Kumble Sandeep Prabhu, PhD - Penn State Cancer Institute
Researcher Profile
Kumble Sandeep Prabhu, PhD
Department Head and Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Selenium
- Macrophages
- Selenoproteins
- Inflammation
- Prostaglandins
- Lipopolysaccharides
- Inositol Oxygenase
- Anti-Inflammatory Agents
- Up-Regulation
- Leukemia
- Proteins
- Peroxisome Proliferator-Activated Receptors
Recent Publications
2023
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Qian, F, Arner, BE, Nettleford, SK, Paulson, RF & Prabhu, KS 2023, 'Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice', Journal of Visualized Experiments, vol. 2023, no. 191, e64834. https://doi.org/10.3791/64834
Misra, S, Lee, TJ, Sebastian, A, McGuigan, J, Liao, C, Koo, I, Patterson, AD, Rossi, RM, Hall, MA, Albert, I & Prabhu, KS 2023, 'Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation', Redox Biology, vol. 59, 102571. https://doi.org/10.1016/j.redox.2022.102571
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850. https://doi.org/10.3390/antiox12040850
Prabhu, KS 2023, 'The selenoprotein P-LRP5/6-WNT3A complex promotes tumorigenesis in sporadic colorectal cancer', Journal of Clinical Investigation, vol. 133, no. 13, e171885. https://doi.org/10.1172/JCI171885
2022
Girdhar, N, Kansal, H, Garg, K, Sharma, S, Prabhu, KS, Chopra, V, Tinkov, AA, Skalny, AV & Prakash, NT 2022, 'Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder', Biological Trace Element Research, vol. 200, no. 12, pp. 4949-4954. https://doi.org/10.1007/s12011-022-03096-8
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
Lee, TJ, Nettleford, SK, McGlynn, A, Carlson, BA, Kirimanjeswara, GS & Prabhu, KS 2022, 'The role of selenoproteins in neutrophils during inflammation', Archives of Biochemistry and Biophysics, vol. 732, 109452. https://doi.org/10.1016/j.abb.2022.109452
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Markley, RL, Restori, KH, Katkere, B, Sumner, SE, Nicol, MJ, Tyryshkina, A, Nettleford, SK, Williamson, DR, Place, DE, Dewan, KK, Shay, AE, Carlson, BA, Girirajan, S, Prabhu, KS & Kirimanjeswara, GS 2021, 'Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity', Frontiers in immunology, vol. 12, 701341. https://doi.org/10.3389/fimmu.2021.701341
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410. https://doi.org/10.1016/j.jbc.2021.100410
2020
Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246. https://doi.org/10.1182/blood.2019003480
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96. https://doi.org/10.3389/fnut.2020.00096