Keith Cheng, MD, PhD - Penn State Cancer Institute
Researcher Profile
Keith Cheng, MD, PhD
Distinguished Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Distinguished Professor, Department of Molecular and Precision Medicine
Division of Experimental Pathology
Distinguished Professor, Department of Molecular and Precision Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Institute for CyberScience (ICS) - Associate
Recent Publications
2025
Ngu, MS, Vanselow, DJ, Zaino, CR, Lin, AY, Copper, JE, Beaton, MJ, Orsini, L, Colbourne, JK, Cheng, K & Ang, KC 2025, 'A web-based histology atlas for the freshwater sentinel species Daphnia magna', Science of the Total Environment, vol. 958, 177930. https://doi.org/10.1016/j.scitotenv.2024.177930
2024
Kronman, FN, Liwang, JK, Betty, R, Vanselow, DJ, Wu, YT, Tustison, NJ, Bhandiwad, A, Manjila, SB, Minteer, JA, Shin, D, Lee, CH, Patil, R, Duda, JT, Xue, J, Lin, Y, Cheng, KC, Puelles, L, Gee, JC, Zhang, J, Ng, L & Kim, Y 2024, 'Developmental mouse brain common coordinate framework', Nature communications, vol. 15, no. 1, 9072. https://doi.org/10.1038/s41467-024-53254-w
Atkins, HM, Uslu, AA, Li, JJ, Shearer, DA, Brendle, SA, Han, C, Kozak, M, Lopez, P, Nayar, D, Balogh, KK, Abendroth, C, Copper, J, Cheng, KC, Christensen, ND, Zhu, Y, Avril, S, Burgener, AD, Murooka, TT & Hu, J 2024, 'Monitoring mouse papillomavirus-associated cancer development using longitudinal Pap smear screening', mBio, vol. 15, no. 8, pp. e0142024. https://doi.org/10.1128/mbio.01420-24
Ngu, MS, Vanselow, DJ, Sugarman, AL, Saint-Fort, RA, Zaino, CR, Yakovlev, MA, Cheng, KC & Ang, KC 2024, 'Staining and resin embedding of whole Daphnia magna samples for micro-CT imaging enabling 3D visualization of cells, tissues, and organs', PloS one, vol. 19, no. 11, e0313389. https://doi.org/10.1371/journal.pone.0313389
2023
Ang, KC, Canfield, VA, Foster, TC, Harbaugh, TD, Early, KA, Harter, RL, Reid, KP, Leong, SL, Kawasawa, YI, Liu, DJ, Hawley, JW & Cheng, KC 2023, 'Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population', eLife, vol. 12. https://doi.org/10.7554/eLife.77514
Kim, HL, Li, T, Kalsi, N, Nguyen, HTT, Shaw, TA, Ang, KC, Cheng, KC, Ratan, A, Peltier, WR, Samanta, D, Pratapneni, M, Schuster, SC & Horton, BP 2023, 'Prehistoric human migration between Sundaland and South Asia was driven by sea-level rise', Communications Biology, vol. 6, no. 1, 150. https://doi.org/10.1038/s42003-023-04510-0
Subbakrishna Adishesha, A, Vanselow, DJ, La Riviere, P, Cheng, KC & Huang, SX 2023, 'Sinogram domain angular upsampling of sparse-view micro-CT with dense residual hierarchical transformer and attention-weighted loss', Computer Methods and Programs in Biomedicine, vol. 242, 107802. https://doi.org/10.1016/j.cmpb.2023.107802
2022
Yakovlev, MA, Vanselow, DJ, Ngu, MS, Zaino, CR, Katz, SR, Ding, Y, Parkinson, D, Wang, SY, Ang, KC, La Riviere, P & Cheng, KC 2022, 'A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale', Journal of Synchrotron Radiation, vol. 29, pp. 505-514. https://doi.org/10.1107/S160057752101287X
Cheng, KC, Burdine, RD, Dickinson, ME, Ekker, SC, Lin, AY, Lloyd, KCK, Lutz, CM, MacRae, CA, Morrison, JH, O'Connor, DH, Postlethwait, JH, Rogers, CD, Sanchez, S, Simpson, JH, Talbot, WS, Wallace, DC, Weimer, JM & Bellen, HJ 2022, 'Promoting validation and cross-phylogenetic integration in model organism research', DMM Disease Models and Mechanisms, vol. 15, no. 9, dmm049600. https://doi.org/10.1242/dmm.049600
Wu, YT, Bennett, HC, Chon, U, Vanselow, DJ, Zhang, Q, Muñoz-Castañeda, R, Cheng, KC, Osten, P, Drew, PJ & Kim, Y 2022, 'Quantitative relationship between cerebrovascular network and neuronal cell types in mice', Cell Reports, vol. 39, no. 12, 110978. https://doi.org/10.1016/j.celrep.2022.110978
Son, S, Manjila, SB, Newmaster, KT, Wu, YT, Vanselow, DJ, Ciarletta, M, Anthony, TE, Cheng, KC & Kim, Y 2022, 'Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice', Journal of Neuroscience, vol. 42, no. 25, pp. 5021-5033. https://doi.org/10.1523/JNEUROSCI.0307-22.2022
2021
Ye, J, Xue, Y, Liu, P, Zaino, R, Cheng, KC & Huang, X 2021, A Multi-attribute Controllable Generative Model for Histopathology Image Synthesis. in M de Bruijne, PC Cattin, S Cotin, N Padoy, S Speidel, Y Zheng & C Essert (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 - 24th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 12908 LNCS, Springer Science and Business Media Deutschland GmbH, pp. 613-623, 24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021, Virtual, Online, 9/27/21. https://doi.org/10.1007/978-3-030-87237-3_59
Van Nuffel, S, Ang, KC, Lin, AY & Cheng, KC 2021, 'Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae Using ToF-SIMS', Journal of the American Society for Mass Spectrometry, vol. 32, no. 1, pp. 255-261. https://doi.org/10.1021/jasms.0c00300
Xue, Y, Ye, J, Zhou, Q, Long, LR, Antani, S, Xue, Z, Cornwell, C, Zaino, R, Cheng, KC & Huang, X 2021, 'Selective synthetic augmentation with HistoGAN for improved histopathology image classification', Medical Image Analysis, vol. 67, 101816. https://doi.org/10.1016/j.media.2020.101816
Katz, SR, Yakovlev, MA, Vanselow, DJ, Ding, Y, Lin, AY, Parkinson, DY, Wang, Y, Canfield, VA, Ang, KC & Cheng, KC 2021, 'Whole-organism 3d quantitative characterization of zebrafish melanin by silver deposition micro-ct', eLife, vol. 10, e68920. https://doi.org/10.7554/eLife.68920
Adishesha, AS, Vanselow, DJ, Riviere, PL, Huang, X & Cheng, KC 2021, Zebrafish histotomography noise removal in projection and reconstruction domains. in 2021 IEEE 18th International Symposium on Biomedical Imaging, ISBI 2021., 9433914, Proceedings - International Symposium on Biomedical Imaging, vol. 2021-April, IEEE Computer Society, pp. 140-144, 18th IEEE International Symposium on Biomedical Imaging, ISBI 2021, Nice, France, 4/13/21. https://doi.org/10.1109/ISBI48211.2021.9433914