Researcher Profile

Researcher Profile

Karam El-Bayoumy, PhD

Karam El-Bayoumy, PhD

Distinguished Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
kee2@psu.edu

Research Interests

The overall goals of Dr. Karam El-Bayoumy’s research are to understand the mechanisms at the cellular and molecular levels that can account for cancer induction and develop biomarkers for early detection. For more than 30 years, his laboratory has been funded from NCI, NIEHS, NIDCR, DOD and The Komen Foundation, and he has more than 240 peer-reviewed publications.

Dr. El-Bayoumy’s research is focused on the prevention of tobacco and environmentally-related cancers by various synthetic and naturally-occurring chemopreventive agents, combined with dietary manipulation initially in preclinical model systems, then translates the findings into clinical cancer prevention initiatives. He discovered novel chemopreventive selenium compounds against the development of several cancers in preclinical animal models and showed for the first time that selenized yeast reduced oxidative stress in healthy men.

His team demonstrated, using a novel animal model developed in his lab, that black raspberry (BRB) inhibited DNA damage, mutagenesis and oral squamous cell carcinoma (OSCC) induced by the tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) in the mouse oral cavity; he also reported that BRB enhanced DNA repair of bulky lesions induced by chemical DB[a,l]P and physical (UV) carcinogens. His team also showed that hypomethylated Fgf3 (a gene frequently amplified in OSCC and is involved in epithelial mesenchymal transition) is a potential biomarker for early detection of OSCC; this gene was altered by BRB in a manner consistent with its chemopreventive action.

Dr. El-Bayoumy focuses on developing highly effective chemopreventive agents against tobacco smoke inducing lung cancer and developing biomarkers for early detection in noninvasive fluids indicative of cigarette smoking using various proteomic approaches.

During the last decade, he has been focusing on understanding the mechanistic role of Omega-3 fatty acids in breast cancer prevention in preclinical and clinical studies as well as developing novel liposomal formulation as an effective strategy to deliver select chemopreventive agents.

  • Neoplasms
  • Carcinogenesis
  • Selenium
  • Carcinogens
  • 1,4-phenylenebis(methylene)selenocyanate
  • Breast Neoplasms
  • Lung
  • Breast
  • Organoselenium Compounds
  • DNA
  • Tobacco
  • Chemoprevention

Clinical Trials

Effect of oral black raspberry administration on oral cell DNA adducts in smokers

Recent Publications

2022

El-Bayoumy, K 2022, Animal studies of tobacco and cancer. in Tobacco And Cancer: The Science And The Story. World Scientific Publishing Co. Pte Ltd, pp. 75-100. https://doi.org/10.1142/9789811239533_0003
Chen, KM, Sun, YW, Sun, D, Gowda, K, Amin, S & El-Bayoumy, K 2022, 'Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells', Chemical research in toxicology, vol. 35, no. 11, pp. 2152-2159. https://doi.org/10.1021/acs.chemrestox.2c00246
Thompson, HJ, Neil, ES, McGinley, JN, Fitzgerald, VK, El Bayoumy, K & Manni, A 2022, 'Building a foundation for precision onco-nutrition: Docosahexaenoic acid and breast cancer', Cancers, vol. 14, no. 1, 157. https://doi.org/10.3390/cancers14010157
Chen, KM, Sun, YW, Krebs, NM, Sun, D, Krzeminski, J, Reinhart, L, Gowda, K, Amin, S, Mallery, S, Richie, JP & El-Bayoumy, K 2022, 'Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells', Carcinogenesis, vol. 43, no. 8, pp. 746-753. https://doi.org/10.1093/carcin/bgac058
Penning, TM, Su, AL & El-Bayoumy, K 2022, 'Nitroreduction: A Critical Metabolic Pathway for Drugs, Environmental Pollutants, and Explosives', Chemical research in toxicology, vol. 35, no. 10, pp. 1747-1765. https://doi.org/10.1021/acs.chemrestox.2c00175
Su, AL, Mesaros, CA, Krzeminski, J, El-Bayoumy, K & Penning, TM 2022, 'Role of Human Aldo-Keto Reductases in the Nitroreduction of 1-Nitropyrene and 1,8-Dinitropyrene', Chemical research in toxicology, vol. 35, no. 12, pp. 2296-2309. https://doi.org/10.1021/acs.chemrestox.2c00271
Sales, AH, Kolbanovskiy, M, Geacintov, NE, Chen, KM, Sun, YW & El-Bayoumy, K 2022, 'Treatment of Human HeLa Cells with Black Raspberry Extracts Enhances the Removal of DNA Lesions by the Nucleotide Excision Repair Mechanism', Antioxidants, vol. 11, no. 11, 2110. https://doi.org/10.3390/antiox11112110
El-Bayoumy, K & Stoner, G 2022, 'Use of Freeze-dried Watercress for Detoxification of Carcinogens and Toxicants in Smokers: Implications of the Findings and Potential Opportunities', Cancer Prevention Research, vol. 15, no. 3, pp. 139-141. https://doi.org/10.1158/1940-6207.CAPR-21-0633

2021

Stairs, DB, Landmesser, ME, Aliaga, C, Chen, KM, Sun, YW & El-Bayoumy, K 2021, 'Black raspberry restores the expression of the tumor suppressor p120ctn in the oral cavity of mice treated with the carcinogen dibenzo[a,l] pyrene diol epoxide', PloS one, vol. 16, no. 11 November, e0259998. https://doi.org/10.1371/journal.pone.0259998
Sun, YW, Chen, KM, Atkins, H, Aliaga, C, Gordon, T, Guttenplan, JB & El-Bayoumy, K 2021, 'Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice', Chemical research in toxicology, vol. 34, no. 4, pp. 1161-1168. https://doi.org/10.1021/acs.chemrestox.1c00033
Chen, KM, Thompson, H, Vanden-Heuvel, JP, Sun, YW, Trushin, N, Aliaga, C, Gowda, K, Amin, S, Stanley, B, Manni, A & El-Bayoumy, K 2021, 'Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer', Scientific reports, vol. 11, no. 1, 410. https://doi.org/10.1038/s41598-020-79716-x

2020

El-Bayoumy, K, Christensen, ND, Hu, J, Viscidi, R, Stairs, DB, Walter, V, Chen, KM, Sun, YW, Muscat, JE & Richie, JP 2020, 'An integrated approach for preventing oral cavity and oropharyngeal cancers: Two etiologies with distinct and shared mechanisms of carcinogenesis', Cancer Prevention Research, vol. 13, no. 8, pp. 649-660. https://doi.org/10.1158/1940-6207.CAPR-20-0096
Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365. https://doi.org/10.1158/1940-6207.CAPR-19-0496
Christensen, ND, Chen, KM, Hu, J, Stairs, DB, Sun, YW, Aliaga, C, Balogh, KK, Atkins, H, Shearer, D, Li, J, Brendle, SA, Gowda, K, Amin, S, Walter, V, Viscidi, R & El-Bayoumy, K 2021, 'The environmental pollutant and tobacco smoke constituent dibenzo[def,p]chrysene is a co-factor for malignant progression of mouse oral papillomavirus infections', Chemico-Biological Interactions, vol. 333, 109321. https://doi.org/10.1016/j.cbi.2020.109321

2019

El-Bayoumy, K & Manni, A 2020, 'Customized Prevention Trials Could Resolve the Controversy of the Effects of Omega-3 Fatty Acids on Cancer', Nutrition and cancer, vol. 72, no. 2, pp. 183-186. https://doi.org/10.1080/01635581.2019.1651348
Guttenplan, JB, Chen, KM, Sun, YW, Shalaby, NAE, Kosinska, W, Desai, D, Gowda, K, Amin, S & El-Bayoumy, K 2019, 'Effects of the Tobacco Carcinogens N′-Nitrosonornicotine and Dibenzo[ a, l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue', Chemical research in toxicology, vol. 32, no. 9, pp. 1893-1899. https://doi.org/10.1021/acs.chemrestox.9b00257
Sun, YW, Xu, H, Benitez, G, Chen, KM, Stanley, A, Stanley, B, Zhu, J, Thompson, H, Manni, A & El-Bayoumy, K 2019, 'Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women', Journal of Proteome Research, vol. 18, no. 9, pp. 3461-3469. https://doi.org/10.1021/acs.jproteome.9b00356

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)