Researcher Profile

Researcher Profile

Jian Yang, PhD

Jian Yang, PhD

Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Next-Generation Therapies
jxy30@psu.edu

Research Interests

  • Citric Acid
  • Polymers
  • Biocompatible Materials
  • Tissue Engineering
  • Nanoparticles
  • Elastomers
  • In Vitro Techniques
  • poly(lactide)
  • Pharmaceutical Preparations
  • Polyesters
  • Fluorescence
  • Theranostic Nanomedicine

Recent Publications

2021

Tang, S, Chi, K, Xu, H, Yong, Q, Yang, J & Catchmark, JM 2021, 'A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications', Carbohydrate Polymers, vol. 252, 117123. https://doi.org/10.1016/j.carbpol.2020.117123

2020

Kuzma, M, Gerhard, E, Shan, D & Yang, J 2020, Advances in bioresorbable electronics and uses in biomedical sensing. in Interfacing Bioelectronics and Biomedical Sensing. Springer International Publishing, pp. 29-72. https://doi.org/10.1007/978-3-030-34467-2_2
Guo, J, Tian, X, Xie, D, Rahn, K, Gerhard, E, Kuzma, ML, Zhou, D, Dong, C, Bai, X, Lu, Z & Yang, J 2020, 'Citrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion', Advanced Functional Materials, vol. 30, no. 27, 2002438. https://doi.org/10.1002/adfm.202002438
Li, Q, Li, L, Yu, M, Zheng, M, Li, Y, Yang, J, Dai, M, Zhong, L, Sun, L & Lu, D 2020, 'Elastomeric polyurethane porous film functionalized with gastrodin for peripheral nerve regeneration', Journal of Biomedical Materials Research - Part A, vol. 108, no. 8, pp. 1713-1725. https://doi.org/10.1002/jbm.a.36937
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Lu, X, Shi, S, Li, H, Gerhard, E, Lu, Z, Tan, X, Li, W, Rahn, KM, Xie, D, Xu, G, Zou, F, Bai, X, Guo, J & Yang, J 2020, 'Magnesium oxide-crosslinked low-swelling citrate-based mussel-inspired tissue adhesives', Biomaterials, vol. 232, 119719. https://doi.org/10.1016/j.biomaterials.2019.119719
Pandey, N, Menon, JU, Takahashi, M, Hsieh, JT, Yang, J, Nguyen, KT & Wadajkar, AS 2020, 'Thermo-responsive fluorescent nanoparticles for multimodal imaging and treatment of cancers', Nanotheranostics, vol. 4, no. 1, pp. 1-13. https://doi.org/10.7150/ntno.39810

2019

Ma, C, Kuzma, ML, Bai, X & Yang, J 2019, 'Biomaterial-Based Metabolic Regulation in Regenerative Engineering', Advanced Science, vol. 6, no. 19, 1900819. https://doi.org/10.1002/advs.201900819
Kuriakose, AE, Pandey, N, Shan, D, Banerjee, S, Yang, J & Nguyen, KT 2019, 'Characterization of Photoluminescent Polylactone-Based Nanoparticles for Their Applications in Cardiovascular Diseases', Frontiers in Bioengineering and Biotechnology, vol. 7, 353. https://doi.org/10.3389/fbioe.2019.00353
Wang, H, Zhang, H, Sun, Q, Yang, J, Zeng, C, Ding, C, Cai, D, Liu, A & Bai, X 2019, 'Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression', Journal of Cellular Physiology, vol. 234, no. 3, pp. 2730-2740. https://doi.org/10.1002/jcp.27088
He, Y, Li, Q, Ma, C, Xie, D, Li, L, Zhao, Y, Shan, D, Chomos, SK, Dong, C, Tierney, JW, Sun, L, Lu, D, Gui, L & Yang, J 2019, 'Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration', Acta Biomaterialia, vol. 93, pp. 180-191. https://doi.org/10.1016/j.actbio.2019.03.050
Tarafder, S, Gulko, J, Kim, D, Sim, KH, Gutman, S, Yang, J, Cook, JL & Lee, CH 2019, 'Effect of dose and release rate of CTGF and TGFβ3 on avascular meniscus healing', Journal of Orthopaedic Research, vol. 37, no. 7, pp. 1555-1562. https://doi.org/10.1002/jor.24287
Shan, D, Ma, C & Yang, J 2019, 'Enabling biodegradable functional biomaterials for the management of neurological disorders', Advanced Drug Delivery Reviews, vol. 148, pp. 219-238. https://doi.org/10.1016/j.addr.2019.06.004
Zou, W, Lai, M, Zhang, Y, Zheng, L, Xing, Z, Li, T, Zou, Z, Song, Q, Zhao, X, Xia, L, Yang, J, Liu, A, Zhang, H, Cui, ZK, Jiang, Y & Bai, X 2019, 'Exosome Release Is Regulated by mTORC1', Advanced Science, vol. 6, no. 3, 1801313. https://doi.org/10.1002/advs.201801313
Yang, J & Kim, G 2019, Local delivery of epigenetically stimulating folic acid for peripheral nerve regeneration. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Iyer, R, Kuriakose, AE, Yaman, S, Su, LC, Shan, D, Yang, J, Liao, J, Tang, L, Banerjee, S, Xu, H & Nguyen, KT 2019, 'Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases', International Journal of Pharmaceutics, vol. 554, pp. 212-223. https://doi.org/10.1016/j.ijpharm.2018.11.011
Liu, W, Wang, Z, Yang, J, Wang, Y, Li, K, Huang, B, Yan, B, Wang, T, Li, M, Zou, Z, Yang, J, Xiao, G, Cui, ZK, Liu, A & Bai, X 2019, 'Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice', Open biology, vol. 9, no. 5, 180262. https://doi.org/10.1098/rsob.180262

2018

Jiang, Z, Tian, Y, Shan, D, Wang, Y, Gerhard, E, Xia, J, Huang, R, He, Y, Li, A, Tang, J, Ruan, H, Li, Y, Li, J, Yang, J & Wu, A 2018, ' pH protective Y 1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time ', Biomaterials, vol. 170, pp. 70-81. https://doi.org/10.1016/j.biomaterials.2018.04.002
Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Chen, H, Wang, Y, Dai, H, Tian, X, Cui, ZK, Chen, Z, Hu, L, Song, Q, Liu, A, Zhang, Z, Xiao, G, Yang, J, Jiang, Y & Bai, X 2018, 'Bone and plasma citrate is reduced in osteoporosis', Bone, vol. 114, pp. 189-197. https://doi.org/10.1016/j.bone.2018.06.014
Ma, C, Gerhard, E, Lu, D & Yang, J 2018, 'Citrate chemistry and biology for biomaterials design', Biomaterials, vol. 178, pp. 383-400. https://doi.org/10.1016/j.biomaterials.2018.05.003
Shan, D, Hsieh, JT, Bai, X & Yang, J 2018, 'Citrate-Based Fluorescent Biomaterials', Advanced Healthcare Materials, vol. 7, no. 18, 1800532. https://doi.org/10.1002/adhm.201800532
Ma, C, Tian, X, Kim, JP, Xie, D, Ao, X, Shan, D, Lin, Q, Hudock, MR, Bai, X & Yang, J 2018, 'Citrate-based materials fuel human stem cells by metabonegenic regulation', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 50, pp. E11741-E11750. https://doi.org/10.1073/pnas.1813000115
Zeng, L, Deng, X & Yang, J 2018, 'Constrained Gaussian process with application in tissue-engineering scaffold biodegradation', IISE Transactions, vol. 50, no. 5, pp. 431-447. https://doi.org/10.1080/24725854.2017.1414973
Zhang, J, Jia, J, Kim, JP, Yang, F, Wang, X, Shen, H, Xu, S, Yang, J & Wu, D 2018, 'Construction of versatile multilayered composite nanoparticles from a customized nanogel template', Bioactive Materials, vol. 3, no. 1, pp. 87-96. https://doi.org/10.1016/j.bioactmat.2017.06.003
Shan, D, Kothapalli, SR, Ravnic, DJ, Gerhard, E, Kim, JP, Guo, J, Ma, C, Guo, J, Gui, L, Sun, L, Lu, D & Yang, J 2018, 'Development of Citrate-Based Dual-Imaging Enabled Biodegradable Electroactive Polymers', Advanced Functional Materials, vol. 28, no. 34, 1801787. https://doi.org/10.1002/adfm.201801787
Guo, J, Sun, W, Kim, JP, Lu, X, Li, Q, Lin, M, Mrowczynski, O, Rizk, EB, Cheng, J, Qian, G & Yang, J 2018, 'Development of tannin-inspired antimicrobial bioadhesives', Acta Biomaterialia, vol. 72, pp. 35-44. https://doi.org/10.1016/j.actbio.2018.03.008
Tarafder, S, Gulko, J, Sim, KH, Yang, J, Cook, JL & Lee, CH 2018, 'Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment', Scientific reports, vol. 8, no. 1, 8150. https://doi.org/10.1038/s41598-018-26545-8
Gyawali, D, Kim, JP & Yang, J 2018, 'Highly photostable nanogels for fluorescence-based theranostics', Bioactive Materials, vol. 3, no. 1, pp. 39-47. https://doi.org/10.1016/j.bioactmat.2017.03.001
Ma, C, Gerhard, E, Lin, Q, Xia, S, Armstrong, AD & Yang, J 2018, 'In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering', Bioactive Materials, vol. 3, no. 1, pp. 19-27. https://doi.org/10.1016/j.bioactmat.2018.01.002
Shan, D, Gerhard, E, Zhang, C, Tierney, JW, Xie, D, Liu, Z & Yang, J 2018, 'Polymeric biomaterials for biophotonic applications', Bioactive Materials, vol. 3, no. 4, pp. 434-445. https://doi.org/10.1016/j.bioactmat.2018.07.001
Lu, J, Zhang, H, Cai, D, Zeng, C, Lai, P, Shao, Y, Fang, H, Li, D, Ouyang, J, Zhao, C, Xie, D, Huang, B, Yang, J, Jiang, Y & Bai, X 2018, 'Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice', Journal of Bone and Mineral Research, vol. 33, no. 5, pp. 909-920. https://doi.org/10.1002/jbmr.3388
Kim, GB, Chen, Y, Kang, W, Guo, J, Payne, R, Li, H, Wei, Q, Baker, J, Dong, C, Zhang, S, Wong, PK, Rizk, EB, Yan, J & Yang, J 2018, 'The critical chemical and mechanical regulation of folic acid on neural engineering', Biomaterials, vol. 178, pp. 504-516. https://doi.org/10.1016/j.biomaterials.2018.03.059

2017

Albaghdadi, MS, Yang, J, Brown, JH, Mansukhani, NA, Ameer, GA & Kibbe, MR 2017, 'A Tailorable In Situ Light-Activated Biodegradable Vascular Scaffold', Advanced Materials Technologies, vol. 2, no. 4, 1600243. https://doi.org/10.1002/admt.201600243
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, 'A smartphone-based chloridometer for point-of-care diagnostics of cystic fibrosis', Biosensors and Bioelectronics, vol. 97, pp. 164-168. https://doi.org/10.1016/j.bios.2017.05.048
Guo, J, Kim, GB, Shan, D, Kim, JP, Hu, J, Wang, W, Hamad, FG, Qian, G, Rizk, EB & Yang, J 2017, 'Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives', Biomaterials, vol. 112, pp. 275-286. https://doi.org/10.1016/j.biomaterials.2016.10.010
Gerhard, EM, Wang, W, Li, C, Guo, J, Ozbolat, IT, Rahn, KM, Armstrong, AD, Xia, J, Qian, G & Yang, J 2017, 'Design strategies and applications of nacre-based biomaterials', Acta Biomaterialia, vol. 54, pp. 21-34. https://doi.org/10.1016/j.actbio.2017.03.003
Sun, J, Jiang, L, Lin, Y, Gerhard, EM, Jiang, X, Li, L, Yang, J & Gu, Z 2017, 'Enhanced anticancer efficacy of paclitaxel through multistage tumor-targeting liposomes modified with RGD and KLA peptides', International Journal of Nanomedicine, vol. 12, pp. 1517-1537. https://doi.org/10.2147/IJN.S122859
Shan, D, Zhang, C, Kalaba, S, Mehta, N, Kim, GB, Liu, Z & Yang, J 2017, 'Flexible biodegradable citrate-based polymeric step-index optical fiber', Biomaterials, vol. 143, pp. 142-148. https://doi.org/10.1016/j.biomaterials.2017.08.003
Zhang, J, Jia, J, Kim, JP, Shen, H, Yang, F, Zhang, Q, Xu, M, Bi, W, Wang, X, Yang, J & Wu, D 2017, 'Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration', Advanced Materials, vol. 29, no. 17, 1605546. https://doi.org/10.1002/adma.201605546
Li, J, Tian, Y, Shan, D, Gong, A, Zeng, L, Ren, W, Xiang, L, Gerhard, E, Zhao, J, Yang, J & Wu, A 2017, 'Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging', Biomaterials, vol. 116, pp. 106-117. https://doi.org/10.1016/j.biomaterials.2016.11.028
Zhang, G, Yang, J, Li, B, Yeung, K & Hong, Y 2017, 'Seeking Convergence to advance Biomaterials Science and Translation by Chinese Association for Biomaterials', Bioactive Materials, vol. 2, no. 4, pp. 281-286. https://doi.org/10.1016/j.bioactmat.2017.06.002
Cheng, G, Hao, SJ, Wan, Y, Shan, DY, Yang, J & Zheng, SY 2017, 'Self-Assembly of Smart Multifunctional Hybrid Compartments with Programmable Bioactivity', Chemistry of Materials, vol. 29, no. 5, pp. 2081-2089. https://doi.org/10.1021/acs.chemmater.6b04326
Zhang, C, Kim, JP, Creer, M, Yang, J & Liu, Z 2017, Smartphone chloridometer for point-of-care applications. in Z Liu, K Shi, IC Khoo & D Psaltis (eds), Ultrafast Nonlinear Imaging and Spectroscopy V., 103800I, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10380, SPIE, Ultrafast Nonlinear Imaging and Spectroscopy V 2017, San Diego, United States, 8/6/17. https://doi.org/10.1117/12.2273982
Xie, Z, Kim, JP, Cai, Q, Zhang, Y, Guo, J, Dhami, RS, Li, L, Kong, B, Su, Y, Schug, KA & Yang, J 2017, 'Synthesis and characterization of citrate-based fluorescent small molecules and biodegradable polymers', Acta Biomaterialia, vol. 50, pp. 361-369. https://doi.org/10.1016/j.actbio.2017.01.019

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)