Researcher Profile

Researcher Profile

Kun-Ming Chen, PhD, MS

Kun-Ming Chen, PhD, MS

Associate Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
kzc3@psu.edu

Research Interests

  • dibenzo(a,l)pyrene
  • Tobacco
  • Neoplasms
  • DNA Damage
  • Carcinogenesis
  • Smoke
  • Carcinogens
  • Mouth
  • Environmental Pollutants
  • Mutagenesis
  • DNA Adducts
  • Tongue

Recent Publications

2021

Sun, YW, Chen, KM, Atkins, H, Aliaga, C, Gordon, T, Guttenplan, JB & El-Bayoumy, K 2021, 'Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice', Chemical research in toxicology, vol. 34, no. 4, pp. 1161-1168. https://doi.org/10.1021/acs.chemrestox.1c00033
Chen, KM, Thompson, H, Vanden-Heuvel, JP, Sun, YW, Trushin, N, Aliaga, C, Gowda, K, Amin, S, Stanley, B, Manni, A & El-Bayoumy, K 2021, 'Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer', Scientific reports, vol. 11, no. 1, 410. https://doi.org/10.1038/s41598-020-79716-x

2020

El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365. https://doi.org/10.1158/1940-6207.CAPR-19-0496
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321

2019

Guttenplan, JB, Chen, KM, Sun, YW, Shalaby, NAE, Kosinska, W, Desai, D, Gowda, K, Amin, S & El-Bayoumy, K 2019, 'Effects of the Tobacco Carcinogens N′-Nitrosonornicotine and Dibenzo[ a, l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue', Chemical research in toxicology, vol. 32, no. 9, pp. 1893-1899. https://doi.org/10.1021/acs.chemrestox.9b00257

2018

Chen, KM, Sun, YW, Cooper, TK, Benitez, G, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2018, 'Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary', Chemical research in toxicology, vol. 31, no. 11, pp. 1111-1118. https://doi.org/10.1021/acs.chemrestox.8b00152
Chen, KM, Guttenplan, JB, Sun, YW, Cooper, T, Shalaby, NAE, Kosinska, W, Benitez, G, Aliaga, C, Zhu, J, Liao, J, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2018, 'Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity', Cancer Prevention Research, vol. 11, no. 3, pp. 157-164. https://doi.org/10.1158/1940-6207.CAPR-17-0278

2017

El-Bayoumy, K, Chen, KM, Zhang, SM, Sun, YW, Amin, S, Stoner, G & Guttenplan, JB 2017, 'Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry', Chemical research in toxicology, vol. 30, no. 1, pp. 126-144. https://doi.org/10.1021/acs.chemrestox.6b00306
Guttenplan, JB, Chen, KM, Sun, YW, Lajara, B, Shalaby, NAE, Kosinska, W, Benitez, G, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2017, 'Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts', Chemical research in toxicology, vol. 30, no. 12, pp. 2159-2164. https://doi.org/10.1021/acs.chemrestox.7b00242
Chen, KM, Schell, TD, Richie, JP, Sun, YW, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Sun, YW, Chen, KM, Kawasawa, YI, Salzberg, AC, Cooper, TK, Caruso, C, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene', PloS one, vol. 12, no. 10, e0186873. https://doi.org/10.1371/journal.pone.0186873

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)