Junxuan Lu, PhD - Penn State Cancer Institute
Researcher Profile
Junxuan Lu, PhD
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Experimental Therapeutics
Recent Publications
2026
Joshi, M, Fan, T, Schell, TD, Liu, X, Perimbeti, S, Wheelden, M, Sun, D, Desai, D, Shank, D, Strong, AL, Raman, JD, Liao, J, Jiang, C & Lu, J 2026, 'Angelica herbal supplement AGN-Cogni.Q acute dose safety and pharmacokinetics (PK) dose-response in prostate cancer patients.', Journal of Clinical Oncology, vol. 44, pp. 372. https://doi.org/10.1200/JCO.2026.44.7_suppl.372
Tiek, D, Song, X, Wu, R, Yu, X, Walker, M, Mao, Y, Sisbarro, D, He, Q, Magassa, A, Singh, A, Lu, J, Sharma, AK, Miska, J, Hu, B, Bonini, MG, Zhang, X & Cheng, SY 2026, 'Cysteine addiction in drug resistant glioblastoma and therapeutic targeting with designer selenium compounds', Neuro-oncology, vol. 28, no. 3, pp. 613-625. https://doi.org/10.1093/neuonc/noaf265
Joshi, M, Schell, TD, Liu, X, Perimbeti, S, Wheelden, M, Polimera, HV, Sun, D, Shank, D, Strong, AL, Raman, JD, Liao, J, Jiang, C & Lu, J 2026, 'Evaluation of the safety and efficacy of daily oral Angelica gigas Nakai (AGN)-INM176 in prostate cancer patients with rising plasma PSA (phase I/II trial).', Journal of Clinical Oncology, vol. 44, pp. TPS413-TPS413. https://doi.org/10.1200/JCO.2026.44.7_suppl.TPS413
2025
Lü, J, Jiang, C, Drabick, JJ, Joshi, M & Perimbeti, S 2025, 'Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets', Pharmaceutical Research, vol. 42, no. 1, pp. 25-47. https://doi.org/10.1007/s11095-024-03809-9
Lü, J, Jiang, C & Hu, H 2025, 'Selenium compounds for cancer prevention and therapy – human clinical trial considerations', Medical Review, vol. 5, no. 3, pp. 203-230. https://doi.org/10.1515/mr-2024-0065
2024
Strong, AL, Karelia, DN, Schell, TD, Hershock, D, Fan, T, Sun, D, Zhu, J, Proctor, EA, Jiang, C, Joshi, M & Lu, J 2024, 'A double-blinded, placebo-controlled, cross-over pilot trial in healthy men to study the effects of Angelica gigas herbal supplement on prostate cancer–relevant inflammatory cytokines.', Journal of Clinical Oncology, vol. 42, pp. 170. https://doi.org/10.1200/JCO.2024.42.4_suppl.170
2023
Carkaci-Salli, N, Raup-Konsavage, WM, Karelia, D, Sun, D, Jiang, C, Lu, J & Vrana, KE 2024, 'Cannabinoids as Potential Cancer Therapeutics: The Concentration Conundrum', Cannabis and Cannabinoid Research, vol. 9, no. 4, pp. e1159-e1169. https://doi.org/10.1089/can.2022.0344
Karelia, D, Corey, Z, Wang, H, Raup-Konsavage, WM, Vrana, KE, Lü, J & Jiang, C 2024, 'Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines', Cannabis and Cannabinoid Research, vol. 9, no. 2, pp. 523-536. https://doi.org/10.1089/can.2022.0270
Freeman, B, Mamallapalli, J, Bian, T, Ballas, K, Lynch, A, Scala, A, Huo, Z, Fredenburg, KM, Bruijnzeel, AW, Baglole, CJ, Lu, J, Salloum, RG, Malaty, J & Xing, C 2023, 'Opportunities and Challenges of Kava in Lung Cancer Prevention', International journal of molecular sciences, vol. 24, no. 11, 9539. https://doi.org/10.3390/ijms24119539
2022
Lü, J, Jiang, C, Schell, TD, Joshi, M, Raman, JD & Xing, C 2022, 'Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges', American Journal of Chinese Medicine, vol. 50, no. 6, pp. 1475-1527. https://doi.org/10.1142/S0192415X2250063X
Kim, S, Li, L, Zhang, J, Jiang, C & Lü, J 2022, 'Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma', Prostate, vol. 82, no. 1, pp. 154-166. https://doi.org/10.1002/pros.24256
Crawford, LTC, Kim, S, Karelia, D, Sepulveda, DE, Morgan, DJ, Lü, J & Henderson-Redmond, AN 2022, 'Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling', Frontiers in Pharmacology, vol. 13, 968976. https://doi.org/10.3389/fphar.2022.968976
Bosland, MC, Schlicht, MJ, Deng, Y & Lü, J 2022, 'Effect of Dietary Methylseleninic Acid and Se-Methylselenocysteine on Carcinogen-Induced, Androgen-Promoted Prostate Carcinogenesis in Rats', Nutrition and cancer, vol. 74, no. 10, pp. 3761-3768. https://doi.org/10.1080/01635581.2022.2093387
Hati, S, Hu, Q, Huo, Z, Lu, J & Xing, C 2022, 'In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice', ChemMedChem, vol. 17, no. 7, e202100727. https://doi.org/10.1002/cmdc.202100727
Karelia, DN, Kim, S, Plano, D, Sharma, AK, Jiang, C & Lu, J 2023, 'Seleno-aspirin compound AS-10 promotes histone acetylation ahead of suppressing androgen receptor transcription, G1 arrest, and apoptosis of prostate cancer cells', Prostate, vol. 83, no. 1, pp. 16-29. https://doi.org/10.1002/pros.24430
Bian, T, Ding, H, Wang, Y, Hu, Q, Chen, S, Fujioka, N, Zahra Aly, F, Lu, J, Huo, Z & Xing, C 2022, 'Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis', Carcinogenesis, vol. 43, no. 7, pp. 659-670. https://doi.org/10.1093/carcin/bgac031