Researcher Profile

Researcher Profile

Kumble Sandeep Prabhu, PhD

Kumble Sandeep Prabhu, PhD

Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
ksp4@psu.edu

Research Interests

  • Selenium
  • Macrophages
  • Selenoproteins
  • Inflammation
  • Prostaglandins
  • Inositol Oxygenase
  • Neoplasms
  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Up-Regulation
  • Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications

2019

Sumanth, MS, Abhilasha, KV, Jacob, SP, Chaithra, VH, Basrur, V, Willard, B, McIntyre, TM, Prabhu, KS & Marathe, GK 2019, 'Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses', Immunobiology, vol. 224, no. 5, pp. 672-680. https://doi.org/10.1016/j.imbio.2019.06.003
Kong, Y, Jia, B, Zhao, C, Claxton, D, Sharma, A, Annageldiyev, C, Fotos, J, Zeng, H, Paulson, R, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients' Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Giblin, PH, Prabhu, KS & Paulson, R 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336. https://doi.org/10.1126/scisignal.aap7336
Dhanjal, NI, Sharma, S, Skalny, AV, Skalnaya, MG, Ajsuvakova, OP, Tinkov, AA, Zhang, F, Guo, X, Prabhu, KS & Tejo Prakash, N 2019, 'Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages', Food and Function, vol. 10, no. 5, pp. 2839-2846. https://doi.org/10.1039/c9fo00186g
Korwar, AM, Shay, AE, Basrur, V, Conlon, K & Prabhu, KS 2019, 'Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 30, no. 7, pp. 1276-1283. https://doi.org/10.1007/s13361-019-02192-9
Abhilasha, KV, Sumanth, MS, Chaithra, VH, Jacob, SP, Thyagarajan, A, Sahu, RP, Rajaiah, R, Prabhu, KS, Kemparaju, K, Travers, JB, Chen, CH & Marathe, GK 2019, 'p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice', Free Radical Biology and Medicine, vol. 143, pp. 275-287. https://doi.org/10.1016/j.freeradbiomed.2019.08.019

2018

Jaiswal, SK, Prakash, R, Prabhu, KS & Tejo Prakash, N 2018, 'Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells', Food and Function, vol. 9, no. 4, pp. 1998-2004. https://doi.org/10.1039/c7fo01644a
Liao, C, Prabhu, KS & Paulson, R 2018, 'Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia', Blood, vol. 132, no. 24, pp. 2580-2593. https://doi.org/10.1182/blood-2018-06-856831
Nettleford, SK & Prabhu, KS 2018, 'Selenium and selenoproteins in gut inflammation—A review', Antioxidants, vol. 7, no. 3, 36. https://doi.org/10.3390/antiox7030036
Liao, C, Hardison, RC, Kennett, MJ, Carlson, BA, Paulson, R & Prabhu, KS 2018, 'Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis', Blood, vol. 131, no. 23, pp. 2568-2580. https://doi.org/10.1182/blood-2017-08-800607
Liao, C, Carlson, BA, Paulson, R & Prabhu, KS 2018, 'The intricate role of selenium and selenoproteins in erythropoiesis', Free Radical Biology and Medicine, vol. 127, pp. 165-171. https://doi.org/10.1016/j.freeradbiomed.2018.04.578

2017

Finch, ER, Tukaramrao, DB, Goodfield, LL, Quickel, MD, Paulson, R & Prabhu, KS 2017, 'Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia', Blood, vol. 129, no. 13, pp. 1802-1810. https://doi.org/10.1182/blood-2016-08-736405
Shay, AE, Diwakar, BT, Guan, BJ, Narayan, V, Urban, JF & Prabhu, KS 2017, 'IL-4 up-regulates cyclooxygenase-1 expression in macrophages', Journal of Biological Chemistry, vol. 292, no. 35, pp. 14544-14555. https://doi.org/10.1074/jbc.M117.785014
Dhanjal, NIK, Sharma, S, Prabhu, KS & Tejo Prakash, N 2017, 'Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages', Food and Agricultural Immunology, vol. 28, no. 6, pp. 1374-1392. https://doi.org/10.1080/09540105.2017.1343805
Diwakar, BT, Korwar, AM, Paulson, R & Prabhu, KS 2017, The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium. in Advances in Cancer Research. Advances in Cancer Research, vol. 136, Academic Press Inc., pp. 153-172. https://doi.org/10.1016/bs.acr.2017.07.003

2016

Lakshmikanth, CL, Jacob, SP, Kudva, AK, Latchoumycandane, C, Yashaswini, PSM, Sumanth, MS, Goncalves-De-Albuquerque, CF, Silva, AR, Singh, SA, Castro-Faria-Neto, HC, Prabhu, KS, McIntyre, TM & Marathe, GK 2016, 'Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia - Like pathology in Swiss albino mice', Scientific reports, vol. 6, 34666. https://doi.org/10.1038/srep34666
Prabhu, KS & Lei, XG 2016, 'Selenium', Advances in Nutrition, vol. 7, no. 2, pp. 415-417. https://doi.org/10.3945/an.115.010785
Nelson, SM, Shay, AE, James, JL, Carlson, BA, Urban, JF & Prabhu, KS 2016, 'Selenoprotein expression in macrophages is critical for optimal clearance of parasitic helminth Nippostrongylus brasiliensis', Journal of Biological Chemistry, vol. 291, no. 6, pp. 2787-2798. https://doi.org/10.1074/jbc.M115.684738
Regina, BF, Gladyshev, VN, Arnér, ES, Berry, MJ, Bruford, EA, Burk, RF, Carlson, BA, Castellano, S, Chavatte, L, Conrad, M, Copeland, PR, Diamond, AM, Driscoll, DM, Ferreiro, A, Flohé, L, Green, FR, Guigó, R, Handy, DE, Hatfield, DL, Hesketh, J, Hoffmann, PR, Holmgren, A, Hondal, RJ, Howard, MT, Huang, K, Kim, HY, Kim, IY, Köhrle, J, Krol, A, Kryukov, GV, Lee, BJ, Lee, BC, Lei, XG, Liu, Q, Lescure, A, Lobanov, AV, Loscalzo, J, Maiorino, M, Mariotti, M, Prabhu, KS, Rayman, MP, Rozovsky, S, Salinas, G, Schmidt, EE, Schomburg, L, Schweizer, U, Simonović, M, Sunde, RA, Tsuji, PA, Tweedie, S, Ursini, FF, Whanger, PD & Zhang, Y 2016, 'Selenoprotein gene nomenclature', Journal of Biological Chemistry, vol. 291, no. 46, pp. 24036-24040. https://doi.org/10.1074/jbc.M116.756155
Diwakar, BT, Finch, ER, Liao, C, Shay, AE & Prabhu, KS 2016, The role of selenoproteins in resolution of inflammation. in Selenium: Its Molecular Biology and Role in Human Health, Fourth Edition. Springer International Publishing, pp. 499-510. https://doi.org/10.1007/978-3-319-41283-2_42

2015

Finch, ER, Kudva, AK, Quickel, MD, Goodfield, LL, Kennett, MJ, Whelan, J, Paulson, R & Prabhu, KS 2015, 'Chemopreventive effects of dietary eicosapentaenoic acid supplementation in experimental myeloid leukemia', Cancer Prevention Research, vol. 8, no. 10, pp. 989-999. https://doi.org/10.1158/1940-6207.CAPR-15-0050
Narayan, V, Ravindra, KC, Liao, C, Kaushal, N, Carlson, BA & Prabhu, KS 2015, 'Epigenetic regulation of inflammatory gene expression in macrophages by selenium', Journal of Nutritional Biochemistry, vol. 26, no. 2, pp. 138-145. https://doi.org/10.1016/j.jnutbio.2014.09.009
Narayan, V, Kudva, AK & Prabhu, KS 2015, 'Reduction of Tetrathionate by Mammalian Thioredoxin Reductase' Biochemistry, vol. 54, no. 33, pp. 5121-5124. https://doi.org/10.1021/acs.biochem.5b00620
Kudva, AK, Shay, AE & Prabhu, KS 2015, 'Selenium and inflammatory bowel disease', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 309, no. 2, pp. G71-G77. https://doi.org/10.1152/ajpgi.00379.2014
Prabhu, KS, Kudva, AK & Nelson, SM 2015, Selenium mediates a switch in macrophage polarization. in Diversity of Selenium Functions in Health and Disease. CRC Press, pp. 293-308. https://doi.org/10.1201/b18810

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)