Researcher Profile

Researcher Profile

Kristin Eckert, PhD

Kristin Eckert, PhD

Professor, Department of Pathology and Laboratory Medicine
Chief, Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA-Directed DNA Polymerase
  • DNA
  • Microsatellite Repeats
  • Mutation
  • Genome
  • Neoplasms
  • Mutagenesis
  • Human Genome
  • In Vitro Techniques
  • Nucleotides
  • Exonucleases
  • Alleles

Recent Publications


Stein, ME, Hile, SE, Weissensteiner, MH, Lee, M, Zhang, S, Kejnovsk√Ĺ, E, Kejnovsk√°, I, Makova, KD & Eckert, KA 2022, 'Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity', DNA Repair, vol. 119, 103402.


Stein, ME & Eckert, KA 2021, 'Impact of g-quadruplexes and chronic inflammation on genome instability: Additive effects during carcinogenesis', Genes, vol. 12, no. 11, 1779.
Guiblet, WM, Cremona, MA, Harris, RS, Chen, D, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2021, 'Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome', Nucleic acids research, vol. 49, no. 3, pp. 1497-1516.
Tsao, WC, Buj, R, Aird, KM, Sidorova, JM & Eckert, KA 2021, 'Overexpression of oncogenic H-Ras in hTERTimmortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion', PloS one, vol. 16, no. May, e0251188.
Guiblet, WM, DeGiorgio, M, Cheng, X, Chiaromonte, F, Eckert, KA, Huang, YF & Makova, KD 2021, 'Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome', Genome research, vol. 31, no. 7, pp. 1136-1149.


Eckert, KA & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621.
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, KA & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5.

Clinical Trials Search

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