Researcher Profile

Researcher Profile

Kumble Sandeep Prabhu, PhD

Kumble Sandeep Prabhu, PhD

Department Head and Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Selenium
  • Macrophages
  • Selenoproteins
  • Inflammation
  • Prostaglandins
  • Lipopolysaccharides
  • Inositol Oxygenase
  • Anti-Inflammatory Agents
  • Up-Regulation
  • Proteins
  • Peroxisome Proliferator-Activated Receptors
  • Enzymes

Recent Publications


Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2021, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology.
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410.


Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246.
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96.


Sumanth, MS, Abhilasha, KV, Jacob, SP, Chaithra, VH, Basrur, V, Willard, B, McIntyre, TM, Prabhu, KS & Marathe, GK 2019, 'Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses', Immunobiology, vol. 224, no. 5, pp. 672-680.
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852.
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40.
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336.
Qian, F, Misra, S & Prabhu, KS 2019, 'Selenium and selenoproteins in prostanoid metabolism and immunity', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, no. 6, pp. 484-516.
Dhanjal, NI, Sharma, S, Skalny, AV, Skalnaya, MG, Ajsuvakova, OP, Tinkov, AA, Zhang, F, Guo, X, Prabhu, KS & Tejo Prakash, N 2019, 'Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages', Food and Function, vol. 10, no. 5, pp. 2839-2846.
Korwar, AM, Shay, AE, Basrur, V, Conlon, K & Prabhu, KS 2019, 'Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 30, no. 7, pp. 1276-1283.
Cheng, WH & Prabhu, KS 2019, 'Special Issue of “Optimal Selenium Status and Selenoproteins in Health”', Biological Trace Element Research, vol. 192, no. 1.
Abhilasha, KV, Sumanth, MS, Chaithra, VH, Jacob, SP, Thyagarajan, A, Sahu, RP, Rajaiah, R, Prabhu, KS, Kemparaju, K, Travers, JB, Chen, CH & Marathe, GK 2019, 'p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice', Free Radical Biology and Medicine, vol. 143, pp. 275-287.


Jaiswal, SK, Prakash, R, Prabhu, KS & Tejo Prakash, N 2018, 'Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells', Food and Function, vol. 9, no. 4, pp. 1998-2004.
Liao, C, Sandeep Prabhu, K & Paulson, RF 2018, 'Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia', Blood, vol. 132, no. 24, pp. 2580-2593.
Nettleford, SK & Prabhu, KS 2018, 'Selenium and selenoproteins in gut inflammation—A review', Antioxidants, vol. 7, no. 3, 36.
Liao, C, Hardison, RC, Kennett, MJ, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis', Blood, vol. 131, no. 23, pp. 2568-2580.
Liao, C, Carlson, BA, Paulson, RF & Prabhu, KS 2018, 'The intricate role of selenium and selenoproteins in erythropoiesis', Free Radical Biology and Medicine, vol. 127, pp. 165-171.


Finch, ER, Tukaramrao, DB, Goodfield, LL, Quickel, MD, Paulson, RF & Prabhu, KS 2017, 'Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia', Blood, vol. 129, no. 13, pp. 1802-1810.
Shay, AE, Diwakar, BT, Guan, BJ, Narayan, V, Urban, JF & Prabhu, KS 2017, 'IL-4 up-regulates cyclooxygenase-1 expression in macrophages', Journal of Biological Chemistry, vol. 292, no. 35, pp. 14544-14555.
Dhanjal, NIK, Sharma, S, Prabhu, KS & Tejo Prakash, N 2017, 'Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages', Food and Agricultural Immunology, vol. 28, no. 6, pp. 1374-1392.
Diwakar, BT, Korwar, AM, Paulson, RF & Prabhu, KS 2017, The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. in Advances in Cancer Research. Advances in Cancer Research, vol. 136, Academic Press Inc., pp. 153-172.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)