Researcher Profile

Researcher Profile

Jacek Krzeminski, PhD

Jacek Krzeminski, PhD

Assistant Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
juk15@psu.edu

Research Interests

The ongoing projects in Dr. Jacek Krzeminski's laboratory are closely related to research on several aspects of chemical carcinogenesis as well as chemoprevention and drug discovery.

The lab is involved in structure elucidation and syntheses in the areas of polyaromatic hydrocarbons (PAHs), nitro-PAHs, nitrosoamines and their metabolites.

Among Dr. Krzeminski's interests are also structurally modified/ adducted oligonucleotides and nucleoside analogues of potential anticancer activity. Other projects include structure-based design approaches to the optimization of leads/small molecules for drug-like properties introduction.

  • Epoxy Compounds
  • 6-nitrochrysene
  • DNA
  • Carcinogens
  • DNA Adducts
  • Breast
  • Benzo(a)pyrene
  • Estuaries
  • Human Mammary Glands
  • Neoplasms
  • Environmental Pollutants
  • DNA Repair

Recent Publications

2018

Sharma, A, Krzeminski, J, Weissig, V, Hegarty, JP & Stewart, DB 2018, 'Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile', Journal of Antibiotics, vol. 71, no. 8, pp. 713-721. https://doi.org/10.1038/s41429-018-0056-9
Dyba, M, Da Silva, B, Coia, H, Hou, Y, Noguchi, S, Pan, J, Berry, D, Creswell, K, Krzeminski, J, Desai, D, Amin, S, Yang, D & Chung, FL 2018, 'Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids', Chemical Research in Toxicology, vol. 31, no. 8, pp. 772-783. https://doi.org/10.1021/acs.chemrestox.8b00111

2017

Gowda, R, Inamdar, GS, Kuzu, O, Dinavahi, SS, Krzeminski, J, Battu, MB, Voleti, SR, Amin, S & Robertson, G 2017, 'Identifying the structure-activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport', Oncotarget, vol. 8, no. 17, pp. 28260-28277. https://doi.org/10.18632/oncotarget.16002
Gowda, ASP, Krzeminski, J, Amin, S, Suo, Z & Spratt, T 2017, 'Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase i and Sulfolobus solfataricus DNA Polymerase IV', Chemical Research in Toxicology, vol. 30, no. 5, pp. 1168-1176. https://doi.org/10.1021/acs.chemrestox.6b00466

2016

Hegarty, JP, Krzeminski, J, Sharma, A, Guzman-Villanueva, D, Weissig, V & Stewart, D 2016, 'Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile', International Journal of Nanomedicine, vol. 11, pp. 3607-3619. https://doi.org/10.2147/IJN.S109600
Chen, W, Padilla, MT, Xu, X, Desai, D, Krzeminski, J, Amin, S & Lin, Y 2016, 'Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide', Molecular Carcinogenesis, vol. 55, no. 11, pp. 1858-1866. https://doi.org/10.1002/mc.22434
Leng, S, Thomas, CL, Snider, AM, Picchi, MA, Chen, W, Willis, DG, Carr, TG, Krzeminski, J, Desai, D, Amin, S, Lin, Y, Jacobson, MR & Belinsky, SA 2016, 'Radon exposure, IL-6 promoter variants, and lung squamous cell carcinoma in former uranium miners', Environmental health perspectives, vol. 124, no. 4, pp. 445-451. https://doi.org/10.1289/ehp.1409437

Clinical Trials Search


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