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Researcher Profile

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Jianming Hu, MD, MS, PhD

Jianming Hu, MD, MS, PhD

Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Hepatitis B virus
  • Proteins
  • RNA-Directed DNA Polymerase
  • RNA
  • Circular DNA
  • DNA
  • Hepadnaviridae
  • Nucleocapsid
  • Reverse Transcription
  • Virion
  • Genome
  • Hepatitis B

Recent Publications


Ghaemi, Z, Nafiu, O, Tajkhorshid, E, Gruebele, M & Hu, J 2023, 'A computational spatial whole-Cell model for hepatitis B viral infection and drug interactions', Scientific reports, vol. 13, no. 1, 21392.
Hong, X, Bianchini, EN, Wang, JCY & Hu, J 2023, 'Characterization of Intracellular Precore-Derived Proteins and Their Functions in Hepatitis B Virus-Infected Human Hepatocytes', mBio, vol. 14, no. 1.
Mendenhall, MA, Hong, X & Hu, J 2023, 'Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation', Viruses, vol. 15, no. 3, 642.


Kramvis, A, Chang, KM, Dandri, M, Farci, P, Glebe, D, Hu, J, Janssen, HLA, Lau, DTY, Penicaud, C, Pollicino, T, Testoni, B, Van Bömmel, F, Andrisani, O, Beumont-Mauviel, M, Block, TM, Chan, HLY, Cloherty, GA, Delaney, WE, Geretti, AM, Gehring, A, Jackson, K, Lenz, O, Maini, MK, Miller, V, Protzer, U, Yang, JC, Yuen, MF, Zoulim, F & Revill, PA 2022, 'A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 11, pp. 727-745.
Hong, X & Hu, J 2022, 'Conserved Lysine Residues of Hepatitis B Virus Core Protein Are Not Required for Covalently Closed Circular DNA Formation', Journal of virology, vol. 96, no. 15.
Hong, X, Menne, S & Hu, J 2022, 'Constrained evolution of overlapping genes in viral host adaptation: Acquisition of glycosylation motifs in hepadnaviral precore/ core genes', PLoS pathogens, vol. 18, no. 7, e1010739.
Liu, H, Hong, X, Xi, J, Menne, S, Hu, J & Che-Yen Wang, J 2022, 'Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles', Science Advances, vol. 8, no. 31, eabo4184.
Hong, X, Kawasawa, YI, Menne, S & Hu, J 2022, 'Host cell-dependent late entry step as determinant of Hepatitis B virus infection', PLoS pathogens, vol. 18, no. 6, e1010633.
Zoulim, F, Zlotnick, A, Buchholz, S, Donaldson, E, Fry, J, Gaggar, A, Hu, J, Kann, M, Lenz, O, Lin, K, Mani, N, Nassal, M, Delaney, W, Wang, S, Westman, G, Miller, V & Janssen, HLA 2022, 'Nomenclature of HBV core protein-targeting antivirals', Nature Reviews Gastroenterology and Hepatology, vol. 19, no. 12, pp. 748-750.
Xi, J, Cui, X, Liu, K, Liu, H, Wang, J & Hu, J 2022, 'Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating', Journal of virology, vol. 96, no. 8.
Xi, J, Liu, H & Hu, J 2022, 'Regulation of Hepatitis B Virus Virion Release and Envelopment Timing by Nucleocapsid and Envelope Interactions', Journal of virology, vol. 96, no. 1, e01305-21.


Hong, X, Luckenbaugh, L, Perlman, D, Revill, PA, Wieland, SF, Menne, S & Hu, J 2021, 'Characterization and Application of Precore/Core-Related Antigens in Animal Models of Hepatitis B Virus Infection', Hepatology, vol. 74, no. 1, pp. 99-115.
Xi, J, Luckenbaugh, L & Hu, J 2021, 'Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication', PLoS pathogens, vol. 17, no. 1, e1009230.
Clark, DN, Tajwar, R, Hu, J & Tavis, JE 2021, The hepatitis B virus polymerase. in CE Cameron, JJ Arnold & LS Kaguni (eds), Viral Replication Enzymes and their Inhibitors Part B. Enzymes, vol. 50, Academic Press, pp. 195-226.
Hong, X & Hu, J 2021, 'Understanding HBcrAg components improves the interpretation of clinical HBcrAg assay results', Journal of Hepatology, vol. 75, no. 4, pp. 997-998.


Luo, J, Luckenbaugh, L, Hu, H, Yan, Z, Gao, L & Hu, J 2020, 'Involvement of host atr-chk1 pathway in hepatitis b virus covalently closed circular dna formation', mBio, vol. 11, no. 1, e03423-19.
Luo, J, Xi, J, Gao, L & Hu, J 2020, 'Role of hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation', PLoS pathogens, vol. 16, no. 3, e1008459.
Hong, X & Hu, J 2020, 'Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover', Journal of Medical Virology, vol. 92, no. 8, pp. 935-937.