Researcher Profile

Researcher Profile

Kristin Eckert, PhD

Kristin Eckert, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA-Directed DNA Polymerase
  • DNA
  • Microsatellite Repeats
  • Mutation
  • Genome
  • Neoplasms
  • Mutagenesis
  • In Vitro Techniques
  • Human Genome
  • Nucleotides
  • Exonucleases
  • Alleles

Recent Publications


Guiblet, WM, Cremona, MA, Harris, RS, Chen, D, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2021, 'Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome', Nucleic acids research, vol. 49, no. 3, pp. 1497-1516.
Tsao, WC, Buj, R, Aird, KM, Sidorova, JM & Eckert, KA 2021, 'Overexpression of oncogenic H-Ras in hTERTimmortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion', PloS one, vol. 16, no. May, e0251188.
Guiblet, WM, DeGiorgio, M, Cheng, X, Chiaromonte, F, Eckert, KA, Huang, Y & Makova, KD 2021, 'Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome', Genome research, vol. 31, no. 7, pp. 1136-1149.


Eckert, KA & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621.
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, KA & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5.


Barnes, RP, Tsao, WC, Moldovan, GL & Eckert, KA 2018, 'DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress', Cancer Research, vol. 78, no. 23, pp. 6549-6560.
Tsao, WC & Eckert, KA 2018, 'Detours to replication: Functions of specialized DNA polymerases during oncogene-induced replication stress', International journal of molecular sciences, vol. 19, no. 10, 3255.
Shastri, N, Tsai, YC, Hile, S, Jordan, D, Powell, B, Chen, J, Maloney, D, Dose, M, Lo, Y, Anastassiadis, T, Rivera, O, Kim, T, Shah, S, Borole, P, Asija, K, Wang, X, Smith, KD, Finn, D, Schug, J, Casellas, R, Yatsunyk, LA, Eckert, KA & Brown, EJ 2018, 'Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition', Molecular cell, vol. 72, no. 2, pp. 222-238.e11.
Guiblet, WM, Cremona, MA, Cechova, M, Harris, RS, Kejnovsk√°, I, Kejnovsky, E, Eckert, K, Chiaromonte, F & Makova, KD 2018, 'Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate', Genome research, vol. 28, no. 12, pp. 1767-1778.


Barnes, RP, Hile, SE, Lee, MY & Eckert, KA 2017, 'DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis', DNA Repair, vol. 57, pp. 1-11.
Barnes, R & Eckert, K 2017, 'Maintenance of genome integrity: How mammalian cells orchestrate genome duplication by coordinating replicative and specialized DNA polymerases', Genes, vol. 8, no. 1, 19.

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