Researcher Profile

Researcher Profile

Jianming Hu, MD, MS, PhD

Jianming Hu, MD, MS, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
juh13@psu.edu

Research Interests

  • Hepatitis B virus
  • Proteins
  • RNA-Directed DNA Polymerase
  • DNA
  • RNA
  • Hepadnaviridae
  • Nucleocapsid
  • Reverse Transcription
  • Circular DNA
  • Virion
  • Duck Hepatitis B Viruses
  • Genome

Recent Publications

2019

Hu, J, Lin, YY, Chen, PJ, Watashi, K & Wakita, T 2019, 'Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development', Gastroenterology, vol. 156, no. 2, pp. 338-354. https://doi.org/10.1053/j.gastro.2018.06.093
Ebad-Allah, J, Afonso, JF, M., K, Hu, J, Zhu, YL, Mao, ZQ, J., K & Kuntscher, CA 2019, 'Chemical pressure effect on the optical conductivity of the nodal-line semimetals ZrSiY (Y= S,Se,Te) and ZrGeY (Y= S,Te)', Physical Review B, vol. 99, no. 12. https://doi.org/10.1103/PhysRevB.99.125154
Hu, J, Liu, K & Luo, J 2019, HIV–HBV and HIV–HCV coinfection and liver cancer development. in Cancer Treatment and Research. Cancer Treatment and Research, vol. 177, Springer International Publishing, pp. 231-250. https://doi.org/10.1007/978-3-030-03502-0_9
Liu, K & Hu, J 2019, 'Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids' Future Virology, vol. 14, no. 2, pp. 95-105. https://doi.org/10.2217/fvl-2018-0128
Boukhvalov, DW, Edla, R, Cupolillo, A, Fabio, V, Sankar, R, Zhu, Y, Mao, Z, Hu, J, Torelli, P, Chiarello, G, Ottaviano, L & Politano, A 2019, 'Surface Instability and Chemical Reactivity of ZrSiS and ZrSiSe Nodal-Line Semimetals' Advanced Functional Materials, vol. 29, no. 18. https://doi.org/10.1002/adfm.201900438

2018

Liu, J, Savici, AT, Granroth, GE, Habicht, K, Qiu, Y, Hu, J, Mao, ZQ & Bao, W 2018, 'A Triplet Resonance in Superconducting Fe1.03Se0.4Te0.6' Chinese Physics Letters, vol. 35, no. 12. https://doi.org/10.1088/0256-307X/35/12/127401
Alter, H, Block, T, Brown, N, Brownstein, A, Brosgart, C, Chang, KM, Chen, PJ, Chisari, FV, Cohen, C, El-Serag, H, Feld, J, Gish, R, Glenn, J, Greten, T, Guo, H, Guo, JT, Hoshida, Y, Hu, J, Kowdley, KV, Li, W, Liang, J, Locarnini, S, Lok, AS, Mason, W, McMahon, B, Mehta, A, Perrillo, R, Revill, P, Rice, CM, Rinaudo, JA, Schinazi, R, Seeger, C, Shetty, K, Tavis, J & Zoulim, F 2018, 'A research agenda for curing chronic hepatitis B virus infection', Hepatology, vol. 67, no. 3, pp. 1127-1131. https://doi.org/10.1002/hep.29509
Nicotra, G, Van Veen, E, Deretzis, I, Wang, L, Hu, J, Mao, Z, Fabio, V, Spinella, C, Chiarello, G, Rudenko, A, Yuan, S & Politano, A 2018, 'Anisotropic ultraviolet-plasmon dispersion in black phosphorus', Nanoscale, vol. 10, no. 46, pp. 21918-21927. https://doi.org/10.1039/c8nr05502e
Zhao, Q, Hu, Z, Cheng, J, Wu, S, Luo, Y, Chang, J, Hu, J & Guo, JT 2018, 'Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation', Journal of virology, vol. 92, no. 13, e02139-17. https://doi.org/10.1128/JVI.02139-17
An, L, Zhang, H, Hu, J, Zhu, X, Gao, W, Zhang, J, Xi, C, Ning, W, Mao, Z & Tian, M 2018, 'Magnetoresistance and Shubnikov-de Haas oscillations in layered Nb3SiTe6 thin flakes', Physical Review B, vol. 97, no. 23. https://doi.org/10.1103/PhysRevB.97.235133
Liu, K, Luckenbaugh, L, Ning, X, Xi, J & Hu, J 2018, 'Multiple roles of core protein linker in hepatitis B virus replication', PLoS Pathogens, vol. 14, no. 5, e1007085. https://doi.org/10.1371/journal.ppat.1007085
Zhu, Y, Zhang, T, Hu, J, Kidd, J, Graf, D, Gui, X, Xie, W, Zhu, M, Ke, X, Cao, H, Fang, Z, Weng, H & Mao, Z 2018, 'Multiple topologically nontrivial bands in noncentrosymmetric YSn2', Physical Review B, vol. 98, no. 3. https://doi.org/10.1103/PhysRevB.98.035117
Shcherbakov, D, Stepanov, P, Weber, D, Wang, Y, Hu, J, Zhu, Y, Watanabe, K, Taniguchi, T, Mao, Z, Windl, W, Goldberger, J, Bockrath, M & Lau, CN 2018, 'Raman Spectroscopy, Photocatalytic Degradation, and Stabilization of Atomically Thin Chromium Tri-iodide', Nano letters, vol. 18, no. 7, pp. 4214-4219. https://doi.org/10.1021/acs.nanolett.8b01131
Iaia, D, Chang, G, Chang, T-R, Hu, J, Mao, Z, Lin, H, Yan, S & Madhavan, V 2018, 'Searching for topological Fermi arcs via quasiparticle interference on a type-II Weyl semimetal MoTe 2', npj Quantum Materials, vol. 3, no. 1. https://doi.org/10.1038/s41535-018-0112-5
Hsieh, T-W, Zou, T, Hu, J, Mao, ZQ, Zhang, PP & Ke, X 2018, 'Thickness evolution of transport properties in exfoliated Fe1+yTe nanoflakes' Journal of Physics Condensed Matter, vol. 30, no. 29. https://doi.org/10.1088/1361-648X/aaca61
Ning, X, Luckenbaugh, L, Liu, K, Bruss, V, Sureau, C & Hu, J 2018, 'common and distinct capsid and surface protein requirements for secretion of complete and genome-free hepatitis B virions', Journal of virology, vol. 92, no. 14, e00272-18. https://doi.org/10.1128/JVI.00272-18

2017

Ning, X, Basagoudanavar, SH, Liu, K, Luckenbaugh, L, Wei, D, Wang, C, Wei, B, Zhao, Y, Yan, T, Delaney, W & Hu, J 2017, 'Capsid phosphorylation state and hepadnavirus virion secretion', Journal of virology, vol. 91, no. 9, e00092-17. https://doi.org/10.1128/JVI.00092-17
Hu, J & Liu, K 2017, 'Complete and incomplete hepatitis B virus particles: Formation, function, and application', Viruses, vol. 9, no. 3, 56. https://doi.org/10.3390/v9030056
Luo, J, Cui, X, Gao, L & Hu, J 2017, 'Identification of an intermediate in hepatitis B virus covalently closed circular (CCC) DNA formation and sensitive and selective CCC DNA detection', Journal of virology, vol. 91, no. 17, e00539-17. https://doi.org/10.1128/JVI.00539-17
Clark, DN, Jones, SA & Hu, J 2017, In vitro assays for RNA binding and protein priming of hepatitis B virus polymerase. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1540, Humana Press Inc., pp. 157-177. https://doi.org/10.1007/978-1-4939-6700-1_13
Clark, DN, Flanagan, J & Hu, J 2017, 'Mapping of functional subdomains in the terminal protein domain of hepatitis B virus polymerase', Journal of Virology, vol. 91, no. 3, e01785-16. https://doi.org/10.1128/JVI.01785-16

2016

Ludgate, L, Liu, K, Luckenbaugh, L, Streck, N, Eng, S, Voitenleitner, C, Delaney, WE & Hu, J 2016, 'Cell-free hepatitis B virus capsid assembly dependent on the core protein C-terminal domain and regulated by phosphorylation', Journal of virology, vol. 90, no. 12, pp. 5830-5844. https://doi.org/10.1128/JVI.00394-16
Li, F, Cheng, L, Murphy, CM, Reszka-Blanco, NJ, Wu, Y, Chi, L, Hu, J & Su, L 2016, 'Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs', Scientific reports, vol. 6, 36483. https://doi.org/10.1038/srep36483
Cui, X, Clark, DN, Liu, K, Xu, XD, Guo, JT & Hu, J 2016, 'Viral DNA-dependent induction of innate immune response to hepatitis B virus in immortalized mouse hepatocytes', Journal of virology, vol. 90, no. 1, pp. 486-496. https://doi.org/10.1128/JVI.01263-15

2015

Cui, X, Luckenbaugh, L, Bruss, V & Hu, J 2015, 'Alteration of mature nucleocapsid and enhancement of covalently closed circular DNA formation by hepatitis B virus core mutants defective in complete-virion formation' Journal of virology, vol. 89, no. 19, pp. 10064-10072. https://doi.org/10.1128/JVI.01481-15
Cui, X, McAllister, R, Boregowda, R, Sohn, JA, Ledesma, FC, Caldecott, KW, Seeger, C & Hu, J 2015, 'Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?', PloS one, vol. 10, no. 6, e0128401. https://doi.org/10.1371/journal.pone.0128401
Luckenbaugh, L, Kitrinos, KM, Delaney, WE & Hu, J 2015, 'Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy', Journal of Viral Hepatitis, vol. 22, no. 6, pp. 561-570. https://doi.org/10.1111/jvh.12361
Hu, J & Seeger, C 2015, 'Hepadnavirus genome replication and persistence', Cold Spring Harbor Perspectives in Medicine, vol. 5, no. 7. https://doi.org/10.1101/cshperspect.a021386
Cui, X, Guo, JT & Hu, J 2015, 'Hepatitis B virus covalently closed circular DNA formation in immortalized mouse hepatocytes associated with nucleocapsid destabilization' Journal of virology, vol. 89, no. 17, pp. 9021-9028. https://doi.org/10.1128/JVI.01261-15
Clark, DN & Hu, J 2015, 'Hepatitis B virus reverse transcriptase - Target of current antiviral therapy and future drug development', Antiviral Research, vol. 123, pp. 132-137. https://doi.org/10.1016/j.antiviral.2015.09.011
Liu, K, Ludgate, L, Yuan, Z & Hu, J 2015, 'Regulation of multiple stages of hepadnavirus replication by the carboxyl-terminal domain of viral core protein in trans' Journal of virology, vol. 89, no. 5, pp. 2918-2930. https://doi.org/10.1128/JVI.03116-14
Clark, DN & Hu, J 2015, 'Unveiling the roles of HBV polymerase for new antiviral strategies', Future Virology, vol. 10, no. 3, pp. 283-295. https://doi.org/10.2217/fvl.14.113

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)