Researcher Profile

Researcher Profile

Jian Yang, PhD

Jian Yang, PhD

Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Next-Generation Therapies

Research Interests

  • Citric Acid
  • Polymers
  • Biocompatible Materials
  • Tissue Engineering
  • Nanoparticles
  • Elastomers
  • In Vitro Techniques
  • poly(lactide)
  • Pharmaceutical Preparations
  • Polyesters
  • Blood Vessels
  • Fluorescence

Recent Publications


Wang, D, Xia, T, Wang, Y, Chen, Y, Zhang, C, Murray, W, Schultz, AT, Liu, Z & Yang, J 2022, 'Citrate-based fluorometric sensor for multi-halide sensing', Smart Materials in Medicine, vol. 3, pp. 374-381.
Tan, X, Gerhard, E, Wang, Y, Tran, RT, Xu, H, Yan, S, Rizk, EB, Armstrong, AD, Zhou, Y, Du, J, Bai, X & Yang, J 2022, 'Development of Biodegradable Osteopromotive Citrate-Based Bone Putty', Small.


Tang, S, Chi, K, Xu, H, Yong, Q, Yang, J & Catchmark, JM 2021, 'A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications', Carbohydrate Polymers, vol. 252, 117123.
Zhu, J, Liu, S, Hu, Z, Zhang, X, Yi, N, Tang, K, Dexheimer, MG, Lian, X, Wang, Q, Yang, J, Gray, J & Cheng, H 2021, 'Laser-induced graphene non-enzymatic glucose sensors for on-body measurements', Biosensors and Bioelectronics, vol. 193, 113606.
Wang, D, Kuzma, ML, Tan, X, He, TC, Dong, C, Liu, Z & Yang, J 2021, 'Phototherapy and optical waveguides for the treatment of infection', Advanced Drug Delivery Reviews, vol. 179, 114036.
Siddiqui, Z, Sarkar, B, Kim, KK, Kumar, A, Paul, R, Mahajan, A, Grasman, JM, Yang, J & Kumar, VA 2021, 'Self-assembling peptide hydrogels facilitate vascularization in two-component scaffolds', Chemical Engineering Journal, vol. 422, 130145.
Zhu, J, Hu, Z, Song, C, Yi, N, Yu, Z, Liu, Z, Liu, S, Wang, M, Dexheimer, MG, Yang, J & Cheng, H 2021, 'Stretchable wideband dipole antennas and rectennas for RF energy harvesting', Materials Today Physics, vol. 18, 100377.
Zheng, M, Guo, J, Li, Q, Yang, J, Han, Y, Yang, H, Yu, M, Zhong, L, Lu, D, Li, L & Sun, L 2021, 'Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering', Bioactive Materials, vol. 6, no. 2, pp. 404-419.
Gonsalves, A, Tambe, P, Le, D, Thakore, D, Wadajkar, AS, Yang, J, Nguyen, KT & Menon, JU 2021, 'Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing', Journal of Materials Chemistry B, vol. 9, no. 46, pp. 9533-9546.


Wei, Q, Shi, X, Zhao, T, Cai, P, Chen, T, Zhang, Y, Huang, C, Yang, J, Chen, X & Zhang, S 2020, 'Actin-ring segment switching drives nonadhesive gap closure', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 52, pp. 33263-33271.
Kuzma, M, Gerhard, E, Shan, D & Yang, J 2020, Advances in bioresorbable electronics and uses in biomedical sensing. in Interfacing Bioelectronics and Biomedical Sensing. Springer International Publishing, pp. 29-72.
Guo, J, Tian, X, Xie, D, Rahn, K, Gerhard, E, Kuzma, ML, Zhou, D, Dong, C, Bai, X, Lu, Z & Yang, J 2020, 'Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion', Advanced Functional Materials, vol. 30, no. 27, 2002438.
Li, Q, Li, L, Yu, M, Zheng, M, Li, Y, Yang, J, Dai, M, Zhong, L, Sun, L & Lu, D 2020, 'Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration', Journal of Biomedical Materials Research - Part A, vol. 108, no. 8, pp. 1713-1725.
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635.
Lu, X, Shi, S, Li, H, Gerhard, E, Lu, Z, Tan, X, Li, W, Rahn, KM, Xie, D, Xu, G, Zou, F, Bai, X, Guo, J & Yang, J 2020, 'Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives', Biomaterials, vol. 232, 119719.
Pandey, N, Menon, JU, Takahashi, M, Hsieh, JT, Yang, J, Nguyen, KT & Wadajkar, AS 2020, 'Thermo-responsive fluorescent nanoparticles for multimodal imaging and treatment of cancers', Nanotheranostics, vol. 4, no. 1, pp. 1-13.


Ma, C, Kuzma, ML, Bai, X & Yang, J 2019, 'Biomaterial-Based Metabolic Regulation in Regenerative Engineering', Advanced Science, vol. 6, no. 19, 1900819.
Kuriakose, AE, Pandey, N, Shan, D, Banerjee, S, Yang, J & Nguyen, KT 2019, 'Characterization of Photoluminescent Polylactone-Based Nanoparticles for Their Applications in Cardiovascular Diseases', Frontiers in Bioengineering and Biotechnology, vol. 7, 353.
Wang, H, Zhang, H, Sun, Q, Yang, J, Zeng, C, Ding, C, Cai, D, Liu, A & Bai, X 2019, 'Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression', Journal of Cellular Physiology, vol. 234, no. 3, pp. 2730-2740.
He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191.
Tarafder, S, Gulko, J, Kim, D, Sim, KH, Gutman, S, Yang, J, Cook, JL & Lee, CH 2019, 'Effect of dose and release rate of CTGF and TGFβ3 on avascular meniscus healing', Journal of Orthopaedic Research, vol. 37, no. 7, pp. 1555-1562.
Shan, D, Ma, C & Yang, J 2019, 'Enabling biodegradable functional biomaterials for the management of neurological disorders', Advanced Drug Delivery Reviews, vol. 148, pp. 219-238.
Zou, W, Lai, M, Zhang, Y, Zheng, L, Xing, Z, Li, T, Zou, Z, Song, Q, Zhao, X, Xia, L, Yang, J, Liu, A, Zhang, H, Cui, ZK, Jiang, Y & Bai, X 2019, 'Exosome Release Is Regulated by mTORC1', Advanced Science, vol. 6, no. 3, 1801313.
Yang, J & Kim, G 2019, Local delivery of epigenetically stimulating folic acid for peripheral nerve regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Iyer, R, Kuriakose, AE, Yaman, S, Su, LC, Shan, D, Yang, J, Liao, J, Tang, L, Banerjee, S, Xu, H & Nguyen, KT 2019, 'Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases', International Journal of Pharmaceutics, vol. 554, pp. 212-223.
Liu, W, Wang, Z, Yang, J, Wang, Y, Li, K, Huang, B, Yan, B, Wang, T, Li, M, Zou, Z, Yang, J, Xiao, G, Cui, ZK, Liu, A & Bai, X 2019, 'Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice', Open biology, vol. 9, no. 5, 180262.


Jiang, Z, Tian, Y, Shan, D, Wang, Y, Gerhard, E, Xia, J, Huang, R, He, Y, Li, A, Tang, J, Ruan, H, Li, Y, Li, J, Yang, J & Wu, A 2018, ' pH protective Y 1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time ', Biomaterials, vol. 170, pp. 70-81.
Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986.
Chen, H, Wang, Y, Dai, H, Tian, X, Cui, ZK, Chen, Z, Hu, L, Song, Q, Liu, A, Zhang, Z, Xiao, G, Yang, J, Jiang, Y & Bai, X 2018, 'Bone and plasma citrate is reduced in osteoporosis', Bone, vol. 114, pp. 189-197.
Ma, C, Gerhard, E, Lu, D & Yang, J 2018, 'Citrate chemistry and biology for biomaterials design', Biomaterials, vol. 178, pp. 383-400.
Shan, D, Hsieh, JT, Bai, X & Yang, J 2018, 'Citrate-Based Fluorescent Biomaterials', Advanced Healthcare Materials, vol. 7, no. 18, 1800532.
Ma, C, Tian, X, Kim, JP, Xie, D, Ao, X, Shan, D, Lin, Q, Hudock, MR, Bai, X & Yang, J 2018, 'Citrate-based materials fuel human stem cells by metabonegenic regulation', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 50, pp. E11741-E11750.
Zeng, L, Deng, X & Yang, J 2018, 'Constrained Gaussian process with application in tissue-engineering scaffold biodegradation', IISE Transactions, vol. 50, no. 5, pp. 431-447.
Zhang, J, Jia, J, Kim, JP, Yang, F, Wang, X, Shen, H, Xu, S, Yang, J & Wu, D 2018, 'Construction of versatile multilayered composite nanoparticles from a customized nanogel template', Bioactive Materials, vol. 3, no. 1, pp. 87-96.
Shan, D, Kothapalli, SR, Ravnic, DJ, Gerhard, E, Kim, JP, Guo, J, Ma, C, Guo, J, Gui, L, Sun, L, Lu, D & Yang, J 2018, 'Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers', Advanced Functional Materials, vol. 28, no. 34, 1801787.
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, EB, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44.
Tarafder, S, Gulko, J, Sim, KH, Yang, J, Cook, JL & Lee, CH 2018, 'Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment', Scientific reports, vol. 8, no. 1, 8150.
Gyawali, D, Kim, JP & Yang, J 2018, 'Highly photostable nanogels for fluorescence-based theranostics', Bioactive Materials, vol. 3, no. 1, pp. 39-47.
Ma, C, Gerhard, E, Lin, Q, Xia, S, Armstrong, AD & Yang, J 2018, 'In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering', Bioactive Materials, vol. 3, no. 1, pp. 19-27.
Shan, D, Gerhard, E, Zhang, C, Tierney, JW, Xie, D, Liu, Z & Yang, J 2018, 'Polymeric biomaterials for biophotonic applications', Bioactive Materials, vol. 3, no. 4, pp. 434-445.
Lu, J, Zhang, H, Cai, D, Zeng, C, Lai, P, Shao, Y, Fang, H, Li, D, Ouyang, J, Zhao, C, Xie, D, Huang, B, Yang, J, Jiang, Y & Bai, X 2018, 'Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice', Journal of Bone and Mineral Research, vol. 33, no. 5, pp. 909-920.
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, EB, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)