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Researcher Profile

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Karen Krok, MD

Karen Krok, MD

Professor and Vice Chair for Clinical Affairs, Department of Medicine
Director of Hepatology, Division of Gastroenterology and Hepatology
Disease Teams:
Cancer Institute, Liver, Pancreas and Foregut Cancer Team
KLK41@psu.edu

Research Interests

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Dr. Karen Krok joined Penn State College of Medicine in 2013. Her research interests include post-liver-transplant outcomes, focusing on patients transplanted for hepatitis C; the cardiovascular complications of patients after a liver transplant; pulmonary complications of liver disease; and outcomes of heart-liver transplants in the congenital heart disease population.

Dr. Krok is the site PI for a multicenter trial, Pulmonary Vascular Complications of Liver Disease 3 Study Group, which assesses the pulmonary complications and hormonal changes in patients with pulmonary hypertension and hepatopulmonary syndrome. She has successfully recruited for and been the site PI for several multi-site and pharmaceutical clinical trials. 

As the congenital heart disease population is aging, there is more evidence of liver disease associated with the Fontan circulation. Dr. Krok has served on an international multi-specialty group that developed recommendations about how to follow these patients clinically.

  • Liver Transplantation
  • Therapeutics
  • Liver Diseases
  • Liver
  • Fibrosis
  • Hepatopulmonary Syndrome
  • Survival
  • Chronic Disease
  • Blood Vessels
  • Incidence
  • Confidence Intervals
  • Crohn Disease
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Recent Publications

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2022

Pulmonary Vascular Complications of Liver Disease Study Group 2022, 'Impact of hepatopulmonary syndrome in liver transplantation candidates and the role of angiogenesis', European Respiratory Journal, vol. 60, no. 2, 2102304. https://doi.org/10.1183/13993003.02304-2021
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Loomba, R, Schmitz, K, Sciamanna, C, Strine, C, Wentzel, R, Marlin, S, Sica, C, Vesek, J, Eyster, E, Sinoway, L, Bentz, K, Handley, N, Hershey Fell, B, Mottilla, S, Christ, C, George, S, Novchich, T, Beyer, M, Clarke, K, Myers, T, Glading-Steinruck, M, Krok, K, Ma, T, Riley, T, Thompson, E, Tressler, H, Broach, J, Doan, T, Patrick, S, Reed, S, Hamilton, C, Slavoski, K & Tregea, D 2022, 'NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH', Hepatology, vol. 76, no. 1, pp. 172-185. https://doi.org/10.1002/hep.32274
Jain, A, Haussner, D, Hranjec, T, Butt, F, Stine, JG, Ankola, A, Al Yousif, H, Dicristina, R, Krok, KL & Arenas, J 2022, 'Review of Sarcopenia and Testosterone Deficiency With Chronic Liver Disease and Postoperative Liver Transplant Utility of Short-Term Testosterone Replacement Therapy', Experimental and Clinical Transplantation, vol. 20, no. 11, pp. 1000-1008. https://doi.org/10.6002/ect.2022.0132

2021

Kadry, Z, Schaefer, E, Krok, K, Faust, A, Stine, JG, Schreibman, IR, Bezinover, D & Riley, TR 2021, 'Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO2 spectrum', JHEP Reports, vol. 3, no. 5, 100351. https://doi.org/10.1016/j.jhepr.2021.100351
Kadry, Z, Stine, JG, Dohi, T, Jain, A, Robyak, KL, Kwon, O, Hamilton, CJ, Janicki, P, Riley, TR, Butt, F, Krok, K, Schreibman, IR, Bezinover, D, Ghahramani, N, Campos, S & Hollenbeak, CS 2021, 'Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial', Transplantation Direct, vol. 7, no. 7, pp. E709. https://doi.org/10.1097/TXD.0000000000001159

2020

Rochon, ER, Krowka, MJ, Bartolome, S, Heresi, GA, Bull, T, Roberts, K, Hemnes, A, Forde, KA, Krok, KL, Patel, M, Lin, G, McNeil, M, Al-Naamani, N, Roman, BL, Yu, PB, Fallon, MB, Gladwin, MT & Kawut, SM 2020, 'BMP9/10 in Pulmonary Vascular Complications of Liver Disease', American journal of respiratory and critical care medicine, vol. 201, no. 12. https://doi.org/10.1164/rccm.201912-2514LE
Pulmonary Vascular Complications of Liver Disease Study Group 2021, 'Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2)', Hepatology, vol. 73, no. 2, pp. 726-737. https://doi.org/10.1002/hep.31314
Jain, A, Riley, TR, Krok, KL, Schreibman, I, Karamchandani, DM, Liao, X, Tian, Y, Dohi, T & Kadry, Z 2020, 'Incidence of post-liver transplant hepatic dysfunction after sustained virologic response following direct-acting anti-hepatitis c therapy', Experimental and Clinical Transplantation, vol. 18, no. 3, pp. 345-352. https://doi.org/10.6002/ect.2018.0127
DuBrock, HM, Krowka, MJ, Krok, K, Forde, K, Mottram, C, Scanlon, P, Al-Naamani, N, Patel, M, McCormick, A, Fallon, MB & Kawut, SM 2020, 'Prevalence and Impact of Restrictive Lung Disease in Liver Transplant Candidates', Liver Transplantation, vol. 26, no. 8, pp. 989-999. https://doi.org/10.1002/lt.25794

2019

Gonzalo, JD, Wolpaw, DR, Krok, KL, Pfeiffer, MP & McCall-Hosenfeld, JS 2019, 'A Developmental Approach to Internal Medicine Residency Education: Lessons Learned from the Design and Implementation of a Novel Longitudinal Coaching Program', Medical education online, vol. 24, no. 1, 1591256. https://doi.org/10.1080/10872981.2019.1591256
Jain, A, Miller, D, Schreibman, I, Riley, TR, Krok, KL, Dohi, T, Sharma, R & Kadry, Z 2019, 'Is there increased risk of hepatocellular carcinoma recurrence in liver transplant patients with direct-acting antiviral therapy?', Hepatology International, vol. 13, no. 2, pp. 190-198. https://doi.org/10.1007/s12072-019-09930-x
REGENERATE Study Investigators 2019, 'Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial', The Lancet, vol. 394, no. 10215, pp. 2184-2196. https://doi.org/10.1016/S0140-6736(19)33041-7
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