Researcher Profile

Researcher Profile

Karam El-Bayoumy, PhD

Karam El-Bayoumy, PhD

Distinguished Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
kee2@psu.edu

Research Interests

The overall goals of Dr. Karam El-Bayoumy’s research are to understand the mechanisms at the cellular and molecular levels that can account for cancer induction and develop biomarkers for early detection. For more than 30 years, his laboratory has been funded from NCI, NIEHS, NIDCR, DOD and The Komen Foundation, and he has more than 240 peer-reviewed publications.

Dr. El-Bayoumy’s research is focused on the prevention of tobacco and environmentally-related cancers by various synthetic and naturally-occurring chemopreventive agents, combined with dietary manipulation initially in preclinical model systems, then translates the findings into clinical cancer prevention initiatives. He discovered novel chemopreventive selenium compounds against the development of several cancers in preclinical animal models and showed for the first time that selenized yeast reduced oxidative stress in healthy men.

His team demonstrated, using a novel animal model developed in his lab, that black raspberry (BRB) inhibited DNA damage, mutagenesis and oral squamous cell carcinoma (OSCC) induced by the tobacco smoke constituent dibenzo[a,l]pyrene (DB[a,l]P) in the mouse oral cavity; he also reported that BRB enhanced DNA repair of bulky lesions induced by chemical DB[a,l]P and physical (UV) carcinogens. His team also showed that hypomethylated Fgf3 (a gene frequently amplified in OSCC and is involved in epithelial mesenchymal transition) is a potential biomarker for early detection of OSCC; this gene was altered by BRB in a manner consistent with its chemopreventive action.

Dr. El-Bayoumy focuses on developing highly effective chemopreventive agents against tobacco smoke inducing lung cancer and developing biomarkers for early detection in noninvasive fluids indicative of cigarette smoking using various proteomic approaches.

During the last decade, he has been focusing on understanding the mechanistic role of Omega-3 fatty acids in breast cancer prevention in preclinical and clinical studies as well as developing novel liposomal formulation as an effective strategy to deliver select chemopreventive agents.

  • Neoplasms
  • Carcinogenesis
  • Selenium
  • Breast Neoplasms
  • Carcinogens
  • Organoselenium Compounds
  • Lung
  • Breast
  • Diet
  • DNA
  • Liver
  • Chemoprevention

Recent Publications

2018

Chen, K-M, Sun, Y-W, Cooper, TK, Benitez, G, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2018, 'Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary' Chemical Research in Toxicology, vol. 31, no. 11, pp. 1111-1118. https://doi.org/10.1021/acs.chemrestox.8b00152
Manni, A, El-Bayoumy, K & Thompson, H 2018, 'Docosahexaenoic acid in combination with dietary energy restriction for reducing the risk of obesity related breast cancer', International journal of molecular sciences, vol. 19, no. 1, 28. https://doi.org/10.3390/ijms19010028
Chen, K-M, Guttenplan, JB, Sun, Y-W, Cooper, T, Shalaby, NAE, Kosinska, W, Benitez, G, Aliaga, C, Zhu, J, Liao, JJ, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2018, 'Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity', Cancer Prevention Research, vol. 11, no. 3, pp. 157-164. https://doi.org/10.1158/1940-6207.CAPR-17-0278

2017

El-Bayoumy, K, Chen, K-M, Zhang, SM, Sun, Y-W, Amin, S, Stoner, G & Guttenplan, JB 2017, 'Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry', Chemical Research in Toxicology, vol. 30, no. 1, pp. 126-144. https://doi.org/10.1021/acs.chemrestox.6b00306
Guttenplan, JB, Chen, K-M, Sun, Y-W, Lajara, B, Shalaby, NAE, Kosinska, W, Benitez, G, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2017, 'Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts', Chemical Research in Toxicology, vol. 30, no. 12, pp. 2159-2164. https://doi.org/10.1021/acs.chemrestox.7b00242
Chen, K-M, Schell, T, Richie, J, Sun, Y-W, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Sun, Y-W, Chen, K-M, Imamura, Y, Salzberg, AC, Cooper, TK, Caruso, C, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene', PloS one, vol. 12, no. 10, e0186873. https://doi.org/10.1371/journal.pone.0186873
Manni, A, Richie, J, Schetter, S, Calcagnotto, A, Trushin, N, Aliaga, C & El-Bayoumy, K 2017, 'Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women', European Journal of Clinical Nutrition, vol. 71, no. 6, pp. 762-765. https://doi.org/10.1038/ejcn.2016.273

2016

Skibinski, CG, Das, A, Chen, K-M, Liao, JJ, Manni, A, Kester, M & El-Bayoumy, K 2016, 'A novel biologically active acid stable liposomal formulation of docosahexaenoic acid in human breast cancer cell lines', Chemico-Biological Interactions, vol. 252, pp. 1-8. https://doi.org/10.1016/j.cbi.2016.03.035
Manni, A & El-Bayoumy, K 2016, 'Do omega-3 fatty acids reduce the risk of breast cancer in postmenopausal obese women?' Expert Review of Endocrinology and Metabolism, vol. 11, no. 5, pp. 365-367. https://doi.org/10.1080/17446651.2016.1220296
Guttenplan, JB, Chen, K-M, Sun, Y-W, Kosinska, W, Zhou, Y, Kim, SA, Sung, Y, Gowda, K, Amin, S, Stoner, GD & El-Bayoumy, K 2016, 'Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells', Cancer Prevention Research, vol. 9, no. 8, pp. 704-712. https://doi.org/10.1158/1940-6207.CAPR-16-0003
Sandhu, N, Schetter, SE, Liao, J, Hartman, TJ, Richie, JP, McGinley, J, Thompson, HJ, Prokopczyk, B, DuBrock, C, Signori, C, Hamilton, C, Calcagnotto, A, Trushin, N, Aliaga, C, Demers, LM, El-Bayoumy, K & Manni, A 2016, 'Influence of obesity on breast density reduction by omega-3 fatty acids: Evidence from a randomized clinical trial', Cancer Prevention Research, vol. 9, no. 4, pp. 275-282. https://doi.org/10.1158/1940-6207.CAPR-15-0235
Manni, A, El-Bayoumy, K, Skibinski, CG, Thompson, HJ, Santucci-Pereira, J, Bidinotto, LT & Russo, J 2016, The role of omega-3 fatty acids in breast cancer prevention. in Trends in Breast Cancer Prevention. Springer International Publishing, pp. 51-81. https://doi.org/10.1007/978-3-319-27135-4_3

2015

Manni, A, El-Bayoumy, K, Skibinski, CG, Thompson, HJ, Santucci-Pereira, J, Bidinotto, LT & Russo, J 2015, 'Combination of antiestrogens and Omega-3 fatty acids for breast cancer prevention' BioMed Research International, vol. 2015, 638645. https://doi.org/10.1155/2015/638645
Turbitt, WJ, Black, AJ, Collins, SD, Meng, H, Xu, H, Washington, S, Aliaga, C, El-Bayoumy, K, Manni, A & Rogers, CJ 2015, 'Fish Oil Enhances T Cell Function and Tumor Infiltration and Is Correlated with a Cancer Prevention Effect in HER-2/neu but Not PyMT Transgenic Mice' Nutrition and cancer, vol. 67, no. 6, pp. 965-975. https://doi.org/10.1080/01635581.2015.1060351
El-Bayoumy, K, Sinha, R & Richie, J 2015, Forms of selenium in cancer prevention. in Diversity of Selenium Functions in Health and Disease. CRC Press, pp. 137-172. https://doi.org/10.1201/b18810
Wilson, R, Bortner, JD, Roff, A, Das, A, Battaglioli, EJ, Richie, J, Barnholtz-Sloan, J, Chinchilli, V, Berg, A, Liu, G, Salzberg, AC & El-Bayoumy, K 2015, 'Genetic and environmental influences on plasma vitamin D binding protein concentrations', Translational Research, vol. 165, no. 6, pp. 667-676. https://doi.org/10.1016/j.trsl.2014.08.003
Rice, SJ, Liu, X, Miller, B, Joshi, M, Zhu, J, Caruso, C, Gilbert, C, Toth, J, Reed, MF, Rassaei, N, Das, A, Barochia, A, El-Bayoumy, K & Belani, C 2015, 'Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung' Proteomics, vol. 15, no. 18, pp. 3267-3277. https://doi.org/10.1002/pmic.201500029
Das, A, Bortner, JD, Aliaga, C, Cooper, T, Stanley, A, Stanley, B, Belani, C & El-Bayoumy, K 2015, 'Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection' EuPA Open Proteomics, vol. 9, pp. 23-33. https://doi.org/10.1016/j.euprot.2015.07.015
Sun, Y-W, El-Bayoumy, K, Aliaga, C, Awad, A, Gowda, K, Amin, S & Chen, K-M 2015, 'Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice' Chemical Research in Toxicology, vol. 28, no. 7, pp. 1427-1433. https://doi.org/10.1021/acs.chemrestox.5b00097

Clinical Trials Search


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