Kristin Eckert, PhD - Penn State Cancer Institute
Researcher Profile
Kristin Eckert, PhD
Professor, Department of Pathology and Laboratory Medicine
Chief, Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Chief, Division of Experimental Pathology
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- DNA
- DNA-Directed DNA Polymerase
- Microsatellite Repeats
- Mutation
- Genome
- Neoplasms
- Mutagenesis
- In Vitro Techniques
- Human Genome
- Nucleotides
- Exonucleases
- Alleles
Recent Publications
2023
Weissensteiner, MH, Cremona, MA, Guiblet, WM, Stoler, N, Harris, RS, Cechova, M, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2023, 'Accurate sequencing of DNA motifs able to form alternative (non-B) structures', Genome research, vol. 33, no. 6, pp. 907-923. https://doi.org/10.1101/gr.277490.122
Eckert, KA 2023, 'Nontraditional Roles of DNA Polymerase Eta Support Genome Duplication and Stability', Genes, vol. 14, no. 1, 175. https://doi.org/10.3390/genes14010175
Zhang, D, Eckert, KA & Lee, MYWT 2023, 'Special Issue “DNA Replication/Repair, and the DNA Damage Response in Human Disease”', Genes, vol. 14, no. 4, 893. https://doi.org/10.3390/genes14040893
2022
Stein, ME, Hile, SE, Weissensteiner, MH, Lee, M, Zhang, S, Kejnovský, E, Kejnovská, I, Makova, KD & Eckert, KA 2022, 'Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity', DNA Repair, vol. 119, 103402. https://doi.org/10.1016/j.dnarep.2022.103402
2021
Stein, ME & Eckert, KA 2021, 'Impact of g-quadruplexes and chronic inflammation on genome instability: Additive effects during carcinogenesis', Genes, vol. 12, no. 11, 1779. https://doi.org/10.3390/genes12111779
Guiblet, WM, Cremona, MA, Harris, RS, Chen, D, Eckert, KA, Chiaromonte, F, Huang, YF & Makova, KD 2021, 'Non-B DNA: A major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome', Nucleic acids research, vol. 49, no. 3, pp. 1497-1516. https://doi.org/10.1093/nar/gkaa1269
Tsao, WC, Buj, R, Aird, KM, Sidorova, JM & Eckert, KA 2021, 'Overexpression of oncogenic H-Ras in hTERTimmortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion', PloS one, vol. 16, no. May, e0251188. https://doi.org/10.1371/journal.pone.0251188
Guiblet, WM, DeGiorgio, M, Cheng, X, Chiaromonte, F, Eckert, KA, Huang, YF & Makova, KD 2021, 'Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome', Genome research, vol. 31, no. 7, pp. 1136-1149. https://doi.org/10.1101/gr.269589.120
2019
Eckert, KA & Barnes, RP 2019, 'DNA polymerases as chemotherapy targets: Promise and challenges', Oncotarget, vol. 10, no. 6, pp. 620-621. https://doi.org/10.18632/oncotarget.26572
Kaushal, S, Wollmuth, CE, Das, K, Hile, SE, Regan, SB, Barnes, RP, Haouzi, A, Lee, SM, House, NCM, Guyumdzhyan, M, Eckert, KA & Freudenreich, CH 2019, 'Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D', Cell Reports, vol. 27, no. 4, pp. 1151-1164.e5. https://doi.org/10.1016/j.celrep.2019.03.103