Researcher Profile

Researcher Profile

James Connor, MS, PhD

James Connor, MS, PhD

Distinguished Professor of Neuroscience and Anatomy and Vice Chair for Research, Department of Neurosurgery
Professor, Department of Neural and Behavioral Sciences
Professor, Department of Pediatrics
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
jrc3@psu.edu

Research Interests

  • Iron
  • Brain
  • Ferritins
  • Transferrin
  • Proteins
  • Restless Legs Syndrome
  • Alzheimer Disease
  • Neoplasms
  • Genes
  • Oligodendroglia
  • Apoferritins
  • Astrocytes

Recent Publications

2022

Du, G, Wang, E, Sica, C, Chen, H, De Jesus, S, Lewis, M, Kong, L, Connor, J, Mailman, RB & Huang, X 2022, 'Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage', Movement Disorders. https://doi.org/10.1002/mds.29062
Wang, GM, Cioffi, G, Patil, N, Waite, KA, Lanese, R, Ostrom, QT, Kruchko, C, Berens, ME, Connor, JR, Lathia, JD, Rubin, JB & Barnholtz-Sloan, JS 2022, 'Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas', Neuro-oncology, vol. 24, no. 2, pp. 302-310. https://doi.org/10.1093/neuonc/noab199

2021

Chen, P, Bornhorst, J, Patton, S, Bagai, K, Nitin, R, Miah, M, Hare, DJ, Kysenius, K, Crouch, PJ, Xiong, L, Rouleau, GA, Schwerdtle, T, Connor, J, Aschner, M, Bowman, AB & Walters, AS 2021, 'A potential role for zinc in restless legs syndrome', Sleep, vol. 44, no. 4, zsaa236. https://doi.org/10.1093/sleep/zsaa236
Lee, SY, Slagle-Webb, B, Schengrund, CL, Zhu, J & Connor, JR 2021, 'Association between iron and cholesterol in neuroblastomas', Anticancer Research, vol. 41, no. 6, pp. 2795-2804. https://doi.org/10.21873/anticanres.15060
Lee, SY, Slagle-Webb, B, Sharma, AK & Connor, JR 2021, 'Biological activity of a thiobarbituric acid compound in neuroblastomas', Anticancer Research, vol. 41, no. 3, pp. 1171-1181. https://doi.org/10.21873/anticanres.14874
Beg, U, Snyder, BM, Madhani, SI, Hamidi, N, Padmanaban, V, Tuanquin, LC, Kruser, TJ, Connor, J & Mansouri, A 2021, 'Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review', World neurosurgery, vol. 151, pp. e839-e856. https://doi.org/10.1016/j.wneu.2021.04.134
Wang, EW, Trojano, ML, Lewis, MM, Du, G, Chen, H, Brown, GL, Jellen, LC, Song, I, Neely, E, Kong, L, Connor, JR & Huang, X 2021, 'HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers', Toxicological Sciences, vol. 181, no. 1, pp. 47-57. https://doi.org/10.1093/toxsci/kfab020
Kaur, H, Bush, WS, Letendre, SL, Ellis, RJ, Heaton, RK, Patton, SM, Connor, JR, Samuels, DC, Franklin, DR, Hulgan, T & Kallianpur, AR 2021, 'Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV', Molecular Neurobiology, vol. 58, no. 10, pp. 4842-4855. https://doi.org/10.1007/s12035-021-02433-7
Patil, N, Somasundaram, E, Waite, KA, Lathia, JD, Machtay, M, Gilbert, MR, Connor, JR, Rubin, JB, Berens, ME, Buerki, RA, Choi, S, Sloan, AE, Penas-Prado, M, Ashby, LS, Blumenthal, DT, Werner-Wasik, M, Hunter, GK, Flickinger, JC, Wendland, MM, Panet-Raymond, V, Robins, HI, Pugh, SL, Mehta, MP & Barnholtz-Sloan, JS 2021, 'Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Journal of neuro-oncology, vol. 155, no. 3, pp. 363-372. https://doi.org/10.1007/s11060-021-03886-5
Jellen, LC, Lewis, MM, Du, G, Wang, X, Galvis, MLE, Krzyzanowski, S, Capan, CD, Snyder, AM, Connor, JR, Kong, L, Mailman, RB, Brundin, P, Brundin, L & Huang, X 2021, 'Low plasma serotonin linked to higher nigral iron in Parkinson’s disease', Scientific reports, vol. 11, no. 1, 24384. https://doi.org/10.1038/s41598-021-03700-2
Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation 2021, 'The Management of Restless Legs Syndrome: An Updated Algorithm', Mayo Clinic Proceedings, vol. 96, no. 7, pp. 1921-1937. https://doi.org/10.1016/j.mayocp.2020.12.026
Kang, YJ, Holley, CK, Abidian, MR, Madhankumar, AB, Connor, J & Majd, S 2021, 'Tumor Targeted Delivery of an Anti-Cancer Therapeutic: An In Vitro and In Vivo Evaluation', Advanced Healthcare Materials, vol. 10, no. 2, 2001261. https://doi.org/10.1002/adhm.202001261

2020

Lee, SY, Slagle-Webb, B, Sharma, AK & Connor, JR 2020, 'Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment', Anticancer Research, vol. 40, no. 11, pp. 6039-6049. https://doi.org/10.21873/anticanres.14625
Connor, JR, Duck, K, Patton, S, Simpson, IA, Trotti, LM, Allen, R, Earley, CJ & Rye, D 2020, 'Evidence for communication of peripheral iron status to cerebrospinal fluid: Clinical implications for therapeutic strategy', Fluids and Barriers of the CNS, vol. 17, no. 1, 28. https://doi.org/10.1186/s12987-020-00190-8
Johansen, ML, Stetson, LC, Vadmal, V, Waite, K, Berens, ME, Connor, JR, Lathia, J, Rubin, JB & Barnholtz-Sloan, JS 2020, 'Gliomas display distinct sex-based differential methylation patterns based on molecular subtype', Neuro-Oncology Advances, vol. 2, no. 1, pp. 1-12. https://doi.org/10.1093/noajnl/vdaa002
Kim, Y, Stahl, MC, Huang, X & Connor, JR 2020, 'H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity', Journal of neurochemistry, vol. 155, no. 2, pp. 177-190. https://doi.org/10.1111/jnc.15107
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Turaga, SM, Silver, DJ, Bayik, D, Paouri, E, Peng, S, Lauko, A, Alban, TJ, Borjini, N, Stanko, S, Naik, UP, Keri, RA, Connor, JR, Barnholtz-Sloan, JS, Rubin, JB, Berens, M, Davalos, D & Lathia, JD 2020, 'JAM-A functions as a female microglial tumor suppressor in glioblastoma', Neuro-oncology, vol. 22, no. 11, pp. 1591-1601. https://doi.org/10.1093/neuonc/noaa148
Dong, M, Cioffi, G, Wang, J, Waite, KA, Ostrom, QT, Kruchko, C, Lathia, JD, Rubin, JB, Berens, ME, Connor, J & Barnholtz-Sloan, JS 2020, 'Sex differences in cancer incidence and survival: a pan-cancer analysis', Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 7, pp. 1389-1397. https://doi.org/10.1158/1055-9965.EPI-20-0036
Nesterova, DS, Midya, V, Zacharia, BE, Proctor, EA, Lee, S, Stetson, LC, Lathia, JD, Rubin, JB, Waite, KA, Berens, ME, Barnholtz-Sloan, JS & Connor, JR 2020, 'Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma', Neuro-Oncology Advances, vol. 2, no. 1, vdaa001. https://doi.org/10.1093/noajnl/vdaa001
Song, IY, Snyder, AM, Kim, Y, Neely, EB, Wade, QW & Connor, JR 2020, 'The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity', Toxicology, vol. 441, 152525. https://doi.org/10.1016/j.tox.2020.152525
Kim, Y & Connor, JR 2020, 'The roles of iron and HFE genotype in neurological diseases', Molecular Aspects of Medicine, vol. 75, 100867. https://doi.org/10.1016/j.mam.2020.100867

2019

Lee, SY, Walter, V, Zhu, J, Salzberg, AC, Liu, DJ & Connor, JR 2019, 'Impact of HFE variants and sex in lung cancer', PloS one, vol. 14, no. 12, e0226821. https://doi.org/10.1371/journal.pone.0226821
Wade, QW, Chiou, B & Connor, J 2019, Iron uptake at the blood-brain barrier is influenced by sex and genotype. in S Clemens & I Ghorayeb (eds), Advances in Pharmacology. Advances in Pharmacology, vol. 84, Academic Press Inc., pp. 123-145. https://doi.org/10.1016/bs.apha.2019.02.005
Möller, HE, Bossoni, L, Connor, JR, Crichton, RR, Does, MD, Ward, RJ, Zecca, L, Zucca, FA & Ronen, I 2019, 'Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology', Trends in Neurosciences, vol. 42, no. 6, pp. 384-401. https://doi.org/10.1016/j.tins.2019.03.009
Ravi, V, Madhankumar, AB, Abraham, T, Slagle-Webb, B & Connor, JR 2019, 'Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms', PloS one, vol. 14, no. 9, e0221952. https://doi.org/10.1371/journal.pone.0221952
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mairuae, N, Connor, JR, Buranrat, B & Lee, SY 2019, 'Oroxylum indicum (L.) extract protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell injury', Molecular medicine reports, vol. 20, no. 2, pp. 1933-1942. https://doi.org/10.3892/mmr.2019.10411
Chiou, B, Neely, E, Kallianpur, A & Connor, J 2019, 'Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo', Journal of neuroinflammation, vol. 16, no. 1, 28. https://doi.org/10.1186/s12974-019-1420-9
Gittleman, H, Ostrom, QT, Stetson, LC, Waite, K, Hodges, TR, Wright, CH, Wright, J, Rubin, JB, Berens, ME, Lathia, J, Connor, JR, Kruchko, C, Sloan, AE & Barnholtz-Sloan, JS 2019, 'Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma', Neuro-Oncology Practice, vol. 6, no. 6, pp. 451-462. https://doi.org/10.1093/nop/npz019
Mrowczynski, OD, Payne, RA, Bourcier, AJ, Mau, CY, Slagle-Webb, B, Shenoy, G, Madhankumar, AB, Abramson, SB, Wolfe, D, Harbaugh, KS, Rizk, EB & Connor, JR 2019, 'Targeting IL-13Ra2 for effective treatment of malignant peripheral nerve sheath tumors in mouse models', Journal of neurosurgery, vol. 131, no. 5, pp. 1369-1379. https://doi.org/10.3171/2018.7.JNS18284
Chiou, B, Neely, EB, Mcdevitt, DS, Simpson, IA & Connor, JR 2020, 'Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype', Journal of neurochemistry, vol. 152, no. 3, pp. 381-396. https://doi.org/10.1111/jnc.14834

2018

Briones, MRS, Snyder, AM, Ferreira, RC, Neely, EB, Connor, JR & Broach, JR 2018, 'A possible role for platelet-activating factor receptor in amyotrophic lateral sclerosis treatment', Frontiers in Neurology, vol. 9, no. FEB, 39. https://doi.org/10.3389/fneur.2018.00039
Duck, KA, Neely, EB, Simpson, IA & Connor, JR 2018, 'A role for sex and a common HFE gene variant in brain iron uptake', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 3, pp. 540-548. https://doi.org/10.1177/0271678X17701949
Connor, JR 2018, 'CSF ferritin predicts CSF Aβ decline in biomarker-determined Alzheimer's disease', Journal of neurology, neurosurgery, and psychiatry, vol. 89, no. 5. https://doi.org/10.1136/jnnp-2017-317050
the CHARTER Study Group 2019, 'Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection', Molecular Neurobiology, vol. 56, no. 5, pp. 3808-3818. https://doi.org/10.1007/s12035-018-1329-9
Peters, DG, Pollack, AN, Cheng, KC, Sun, D, Saido, T, Haaf, MP, Yang, QX, Connor, JR & Meadowcroft, MD 2018, 'Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice', Metallomics, vol. 10, no. 3, pp. 426-443. https://doi.org/10.1039/c8mt00004b
Du, G, Lewis, M, Sica, C, He, L, Connor, J, Kong, L, Mailman, R & Huang, X 2018, 'Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients', Movement Disorders, vol. 33, no. 9, pp. 1423-1431. https://doi.org/10.1002/mds.27318
Chiou, B & Connor, JR 2018, 'Emerging and dynamic biomedical uses of ferritin', Pharmaceuticals, vol. 11, no. 4, 124. https://doi.org/10.3390/ph11040124
Chiou, B, Neal, EH, Bowman, AB, Lippmann, ES, Simpson, IA & Connor, JR 2019, 'Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 11, pp. 2117-2131. https://doi.org/10.1177/0271678X18783372
on behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) 2018, 'Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report', Sleep Medicine, vol. 41, pp. 27-44. https://doi.org/10.1016/j.sleep.2017.11.1126
Mrowczynski, OD, Zacharia, B & Connor, J 2019, 'Exosomes and their implications in central nervous system tumor biology', Progress in Neurobiology, vol. 172, pp. 71-83. https://doi.org/10.1016/j.pneurobio.2018.06.006
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Meadowcroft, M, Cooper, TK, Rupprecht, S, Wright, TC, Neely, EE, Ferenci, M, Kang, W, Yang, Q, Harbaugh, R, Connor, J & McInerney, J 2018, 'Gamma Knife radiosurgery of saccular aneurysms in a rabbit model', Journal of neurosurgery, vol. 129, no. 6, pp. 1530-1540. https://doi.org/10.3171/2017.6.JNS17722
Nixon, AM, Meadowcroft, MD, Neely, EB, Snyder, AM, Purnell, CJ, Wright, J, Lamendella, R, Nandar, W, Huang, X & Connor, JR 2018, 'HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity', Journal of neurochemistry, vol. 145, no. 4, pp. 299-311. https://doi.org/10.1111/jnc.14299
Lee, BY, Kim, J, Connor, J, Podskalny, GD, Ryu, Y & Yang, Q 2018, 'Involvement of the central somatosensory system in restless legs syndrome: A neuroimaging study', Neurology, vol. 90, no. 21, pp. e1834-e1841. https://doi.org/10.1212/WNL.0000000000005562
Chiou, B, Neal, EH, Bowman, AB, Lippmann, ES, Simpson, IA & Connor, JR 2018, 'Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier', PloS one, vol. 13, no. 6, e0198775. https://doi.org/10.1371/journal.pone.0198775
Connor, JR 2018, Proteins of iron regulation in the brain in alzheimer's disease. in Iron and Human Disease. CRC Press, pp. 365-394. https://doi.org/10.1201/9781351073899
Chiou, B, Lucassen, E, Sather, M, Kallianpur, A & Connor, J 2018, 'Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis', Glia, vol. 66, no. 7, pp. 1317-1330. https://doi.org/10.1002/glia.23313
Lewis, M, Du, G, Baccon, J, Snyder, A, Murie, B, Cooper, F, Stetter, C, Kong, L, Sica, C, Mailman, R, Connor, J & Huang, X 2018, 'Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes', Movement Disorders, vol. 33, no. 9, pp. 1432-1439. https://doi.org/10.1002/mds.27381
Nixon, AM, Neely, E, Simpson, IA & Connor, JR 2018, 'The role of HFE genotype in macrophage phenotype', Journal of neuroinflammation, vol. 15, no. 1, 30. https://doi.org/10.1186/s12974-018-1057-0
Madhankumar, AB, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, KS, Rizk, E & Connor, JR 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)