Researcher Profile

Researcher Profile

Kristin Eckert, PhD

Kristin Eckert, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
kae4@psu.edu

Research Interests

  • DNA-Directed DNA Polymerase
  • DNA
  • Microsatellite Repeats
  • Mutation
  • Neoplasms
  • Genome
  • Mutagenesis
  • Human Genome
  • Exonucleases
  • Alleles
  • Nucleotides
  • Enzymes

Recent Publications

2019

Eckert, K & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621. https://doi.org/10.18632/oncotarget.26572
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, K & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5. https://doi.org/10.1016/j.celrep.2019.03.103

2018

Barnes, RP, Tsao, WC, Moldovan, G-L & Eckert, K 2018, 'DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress', Cancer Research, vol. 78, no. 23, pp. 6549-6560. https://doi.org/10.1158/0008-5472.CAN-17-3931
Tsao, WC & Eckert, K 2018, 'Detours to replication: Functions of specialized DNA polymerases during oncogene-induced replication stress', International journal of molecular sciences, vol. 19, no. 10, 3255. https://doi.org/10.3390/ijms19103255
Shastri, N, Tsai, YC, Hile, S, Jordan, D, Powell, B, Chen, J, Maloney, D, Dose, M, Lo, Y, Anastassiadis, T, Rivera, O, Kim, T, Shah, S, Borole, P, Asija, K, Wang, X, Smith, KD, Finn, D, Schug, J, Casellas, R, Yatsunyk, LA, Eckert, K & Brown, EJ 2018, 'Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition', Molecular cell, vol. 72, no. 2, pp. 222-238.e11. https://doi.org/10.1016/j.molcel.2018.08.047
Guiblet, WM, Cremona, M, Cechova, M, Harris, RS, Kejnovsk√°, I, Kejnovsky, E, Eckert, K, Chiaromonte, F & Makova, KD 2018, 'Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate', Genome research, vol. 28, no. 12, pp. 1767-1778. https://doi.org/10.1101/gr.241257.118

2017

Barnes, RP, Hile, SE, Lee, MY & Eckert, K 2017, 'DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis', DNA Repair, vol. 57, pp. 1-11. https://doi.org/10.1016/j.dnarep.2017.05.006
Barnes, R & Eckert, K 2017, 'Maintenance of genome integrity: How mammalian cells orchestrate genome duplication by coordinating replicative and specialized DNA polymerases', Genes, vol. 8, no. 1, 19. https://doi.org/10.3390/genes8010019

2016

Fungtammasan, A, Hoover, M, Campos-S√°nchez, R, Eckert, K, DeGiorgio, M & Makova, KD 2016, 'Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats', Molecular biology and evolution, vol. 33, no. 10, pp. 2744-2758. https://doi.org/10.1093/molbev/msw139

2015

Fungtammasan, A, Ananda, G, Hile, SE, Su, MSW, Sun, C, Harris, RS, Medvedev, P, Eckert, K & Makova, KD 2015, 'Accurate typing of short tandem repeats from genome-wide sequencing data and its applications' Genome research, vol. 125, no. 5, pp. 736-749. https://doi.org/10.1101/gr.185892.114
Baptiste, BA, Jacob, KD & Eckert, K 2015, 'Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites' DNA Repair, vol. 29, pp. 91-100. https://doi.org/10.1016/j.dnarep.2015.02.016
Guilliam, TA, Jozwiakowski, SK, Ehlinger, A, Barnes, RP, Rudd, SG, Bailey, LJ, Skehel, JM, Eckert, K, Chazin, WJ & Doherty, AJ 2015, 'Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins', Nucleic acids research, vol. 43, no. 2, pp. 1056-1068. https://doi.org/10.1093/nar/gku1321

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