Researcher Profile

Researcher Profile

Jian Yang, PhD

Jian Yang, PhD

Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics
jxy30@psu.edu

Research Interests

  • Citric Acid
  • Polymers
  • Biocompatible Materials
  • Tissue Engineering
  • Elastomers
  • Nanoparticles
  • Pharmaceutical Preparations
  • Polyesters
  • Fluorescence
  • Orthopedics
  • Injections
  • Neoplasms

Recent Publications

2019

Wang, H, Zhang, H, Sun, Q, Yang, J, Zeng, C, Ding, C, Cai, D, Liu, A & Bai, X 2019, 'Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression', Journal of Cellular Physiology, vol. 234, no. 3, pp. 2730-2740. https://doi.org/10.1002/jcp.27088
He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191. https://doi.org/10.1016/j.actbio.2019.03.050
Zou, W, Lai, M, Zhang, Y, Zheng, L, Xing, Z, Li, T, Zou, Z, Song, Q, Zhao, X, Xia, L, Yang, J, Liu, A, Zhang, H, Cui, ZK, Jiang, Y & Bai, X 2019, 'Exosome Release Is Regulated by mTORC1', Advanced Science, vol. 6, no. 3, 1801313. https://doi.org/10.1002/advs.201801313
Yang, J & Kim, G 2019, Local delivery of epigenetically stimulating folic acid for peripheral nerve regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Iyer, R, Kuriakose, AE, Yaman, S, Su, LC, Shan, D, Yang, J, Liao, J, Tang, L, Banerjee, S, Xu, H & Nguyen, KT 2019, 'Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases', International Journal of Pharmaceutics, vol. 554, pp. 212-223. https://doi.org/10.1016/j.ijpharm.2018.11.011

2018

Jiang, Z, Tian, Y, Shan, D, Wang, Y, Gerhard, E, Xia, J, Huang, R, He, Y, Li, A, Tang, J, Ruan, H, Li, Y, Li, J, Yang, J & Wu, A 2018, ' pH protective Y 1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time ', Biomaterials, vol. 170, pp. 70-81. https://doi.org/10.1016/j.biomaterials.2018.04.002
Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, G, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Chen, H, Wang, Y, Dai, H, Tian, X, Cui, ZK, Chen, Z, Hu, L, Song, Q, Liu, A, Zhang, Z, Xiao, G, Yang, J, Jiang, Y & Bai, X 2018, 'Bone and plasma citrate is reduced in osteoporosis', Bone, vol. 114, pp. 189-197. https://doi.org/10.1016/j.bone.2018.06.014
Ma, C, Gerhard, E, Lu, D & Yang, J 2018, 'Citrate chemistry and biology for biomaterials design', Biomaterials, vol. 178, pp. 383-400. https://doi.org/10.1016/j.biomaterials.2018.05.003
Shan, D, Hsieh, JT, Bai, X & Yang, J 2018, 'Citrate-Based Fluorescent Biomaterials', Advanced Healthcare Materials, vol. 7, no. 18, 1800532. https://doi.org/10.1002/adhm.201800532
Ma, C, Tian, X, Kim, JP, Xie, D, Ao, X, Shan, D, Lin, Q, Hudock, MR, Bai, X & Yang, J 2018, 'Citrate-based materials fuel human stem cells by metabonegenic regulation', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 50, pp. E11741-E11750. https://doi.org/10.1073/pnas.1813000115
Zeng, L, Deng, X & Yang, J 2018, 'Constrained Gaussian process with application in tissue-engineering scaffold biodegradation' IISE Transactions, vol. 50, no. 5, pp. 431-447. https://doi.org/10.1080/24725854.2017.1414973
Zhang, J, Jia, J, Kim, JP, Yang, F, Wang, X, Shen, H, Xu, S, Yang, J & Wu, D 2018, 'Construction of versatile multilayered composite nanoparticles from a customized nanogel template', Bioactive Materials, vol. 3, no. 1, pp. 87-96. https://doi.org/10.1016/j.bioactmat.2017.06.003
Shan, D, Kothapalli, S-R, Ravnic, D, Gerhard, E, Kim, JP, Guo, J, Ma, C, Guo, J, Gui, L, Sun, L, Lu, D & Yang, J 2018, 'Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers', Advanced Functional Materials, vol. 28, no. 34, 1801787. https://doi.org/10.1002/adfm.201801787
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, E, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Tarafder, S, Gulko, J, Sim, KH, Yang, J, Cook, JL & Lee, CH 2018, 'Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment', Scientific reports, vol. 8, no. 1, 8150. https://doi.org/10.1038/s41598-018-26545-8
Gyawali, D, Kim, JP & Yang, J 2018, 'Highly photostable nanogels for fluorescence-based theranostics', Bioactive Materials, vol. 3, no. 1, pp. 39-47. https://doi.org/10.1016/j.bioactmat.2017.03.001
Ma, C, Gerhard, E, Lin, Q, Xia, S, Armstrong, A & Yang, J 2018, 'In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering', Bioactive Materials, vol. 3, no. 1, pp. 19-27. https://doi.org/10.1016/j.bioactmat.2018.01.002
Shan, D, Gerhard, E, Zhang, C, Tierney, JW, Xie, D, Liu, Z & Yang, J 2018, 'Polymeric biomaterials for biophotonic applications', Bioactive Materials, vol. 3, no. 4, pp. 434-445. https://doi.org/10.1016/j.bioactmat.2018.07.001
Lu, J, Zhang, H, Cai, D, Zeng, C, Lai, P, Shao, Y, Fang, H, Li, D, Ouyang, J, Zhao, C, Xie, D, Huang, B, Yang, J, Jiang, Y & Bai, X 2018, 'Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice', Journal of Bone and Mineral Research, vol. 33, no. 5, pp. 909-920. https://doi.org/10.1002/jbmr.3388
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059

2017

Albaghdadi, MS, Yang, J, Brown, JH, Mansukhani, NA, Ameer, GA & Kibbe, MR 2017, 'A Tailorable In Situ Light-Activated Biodegradable Vascular Scaffold', Advanced Materials Technologies, vol. 2, no. 4, 1600243. https://doi.org/10.1002/admt.201600243
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, 'A smartphone-based chloridometer for point-of-care diagnostics of cystic fibrosis', Biosensors and Bioelectronics, vol. 97, pp. 164-168. https://doi.org/10.1016/j.bios.2017.05.048
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, E & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286. https://doi.org/10.1016/j.biomaterials.2016.10.010
Gerhard, EM, Wang, W, Li, C, Guo, J, Ozbolat, IT, Rahn, KM, Armstrong, A, Xia, J, Qian, G & Yang, J 2017, 'Design strategies and applications of nacre-based biomaterials', Acta Biomaterialia, vol. 54, pp. 21-34. https://doi.org/10.1016/j.actbio.2017.03.003
Sun, J, Jiang, L, Lin, Y, Gerhard, EM, Jiang, X, Li, L, Yang, J & Gu, Z 2017, 'Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides', International Journal of Nanomedicine, vol. 12, pp. 1517-1537. https://doi.org/10.2147/IJN.S122859
Shan, D, Zhang, C, Kalaba, S, Mehta, N, Kim, GB, Liu, Z & Yang, J 2017, 'Flexible biodegradable citrate-based polymeric step-index optical fiber', Biomaterials, vol. 143, pp. 142-148. https://doi.org/10.1016/j.biomaterials.2017.08.003
Zhang, J, Jia, J, Kim, JP, Shen, H, Yang, F, Zhang, Q, Xu, M, Bi, W, Wang, X, Yang, J & Wu, D 2017, 'Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration', Advanced Materials, vol. 29, no. 17, 1605546. https://doi.org/10.1002/adma.201605546
Li, J, Tian, Y, Shan, D, Gong, A, Zeng, L, Ren, W, Xiang, L, Gerhard, E, Zhao, J, Yang, J & Wu, A 2017, 'Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging', Biomaterials, vol. 116, pp. 106-117. https://doi.org/10.1016/j.biomaterials.2016.11.028
Zhang, G, Yang, J, Li, B, Yeung, K & Hong, Y 2017, 'Seeking Convergence to advance Biomaterials Science and Translation by Chinese Association for Biomaterials' Bioactive Materials, vol. 2, no. 4, pp. 281-286. https://doi.org/10.1016/j.bioactmat.2017.06.002
Cheng, G, Hao, SJ, Wan, Y, Shan, DY, Yang, J & Zheng, S 2017, 'Self-Assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity', Chemistry of Materials, vol. 29, no. 5, pp. 2081-2089. https://doi.org/10.1021/acs.chemmater.6b04326
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, Smartphone chloridometer for point-of-care applications. in Z Liu, K Shi, IC Khoo & D Psaltis (eds), Ultrafast Nonlinear Imaging and Spectroscopy V., 103800I, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10380, SPIE, Ultrafast Nonlinear Imaging and Spectroscopy V 2017, San Diego, United States, 8/6/17. https://doi.org/10.1117/12.2273982
Xie, Z, Kim, JP, Cai, Q, Zhang, Y, Guo, J, Dhami, RS, Li, L, Kong, B, Su, Y, Schug, KA & Yang, J 2017, 'Synthesis and characterization of citrate-based fluorescent small molecules and biodegradable polymers', Acta Biomaterialia, vol. 50, pp. 361-369. https://doi.org/10.1016/j.actbio.2017.01.019

2016

van Lith, R, Baker, E, Ware, H, Yang, J, Farsheed, AC, Sun, C & Ameer, G 2016, '3D-Printing Strong High-Resolution Antioxidant Bioresorbable Vascular Stents', Advanced Materials Technologies, vol. 1, no. 9, 1600138. https://doi.org/10.1002/admt.201600138
Ye, J, Wang, J, Zhu, Y, Wei, Q, Wang, X, Yang, J, Tang, S, Liu, H, Fan, J, Zhang, F, Farina, EM, Mohammed, MK, Zou, Y, Song, D, Liao, J, Huang, J, Guo, D, Lu, M, Liu, F, Liu, J, Li, L, Ma, C, Hu, X, Haydon, RC, Lee, MJ, Reid, RR, Ameer, GA, Yang, L & He, TC 2016, 'A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells', Biomedical Materials (Bristol), vol. 11, no. 2, 025021. https://doi.org/10.1088/1748-6041/11/2/025021
Kim, JP, Xie, Z, Creer, M, Liu, Z & Yang, J 2016, 'Citrate-based fluorescent materials for low-cost chloride sensing in the diagnosis of cystic fibrosis', Chemical Science, vol. 8, no. 1, pp. 550-558. https://doi.org/10.1039/c6sc02962k
Hu, J, Peng, K, Guo, J, Shan, D, Kim, GB, Li, Q, Gerhard, E, Zhu, L, Tu, W, Lv, W, Hickner, MA & Yang, J 2016, 'Click Cross-Linking-Improved Waterborne Polymers for Environment-Friendly Coatings and Adhesives', ACS Applied Materials and Interfaces, vol. 8, no. 27, pp. 17499-17510. https://doi.org/10.1021/acsami.6b02131
Zeng, L, Deng, X & Yang, J 2016, 'Constrained hierarchical modeling of degradation data in tissue-engineered scaffold fabrication', IIE Transactions (Institute of Industrial Engineers), vol. 48, no. 1, pp. 16-33. https://doi.org/10.1080/0740817X.2015.1019164
Kalaba, S, Gerhard, E, Winder, JS, Pauli, E, Haluck, R & Yang, J 2016, 'Design strategies and applications of biomaterials and devices for Hernia repair', Bioactive Materials, vol. 1, no. 1, pp. 2-17. https://doi.org/10.1016/j.bioactmat.2016.05.002
Hu, J, Guo, J, Xie, Z, Shan, D, Gerhard, E, Qian, G & Yang, J 2016, 'Fluorescence imaging enabled poly(lactide-co-glycolide)', Acta Biomaterialia, vol. 29, pp. 307-319. https://doi.org/10.1016/j.actbio.2015.10.010
Xie, Z, Su, Y, Kim, GB, Selvi, E, Ma, C, Aragon-Sanabria, V, Hsieh, JT, Dong, C & Yang, J 2017, 'Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery', Small, vol. 13, no. 10, 1603121. https://doi.org/10.1002/smll.201603121
Kim, GB, Guo, J, Hu, J, Shan, D & Yang, J 2016, Novel Applications of Urethane/Urea Chemistry in the Field of Biomaterials. in Advances in Polyurethane Biomaterials. Elsevier Inc., pp. 115-147. https://doi.org/10.1016/B978-0-08-100614-6.00004-4
Komabayashi, T, Wadajkar, A, Santimano, S, Ahn, C, Zhu, Q, Opperman, LA, Bellinger, LL, Yang, J & Nguyen, KT 2016, 'Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle', Journal of investigative and clinical dentistry, vol. 7, no. 1, pp. 87-92. https://doi.org/10.1111/jicd.12118
Zhou, D, Guo, J, Kim, GB, Li, J, Chen, X, Yang, J & Huang, Y 2016, 'Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery', Advanced Healthcare Materials, vol. 5, no. 19, pp. 2493-2499. https://doi.org/10.1002/adhm.201600470
Lata, JP, Guo, F, Guo, J, Huang, PH, Yang, J & Huang, TJ 2016, 'Surface Acoustic Waves Grant Superior Spatial Control of Cells Embedded in Hydrogel Fibers', Advanced Materials, vol. 28, no. 39, pp. 8632-8638. https://doi.org/10.1002/adma.201602947
Guo, J, Wang, W, Hu, J, Xie, D, Gerhard, E, Nisic, M, Shan, D, Qian, G, Zheng, S & Yang, J 2016, 'Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives', Biomaterials, vol. 85, pp. 204-217. https://doi.org/10.1016/j.biomaterials.2016.01.069
Guo, F, Mao, Z, Chen, Y, Xie, Z, Lata, JP, Li, P, Ren, L, Liu, J, Yang, J, Dao, M, Suresh, S & Huang, TJ 2016, 'Three-dimensional manipulation of single cells using surface acoustic waves', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 6, pp. 1522-1527. https://doi.org/10.1073/pnas.1524813113

2015

Tang, J, Guo, J, Li, Z, Yang, C, Xie, D, Chen, J, Li, S, Li, S, Kim, GB, Bai, X, Zhang, Z & Yang, J 2015, 'A fast degradable citrate-based bone scaffold promotes spinal fusion' Journal of Materials Chemistry B, vol. 3, no. 27, pp. 5569-5576. https://doi.org/10.1039/c5tb00607d
Hwang, SW, Lee, CH, Cheng, H, Jeong, JW, Kang, SK, Kim, JH, Shin, J, Yang, J, Liu, Z, Ameer, GA, Huang, Y & Rogers, JA 2015, 'Biodegradable elastomers and silicon nanomembranes/nanoribbons for stretchable, transient electronics, and biosensors', Nano letters, vol. 15, no. 5, pp. 2801-2808. https://doi.org/10.1021/nl503997m
Tran, RT, Yang, J & Ameer, GA 2015, 'Citrate-Based Biomaterials and Their Applications in Regenerative Engineering', Annual Review of Materials Research, vol. 45, pp. 277-310. https://doi.org/10.1146/annurev-matsci-070214-020815
Guo, Y, Tran, RT, Xie, D, Wang, Y, Nguyen, DY, Gerhard, E, Guo, J, Tang, J, Zhang, Z, Bai, X & Yang, J 2015, 'Citrate-based biphasic scaffolds for the repair of large segmental bone defects', Journal of Biomedical Materials Research - Part A, vol. 103, no. 2, pp. 772-781. https://doi.org/10.1002/jbm.a.35228
Su, Y, Xie, Z, Kim, GB, Dong, C & Yang, J 2015, 'Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems', ACS Biomaterials Science and Engineering, vol. 1, no. 4, pp. 201-217. https://doi.org/10.1021/ab500179h
Xie, Z, Aphale, NV, Kadapure, TD, Wadajkar, AS, Orr, S, Gyawali, D, Qian, G, Nguyen, KT & Yang, J 2015, 'Design of antimicrobial peptides conjugated biodegradable citric acid derived hydrogels for wound healing', Journal of Biomedical Materials Research - Part A, vol. 103, no. 12, pp. 3907-3918. https://doi.org/10.1002/jbm.a.35512
Xie, D, Guo, J, Mehdizadeh, MR, Tran, RT, Chen, R, Sun, D, Qian, G, Jin, D, Bai, X & Yang, J 2015, 'Development of injectable citrate-based bioadhesive bone implants' Journal of Materials Chemistry B, vol. 3, no. 3, pp. 387-398. https://doi.org/10.1039/c4tb01498g
Van Lith, R, Yang, J & Ameer, GA 2015, 'Diazeniumdiolation of protamine sulfate reverses mitogenic effects on smooth muscle cells and fibroblasts', Free Radical Biology and Medicine, vol. 82, pp. 13-21. https://doi.org/10.1016/j.freeradbiomed.2015.01.022
Nguyen, DY, Tran, RT, Costanzo, F & Yang, J 2015, Tissue-Engineered Peripheral Nerve Guide Fabrication Techniques. in Pain, Treatment, Injury, Disease and Future Directions. vol. 2, Elsevier, pp. 971-992. https://doi.org/10.1016/B978-0-12-802653-3.00109-3

Clinical Trials Search


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