Jianming Hu, MD, MS, PhD - Penn State Cancer Institute
Researcher Profile
Jianming Hu, MD, MS, PhD
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Hepatitis B virus
- Proteins
- RNA-Directed DNA Polymerase
- RNA
- Circular DNA
- DNA
- Hepadnaviridae
- Nucleocapsid
- Reverse Transcription
- Virion
- Genome
- Hepatitis B
Recent Publications
2023
Hong, X, Bianchini, EN, Wang, JCY & Hu, J 2023, 'Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes', mBio, vol. 14, no. 1. https://doi.org/10.1128/mbio.03501-22
Mendenhall, MA, Hong, X & Hu, J 2023, 'Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation', Viruses, vol. 15, no. 3, 642. https://doi.org/10.3390/v15030642
2022
Kramvis, A, Chang, KM, Dandri, M, Farci, P, Glebe, D, Hu, J, Janssen, HLA, Lau, DTY, Penicaud, C, Pollicino, T, Testoni, B, Van Bömmel, F, Andrisani, O, Beumont-Mauviel, M, Block, TM, Chan, HLY, Cloherty, GA, Delaney, WE, Geretti, AM, Gehring, A, Jackson, K, Lenz, O, Maini, MK, Miller, V, Protzer, U, Yang, JC, Yuen, MF, Zoulim, F & Revill, PA 2022, 'A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 11, pp. 727-745. https://doi.org/10.1038/s41575-022-00649-z
Hong, X & Hu, J 2022, 'Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation', Journal of virology, vol. 96, no. 15. https://doi.org/10.1128/jvi.00718-22
Hong, X, Menne, S & Hu, J 2022, 'Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/ core genes', PLoS pathogens, vol. 18, no. 7, e1010739. https://doi.org/10.1371/journal.ppat.1010739
Liu, H, Hong, X, Xi, J, Menne, S, Hu, J & Che-Yen Wang, J 2022, 'Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles', Science Advances, vol. 8, no. 31, eabo4184. https://doi.org/10.1126/sciadv.abo4184
Hong, X, Kawasawa, YI, Menne, S & Hu, J 2022, 'Host cell-dependent late entry step as determinant of Hepatitis B virus infection', PLoS pathogens, vol. 18, no. 6, e1010633. https://doi.org/10.1371/journal.ppat.1010633
Zoulim, F, Zlotnick, A, Buchholz, S, Donaldson, E, Fry, J, Gaggar, A, Hu, J, Kann, M, Lenz, O, Lin, K, Mani, N, Nassal, M, Delaney, W, Wang, S, Westman, G, Miller, V & Janssen, HLA 2022, 'Nomenclature of HBV core protein-targeting antivirals', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 12, pp. 748-750. https://doi.org/10.1038/s41575-022-00700-z
Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8. https://doi.org/10.1128/jvi.00399-22
Xi, J, Liu, H & Hu, J 2022, 'Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions', Journal of virology, vol. 96, no. 1, e01305-21. https://doi.org/10.1128/JVI.01305-21
2021
Hong, X, Luckenbaugh, L, Perlman, D, Revill, PA, Wieland, SF, Menne, S & Hu, J 2021, 'Characterization and Application of Precore/Core-Related Antigens in Animal Models of Hepatitis B Virus Infection', Hepatology, vol. 74, no. 1, pp. 99-115. https://doi.org/10.1002/hep.31720
Xi, J, Luckenbaugh, L & Hu, J 2021, 'Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication', PLoS pathogens, vol. 17, no. 1, e1009230. https://doi.org/10.1371/journal.ppat.1009230
Clark, DN, Tajwar, R, Hu, J & Tavis, JE 2021, The hepatitis B virus polymerase. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part B. Enzymes, vol. 50, Academic Press, pp. 195-226. https://doi.org/10.1016/bs.enz.2021.06.010
Hong, X & Hu, J 2021, 'Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results', Journal of Hepatology, vol. 75, no. 4, pp. 997-998. https://doi.org/10.1016/j.jhep.2021.04.041
2020
Luo, J, Luckenbaugh, L, Hu, H, Yan, Z, Gao, L & Hu, J 2020, 'Involvement of host atr-chk1 pathway in hepatitis b virus covalently closed circular dna formation', mBio, vol. 11, no. 1, e03423-19. https://doi.org/10.1128/mBio.03423-19
Luo, J, Xi, J, Gao, L & Hu, J 2020, 'Role of hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation', PLoS pathogens, vol. 16, no. 3, e1008459. https://doi.org/10.1371/journal.ppat.1008459
Hong, X & Hu, J 2020, 'Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover', Journal of Medical Virology, vol. 92, no. 8, pp. 935-937. https://doi.org/10.1002/jmv.25925
2019
Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors 2019, 'A global scientific strategy to cure hepatitis B', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. 545-558. https://doi.org/10.1016/S2468-1253(19)30119-0
Hu, J, Lin, YY, Chen, PJ, Watashi, K & Wakita, T 2019, 'Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development', Gastroenterology, vol. 156, no. 2, pp. 338-354. https://doi.org/10.1053/j.gastro.2018.06.093
Ebad-Allah, J, Afonso, JF, M., K, Hu, J, Zhu, YL, Mao, ZQ, J., K & Kuntscher, CA 2019, 'Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)', Physical Review B, vol. 99, no. 12. https://doi.org/10.1103/PhysRevB.99.125154
Hu, J, Liu, K & Luo, J 2019, HIV–HBV and HIV–HCV coinfection and liver cancer development. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 177, Springer International Publishing, pp. 231-250. https://doi.org/10.1007/978-3-030-03502-0_9
Hu, J, Protzer, U & Siddiqui, A 2019, 'Revisiting Hepatitis B virus: Challenges of curative therapies', Journal of virology, vol. 93, no. 20, e01032-19. https://doi.org/10.1128/JVI.01032-19
Liu, K & Hu, J 2019, 'Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids', Future Virology, vol. 14, no. 2, pp. 95-105. https://doi.org/10.2217/fvl-2018-0128
Boukhvalov, DW, Edla, R, Cupolillo, A, Fabio, V, Sankar, R, Zhu, Y, Mao, Z, Hu, J, Torelli, P, Chiarello, G, Ottaviano, L & Politano, A 2019, 'Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals', Advanced Functional Materials, vol. 29, no. 18. https://doi.org/10.1002/adfm.201900438