Researcher Profile

Researcher Profile

Katherine Aird, PhD

Katherine Aird, PhD

Assistant Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Therapeutics
  • Cell Aging
  • Inflammatory Breast Neoplasms
  • Apoptosis
  • Oncogenes
  • Nucleotides
  • Mutation
  • Growth
  • Ovarian Neoplasms
  • Deoxyribonucleotides
  • X-Linked Inhibitor of Apoptosis Protein

Recent Publications


Kuskovsky, R, Buj, R, Xu, P, Hofbauer, S, Doan, MT, Jiang, H, Bostwick, A, Mesaros, C, Aird, K & Snyder, NW 2019, 'Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry', Analytical Biochemistry, vol. 568, pp. 65-72.


Singha, B, Harper, SL, Goldman, AR, Bitler, BG, Aird, K, Borowsky, ME, Cadungog, MG, Liu, Q, Zhang, R, Jean, S, Drapkin, R & Speicher, DW 2018, 'CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer' Scientific Reports, vol. 8, no. 1, 14725.
Buj, R & Aird, K 2018, 'Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease', Frontiers in Endocrinology, vol. 9, no. APR, 177.
Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, J, Timmins, PF, Kesterson, J, Phaeton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, K & Hempel, N 2018, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology.


Bitler, BG, Wu, S, Park, PH, Hai, Y, Aird, K, Wang, Y, Zhai, Y, Kossenkov, AV, Vara-Ailor, A, Rauscher, FJ, Zou, W, Speicher, DW, Huntsman, DG, Conejo-Garcia, JR, Cho, KR, Christianson, DW & Zhang, R 2017, 'ARID1A-mutated ovarian cancers depend on HDAC6 activity', Nature Cell Biology, vol. 19, no. 8, pp. 962-973.
Dahl, ES & Aird, K 2017, 'Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer', Frontiers in Oncology, vol. 7, no. NOV, 291.
Karakashev, S & Aird, K 2017, 'Ovarian cancer: How can resistance to chemotherapy be tackled?', Future Oncology, vol. 13, no. 30, pp. 2737-2739.


Bitler, BG, Aird, K & Zhang, R 2016, 'Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations' Molecular and Cellular Oncology, vol. 3, no. 1, e1032476.
Aird, K, Iwasaki, O, Kossenkov, AV, Tanizawa, H, Fatkhutdinov, N, Bitler, BG, Le, L, Alicea, G, Yang, TL, Johnson, FB, Noma, KI & Zhang, R 2016, 'HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci', Journal of Cell Biology, vol. 215, no. 3, pp. 325-334.
Kaur, A, Webster, MR, Marchbank, K, Behera, R, Ndoye, A, Kugel, CH, Dang, VM, Appleton, J, O'Connell, MP, Cheng, P, Valiga, AA, Morissette, R, McDonnell, NB, Ferrucci, L, Kossenkov, AV, Meeth, K, Tang, HY, Yin, X, Wood, WH, Lehrmann, E, Becker, KG, Flaherty, KT, Frederick, DT, Wargo, JA, Cooper, ZA, Tetzlaff, MT, Hudgens, C, Aird, K, Zhang, R, Xu, X, Liu, Q, Bartlett, E, Karakousis, G, Eroglu, Z, Lo, RS, Chan, M, Menzies, AM, Long, GV, Johnson, DB, Sosman, J, Schilling, B, Schadendorf, D, Speicher, DW, Bosenberg, M, Ribas, A & Weeraratna, AT 2016, 'SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance', Nature, vol. 532, no. 7598, pp. 250-254.
Fatkhutdinov, N, Sproesser, K, Krepler, C, Liu, Q, Brafford, PA, Herlyn, M, Aird, K & Zhang, R 2016, 'Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma' Molecular Cancer Research, vol. 14, no. 9, pp. 767-775.


Aird, K, Worth, AJ, Snyder, NW, Lee, JV, Sivanand, S, Liu, Q, Blair, IA, Wellen, KE & Zhang, R 2015, 'ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence', Cell Reports, vol. 11, no. 6, pp. 893-901.
Aird, K & Zhang, R 2015, 'ATM in senescence' Oncotarget, vol. 6, no. 17, pp. 14729-14730.
Zhang, J, Wang, C, Chen, X, Takada, M, Fan, C, Zheng, X, Wen, H, Liu, Y, Wang, C, Pestell, RG, Aird, K, Kaelin, WG, Liu, XS & Zhang, Q 2015, 'EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer', EMBO Journal, vol. 34, no. 23, pp. 2953-2970.
Aird, K & Zhang, R 2015, 'Nucleotide metabolism, oncogene-induced senescence and cancer' Cancer Letters, vol. 356, no. 2, pp. 204-210.
Caino, MC, Ghosh, JC, Chae, YC, Vaira, V, Rivadeneira, DB, Faversani, A, Rampini, P, Kossenkov, AV, Aird, K, Zhang, R, Webster, MR, Weeraratna, AT, Bosari, S, Languino, LR & Altieri, DC 2015, 'PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 28, pp. 8638-8643.
Zhu, H, Ren, S, Bitler, BG, Aird, K, Tu, Z, Skordalakes, E, Zhu, Y, Yan, J, Sun, Y & Zhang, R 2015, 'SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase' Cell Reports, vol. 13, no. 6, pp. 1183-1193.
Bitler, BG, Aird, K, Garipov, A, Li, H, Amatangelo, M, Kossenkov, AV, Schultz, DC, Liu, Q, Shih, IM, Conejo-Garcia, JR, Speicher, DW & Zhang, R 2015, 'Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers', Nature Medicine, vol. 21, no. 3, pp. 231-238.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)