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Kumble Sandeep Prabhu, PhD

Kumble Sandeep Prabhu, PhD

Department Head and Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Selenium
  • Macrophages
  • Selenoproteins
  • Inflammation
  • Prostaglandins
  • Lipopolysaccharides
  • Inositol Oxygenase
  • Anti-Inflammatory Agents
  • Up-Regulation
  • Leukemia
  • Proteins
  • Peroxisome Proliferator-Activated Receptors

Recent Publications


Qian, F, Arner, BE, Nettleford, SK, Paulson, RF & Prabhu, KS 2023, 'Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice', Journal of Visualized Experiments, vol. 2023, no. 191, e64834.
Misra, S, Lee, TJ, Sebastian, A, McGuigan, J, Liao, C, Koo, I, Patterson, AD, Rossi, RM, Hall, MA, Albert, I & Prabhu, KS 2023, 'Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation', Redox Biology, vol. 59, 102571.
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850.


Girdhar, N, Kansal, H, Garg, K, Sharma, S, Prabhu, KS, Chopra, V, Tinkov, AA, Skalny, AV & Prakash, NT 2022, 'Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder', Biological Trace Element Research, vol. 200, no. 12, pp. 4949-4954.
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328.
Lee, TJ, Nettleford, SK, McGlynn, A, Carlson, BA, Kirimanjeswara, GS & Prabhu, KS 2022, 'The role of selenoproteins in neutrophils during inflammation', Archives of Biochemistry and Biophysics, vol. 732, 109452.


Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437.
Markley, RL, Restori, KH, Katkere, B, Sumner, SE, Nicol, MJ, Tyryshkina, A, Nettleford, SK, Williamson, DR, Place, DE, Dewan, KK, Shay, AE, Carlson, BA, Girirajan, S, Prabhu, KS & Kirimanjeswara, GS 2021, 'Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity', Frontiers in immunology, vol. 12, 701341.
Korwar, AM, Hossain, A, Lee, TJ, Shay, AE, Basrur, V, Conlon, K, Smith, PB, Carlson, BA, Salis, HM, Patterson, AD & Prabhu, KS 2021, 'Selenium-dependent metabolic reprogramming during inflammation and resolution', Journal of Biological Chemistry, vol. 296, 100410.


Chen, Y, Xiang, J, Qian, F, Diwakar, BT, Ruan, B, Hao, S, Sandeep Prabhu, K & Paulson, RF 2020, 'Epo receptor signaling in macrophages alters the splenic niche to promote erythroid differentiation', Blood, vol. 136, no. 2, pp. 235-246.
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96.


Sumanth, MS, Abhilasha, KV, Jacob, SP, Chaithra, VH, Basrur, V, Willard, B, McIntyre, TM, Prabhu, KS & Marathe, GK 2019, 'Acute phase protein, α – 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses', Immunobiology, vol. 224, no. 5, pp. 672-680.
Diwakar, BT, Yoast, R, Nettleford, S, Qian, F, Lee, TJ, Berry, S, Huffnagle, I, Rossi, RM, Trebak, M, Paulson, RF & Prabhu, KS 2019, 'Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-αB activation in murine macrophages via changes in intracellular calcium', FASEB Journal, vol. 33, no. 11, pp. 12838-12852.
Kong, Y, Jia, B, Zhao, C, Claxton, DF, Sharma, A, Annageldiyev, C, Fotos, JS, Zeng, H, Paulson, RF, Prabhu, KS & Zheng, H 2019, 'Downregulation of CD73 associates with T cell exhaustion in AML patients', Journal of Hematology and Oncology, vol. 12, no. 1, 40.
Bennett, LF, Liao, C, Quickel, MD, Yeoh, BS, Vijay-Kumar, M, Hankey-Giblin, P, Prabhu, KS & Paulson, RF 2019, 'Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C', Science signaling, vol. 12, no. 598, eaap7336.
Qian, F, Misra, S & Prabhu, KS 2019, 'Selenium and selenoproteins in prostanoid metabolism and immunity', Critical Reviews in Biochemistry and Molecular Biology, vol. 54, no. 6, pp. 484-516.
Dhanjal, NI, Sharma, S, Skalny, AV, Skalnaya, MG, Ajsuvakova, OP, Tinkov, AA, Zhang, F, Guo, X, Prabhu, KS & Tejo Prakash, N 2019, 'Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages', Food and Function, vol. 10, no. 5, pp. 2839-2846.
Korwar, AM, Shay, AE, Basrur, V, Conlon, K & Prabhu, KS 2019, 'Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 30, no. 7, pp. 1276-1283.
Cheng, WH & Prabhu, KS 2019, 'Special Issue of “Optimal Selenium Status and Selenoproteins in Health”', Biological Trace Element Research, vol. 192, no. 1.
Abhilasha, KV, Sumanth, MS, Chaithra, VH, Jacob, SP, Thyagarajan, A, Sahu, RP, Rajaiah, R, Prabhu, KS, Kemparaju, K, Travers, JB, Chen, CH & Marathe, GK 2019, 'p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice', Free Radical Biology and Medicine, vol. 143, pp. 275-287.