Researcher Profile

Researcher Profile

Jianming Hu, MD, MS, PhD

Jianming Hu, MD, MS, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
juh13@psu.edu

Research Interests

  • Hepatitis B virus
  • Proteins
  • RNA-Directed DNA Polymerase
  • RNA
  • DNA
  • Circular DNA
  • Hepadnaviridae
  • Nucleocapsid
  • Reverse Transcription
  • Virion
  • Genome
  • Duck Hepatitis B Viruses

Recent Publications

2022

Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8. https://doi.org/10.1128/jvi.00399-22
Xi, J, Liu, H & Hu, J 2022, 'Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions', Journal of virology, vol. 96, no. 1, e01305-21. https://doi.org/10.1128/JVI.01305-21

2021

Hong, X, Luckenbaugh, L, Perlman, D, Revill, PA, Wieland, SF, Menne, S & Hu, J 2021, 'Characterization and Application of Precore/Core-Related Antigens in Animal Models of Hepatitis B Virus Infection', Hepatology, vol. 74, no. 1, pp. 99-115. https://doi.org/10.1002/hep.31720
Xi, J, Luckenbaugh, L & Hu, J 2021, 'Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication', PLoS pathogens, vol. 17, no. 1, e1009230. https://doi.org/10.1371/journal.ppat.1009230
Clark, DN, Tajwar, R, Hu, J & Tavis, JE 2021, The hepatitis B virus polymerase. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part B. Enzymes, vol. 50, Academic Press, pp. 195-226. https://doi.org/10.1016/bs.enz.2021.06.010
Hong, X & Hu, J 2021, 'Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results', Journal of Hepatology, vol. 75, no. 4, pp. 997-998. https://doi.org/10.1016/j.jhep.2021.04.041

2020

Luo, J, Luckenbaugh, L, Hu, H, Yan, Z, Gao, L & Hu, J 2020, 'Involvement of host atr-chk1 pathway in hepatitis b virus covalently closed circular dna formation', mBio, vol. 11, no. 1, e03423-19. https://doi.org/10.1128/mBio.03423-19
Luo, J, Xi, J, Gao, L & Hu, J 2020, 'Role of hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation', PLoS pathogens, vol. 16, no. 3, e1008459. https://doi.org/10.1371/journal.ppat.1008459
Hong, X & Hu, J 2020, 'Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover', Journal of Medical Virology, vol. 92, no. 8, pp. 935-937. https://doi.org/10.1002/jmv.25925

2019

Members of the ICE-HBV Working Groups, ICE-HBV Stakeholders Group Chairs & ICE-HBV Senior Advisors 2019, 'A global scientific strategy to cure hepatitis B', The Lancet Gastroenterology and Hepatology, vol. 4, no. 7, pp. 545-558. https://doi.org/10.1016/S2468-1253(19)30119-0
Hu, J, Lin, YY, Chen, PJ, Watashi, K & Wakita, T 2019, 'Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development', Gastroenterology, vol. 156, no. 2, pp. 338-354. https://doi.org/10.1053/j.gastro.2018.06.093
Ebad-Allah, J, Afonso, JF, M., K, Hu, J, Zhu, YL, Mao, ZQ, J., K & Kuntscher, CA 2019, 'Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)', Physical Review B, vol. 99, no. 12. https://doi.org/10.1103/PhysRevB.99.125154
Hu, J, Liu, K & Luo, J 2019, HIV–HBV and HIV–HCV coinfection and liver cancer development. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 177, Springer International Publishing, pp. 231-250. https://doi.org/10.1007/978-3-030-03502-0_9
Hu, J, Protzer, U & Siddiqui, A 2019, 'Revisiting Hepatitis B virus: Challenges of curative therapies', Journal of virology, vol. 93, no. 20, e01032-19. https://doi.org/10.1128/JVI.01032-19
Liu, K & Hu, J 2019, 'Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids', Future Virology, vol. 14, no. 2, pp. 95-105. https://doi.org/10.2217/fvl-2018-0128
Boukhvalov, DW, Edla, R, Cupolillo, A, Fabio, V, Sankar, R, Zhu, Y, Mao, Z, Hu, J, Torelli, P, Chiarello, G, Ottaviano, L & Politano, A 2019, 'Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals', Advanced Functional Materials, vol. 29, no. 18. https://doi.org/10.1002/adfm.201900438

2018

Liu, J, Savici, AT, Granroth, GE, Habicht, K, Qiu, Y, Hu, J, Mao, ZQ & Bao, W 2018, 'A Triplet Resonance in Superconducting Fe1.03Se0.4Te0.6', Chinese Physics Letters, vol. 35, no. 12. https://doi.org/10.1088/0256-307X/35/12/127401
Alter, H, Block, T, Brown, N, Brownstein, A, Brosgart, C, Chang, KM, Chen, PJ, Chisari, FV, Cohen, C, El-Serag, H, Feld, J, Gish, R, Glenn, J, Greten, T, Guo, H, Guo, JT, Hoshida, Y, Hu, J, Kowdley, KV, Li, W, Liang, J, Locarnini, S, Lok, AS, Mason, W, McMahon, B, Mehta, A, Perrillo, R, Revill, P, Rice, CM, Rinaudo, JA, Schinazi, R, Seeger, C, Shetty, K, Tavis, J & Zoulim, F 2018, 'A research agenda for curing chronic hepatitis B virus infection', Hepatology, vol. 67, no. 3, pp. 1127-1131. https://doi.org/10.1002/hep.29509
Nicotra, G, Van Veen, E, Deretzis, I, Wang, L, Hu, J, Mao, Z, Fabio, V, Spinella, C, Chiarello, G, Rudenko, A, Yuan, S & Politano, A 2018, 'Anisotropic ultraviolet-plasmon dispersion in black phosphorus', Nanoscale, vol. 10, no. 46, pp. 21918-21927. https://doi.org/10.1039/c8nr05502e
Zhao, Q, Hu, Z, Cheng, J, Wu, S, Luo, Y, Chang, J, Hu, J & Guo, JT 2018, 'Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation', Journal of virology, vol. 92, no. 13, e02139-17. https://doi.org/10.1128/JVI.02139-17
An, L, Zhang, H, Hu, J, Zhu, X, Gao, W, Zhang, J, Xi, C, Ning, W, Mao, Z & Tian, M 2018, 'Magnetoresistance and Shubnikov-de Haas oscillations in layered Nb3SiTe6 thin flakes', Physical Review B, vol. 97, no. 23. https://doi.org/10.1103/PhysRevB.97.235133
Liu, K, Luckenbaugh, L, Ning, X, Xi, J & Hu, J 2018, 'Multiple roles of core protein linker in hepatitis B virus replication', PLoS pathogens, vol. 14, no. 5, e1007085. https://doi.org/10.1371/journal.ppat.1007085
Zhu, Y, Zhang, T, Hu, J, Kidd, J, Graf, D, Gui, X, Xie, W, Zhu, M, Ke, X, Cao, H, Fang, Z, Weng, H & Mao, Z 2018, 'Multiple topologically nontrivial bands in noncentrosymmetric YSn2', Physical Review B, vol. 98, no. 3. https://doi.org/10.1103/PhysRevB.98.035117
Shcherbakov, D, Stepanov, P, Weber, D, Wang, Y, Hu, J, Zhu, Y, Watanabe, K, Taniguchi, T, Mao, Z, Windl, W, Goldberger, J, Bockrath, M & Lau, CN 2018, 'Raman Spectroscopy, Photocatalytic Degradation, and Stabilization of Atomically Thin Chromium Tri-iodide', Nano letters, vol. 18, no. 7, pp. 4214-4219. https://doi.org/10.1021/acs.nanolett.8b01131
Iaia, D, Chang, G, Chang, T-R, Hu, J, Mao, Z, Lin, H, Yan, S & Madhavan, V 2018, 'Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe 2', npj Quantum Materials, vol. 3, no. 1. https://doi.org/10.1038/s41535-018-0112-5
Hsieh, T-W, Zou, T, Hu, J, Mao, ZQ, Zhang, PP & Ke, X 2018, 'Thickness evolution of transport properties in exfoliated Fe1+yTe nanoflakes', Journal of Physics Condensed Matter, vol. 30, no. 29. https://doi.org/10.1088/1361-648X/aaca61
Ning, X, Luckenbaugh, L, Liu, K, Bruss, V, Sureau, C & Hu, J 2018, 'common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions', Journal of virology, vol. 92, no. 14, e00272-18. https://doi.org/10.1128/JVI.00272-18

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