Sun, YW, Krebs, NM, Reinhart, L, Sun, D, Liao, J, Cook, R, Bond, PE, Mallery, SR & El-Bayoumy, K 2024, 'The Effects of Black Raspberry as a Whole Food–Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers', Cancer Prevention Research, vol. 17, no. 4, pp. 157-167.


Manni, A, Sun, YW, Schell, TD, Lutsiv, T, Thompson, H, Chen, KM, Aliaga, C, Zhu, J & El-Bayoumy, K 2023, 'Complementarity between Microbiome and Immunity May Account for the Potentiating Effect of Quercetin on the Antitumor Action of Cyclophosphamide in a Triple-Negative Breast Cancer Model', Pharmaceuticals, vol. 16, no. 10, 1422.
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega.


Chen, KM, Sun, YW, Sun, D, Gowda, K, Amin, S & El-Bayoumy, K 2022, 'Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells', Chemical research in toxicology, vol. 35, no. 11, pp. 2152-2159.
Chen, KM, Sun, YW, Krebs, NM, Sun, D, Krzeminski, J, Reinhart, L, Gowda, K, Amin, S, Mallery, S, Richie, JP & El-Bayoumy, K 2022, 'Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells', Carcinogenesis, vol. 43, no. 8, pp. 746-753.
Sales, AH, Kolbanovskiy, M, Geacintov, NE, Chen, KM, Sun, YW & El-Bayoumy, K 2022, 'Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism', Antioxidants, vol. 11, no. 11, 2110.


Stairs, DB, Landmesser, ME, Aliaga, C, Chen, KM, Sun, YW & El-Bayoumy, K 2021, 'Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l] pyrene diol epoxide', PloS one, vol. 16, no. 11 November, e0259998.
Sun, YW, Chen, KM, Atkins, H, Aliaga, C, Gordon, T, Guttenplan, JB & El-Bayoumy, K 2021, 'Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice', Chemical research in toxicology, vol. 34, no. 4, pp. 1161-1168.
Chen, KM, Thompson, H, Vanden-Heuvel, JP, Sun, YW, Trushin, N, Aliaga, C, Gowda, K, Amin, S, Stanley, B, Manni, A & El-Bayoumy, K 2021, 'Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer', Scientific reports, vol. 11, no. 1, 410.


El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660.
Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365.
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321.