Kumble Sandeep Prabhu, PhD - Penn State Cancer Institute
Researcher Profile
Kumble Sandeep Prabhu, PhD
Department Head and Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Selenium
- Macrophages
- Selenoproteins
- Inflammation
- Prostaglandins
- Lipopolysaccharides
- Inositol Oxygenase
- Anti-Inflammatory Agents
- Up-Regulation
- Leukemia
- Proteins
- Peroxisome Proliferator-Activated Receptors
Recent Publications
2023
Qian, F, Arner, BE, Nettleford, SK, Paulson, RF & Prabhu, KS 2023, 'Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice', Journal of Visualized Experiments, vol. 2023, no. 191, e64834. https://doi.org/10.3791/64834
Misra, S, Lee, TJ, Sebastian, A, McGuigan, J, Liao, C, Koo, I, Patterson, AD, Rossi, RM, Hall, MA, Albert, I & Prabhu, KS 2023, 'Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation', Redox Biology, vol. 59, 102571. https://doi.org/10.1016/j.redox.2022.102571
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850. https://doi.org/10.3390/antiox12040850
2022
Girdhar, N, Kansal, H, Garg, K, Sharma, S, Prabhu, KS, Chopra, V, Tinkov, AA, Skalny, AV & Prakash, NT 2022, 'Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder', Biological Trace Element Research, vol. 200, no. 12, pp. 4949-4954. https://doi.org/10.1007/s12011-022-03096-8
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
Lee, TJ, Nettleford, SK, McGlynn, A, Carlson, BA, Kirimanjeswara, GS & Prabhu, KS 2022, 'The role of selenoproteins in neutrophils during inflammation', Archives of Biochemistry and Biophysics, vol. 732, 109452. https://doi.org/10.1016/j.abb.2022.109452
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Markley, RL, Restori, KH, Katkere, B, Sumner, SE, Nicol, MJ, Tyryshkina, A, Nettleford, SK, Williamson, DR, Place, DE, Dewan, KK, Shay, AE, Carlson, BA, Girirajan, S, Prabhu, KS & Kirimanjeswara, GS 2021, 'Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity', Frontiers in immunology, vol. 12, 701341. https://doi.org/10.3389/fimmu.2021.701341
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410. https://doi.org/10.1016/j.jbc.2021.100410
2020
Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246. https://doi.org/10.1182/blood.2019003480
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96. https://doi.org/10.3389/fnut.2020.00096
2019
Sumanth, MS, Abhilasha, KV, Jacob, SP, Chaithra, VH, Basrur, V, Willard, B, McIntyre, TM, Prabhu, KS & Marathe, GK 2019, 'Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses', Immunobiology, vol. 224, no. 5, pp. 672-680. https://doi.org/10.1016/j.imbio.2019.06.003
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852. https://doi.org/10.1096/fj.201802608R
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40. https://doi.org/10.1186/s13045-019-0728-3
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336. https://doi.org/10.1126/scisignal.aap7336
Qian, F, Misra, S & Prabhu, KS 2019, 'Selenium and selenoproteins in prostanoid metabolism and immunity', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, no. 6, pp. 484-516. https://doi.org/10.1080/10409238.2020.1717430
Dhanjal, NI, Sharma, S, Skalny, AV, Skalnaya, MG, Ajsuvakova, OP, Tinkov, AA, Zhang, F, Guo, X, Prabhu, KS & Tejo Prakash, N 2019, 'Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages', Food and Function, vol. 10, no. 5, pp. 2839-2846. https://doi.org/10.1039/c9fo00186g
Korwar, AM, Shay, AE, Basrur, V, Conlon, K & Prabhu, KS 2019, 'Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 30, no. 7, pp. 1276-1283. https://doi.org/10.1007/s13361-019-02192-9
Cheng, WH & Prabhu, KS 2019, 'Special Issue of “Optimal Selenium Status and Selenoproteins in Health”', Biological Trace Element Research, vol. 192, no. 1. https://doi.org/10.1007/s12011-019-01898-x
Abhilasha, KV, Sumanth, MS, Chaithra, VH, Jacob, SP, Thyagarajan, A, Sahu, RP, Rajaiah, R, Prabhu, KS, Kemparaju, K, Travers, JB, Chen, CH & Marathe, GK 2019, 'p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice', Free Radical Biology and Medicine, vol. 143, pp. 275-287. https://doi.org/10.1016/j.freeradbiomed.2019.08.019