Researcher Profile

Researcher Profile

Kristin Eckert, PhD

Kristin Eckert, PhD

Professor, Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • DNA-Directed DNA Polymerase
  • DNA
  • Microsatellite Repeats
  • Mutation
  • Neoplasms
  • Genome
  • Mutagenesis
  • In Vitro Techniques
  • Human Genome
  • Exonucleases
  • Alleles
  • Nucleotides

Recent Publications


Eckert, KA & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621.
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, KA & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5.


Barnes, RP, Tsao, WC, Moldovan, GL & Eckert, KA 2018, 'DNA polymerase eta prevents tumor cell-cycle arrest and cell death during recovery from replication stress', Cancer Research, vol. 78, no. 23, pp. 6549-6560.
Tsao, WC & Eckert, KA 2018, 'Detours to replication: Functions of specialized DNA polymerases during oncogene-induced replication stress', International journal of molecular sciences, vol. 19, no. 10, 3255.
Shastri, N, Tsai, YC, Hile, S, Jordan, D, Powell, B, Chen, J, Maloney, D, Dose, M, Lo, Y, Anastassiadis, T, Rivera, O, Kim, T, Shah, S, Borole, P, Asija, K, Wang, X, Smith, KD, Finn, D, Schug, J, Casellas, R, Yatsunyk, LA, Eckert, KA & Brown, EJ 2018, 'Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition', Molecular cell, vol. 72, no. 2, pp. 222-238.e11.
Guiblet, WM, Cremona, MA, Cechova, M, Harris, RS, Kejnovsk√°, I, Kejnovsky, E, Eckert, K, Chiaromonte, F & Makova, KD 2018, 'Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate', Genome research, vol. 28, no. 12, pp. 1767-1778.


Barnes, RP, Hile, SE, Lee, MY & Eckert, KA 2017, 'DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis', DNA Repair, vol. 57, pp. 1-11.
Barnes, R & Eckert, K 2017, 'Maintenance of genome integrity: How mammalian cells orchestrate genome duplication by coordinating replicative and specialized DNA polymerases', Genes, vol. 8, no. 1, 19.


Fungtammasan, A, Tomaszkiewicz, M, Campos-S√°nchez, R, Eckert, KA, Degiorgio, M & Makova, KD 2016, 'Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats', Molecular biology and evolution, vol. 33, no. 10, pp. 2744-2758.

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