Researcher Profile

Researcher Profile

Jian Yang, PhD

Jian Yang, PhD

Professor, Biomedical Engineering
Scientific Program:Experimental Therapeutics

Research Interests

  • Citric Acid
  • Polymers
  • Biocompatible Materials
  • Tissue Engineering
  • Elastomers
  • Nanoparticles
  • Pharmaceutical Preparations
  • Polyesters
  • Fluorescence
  • Orthopedics
  • Injections
  • Neoplasms

Recent Publications


Wang, H, Zhang, H, Sun, Q, Yang, J, Zeng, C, Ding, C, Cai, D, Liu, A & Bai, X 2019, 'Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression', Journal of Cellular Physiology, vol. 234, no. 3, pp. 2730-2740.
He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191.
Zou, W, Lai, M, Zhang, Y, Zheng, L, Xing, Z, Li, T, Zou, Z, Song, Q, Zhao, X, Xia, L, Yang, J, Liu, A, Zhang, H, Cui, ZK, Jiang, Y & Bai, X 2019, 'Exosome Release Is Regulated by mTORC1', Advanced Science, vol. 6, no. 3, 1801313.
Yang, J & Kim, G 2019, Local delivery of epigenetically stimulating folic acid for peripheral nerve regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Iyer, R, Kuriakose, AE, Yaman, S, Su, LC, Shan, D, Yang, J, Liao, J, Tang, L, Banerjee, S, Xu, H & Nguyen, KT 2019, 'Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases', International Journal of Pharmaceutics, vol. 554, pp. 212-223.


Jiang, Z, Tian, Y, Shan, D, Wang, Y, Gerhard, E, Xia, J, Huang, R, He, Y, Li, A, Tang, J, Ruan, H, Li, Y, Li, J, Yang, J & Wu, A 2018, ' pH protective Y 1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time ', Biomaterials, vol. 170, pp. 70-81.
Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, G, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986.
Chen, H, Wang, Y, Dai, H, Tian, X, Cui, ZK, Chen, Z, Hu, L, Song, Q, Liu, A, Zhang, Z, Xiao, G, Yang, J, Jiang, Y & Bai, X 2018, 'Bone and plasma citrate is reduced in osteoporosis', Bone, vol. 114, pp. 189-197.
Ma, C, Gerhard, E, Lu, D & Yang, J 2018, 'Citrate chemistry and biology for biomaterials design', Biomaterials, vol. 178, pp. 383-400.
Shan, D, Hsieh, JT, Bai, X & Yang, J 2018, 'Citrate-Based Fluorescent Biomaterials', Advanced Healthcare Materials, vol. 7, no. 18, 1800532.
Ma, C, Tian, X, Kim, JP, Xie, D, Ao, X, Shan, D, Lin, Q, Hudock, MR, Bai, X & Yang, J 2018, 'Citrate-based materials fuel human stem cells by metabonegenic regulation', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 50, pp. E11741-E11750.
Zeng, L, Deng, X & Yang, J 2018, 'Constrained Gaussian process with application in tissue-engineering scaffold biodegradation' IISE Transactions, vol. 50, no. 5, pp. 431-447.
Zhang, J, Jia, J, Kim, JP, Yang, F, Wang, X, Shen, H, Xu, S, Yang, J & Wu, D 2018, 'Construction of versatile multilayered composite nanoparticles from a customized nanogel template', Bioactive Materials, vol. 3, no. 1, pp. 87-96.
Shan, D, Kothapalli, S-R, Ravnic, D, Gerhard, E, Kim, JP, Guo, J, Ma, C, Guo, J, Gui, L, Sun, L, Lu, D & Yang, J 2018, 'Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers', Advanced Functional Materials, vol. 28, no. 34, 1801787.
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, E, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44.
Tarafder, S, Gulko, J, Sim, KH, Yang, J, Cook, JL & Lee, CH 2018, 'Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment', Scientific reports, vol. 8, no. 1, 8150.
Gyawali, D, Kim, JP & Yang, J 2018, 'Highly photostable nanogels for fluorescence-based theranostics', Bioactive Materials, vol. 3, no. 1, pp. 39-47.
Ma, C, Gerhard, E, Lin, Q, Xia, S, Armstrong, A & Yang, J 2018, 'In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering', Bioactive Materials, vol. 3, no. 1, pp. 19-27.
Shan, D, Gerhard, E, Zhang, C, Tierney, JW, Xie, D, Liu, Z & Yang, J 2018, 'Polymeric biomaterials for biophotonic applications', Bioactive Materials, vol. 3, no. 4, pp. 434-445.
Lu, J, Zhang, H, Cai, D, Zeng, C, Lai, P, Shao, Y, Fang, H, Li, D, Ouyang, J, Zhao, C, Xie, D, Huang, B, Yang, J, Jiang, Y & Bai, X 2018, 'Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice', Journal of Bone and Mineral Research, vol. 33, no. 5, pp. 909-920.
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, E, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516.


Albaghdadi, MS, Yang, J, Brown, JH, Mansukhani, NA, Ameer, GA & Kibbe, MR 2017, 'A Tailorable In Situ Light-Activated Biodegradable Vascular Scaffold', Advanced Materials Technologies, vol. 2, no. 4, 1600243.
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, 'A smartphone-based chloridometer for point-of-care diagnostics of cystic fibrosis', Biosensors and Bioelectronics, vol. 97, pp. 164-168.
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, E & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286.
Gerhard, EM, Wang, W, Li, C, Guo, J, Ozbolat, IT, Rahn, KM, Armstrong, A, Xia, J, Qian, G & Yang, J 2017, 'Design strategies and applications of nacre-based biomaterials', Acta Biomaterialia, vol. 54, pp. 21-34.
Sun, J, Jiang, L, Lin, Y, Gerhard, EM, Jiang, X, Li, L, Yang, J & Gu, Z 2017, 'Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides', International Journal of Nanomedicine, vol. 12, pp. 1517-1537.
Shan, D, Zhang, C, Kalaba, S, Mehta, N, Kim, GB, Liu, Z & Yang, J 2017, 'Flexible biodegradable citrate-based polymeric step-index optical fiber', Biomaterials, vol. 143, pp. 142-148.
Zhang, J, Jia, J, Kim, JP, Shen, H, Yang, F, Zhang, Q, Xu, M, Bi, W, Wang, X, Yang, J & Wu, D 2017, 'Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration', Advanced Materials, vol. 29, no. 17, 1605546.
Li, J, Tian, Y, Shan, D, Gong, A, Zeng, L, Ren, W, Xiang, L, Gerhard, E, Zhao, J, Yang, J & Wu, A 2017, 'Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging', Biomaterials, vol. 116, pp. 106-117.
Zhang, G, Yang, J, Li, B, Yeung, K & Hong, Y 2017, 'Seeking Convergence to advance Biomaterials Science and Translation by Chinese Association for Biomaterials' Bioactive Materials, vol. 2, no. 4, pp. 281-286.
Cheng, G, Hao, SJ, Wan, Y, Shan, DY, Yang, J & Zheng, S 2017, 'Self-Assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity', Chemistry of Materials, vol. 29, no. 5, pp. 2081-2089.
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, Smartphone chloridometer for point-of-care applications. in Z Liu, K Shi, IC Khoo & D Psaltis (eds), Ultrafast Nonlinear Imaging and Spectroscopy V., 103800I, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10380, SPIE, Ultrafast Nonlinear Imaging and Spectroscopy V 2017, San Diego, United States, 8/6/17.
Xie, Z, Kim, JP, Cai, Q, Zhang, Y, Guo, J, Dhami, RS, Li, L, Kong, B, Su, Y, Schug, KA & Yang, J 2017, 'Synthesis and characterization of citrate-based fluorescent small molecules and biodegradable polymers', Acta Biomaterialia, vol. 50, pp. 361-369.


van Lith, R, Baker, E, Ware, H, Yang, J, Farsheed, AC, Sun, C & Ameer, G 2016, '3D-Printing Strong High-Resolution Antioxidant Bioresorbable Vascular Stents', Advanced Materials Technologies, vol. 1, no. 9, 1600138.
Ye, J, Wang, J, Zhu, Y, Wei, Q, Wang, X, Yang, J, Tang, S, Liu, H, Fan, J, Zhang, F, Farina, EM, Mohammed, MK, Zou, Y, Song, D, Liao, J, Huang, J, Guo, D, Lu, M, Liu, F, Liu, J, Li, L, Ma, C, Hu, X, Haydon, RC, Lee, MJ, Reid, RR, Ameer, GA, Yang, L & He, TC 2016, 'A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells', Biomedical Materials (Bristol), vol. 11, no. 2, 025021.
Kim, JP, Xie, Z, Creer, M, Liu, Z & Yang, J 2016, 'Citrate-based fluorescent materials for low-cost chloride sensing in the diagnosis of cystic fibrosis', Chemical Science, vol. 8, no. 1, pp. 550-558.
Hu, J, Peng, K, Guo, J, Shan, D, Kim, GB, Li, Q, Gerhard, E, Zhu, L, Tu, W, Lv, W, Hickner, MA & Yang, J 2016, 'Click Cross-Linking-Improved Waterborne Polymers for Environment-Friendly Coatings and Adhesives', ACS Applied Materials and Interfaces, vol. 8, no. 27, pp. 17499-17510.
Zeng, L, Deng, X & Yang, J 2016, 'Constrained hierarchical modeling of degradation data in tissue-engineered scaffold fabrication', IIE Transactions (Institute of Industrial Engineers), vol. 48, no. 1, pp. 16-33.
Kalaba, S, Gerhard, E, Winder, JS, Pauli, E, Haluck, R & Yang, J 2016, 'Design strategies and applications of biomaterials and devices for Hernia repair', Bioactive Materials, vol. 1, no. 1, pp. 2-17.
Hu, J, Guo, J, Xie, Z, Shan, D, Gerhard, E, Qian, G & Yang, J 2016, 'Fluorescence imaging enabled poly(lactide-co-glycolide)', Acta Biomaterialia, vol. 29, pp. 307-319.
Xie, Z, Su, Y, Kim, GB, Selvi, E, Ma, C, Aragon-Sanabria, V, Hsieh, JT, Dong, C & Yang, J 2017, 'Immune Cell-Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting and Drug Delivery', Small, vol. 13, no. 10, 1603121.
Kim, GB, Guo, J, Hu, J, Shan, D & Yang, J 2016, Novel Applications of Urethane/Urea Chemistry in the Field of Biomaterials. in Advances in Polyurethane Biomaterials. Elsevier Inc., pp. 115-147.
Komabayashi, T, Wadajkar, A, Santimano, S, Ahn, C, Zhu, Q, Opperman, LA, Bellinger, LL, Yang, J & Nguyen, KT 2016, 'Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle', Journal of investigative and clinical dentistry, vol. 7, no. 1, pp. 87-92.
Zhou, D, Guo, J, Kim, GB, Li, J, Chen, X, Yang, J & Huang, Y 2016, 'Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery', Advanced Healthcare Materials, vol. 5, no. 19, pp. 2493-2499.
Lata, JP, Guo, F, Guo, J, Huang, PH, Yang, J & Huang, TJ 2016, 'Surface Acoustic Waves Grant Superior Spatial Control of Cells Embedded in Hydrogel Fibers', Advanced Materials, vol. 28, no. 39, pp. 8632-8638.
Guo, J, Wang, W, Hu, J, Xie, D, Gerhard, E, Nisic, M, Shan, D, Qian, G, Zheng, S & Yang, J 2016, 'Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives', Biomaterials, vol. 85, pp. 204-217.
Guo, F, Mao, Z, Chen, Y, Xie, Z, Lata, JP, Li, P, Ren, L, Liu, J, Yang, J, Dao, M, Suresh, S & Huang, TJ 2016, 'Three-dimensional manipulation of single cells using surface acoustic waves', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 6, pp. 1522-1527.


Tang, J, Guo, J, Li, Z, Yang, C, Xie, D, Chen, J, Li, S, Li, S, Kim, GB, Bai, X, Zhang, Z & Yang, J 2015, 'A fast degradable citrate-based bone scaffold promotes spinal fusion' Journal of Materials Chemistry B, vol. 3, no. 27, pp. 5569-5576.
Hwang, SW, Lee, CH, Cheng, H, Jeong, JW, Kang, SK, Kim, JH, Shin, J, Yang, J, Liu, Z, Ameer, GA, Huang, Y & Rogers, JA 2015, 'Biodegradable elastomers and silicon nanomembranes/nanoribbons for stretchable, transient electronics, and biosensors', Nano letters, vol. 15, no. 5, pp. 2801-2808.
Tran, RT, Yang, J & Ameer, GA 2015, 'Citrate-Based Biomaterials and Their Applications in Regenerative Engineering', Annual Review of Materials Research, vol. 45, pp. 277-310.
Guo, Y, Tran, RT, Xie, D, Wang, Y, Nguyen, DY, Gerhard, E, Guo, J, Tang, J, Zhang, Z, Bai, X & Yang, J 2015, 'Citrate-based biphasic scaffolds for the repair of large segmental bone defects', Journal of Biomedical Materials Research - Part A, vol. 103, no. 2, pp. 772-781.
Su, Y, Xie, Z, Kim, GB, Dong, C & Yang, J 2015, 'Design Strategies and Applications of Circulating Cell-Mediated Drug Delivery Systems', ACS Biomaterials Science and Engineering, vol. 1, no. 4, pp. 201-217.
Xie, Z, Aphale, NV, Kadapure, TD, Wadajkar, AS, Orr, S, Gyawali, D, Qian, G, Nguyen, KT & Yang, J 2015, 'Design of antimicrobial peptides conjugated biodegradable citric acid derived hydrogels for wound healing', Journal of Biomedical Materials Research - Part A, vol. 103, no. 12, pp. 3907-3918.
Xie, D, Guo, J, Mehdizadeh, MR, Tran, RT, Chen, R, Sun, D, Qian, G, Jin, D, Bai, X & Yang, J 2015, 'Development of injectable citrate-based bioadhesive bone implants' Journal of Materials Chemistry B, vol. 3, no. 3, pp. 387-398.
Van Lith, R, Yang, J & Ameer, GA 2015, 'Diazeniumdiolation of protamine sulfate reverses mitogenic effects on smooth muscle cells and fibroblasts', Free Radical Biology and Medicine, vol. 82, pp. 13-21.
Nguyen, DY, Tran, RT, Costanzo, F & Yang, J 2015, Tissue-Engineered Peripheral Nerve Guide Fabrication Techniques. in Pain, Treatment, Injury, Disease and Future Directions. vol. 2, Elsevier, pp. 971-992.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)