Researcher Profile

Researcher Profile

Jacek Krzeminski, PhD

Jacek Krzeminski, PhD

Assistant Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
juk15@psu.edu

Research Interests

Dr. Jacek Krzeminski’s expertise and research is centered on the design and synthesis of novel small, pharmacologically active molecules that could be potentially developed into therapeutic agents.

His related interest in chemoprevention and investigation of active metabolites led to several publications in the field.

Recently, a nanoformulation project that encompasses design and synthesis of cationic bolaamphiphiles as a self-assembling vehicles for delivery of antisense oligos into C. difficile cells is being developed with the prospect of developing an innovative therapy. Synthesis of derivatives of certain natural products exhibiting antiproliferating potential, as well as analogs of some plant-derived opioid receptor modulators, are also currently of interest to Dr. Krzeminski.

As a practitioner of medicinal and bioorganic chemistry, Dr. Krzeminski synthesized more than 800 compounds belonging to many diverse areas, including modified nucleosides, polyaromatic hydrocarbons, nitrosamines, various heterocycles and natural products’ derivatives.

  • Epoxy Compounds
  • DNA
  • 6-nitrochrysene
  • Carcinogens
  • Benzo(a)pyrene
  • Breast
  • DNA Adducts
  • Human Mammary Glands
  • Estuaries
  • Environmental Pollutants
  • DNA Repair
  • Tobacco

Recent Publications

2018

Sharma, AK, Krzeminski, J, Weissig, V, Hegarty, JP & Stewart, DB 2018, 'Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile', Journal of Antibiotics, vol. 71, no. 8, pp. 713-721. https://doi.org/10.1038/s41429-018-0056-9
Dyba, M, Da Silva, B, Coia, H, Hou, Y, Noguchi, S, Pan, J, Berry, D, Creswell, K, Krzeminski, J, Desai, D, Amin, S, Yang, D & Chung, FL 2018, 'Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids', Chemical research in toxicology, vol. 31, no. 8, pp. 772-783. https://doi.org/10.1021/acs.chemrestox.8b00111

2017

Gowda, R, Inamdar, GS, Kuzu, O, Dinavahi, SS, Krzeminski, J, Battu, MB, Voleti, SR, Amin, S & Robertson, GP 2017, 'Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport', Oncotarget, vol. 8, no. 17, pp. 28260-28277. https://doi.org/10.18632/oncotarget.16002
Gowda, ASP, Krzeminski, J, Amin, S, Suo, Z & Spratt, TE 2017, 'Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV', Chemical research in toxicology, vol. 30, no. 5, pp. 1168-1176. https://doi.org/10.1021/acs.chemrestox.6b00466

2016

Hegarty, JP, Krzeminski, J, Sharma, AK, Guzman-Villanueva, D, Weissig, V & Stewart, DB 2016, 'Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile', International Journal of Nanomedicine, vol. 11, pp. 3607-3619. https://doi.org/10.2147/IJN.S109600
Chen, W, Padilla, MT, Xu, X, Desai, D, Krzeminski, J, Amin, S & Lin, Y 2016, 'Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide', Molecular Carcinogenesis, vol. 55, no. 11, pp. 1858-1866. https://doi.org/10.1002/mc.22434
Leng, S, Thomas, CL, Snider, AM, Picchi, MA, Chen, W, Willis, DG, Carr, TG, Krzeminski, J, Desai, D, Shantu, A, Lin, Y, Jacobson, MR & Belinsky, SA 2016, 'Radon exposure, IL-6 promoter variants, and lung squamous cell carcinoma in former uranium miners', Environmental health perspectives, vol. 124, no. 4, pp. 445-451. https://doi.org/10.1289/ehp.1409437

Clinical Trials Search


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