Researcher Profile

Researcher Profile

Katherine Aird, PhD

Katherine Aird, PhD

Assistant Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
kma66@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Cell Aging
  • Inflammatory Breast Neoplasms
  • Apoptosis
  • Oncogenes
  • Nucleotides
  • Mutation
  • Growth
  • Rabbits
  • X-Linked Inhibitor of Apoptosis Protein
  • DNA Damage

Recent Publications

2018

Singha, B, Harper, SL, Goldman, AR, Bitler, BG, Aird, KM, Borowsky, ME, Cadungog, MG, Liu, Q, Zhang, R, Jean, S, Drapkin, R & Speicher, DW 2018, 'CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer' Scientific Reports, vol. 8, no. 1, 14725. https://doi.org/10.1038/s41598-018-32885-2
Buj, R & Aird, KM 2018, 'Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease' Frontiers in Endocrinology, vol. 9, no. APR, 177. https://doi.org/10.3389/fendo.2018.00177

2017

Bitler, BG, Wu, S, Park, PH, Hai, Y, Aird, K, Wang, Y, Zhai, Y, Kossenkov, AV, Vara-Ailor, A, Rauscher, FJ, Zou, W, Speicher, DW, Huntsman, DG, Conejo-Garcia, JR, Cho, KR, Christianson, DW & Zhang, R 2017, 'ARID1A-mutated ovarian cancers depend on HDAC6 activity' Nature Cell Biology, vol. 19, no. 8, pp. 962-973. https://doi.org/10.1038/ncb3582
Dahl, ES & Aird, K 2017, 'Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer' Frontiers in Oncology, vol. 7, no. NOV, 291. https://doi.org/10.3389/fonc.2017.00291
Karakashev, S & Aird, K 2017, 'Ovarian cancer: How can resistance to chemotherapy be tackled?' Future Oncology, vol. 13, no. 30, pp. 2737-2739. https://doi.org/10.2217/fon-2017-0235

2016

Bitler, BG, Aird, K & Zhang, R 2016, 'Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations' Molecular and Cellular Oncology, vol. 3, no. 1, e1032476. https://doi.org/10.1080/23723556.2015.1032476
Aird, K, Iwasaki, O, Kossenkov, AV, Tanizawa, H, Fatkhutdinov, N, Bitler, BG, Le, L, Alicea, G, Yang, TL, Johnson, FB, Noma, KI & Zhang, R 2016, 'HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci' Journal of Cell Biology, vol. 215, no. 3, pp. 325-334. https://doi.org/10.1083/jcb.201608026
Kaur, A, Webster, MR, Marchbank, K, Behera, R, Ndoye, A, Kugel, CH, Dang, VM, Appleton, J, O'Connell, MP, Cheng, P, Valiga, AA, Morissette, R, McDonnell, NB, Ferrucci, L, Kossenkov, AV, Meeth, K, Tang, HY, Yin, X, Wood, WH, Lehrmann, E, Becker, KG, Flaherty, KT, Frederick, DT, Wargo, JA, Cooper, ZA, Tetzlaff, MT, Hudgens, C, Aird, K, Zhang, R, Xu, X, Liu, Q, Bartlett, E, Karakousis, G, Eroglu, Z, Lo, RS, Chan, M, Menzies, AM, Long, GV, Johnson, DB, Sosman, J, Schilling, B, Schadendorf, D, Speicher, DW, Bosenberg, M, Ribas, A & Weeraratna, AT 2016, 'SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance' Nature, vol. 532, no. 7598, pp. 250-254. https://doi.org/10.1038/nature17392
Fatkhutdinov, N, Sproesser, K, Krepler, C, Liu, Q, Brafford, PA, Herlyn, M, Aird, K & Zhang, R 2016, 'Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma' Molecular Cancer Research, vol. 14, no. 9, pp. 767-775. https://doi.org/10.1158/1541-7786.MCR-16-0099

2015

Aird, K, Worth, AJ, Snyder, NW, Lee, JV, Sivanand, S, Liu, Q, Blair, IA, Wellen, KE & Zhang, R 2015, 'ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence' Cell Reports, vol. 11, no. 6, pp. 893-901. https://doi.org/10.1016/j.celrep.2015.04.014
Aird, K & Zhang, R 2015, 'ATM in senescence' Oncotarget, vol. 6, no. 17, pp. 14729-14730. https://doi.org/10.18632/oncotarget.4411
Zhang, J, Wang, C, Chen, X, Takada, M, Fan, C, Zheng, X, Wen, H, Liu, Y, Wang, C, Pestell, RG, Aird, K, Kaelin, WG, Liu, XS & Zhang, Q 2015, 'EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer' EMBO Journal, vol. 34, no. 23, pp. 2953-2970. https://doi.org/10.15252/embj.201591437
Aird, K & Zhang, R 2015, 'Nucleotide metabolism, oncogene-induced senescence and cancer' Cancer Letters, vol. 356, no. 2, pp. 204-210. https://doi.org/10.1016/j.canlet.2014.01.017
Caino, MC, Ghosh, JC, Chae, YC, Vaira, V, Rivadeneira, DB, Faversani, A, Rampini, P, Kossenkov, AV, Aird, K, Zhang, R, Webster, MR, Weeraratna, AT, Bosari, S, Languino, LR & Altieri, DC 2015, 'PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion' Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 28, pp. 8638-8643. https://doi.org/10.1073/pnas.1500722112
Zhu, H, Ren, S, Bitler, BG, Aird, K, Tu, Z, Skordalakes, E, Zhu, Y, Yan, J, Sun, Y & Zhang, R 2015, 'SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase' Cell Reports, vol. 13, no. 6, pp. 1183-1193. https://doi.org/10.1016/j.celrep.2015.09.083
Bitler, BG, Aird, K, Garipov, A, Li, H, Amatangelo, M, Kossenkov, AV, Schultz, DC, Liu, Q, Shih, IM, Conejo-Garcia, JR, Speicher, DW & Zhang, R 2015, 'Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers' Nature Medicine, vol. 21, no. 3, pp. 231-238. https://doi.org/10.1038/nm.3799

2014

Aird, K, Li, H, Xin, F, Konstantinopoulos, PA & Zhang, R 2014, 'Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer' Cell Cycle, vol. 13, no. 2, pp. 199-207. https://doi.org/10.4161/cc.26953
Aird, KM & Zhang, R 2014, 'Metabolic alterations accompanying oncogene-induced senescence' Molecular and Cellular Oncology, vol. 1, no. 3, e963481. https://doi.org/10.4161/23723548.2014.963481

Clinical Trials Search


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Adults (age >= 18 years)