Researcher Profile

Researcher Profile

Krishne Gowda, PhD

Krishne Gowda, PhD

Assistant Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
kxg21@psu.edu
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Research Interests

Dr. Krishne Gowda's research efforts combine synthetic organic chemistry, biochemical and molecular biological tools in an interdisciplinary approach to designing and synthesis of small molecules that specifically target diseased cells or infectious agents.

The long-term goal of the research is the development of selective strategies for the treatment of cancer and infectious diseases. Topics of current interest include:

  • Development of selective modulators of Aryl hydrocarbon receptor (SAhRM) activity. Recently, the lab developed a molecule SGA360 and analogs as selective modulators of aryl hydrocarbon receptor, which was shown to inhibit a set of inflammatory cytokines. Future studies are needed to test whether SGA360 and analogs would be useful in treating chronic inflammatory diseases.
  • Development of novel therapeutic agents for cancer. Currently, the lab has developed novel isatin derivatives that were demonstrated as aldehyde dehydrogenase (ALDH) inhibitors and suitable candidates for further study for the anticancer activity. The lab developed maritoclax and pyoluteorin derivatives as Mcl-1 inhibitors and is also involved in the synthesis of various carcinogens like polycyclic aromatic hydrocarbons and their metabolites like diols and diol epoxides and tobacco-specific N-nitrosamines, wherein they prepare specific carcinogens and their metabolites for bioassays and the exploration of DNA adducts formation. The lab uses mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer.
  • Plasmodium falciparum
  • Neoplasms
  • Glycosylphosphatidylinositols
  • Aryl Hydrocarbon Receptors
  • Ligands
  • Cytokines
  • Macrophages
  • Therapeutics
  • DNA Damage
  • Apoptosis
  • Parasites
  • Cell Line

Recent Publications

2019

Hubbard, TD, Liu, Q, Murray, IA, Dong, F, Miller, C, Smith, PB, Gowda, K, Lin, JM, Amin, S, Patterson, AD & Perdew, GH 2019, 'Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline' Journal of Proteome Research, vol. 18, no. 4, pp. 1715-1724. https://doi.org/10.1021/acs.jproteome.8b00946

2018

Chen, K-M, Sun, Y-W, Cooper, TK, Benitez, G, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2018, 'Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary' Chemical Research in Toxicology, vol. 31, no. 11, pp. 1111-1118. https://doi.org/10.1021/acs.chemrestox.8b00152
Yang, Y, Lee, SM, Imamura, F, Gowda, K, Amin, S & Mailman, R 2018, 'D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex', Molecular Psychiatry. https://doi.org/10.1038/s41380-018-0312-1
Chen, K-M, Guttenplan, JB, Sun, Y-W, Cooper, T, Shalaby, NAE, Kosinska, W, Benitez, G, Aliaga, C, Zhu, J, Liao, JJ, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2018, 'Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity', Cancer Prevention Research, vol. 11, no. 3, pp. 157-164. https://doi.org/10.1158/1940-6207.CAPR-17-0278

2017

Pandey, MK, Gowda, K, Sung, S, Abraham, T, Budak-Alpdogan, T, Talamo, G, Dovat, S & Amin, S 2017, 'A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis', Experimental Hematology, vol. 53, pp. 31-42. https://doi.org/10.1016/j.exphem.2017.06.003
Smith, KJ, Boyer, JA, Muku, GE, Murray, IA, Gowda, K, Desai, D, Amin, S, Glick, AB & Perdew, GH 2017, 'Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin', Toxicological Sciences, vol. 160, no. 1, pp. 83-94. https://doi.org/10.1093/toxsci/kfx160
Guttenplan, JB, Chen, K-M, Sun, Y-W, Lajara, B, Shalaby, NAE, Kosinska, W, Benitez, G, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2017, 'Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts', Chemical Research in Toxicology, vol. 30, no. 12, pp. 2159-2164. https://doi.org/10.1021/acs.chemrestox.7b00242
Chen, K-M, Schell, T, Richie, J, Sun, Y-W, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Sun, Y-W, Chen, K-M, Imamura, Y, Salzberg, AC, Cooper, TK, Caruso, C, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene', PloS one, vol. 12, no. 10, e0186873. https://doi.org/10.1371/journal.pone.0186873
Muku, GE, Lahoti, TS, Murray, IA, Podolsky, MA, Smith, KJ, Hubbard, TD, Kuzu, G, Gowda, K, Amin, S & Perdew, GH 2017, 'Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses', Laboratory Investigation, vol. 97, no. 12, pp. 1471-1487. https://doi.org/10.1038/labinvest.2017.92

2016

Guttenplan, JB, Chen, K-M, Sun, Y-W, Kosinska, W, Zhou, Y, Kim, SA, Sung, Y, Gowda, K, Amin, S, Stoner, GD & El-Bayoumy, K 2016, 'Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells', Cancer Prevention Research, vol. 9, no. 8, pp. 704-712. https://doi.org/10.1158/1940-6207.CAPR-16-0003

2015

Hubbard, TD, Murray, IA, Bisson, WH, Lahoti, TS, Gowda, K, Amin, S, Patterson, AD & Perdew, GH 2015, 'Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles', Scientific reports, vol. 5, 12689. https://doi.org/10.1038/srep12689
Mohinta, S, Kannan, AK, Gowda, K, Amin, S, Perdew, GH & August, A 2015, 'Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways' Toxicological Sciences, vol. 145, no. 2, pp. 233-243. https://doi.org/10.1093/toxsci/kfv046
Van Den Bogaard, EH, Podolsky, MA, Smits, JP, Cui, X, John, C, Gowda, K, Desai, D, Amin, S, Schalkwijk, J, Perdew, GH & Glick, AB 2015, 'Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation', Journal of Investigative Dermatology, vol. 135, no. 5, pp. 1320-1328. https://doi.org/10.1038/jid.2015.6
Varadarajan, S, Poornima, P, Milani, M, Gowda, K, Amin, S, Wang, H-G & Cohen, GM 2015, 'Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner', Oncotarget, vol. 6, no. 14, pp. 12668-12681. https://doi.org/10.18632/oncotarget.3706
Song, C, Gowda, C, Pan, X, Ding, Y, Tong, Y, Tan, B, Wang, H, Muthusami, S, Ge, Z, Sachdev, M, Amin, S, Desai, D, Gowda, K, Gowda, R, Robertson, G, Schjerven, H, Muschen, M, Payne, KJ & Dovat, S 2015, 'Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia', Blood, vol. 126, no. 15, pp. 1813-1822. https://doi.org/10.1182/blood-2015-06-651505
Sun, Y-W, El-Bayoumy, K, Aliaga, C, Awad, A, Gowda, K, Amin, S & Chen, K-M 2015, 'Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice' Chemical Research in Toxicology, vol. 28, no. 7, pp. 1427-1433. https://doi.org/10.1021/acs.chemrestox.5b00097

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