Junxuan Lu, PhD - Penn State Cancer Institute
Researcher Profile
Junxuan Lu, PhD
Bernard B. Brodie Professor, Department of Neuroscience and Experimental Therapeutics
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Penn State Neuroscience Institute
Center for Cannabis and Natural Product Pharmaceuticals (CCNPP)
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Lü, J, Jiang, C, Drabick, JJ, Joshi, M & Perimbeti, S 2025, 'Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy – active Phytochemicals and In Vivo Molecular Targets', Pharmaceutical Research, vol. 42, no. 1, pp. 25-47. https://doi.org/10.1007/s11095-024-03809-9
Lü, J, Jiang, C & Hu, H 2025, 'Selenium compounds for cancer prevention and therapy - Human clinical trial considerations', Medical Review. https://doi.org/10.1515/mr-2024-0065
2023
Carkaci-Salli, N, Raup-Konsavage, WM, Karelia, D, Sun, D, Jiang, C, Lu, J & Vrana, KE 2024, 'Cannabinoids as Potential Cancer Therapeutics: The Concentration Conundrum', Cannabis and Cannabinoid Research, vol. 9, no. 4, pp. e1159-e1169. https://doi.org/10.1089/can.2022.0344
Karelia, D, Corey, Z, Wang, H, Raup-Konsavage, WM, Vrana, KE, Lü, J & Jiang, C 2024, 'Library Screening and Preliminary Characterization of Synthetic Cannabinoids Against Prostate and Pancreatic Cancer Cell Lines', Cannabis and Cannabinoid Research, vol. 9, no. 2, pp. 523-536. https://doi.org/10.1089/can.2022.0270
Freeman, B, Mamallapalli, J, Bian, T, Ballas, K, Lynch, A, Scala, A, Huo, Z, Fredenburg, KM, Bruijnzeel, AW, Baglole, CJ, Lu, J, Salloum, RG, Malaty, J & Xing, C 2023, 'Opportunities and Challenges of Kava in Lung Cancer Prevention', International journal of molecular sciences, vol. 24, no. 11, 9539. https://doi.org/10.3390/ijms24119539
2022
Lü, J, Jiang, C, Schell, TD, Joshi, M, Raman, JD & Xing, C 2022, 'Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges', American Journal of Chinese Medicine, vol. 50, no. 6, pp. 1475-1527. https://doi.org/10.1142/S0192415X2250063X
Kim, S, Li, L, Zhang, J, Jiang, C & Lü, J 2022, 'Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma', Prostate, vol. 82, no. 1, pp. 154-166. https://doi.org/10.1002/pros.24256
Crawford, LTC, Kim, S, Karelia, D, Sepulveda, DE, Morgan, DJ, Lü, J & Henderson-Redmond, AN 2022, 'Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling', Frontiers in Pharmacology, vol. 13, 968976. https://doi.org/10.3389/fphar.2022.968976
Bosland, MC, Schlicht, MJ, Deng, Y & Lü, J 2022, 'Effect of Dietary Methylseleninic Acid and Se-Methylselenocysteine on Carcinogen-Induced, Androgen-Promoted Prostate Carcinogenesis in Rats', Nutrition and cancer, vol. 74, no. 10, pp. 3761-3768. https://doi.org/10.1080/01635581.2022.2093387
Hati, S, Hu, Q, Huo, Z, Lu, J & Xing, C 2022, 'In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice', ChemMedChem, vol. 17, no. 7, e202100727. https://doi.org/10.1002/cmdc.202100727
Karelia, DN, Kim, S, Plano, D, Sharma, AK, Jiang, C & Lu, J 2023, 'Seleno-aspirin compound AS-10 promotes histone acetylation ahead of suppressing androgen receptor transcription, G1 arrest, and apoptosis of prostate cancer cells', Prostate, vol. 83, no. 1, pp. 16-29. https://doi.org/10.1002/pros.24430
Bian, T, Ding, H, Wang, Y, Hu, Q, Chen, S, Fujioka, N, Zahra Aly, F, Lu, J, Huo, Z & Xing, C 2022, 'Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis', Carcinogenesis, vol. 43, no. 7, pp. 659-670. https://doi.org/10.1093/carcin/bgac031
2021
Tang, SN, Jiang, P, Kim, S, Zhang, J, Jiang, C & Lu, J 2021, 'Interception targets of angelica gigas nakai root extract versus pyranocoumarins in prostate early lesions and neuroendocrine carcinomas in TRAMP Mice', Cancer Prevention Research, vol. 14, no. 6, pp. 635-648. https://doi.org/10.1158/1940-6207.CAPR-20-0589
Karelia, DN, Kim, S, Pandey, MK, Plano, D, Amin, S, Lu, J & Sharma, AK 2021, 'Novel seleno-aspirinyl compound as-10 induces apoptosis, g1 arrest of pancreatic ductal adenocarcinoma cells, inhibits their nf-κb signaling, and synergizes with gemcitabine cytotoxicity', International journal of molecular sciences, vol. 22, no. 9, 4966. https://doi.org/10.3390/ijms22094966