Kristin Eckert, PhD - Penn State Cancer Institute
Researcher Profile
Kristin Eckert, PhD
Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Molecular and Precision Medicine
Division of Experimental Pathology
Professor, Department of Molecular and Precision Medicine
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Das, M, Hile, SE, Brewster, J, Boer, JL, Bezalel-Buch, R, Guo, Q, Yang, W, Burgers, PM, Eckert, KA & Freudenreich, CH 2025, 'DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion', Nucleic acids research, vol. 53, no. 3, gkae1254. https://doi.org/10.1093/nar/gkae1254
2024
Pytko, KG, Dannenberg, RL, Eckert, KA & Hedglin, M 2024, 'Replication of [AT/TA]25 Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels', Biochemistry, vol. 63, no. 8, pp. 969-983. https://doi.org/10.1021/acs.biochem.4c00006
2023
Weissensteiner, MH, Cremona, MA, Guiblet, WM, Stoler, N, Harris, RS, Cechova, M, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2023, 'Accurate sequencing of DNA motifs able to form alternative (non-B) structures', Genome research, vol. 33, no. 6, pp. 907-923. https://doi.org/10.1101/gr.277490.122
Eckert, KA 2023, 'Nontraditional Roles of DNA Polymerase Eta Support Genome Duplication and Stability', Genes, vol. 14, no. 1, 175. https://doi.org/10.3390/genes14010175
Zhang, D, Eckert, KA & Lee, MYWT 2023, 'Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”', Genes, vol. 14, no. 4, 893. https://doi.org/10.3390/genes14040893
2022
Stein, ME, Hile, SE, Weissensteiner, MH, Lee, M, Zhang, S, Kejnovský, E, Kejnovská, I, Makova, KD & Eckert, KA 2022, 'Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity', DNA Repair, vol. 119, 103402. https://doi.org/10.1016/j.dnarep.2022.103402
2021
Stein, ME & Eckert, KA 2021, 'Impact of g-quadruplexes and chronic inflammation on genome instability: Additive effects during carcinogenesis', Genes, vol. 12, no. 11, 1779. https://doi.org/10.3390/genes12111779
Guiblet, WM, Cremona, MA, Harris, RS, Chen, D, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2021, 'Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome', Nucleic acids research, vol. 49, no. 3, pp. 1497-1516. https://doi.org/10.1093/nar/gkaa1269
Tsao, WC, Buj, R, Aird, KM, Sidorova, JM & Eckert, KA 2021, 'Overexpression of oncogenic H-Ras in hTERTimmortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion', PloS one, vol. 16, no. May, e0251188. https://doi.org/10.1371/journal.pone.0251188
Guiblet, WM, DeGiorgio, M, Cheng, X, Chiaromonte, F, Eckert, KA, Huang, YF & Makova, KD 2021, 'Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome', Genome research, vol. 31, no. 7, pp. 1136-1149. https://doi.org/10.1101/gr.269589.120