Researcher Profile

Researcher Profile

Jacek Krzeminski, PhD

Jacek Krzeminski, PhD

Assistant Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
juk15@psu.edu

Research Interests

The ongoing projects in Dr. Jacek Krzeminski's laboratory are closely related to research on several aspects of chemical carcinogenesis as well as chemoprevention and drug discovery.

The lab is involved in structure elucidation and syntheses in the areas of polyaromatic hydrocarbons (PAHs), nitro-PAHs, nitrosoamines and their metabolites.

Among Dr. Krzeminski's interests are also structurally modified/ adducted oligonucleotides and nucleoside analogues of potential anticancer activity. Other projects include structure-based design approaches to the optimization of leads/small molecules for drug-like properties introduction.

  • Epoxy Compounds
  • 6-nitrochrysene
  • DNA
  • Carcinogens
  • DNA Adducts
  • Breast
  • Benzo(a)pyrene
  • Estuaries
  • Human Mammary Glands
  • Neoplasms
  • Environmental Pollutants
  • DNA Repair

Recent Publications

2018

[C@767ab44f
Dyba, M, Da Silva, B, Coia, H, Hou, Y, Noguchi, S, Pan, J, Berry, D, Creswell, K, Krzeminski, J, Desai, D, Amin, S, Yang, D & Chung, FL 2018, 'Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids', Chemical research in toxicology, vol. 31, no. 8, pp. 772-783. https://doi.org/10.1021/acs.chemrestox.8b00111

2017

[C@594f503
[C@5af11092

2016

[C@5241bf7c
[C@281d87e8
[C@8abfc87

Clinical Trials Search


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