Researcher Profile

Researcher Profile

Jianming Hu, MD, MS, PhD

Jianming Hu, MD, MS, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Hepatitis B virus
  • Proteins
  • RNA-Directed DNA Polymerase
  • DNA
  • RNA
  • Hepadnaviridae
  • Nucleocapsid
  • Reverse Transcription
  • Circular DNA
  • Virion
  • Duck Hepatitis B Viruses
  • Genome

Recent Publications


Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors 2019, 'A global scientific strategy to cure hepatitis B', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. 545-558.
Hu, J, Lin, YY, Chen, PJ, Watashi, K & Wakita, T 2019, 'Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development', Gastroenterology, vol. 156, no. 2, pp. 338-354.
Ebad-Allah, J, Afonso, JF, M., K, Hu, J, Zhu, YL, Mao, ZQ, J., K & Kuntscher, CA 2019, 'Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)', Physical Review B, vol. 99, no. 12.
Hu, J, Liu, K & Luo, J 2019, HIV–HBV and HIV–HCV coinfection and liver cancer development. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 177, Springer International Publishing, pp. 231-250.
Liu, K & Hu, J 2019, 'Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids' Future Virology, vol. 14, no. 2, pp. 95-105.
Boukhvalov, DW, Edla, R, Cupolillo, A, Fabio, V, Sankar, R, Zhu, Y, Mao, Z, Hu, J, Torelli, P, Chiarello, G, Ottaviano, L & Politano, A 2019, 'Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals', Advanced Functional Materials, vol. 29, no. 18.


Liu, J, Savici, AT, Granroth, GE, Habicht, K, Qiu, Y, Hu, J, Mao, ZQ & Bao, W 2018, 'A Triplet Resonance in Superconducting Fe1.03Se0.4Te0.6', Chinese Physics Letters, vol. 35, no. 12.
Alter, H, Block, T, Brown, N, Brownstein, A, Brosgart, C, Chang, KM, Chen, PJ, Chisari, FV, Cohen, C, El-Serag, H, Feld, J, Gish, R, Glenn, J, Greten, T, Guo, H, Guo, JT, Hoshida, Y, Hu, J, Kowdley, KV, Li, W, Liang, J, Locarnini, S, Lok, AS, Mason, W, McMahon, B, Mehta, A, Perrillo, R, Revill, P, Rice, CM, Rinaudo, JA, Schinazi, R, Seeger, C, Shetty, K, Tavis, J & Zoulim, F 2018, 'A research agenda for curing chronic hepatitis B virus infection', Hepatology, vol. 67, no. 3, pp. 1127-1131.
Nicotra, G, Van Veen, E, Deretzis, I, Wang, L, Hu, J, Mao, Z, Fabio, V, Spinella, C, Chiarello, G, Rudenko, A, Yuan, S & Politano, A 2018, 'Anisotropic ultraviolet-plasmon dispersion in black phosphorus', Nanoscale, vol. 10, no. 46, pp. 21918-21927.
Zhao, Q, Hu, Z, Cheng, J, Wu, S, Luo, Y, Chang, J, Hu, J & Guo, JT 2018, 'Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation', Journal of virology, vol. 92, no. 13, e02139-17.
An, L, Zhang, H, Hu, J, Zhu, X, Gao, W, Zhang, J, Xi, C, Ning, W, Mao, Z & Tian, M 2018, 'Magnetoresistance and Shubnikov-de Haas oscillations in layered Nb3SiTe6 thin flakes', Physical Review B, vol. 97, no. 23.
Liu, K, Luckenbaugh, L, Ning, X, Xi, J & Hu, J 2018, 'Multiple roles of core protein linker in hepatitis B virus replication', PLoS pathogens, vol. 14, no. 5, e1007085.
Zhu, Y, Zhang, T, Hu, J, Kidd, J, Graf, D, Gui, X, Xie, W, Zhu, M, Ke, X, Cao, H, Fang, Z, Weng, H & Mao, Z 2018, 'Multiple topologically nontrivial bands in noncentrosymmetric YSn2', Physical Review B, vol. 98, no. 3.
Shcherbakov, D, Stepanov, P, Weber, D, Wang, Y, Hu, J, Zhu, Y, Watanabe, K, Taniguchi, T, Mao, Z, Windl, W, Goldberger, J, Bockrath, M & Lau, CN 2018, 'Raman Spectroscopy, Photocatalytic Degradation, and Stabilization of Atomically Thin Chromium Tri-iodide', Nano letters, vol. 18, no. 7, pp. 4214-4219.
Iaia, D, Chang, G, Chang, T-R, Hu, J, Mao, Z, Lin, H, Yan, S & Madhavan, V 2018, 'Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe 2', npj Quantum Materials, vol. 3, no. 1.
Hsieh, T-W, Zou, T, Hu, J, Mao, ZQ, Zhang, PP & Ke, X 2018, 'Thickness evolution of transport properties in exfoliated Fe1+yTe nanoflakes', Journal of Physics Condensed Matter, vol. 30, no. 29.
Ning, X, Luckenbaugh, L, Liu, K, Bruss, V, Sureau, C & Hu, J 2018, 'common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions', Journal of virology, vol. 92, no. 14, e00272-18.


Ning, X, Basagoudanavar, SH, Liu, K, Luckenbaugh, L, Wei, D, Wang, C, Wei, B, Zhao, Y, Yan, T, Delaney, W & Hu, J 2017, 'Capsid phosphorylation state and hepadnavirus virion secretion', Journal of virology, vol. 91, no. 9, e00092-17.
Hu, J & Liu, K 2017, 'Complete and incomplete hepatitis B virus particles: Formation, function, and application', Viruses, vol. 9, no. 3, 56.
Luo, J, Cui, X, Gao, L & Hu, J 2017, 'Identification of an intermediate in hepatitis B virus covalently closed circular (CCC) DNA formation and sensitive and selective CCC DNA detection', Journal of virology, vol. 91, no. 17, e00539-17.
Clark, DN, Jones, SA & Hu, J 2017, In vitro assays for RNA binding and protein priming of hepatitis B virus polymerase. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1540, Humana Press Inc., pp. 157-177.
Clark, DN, Flanagan, J & Hu, J 2017, 'Mapping of functional subdomains in the terminal protein domain of hepatitis B virus polymerase', Journal of virology, vol. 91, no. 3, e01785-16.


Ludgate, L, Liu, K, Luckenbaugh, L, Streck, N, Eng, S, Voitenleitner, C, Delaney, WE & Hu, J 2016, 'Cell-free hepatitis B virus capsid assembly dependent on the core protein C-terminal domain and regulated by phosphorylation', Journal of virology, vol. 90, no. 12, pp. 5830-5844.
Li, F, Cheng, L, Murphy, CM, Reszka-Blanco, NJ, Wu, Y, Chi, L, Hu, J & Su, L 2016, 'Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs', Scientific reports, vol. 6, 36483.
Cui, X, Clark, DN, Liu, K, Xu, XD, Guo, JT & Hu, J 2016, 'Viral DNA-dependent induction of innate immune response to hepatitis B virus in immortalized mouse hepatocytes', Journal of virology, vol. 90, no. 1, pp. 486-496.


Cui, X, Luckenbaugh, L, Bruss, V & Hu, J 2015, 'Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by hepatitis B virus core mutants defective in complete-virion formation' Journal of virology, vol. 89, no. 19, pp. 10064-10072.
Cui, X, McAllister, R, Boregowda, R, Sohn, JA, Ledesma, FC, Caldecott, KW, Seeger, C & Hu, J 2015, 'Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?', PloS one, vol. 10, no. 6, e0128401.
Luckenbaugh, L, Kitrinos, KM, Delaney, WE & Hu, J 2015, 'Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy', Journal of Viral Hepatitis, vol. 22, no. 6, pp. 561-570.
Hu, J & Seeger, C 2015, 'Hepadnavirus genome replication and persistence', Cold Spring Harbor Perspectives in Medicine, vol. 5, no. 7.
Cui, X, Guo, JT & Hu, J 2015, 'Hepatitis B virus covalently closed circular DNA formation in immortalized mouse hepatocytes associated with nucleocapsid destabilization' Journal of virology, vol. 89, no. 17, pp. 9021-9028.
Clark, DN & Hu, J 2015, 'Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development', Antiviral Research, vol. 123, pp. 132-137.
Liu, K, Ludgate, L, Yuan, Z & Hu, J 2015, 'Regulation of multiple stages of hepadnavirus replication by the carboxyl-terminal domain of viral core protein in trans' Journal of virology, vol. 89, no. 5, pp. 2918-2930.
Clark, DN & Hu, J 2015, 'Unveiling the roles of HBV polymerase for new antiviral strategies', Future Virology, vol. 10, no. 3, pp. 283-295.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)