Researcher Profile

Researcher Profile

Kristin Eckert, PhD

Kristin Eckert, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
kae4@psu.edu

Research Interests

  • DNA-Directed DNA Polymerase
  • DNA
  • Microsatellite Repeats
  • Mutation
  • Genome
  • Neoplasms
  • Mutagenesis
  • In Vitro Techniques
  • Human Genome
  • Nucleotides
  • Exonucleases
  • Alleles

Recent Publications

2021

Guiblet, WM, Cremona, MA, Harris, RS, Chen, D, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2021, 'Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome', Nucleic acids research, vol. 49, no. 3, pp. 1497-1516. https://doi.org/10.1093/nar/gkaa1269
Tsao, WC, Buj, R, Aird, KM, Sidorova, JM & Eckert, KA 2021, 'Overexpression of oncogenic H-Ras in hTERTimmortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion', PloS one, vol. 16, no. May, e0251188. https://doi.org/10.1371/journal.pone.0251188
Guiblet, WM, DeGiorgio, M, Cheng, X, Chiaromonte, F, Eckert, KA, Huang, Y & Makova, KD 2021, 'Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome', Genome research, vol. 31, no. 7, pp. 1136-1149. https://doi.org/10.1101/gr.269589.120

2019

Eckert, KA & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621. https://doi.org/10.18632/oncotarget.26572
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, KA & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5. https://doi.org/10.1016/j.celrep.2019.03.103

2018

Barnes, RP, Tsao, WC, Moldovan, GL & Eckert, KA 2018, 'DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress', Cancer Research, vol. 78, no. 23, pp. 6549-6560. https://doi.org/10.1158/0008-5472.CAN-17-3931
Tsao, WC & Eckert, KA 2018, 'Detours to replication: Functions of specialized DNA polymerases during oncogene-induced replication stress', International journal of molecular sciences, vol. 19, no. 10, 3255. https://doi.org/10.3390/ijms19103255
Shastri, N, Tsai, YC, Hile, S, Jordan, D, Powell, B, Chen, J, Maloney, D, Dose, M, Lo, Y, Anastassiadis, T, Rivera, O, Kim, T, Shah, S, Borole, P, Asija, K, Wang, X, Smith, KD, Finn, D, Schug, J, Casellas, R, Yatsunyk, LA, Eckert, KA & Brown, EJ 2018, 'Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition', Molecular cell, vol. 72, no. 2, pp. 222-238.e11. https://doi.org/10.1016/j.molcel.2018.08.047
Guiblet, WM, Cremona, MA, Cechova, M, Harris, RS, Kejnovsk√°, I, Kejnovsky, E, Eckert, K, Chiaromonte, F & Makova, KD 2018, 'Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate', Genome research, vol. 28, no. 12, pp. 1767-1778. https://doi.org/10.1101/gr.241257.118

2017

Barnes, RP, Hile, SE, Lee, MY & Eckert, KA 2017, 'DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis', DNA Repair, vol. 57, pp. 1-11. https://doi.org/10.1016/j.dnarep.2017.05.006
Barnes, R & Eckert, K 2017, 'Maintenance of genome integrity: How mammalian cells orchestrate genome duplication by coordinating replicative and specialized DNA polymerases', Genes, vol. 8, no. 1, 19. https://doi.org/10.3390/genes8010019

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