Jianming Hu, MD, MS, PhD - Penn State Cancer Institute
Researcher Profile
Jianming Hu, MD, MS, PhD
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Hepatitis B virus
- Proteins
- RNA-Directed DNA Polymerase
- RNA
- Circular DNA
- DNA
- Hepadnaviridae
- Nucleocapsid
- Reverse Transcription
- Virion
- Genome
- Hepatitis B
Recent Publications
2023
Ghaemi, Z, Nafiu, O, Tajkhorshid, E, Gruebele, M & Hu, J 2023, 'A computational spatial whole-Cell model for hepatitis B viral infection and drug interactions', Scientific reports, vol. 13, no. 1, 21392. https://doi.org/10.1038/s41598-023-45998-0
Hong, X, Bianchini, EN, Wang, JCY & Hu, J 2023, 'Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes', mBio, vol. 14, no. 1. https://doi.org/10.1128/mbio.03501-22
Mendenhall, MA, Hong, X & Hu, J 2023, 'Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation', Viruses, vol. 15, no. 3, 642. https://doi.org/10.3390/v15030642
2022
Kramvis, A, Chang, KM, Dandri, M, Farci, P, Glebe, D, Hu, J, Janssen, HLA, Lau, DTY, Penicaud, C, Pollicino, T, Testoni, B, Van Bömmel, F, Andrisani, O, Beumont-Mauviel, M, Block, TM, Chan, HLY, Cloherty, GA, Delaney, WE, Geretti, AM, Gehring, A, Jackson, K, Lenz, O, Maini, MK, Miller, V, Protzer, U, Yang, JC, Yuen, MF, Zoulim, F & Revill, PA 2022, 'A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 11, pp. 727-745. https://doi.org/10.1038/s41575-022-00649-z
Hong, X & Hu, J 2022, 'Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation', Journal of virology, vol. 96, no. 15. https://doi.org/10.1128/jvi.00718-22
Hong, X, Menne, S & Hu, J 2022, 'Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/ core genes', PLoS pathogens, vol. 18, no. 7, e1010739. https://doi.org/10.1371/journal.ppat.1010739
Liu, H, Hong, X, Xi, J, Menne, S, Hu, J & Che-Yen Wang, J 2022, 'Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles', Science Advances, vol. 8, no. 31, eabo4184. https://doi.org/10.1126/sciadv.abo4184
Hong, X, Kawasawa, YI, Menne, S & Hu, J 2022, 'Host cell-dependent late entry step as determinant of Hepatitis B virus infection', PLoS pathogens, vol. 18, no. 6, e1010633. https://doi.org/10.1371/journal.ppat.1010633
Zoulim, F, Zlotnick, A, Buchholz, S, Donaldson, E, Fry, J, Gaggar, A, Hu, J, Kann, M, Lenz, O, Lin, K, Mani, N, Nassal, M, Delaney, W, Wang, S, Westman, G, Miller, V & Janssen, HLA 2022, 'Nomenclature of HBV core protein-targeting antivirals', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 12, pp. 748-750. https://doi.org/10.1038/s41575-022-00700-z
Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8. https://doi.org/10.1128/jvi.00399-22
Xi, J, Liu, H & Hu, J 2022, 'Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions', Journal of virology, vol. 96, no. 1, e01305-21. https://doi.org/10.1128/JVI.01305-21
2021
Hong, X, Luckenbaugh, L, Perlman, D, Revill, PA, Wieland, SF, Menne, S & Hu, J 2021, 'Characterization and Application of Precore/Core-Related Antigens in Animal Models of Hepatitis B Virus Infection', Hepatology, vol. 74, no. 1, pp. 99-115. https://doi.org/10.1002/hep.31720
Xi, J, Luckenbaugh, L & Hu, J 2021, 'Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication', PLoS pathogens, vol. 17, no. 1, e1009230. https://doi.org/10.1371/journal.ppat.1009230
Clark, DN, Tajwar, R, Hu, J & Tavis, JE 2021, The hepatitis B virus polymerase. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part B. Enzymes, vol. 50, Academic Press, pp. 195-226. https://doi.org/10.1016/bs.enz.2021.06.010
Hong, X & Hu, J 2021, 'Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results', Journal of Hepatology, vol. 75, no. 4, pp. 997-998. https://doi.org/10.1016/j.jhep.2021.04.041
2020
Luo, J, Luckenbaugh, L, Hu, H, Yan, Z, Gao, L & Hu, J 2020, 'Involvement of host atr-chk1 pathway in hepatitis b virus covalently closed circular dna formation', mBio, vol. 11, no. 1, e03423-19. https://doi.org/10.1128/mBio.03423-19
Luo, J, Xi, J, Gao, L & Hu, J 2020, 'Role of hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation', PLoS pathogens, vol. 16, no. 3, e1008459. https://doi.org/10.1371/journal.ppat.1008459
Hong, X & Hu, J 2020, 'Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover', Journal of Medical Virology, vol. 92, no. 8, pp. 935-937. https://doi.org/10.1002/jmv.25925