Krishne Gowda, PhD - Penn State Cancer Institute
Researcher Profile
Krishne Gowda, PhD
Associate Professor, Department of Pharmacology
Assistant Professor, Department of Pharmacology
Assistant Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Gowda, K, Raza, A, Vangala, V, Lone, NA, Lin, JM, Singh, JK, Srivastava, SK, Schell, TD, Robertson, GP, Amin, S & Sharma, AK 2024, 'Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor', Molecules, vol. 29, no. 13, 3114. https://doi.org/10.3390/molecules29133114
Johnson, H, Singh, A, Raza, A, Sha, CM, Wang, J, Gowda, K, Shen, Z, Nair, H, Li, C, Dokholyan, NV, Narayan, S & Sharma, AK 2024, 'Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer', Journal of Medicinal Chemistry, vol. 67, no. 20, pp. 18070-18089. https://doi.org/10.1021/acs.jmedchem.4c01077
Al-Odat, OS, Elbezanti, WO, Gowda, K, Srivastava, SK, Amin, SG, Jonnalagadda, SC, Budak-Alpdogan, T & Pandey, MK 2024, 'KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis', Frontiers in Pharmacology, vol. 15, 1436786. https://doi.org/10.3389/fphar.2024.1436786
Chen, YC, Gowda, K, Amin, S, Schell, TD, Sharma, AK & Robertson, GP 2024, 'Pharmacological agents targeting drug-tolerant persister cells in cancer', Pharmacological Research, vol. 203, 107163. https://doi.org/10.1016/j.phrs.2024.107163
Vangala, V, Chen, YC, Dinavahi, SS, Gowda, K, Lone, NA, Herlyn, M, Drabick, J, Helm, K, Zhu, J, Neves, RI, Sharma, AK, Berg, A, Archetti, M, Amin, S, Schell, TD & Robertson, GP 2024, 'Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations', ACS Pharmacology and Translational Science, vol. 7, no. 11, pp. 3573-3584. https://doi.org/10.1021/acsptsci.4c00453
2023
Dong, F, Murray, IA, Annalora, A, Coslo, DM, Desai, D, Gowda, K, Yang, J, Wang, D, Koo, I, Hao, F, Amin, SG, Patterson, AD, Marcus, C & Perdew, GH 2023, 'Complex chemical signals dictate Ah receptor activation through the gut-lung axis', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 37, no. 7, pp. e23010. https://doi.org/10.1096/fj.202300703R
Morgan, EW, Dong, F, Annalora, AJ, Murray, IA, Wolfe, T, Erickson, R, Gowda, K, Amin, SG, Petersen, KS, Kris-Etherton, PM, Marcus, CB, Walk, ST, Patterson, AD & Perdew, GH 2023, 'Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation', International Journal of Tryptophan Research, vol. 16. https://doi.org/10.1177/11786469231182510
Chen, K-M, Sun, Y-W, Hu, J, Balogh, K, Gowda, K, Aliaga, C, Sun, D, Christensen, N, Amin, S & El-Bayoumy, K 2023, 'Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity', ACS Omega. https://doi.org/10.1021/acsomega.3c09611
Patel, D, Murray, IA, Dong, F, Annalora, AJ, Gowda, K, Coslo, DM, Krzeminski, J, Koo, I, Hao, F, Amin, SG, Marcus, CB, Patterson, AD & Perdew, GH 2023, 'Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites', Metabolites, vol. 13, no. 9, 985. https://doi.org/10.3390/metabo13090985
Rikken, G, Smith, KJ, van den Brink, NJM, Smits, JPH, Gowda, K, Alnemri, A, Kuzu, GE, Murray, IA, Lin, JM, Smits, JGA, van Vlijmen-Willems, IM, Amin, SG, Perdew, GH & van den Bogaard, EH 2023, 'Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders', Biochemical Pharmacology, vol. 208, 115400. https://doi.org/10.1016/j.bcp.2022.115400
2022
Chen, KM, Sun, YW, Sun, D, Gowda, K, Amin, S & El-Bayoumy, K 2022, 'Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells', Chemical research in toxicology, vol. 35, no. 11, pp. 2152-2159. https://doi.org/10.1021/acs.chemrestox.2c00246
Alden, NA, Arrizabalaga, JH, Liu, Y, Amin, S, Gowda, K, Yao, S, Archetti, M, Glick, AB & Hayes, DJ 2022, 'Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells', Langmuir, vol. 38, no. 32, pp. 9833-9843. https://doi.org/10.1021/acs.langmuir.2c00913
Chen, KM, Sun, YW, Krebs, NM, Sun, D, Krzeminski, J, Reinhart, L, Gowda, K, Amin, S, Mallery, S, Richie, JP & El-Bayoumy, K 2022, 'Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells', Carcinogenesis, vol. 43, no. 8, pp. 746-753. https://doi.org/10.1093/carcin/bgac058
Elbezanti, WO, Al-Odat, OS, Chitren, R, Singh, JK, Srivastava, SK, Gowda, K, Amin, S, Robertson, GP, Nemmara, VV, Jonnalagadda, SC, Budak-Alpdogan, T & Pandey, MK 2022, 'Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells', Frontiers in Pharmacology, vol. 13, 894535. https://doi.org/10.3389/fphar.2022.894535
2021
Chen, KM, Thompson, H, Vanden-Heuvel, JP, Sun, YW, Trushin, N, Aliaga, C, Gowda, K, Amin, S, Stanley, B, Manni, A & El-Bayoumy, K 2021, 'Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer', Scientific reports, vol. 11, no. 1, 410. https://doi.org/10.1038/s41598-020-79716-x
2020
Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365. https://doi.org/10.1158/1940-6207.CAPR-19-0496
Dinavahi, SS, Gowda, R, Bazewicz, CG, Battu, MB, Lin, JM, Chitren, RJ, Pandey, MK, Amin, S, Robertson, GP & Gowda, K 2020, 'Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents', European Journal of Medicinal Chemistry, vol. 187, 111962. https://doi.org/10.1016/j.ejmech.2019.111962
Dinavahi, SS, Gowda, R, Gowda, K, Bazewicz, CG, Chirasani, VR, Battu, MB, Berg, A, Dokholyan, NV, Amin, S & Robertson, GP 2020, 'Development of a Novel Multi-Isoform ALDH Inhibitor Effective as an Antimelanoma Agent', Molecular cancer therapeutics, vol. 19, no. 2, pp. 447-459. https://doi.org/10.1158/1535-7163.MCT-19-0360
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Dong, F, Hao, F, Murray, IA, Smith, PB, Koo, I, Tindall, AM, Kris-Etherton, PM, Gowda, K, Amin, SG, Patterson, AD & Perdew, GH 2020, 'Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity', Gut microbes, vol. 12, no. 1, pp. 1-24. https://doi.org/10.1080/19490976.2020.1788899
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321
Annageldiyev, C, Gowda, K, Patel, T, Bhattacharya, P, Tan, SF, Iyer, S, Desai, D, Dovat, S, Feith, DJ, Loughran, TP, Amin, S, Claxton, D & Sharma, A 2020, 'The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia', Haematologica, vol. 105, no. 3, pp. 687-696. https://doi.org/10.3324/haematol.2018.212886