Researcher Profile

Researcher Profile

Katherine Aird, PhD

Katherine Aird, PhD

Assistant Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
kma66@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Cellular Senescence
  • Inflammatory Breast Neoplasms
  • Nucleotides
  • Apoptosis
  • Ovarian Neoplasms
  • Oncogenes
  • Chromatin
  • Growth
  • triphosphoric acid
  • Deoxyribonucleotides

Recent Publications

2020

Zhao, B, Liu, P, Fukumoto, T, Nacarelli, T, Fatkhutdinov, N, Wu, S, Lin, J, Aird, KM, Tang, HY, Liu, Q, Speicher, DW & Zhang, R 2020, 'Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence', Nature communications, vol. 11, no. 1, 908. https://doi.org/10.1038/s41467-020-14652-y

2019

Nacarelli, T, Lau, L, Fukumoto, T, Zundell, J, Fatkhutdinov, N, Wu, S, Aird, KM, Iwasaki, O, Kossenkov, AV, Schultz, D, Noma, KI, Baur, JA, Schug, Z, Tang, HY, Speicher, DW, David, G & Zhang, R 2019, ' NAD + metabolism governs the proinflammatory senescence-associated secretome ', Nature Cell Biology, vol. 21, no. 3, pp. 397-407. https://doi.org/10.1038/s41556-019-0287-4
Kim, YS, Gupta Vallur, P, Jones, VM, Worley, BL, Shimko, S, Shin, DH, Crawford, LTC, Chen, CW, Aird, KM, Abraham, T, Shepherd, TG, Warrick, JI, Lee, NY, Phaeton, R, Mythreye, K & Hempel, N 2020, 'Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells', Oncogene, vol. 39, no. 8, pp. 1619-1633. https://doi.org/10.1038/s41388-019-1097-7
Leon, KE & Aird, KM 2019, 'Jumonji C demethylases in cellular senescence', Genes, vol. 10, no. 1, 33. https://doi.org/10.3390/genes10010033
Kuskovsky, R, Buj, R, Xu, P, Hofbauer, S, Doan, MT, Jiang, H, Bostwick, A, Mesaros, C, Aird, KM & Snyder, NW 2019, 'Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry', Analytical Biochemistry, vol. 568, pp. 65-72. https://doi.org/10.1016/j.ab.2018.12.023
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8. https://doi.org/10.1016/j.celrep.2019.07.084
Dahl, ES, Buj, R, Leon, KE, Newell, JM, Imamura, Y, Bitler, BG, Snyder, NW & Aird, KM 2019, 'Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer', Molecular Cancer Research, vol. 17, no. 8, pp. 1710-1720. https://doi.org/10.1158/1541-7786.MCR-18-1233
Buj, R & Aird, KM 2019, 'p16: cycling off the beaten path', Molecular and Cellular Oncology, vol. 6, no. 6, e1677140. https://doi.org/10.1080/23723556.2019.1677140

2018

Singha, B, Harper, SL, Goldman, AR, Bitler, BG, Aird, KM, Borowsky, ME, Cadungog, MG, Liu, Q, Zhang, R, Jean, S, Drapkin, R & Speicher, DW 2018, 'CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer', Scientific reports, vol. 8, no. 1, 14725. https://doi.org/10.1038/s41598-018-32885-2
Buj, R & Aird, KM 2018, 'Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease', Frontiers in Endocrinology, vol. 9, no. APR, 177. https://doi.org/10.3389/fendo.2018.00177
Worley, BL, Kim, YS, Mardini, J, Zaman, R, Leon, KE, Vallur, PG, Nduwumwami, A, Warrick, JI, Timmins, PF, Kesterson, JP, Phaƫton, R, Lee, NY, Walter, V, Endres, L, Mythreye, K, Aird, KM & Hempel, N 2019, 'GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment', Redox Biology, vol. 25, 101051. https://doi.org/10.1016/j.redox.2018.11.009

2017

Bitler, BG, Wu, S, Park, PH, Hai, Y, Aird, KM, Wang, Y, Zhai, Y, Kossenkov, AV, Vara-Ailor, A, Rauscher, FJ, Zou, W, Speicher, DW, Huntsman, DG, Conejo-Garcia, JR, Cho, KR, Christianson, DW & Zhang, R 2017, 'ARID1A-mutated ovarian cancers depend on HDAC6 activity', Nature Cell Biology, vol. 19, no. 8, pp. 962-973. https://doi.org/10.1038/ncb3582
Dahl, ES & Aird, KM 2017, 'Ataxia-telangiectasia mutated modulation of carbon metabolism in cancer', Frontiers in Oncology, vol. 7, no. NOV, 291. https://doi.org/10.3389/fonc.2017.00291
Karakashev, S & Aird, KM 2017, 'Ovarian cancer: How can resistance to chemotherapy be tackled?', Future Oncology, vol. 13, no. 30, pp. 2737-2739. https://doi.org/10.2217/fon-2017-0235

2016

Bitler, BG, Aird, KM & Zhang, R 2016, 'Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations', Molecular and Cellular Oncology, vol. 3, no. 1, e1032476. https://doi.org/10.1080/23723556.2015.1032476
Aird, KM, Iwasaki, O, Kossenkov, AV, Tanizawa, H, Fatkhutdinov, N, Bitler, BG, Le, L, Alicea, G, Yang, TL, Johnson, FB, Noma, KI & Zhang, R 2016, 'HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci', Journal of Cell Biology, vol. 215, no. 3, pp. 325-334. https://doi.org/10.1083/jcb.201608026
Kaur, A, Webster, MR, Marchbank, K, Behera, R, Ndoye, A, Kugel, CH, Dang, VM, Appleton, J, O'Connell, MP, Cheng, P, Valiga, AA, Morissette, R, McDonnell, NB, Ferrucci, L, Kossenkov, AV, Meeth, K, Tang, HY, Yin, X, Wood, WH, Lehrmann, E, Becker, KG, Flaherty, KT, Frederick, DT, Wargo, JA, Cooper, ZA, Tetzlaff, MT, Hudgens, C, Aird, KM, Zhang, R, Xu, X, Liu, Q, Bartlett, E, Karakousis, G, Eroglu, Z, Lo, RS, Chan, M, Menzies, AM, Long, GV, Johnson, DB, Sosman, J, Schilling, B, Schadendorf, D, Speicher, DW, Bosenberg, M, Ribas, A & Weeraratna, AT 2016, 'SFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance', Nature, vol. 532, no. 7598, pp. 250-254. https://doi.org/10.1038/nature17392
Fatkhutdinov, N, Sproesser, K, Krepler, C, Liu, Q, Brafford, PA, Herlyn, M, Aird, KM & Zhang, R 2016, 'Targeting RRM2 and mutant BRAF is a novel combinatorial strategy for melanoma', Molecular Cancer Research, vol. 14, no. 9, pp. 767-775. https://doi.org/10.1158/1541-7786.MCR-16-0099

Clinical Trials Search


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