Researcher Profile

Researcher Profile

Jianming Hu, MD, MS, PhD

Jianming Hu, MD, MS, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Hepatitis B virus
  • Proteins
  • RNA-Directed DNA Polymerase
  • RNA
  • DNA
  • Circular DNA
  • Hepadnaviridae
  • Nucleocapsid
  • Reverse Transcription
  • Virion
  • Genome
  • Duck Hepatitis B Viruses

Recent Publications


Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8.
Xi, J, Liu, H & Hu, J 2022, 'Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions', Journal of virology, vol. 96, no. 1, e01305-21.


Hong, X, Luckenbaugh, L, Perlman, D, Revill, PA, Wieland, SF, Menne, S & Hu, J 2021, 'Characterization and Application of Precore/Core-Related Antigens in Animal Models of Hepatitis B Virus Infection', Hepatology, vol. 74, no. 1, pp. 99-115.
Xi, J, Luckenbaugh, L & Hu, J 2021, 'Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication', PLoS pathogens, vol. 17, no. 1, e1009230.
Clark, DN, Tajwar, R, Hu, J & Tavis, JE 2021, The hepatitis B virus polymerase. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part B. Enzymes, vol. 50, Academic Press, pp. 195-226.
Hong, X & Hu, J 2021, 'Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results', Journal of Hepatology, vol. 75, no. 4, pp. 997-998.


Luo, J, Luckenbaugh, L, Hu, H, Yan, Z, Gao, L & Hu, J 2020, 'Involvement of host atr-chk1 pathway in hepatitis b virus covalently closed circular dna formation', mBio, vol. 11, no. 1, e03423-19.
Luo, J, Xi, J, Gao, L & Hu, J 2020, 'Role of hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation', PLoS pathogens, vol. 16, no. 3, e1008459.
Hong, X & Hu, J 2020, 'Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover', Journal of Medical Virology, vol. 92, no. 8, pp. 935-937.


Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors 2019, 'A global scientific strategy to cure hepatitis B', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. 545-558.
Hu, J, Lin, YY, Chen, PJ, Watashi, K & Wakita, T 2019, 'Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development', Gastroenterology, vol. 156, no. 2, pp. 338-354.
Ebad-Allah, J, Afonso, JF, M., K, Hu, J, Zhu, YL, Mao, ZQ, J., K & Kuntscher, CA 2019, 'Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)', Physical Review B, vol. 99, no. 12.
Hu, J, Liu, K & Luo, J 2019, HIV–HBV and HIV–HCV coinfection and liver cancer development. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 177, Springer International Publishing, pp. 231-250.
Hu, J, Protzer, U & Siddiqui, A 2019, 'Revisiting Hepatitis B virus: Challenges of curative therapies', Journal of virology, vol. 93, no. 20, e01032-19.
Liu, K & Hu, J 2019, 'Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids', Future Virology, vol. 14, no. 2, pp. 95-105.
Boukhvalov, DW, Edla, R, Cupolillo, A, Fabio, V, Sankar, R, Zhu, Y, Mao, Z, Hu, J, Torelli, P, Chiarello, G, Ottaviano, L & Politano, A 2019, 'Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals', Advanced Functional Materials, vol. 29, no. 18.


Liu, J, Savici, AT, Granroth, GE, Habicht, K, Qiu, Y, Hu, J, Mao, ZQ & Bao, W 2018, 'A Triplet Resonance in Superconducting Fe1.03Se0.4Te0.6', Chinese Physics Letters, vol. 35, no. 12.
Alter, H, Block, T, Brown, N, Brownstein, A, Brosgart, C, Chang, KM, Chen, PJ, Chisari, FV, Cohen, C, El-Serag, H, Feld, J, Gish, R, Glenn, J, Greten, T, Guo, H, Guo, JT, Hoshida, Y, Hu, J, Kowdley, KV, Li, W, Liang, J, Locarnini, S, Lok, AS, Mason, W, McMahon, B, Mehta, A, Perrillo, R, Revill, P, Rice, CM, Rinaudo, JA, Schinazi, R, Seeger, C, Shetty, K, Tavis, J & Zoulim, F 2018, 'A research agenda for curing chronic hepatitis B virus infection', Hepatology, vol. 67, no. 3, pp. 1127-1131.
Nicotra, G, Van Veen, E, Deretzis, I, Wang, L, Hu, J, Mao, Z, Fabio, V, Spinella, C, Chiarello, G, Rudenko, A, Yuan, S & Politano, A 2018, 'Anisotropic ultraviolet-plasmon dispersion in black phosphorus', Nanoscale, vol. 10, no. 46, pp. 21918-21927.
Zhao, Q, Hu, Z, Cheng, J, Wu, S, Luo, Y, Chang, J, Hu, J & Guo, JT 2018, 'Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation', Journal of virology, vol. 92, no. 13, e02139-17.
An, L, Zhang, H, Hu, J, Zhu, X, Gao, W, Zhang, J, Xi, C, Ning, W, Mao, Z & Tian, M 2018, 'Magnetoresistance and Shubnikov-de Haas oscillations in layered Nb3SiTe6 thin flakes', Physical Review B, vol. 97, no. 23.
Liu, K, Luckenbaugh, L, Ning, X, Xi, J & Hu, J 2018, 'Multiple roles of core protein linker in hepatitis B virus replication', PLoS pathogens, vol. 14, no. 5, e1007085.
Zhu, Y, Zhang, T, Hu, J, Kidd, J, Graf, D, Gui, X, Xie, W, Zhu, M, Ke, X, Cao, H, Fang, Z, Weng, H & Mao, Z 2018, 'Multiple topologically nontrivial bands in noncentrosymmetric YSn2', Physical Review B, vol. 98, no. 3.
Shcherbakov, D, Stepanov, P, Weber, D, Wang, Y, Hu, J, Zhu, Y, Watanabe, K, Taniguchi, T, Mao, Z, Windl, W, Goldberger, J, Bockrath, M & Lau, CN 2018, 'Raman Spectroscopy, Photocatalytic Degradation, and Stabilization of Atomically Thin Chromium Tri-iodide', Nano letters, vol. 18, no. 7, pp. 4214-4219.
Iaia, D, Chang, G, Chang, T-R, Hu, J, Mao, Z, Lin, H, Yan, S & Madhavan, V 2018, 'Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe 2', npj Quantum Materials, vol. 3, no. 1.
Hsieh, T-W, Zou, T, Hu, J, Mao, ZQ, Zhang, PP & Ke, X 2018, 'Thickness evolution of transport properties in exfoliated Fe1+yTe nanoflakes', Journal of Physics Condensed Matter, vol. 30, no. 29.
Ning, X, Luckenbaugh, L, Liu, K, Bruss, V, Sureau, C & Hu, J 2018, 'common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions', Journal of virology, vol. 92, no. 14, e00272-18.

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