Researcher Profile

Researcher Profile

James Connor, MS, PhD

James Connor, MS, PhD

Distinguished Professor of Neuroscience and Anatomy and Vice Chair for Research, Department of Neurosurgery
Professor, Department of Neural and Behavioral Sciences
Professor, Department of Pediatrics
Scientific Program:Experimental Therapeutics
jrc3@psu.edu

Research Interests

  • Iron
  • Brain
  • Ferritins
  • Transferrin
  • Proteins
  • Alzheimer Disease
  • Oligodendroglia
  • Restless Legs Syndrome
  • Genes
  • Apoferritins
  • Neoplasms
  • Myelin Sheath

Recent Publications

2019

Wade, QW, Chiou, B & Connor, J 2019, Iron uptake at the blood-brain barrier is influenced by sex and genotype. in S Clemens & I Ghorayeb (eds), Advances in Pharmacology. Advances in Pharmacology, vol. 84, Academic Press Inc., pp. 123-145. https://doi.org/10.1016/bs.apha.2019.02.005
Möller, HE, Bossoni, L, Connor, J, Crichton, RR, Does, MD, Ward, RJ, Zecca, L, Zucca, FA & Ronen, I 2019, 'Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology', Trends in Neurosciences, vol. 42, no. 6, pp. 384-401. https://doi.org/10.1016/j.tins.2019.03.009
Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, A, Lee, SY, Harbaugh, K, Connor, J & Rizk, E 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Mairuae, N, Connor, J, Buranrat, B & Lee, SY 2019, 'Oroxylum indicum (L.) extract protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell injury', Molecular medicine reports, vol. 20, no. 2, pp. 1933-1942. https://doi.org/10.3892/mmr.2019.10411
Chiou, B, Neely, E, Kallianpur, A & Connor, J 2019, 'Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo' Journal of Neuroinflammation, vol. 16, no. 1, 28. https://doi.org/10.1186/s12974-019-1420-9

2018

Briones, MRS, Snyder, A, Ferreira, RC, Neely, EB, Connor, J & Broach, J 2018, 'A possible role for platelet-activating factor receptor in amyotrophic lateral sclerosis treatment', Frontiers in Neurology, vol. 9, no. FEB, 39. https://doi.org/10.3389/fneur.2018.00039
Duck, KA, Neely, EB, Simpson, I & Connor, J 2018, 'A role for sex and a common HFE gene variant in brain iron uptake', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 3, pp. 540-548. https://doi.org/10.1177/0271678X17701949
the CHARTER Study Group 2019, 'Cerebrospinal Fluid Ceruloplasmin, Haptoglobin, and Vascular Endothelial Growth Factor Are Associated with Neurocognitive Impairment in Adults with HIV Infection', Molecular Neurobiology, vol. 56, no. 5, pp. 3808-3818. https://doi.org/10.1007/s12035-018-1329-9
Peters, DG, Pollack, AN, Cheng, K, Sun, D, Saido, T, Haaf, MP, Yang, Q, Connor, J & Meadowcroft, M 2018, 'Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice', Metallomics, vol. 10, no. 3, pp. 426-443. https://doi.org/10.1039/c8mt00004b
Du, G, Lewis, M, Sica, C, He, L, Connor, J, Kong, L, Mailman, R & Huang, X 2018, 'Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients', Movement Disorders, vol. 33, no. 9, pp. 1423-1431. https://doi.org/10.1002/mds.27318
Chiou, B & Connor, J 2018, 'Emerging and dynamic biomedical uses of ferritin', Pharmaceuticals, vol. 11, no. 4, 124. https://doi.org/10.3390/ph11040124
Chiou, B, Neal, EH, Bowman, AB, Lippmann, ES, Simpson, I & Connor, J 2018, 'Endothelial cells are critical regulators of iron transport in a model of the human blood–brain barrier', Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X18783372
on behalf of the & International Restless Legs Syndrome Study Group (IRLSSG) 2018, 'Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report', Sleep Medicine, vol. 41, pp. 27-44. https://doi.org/10.1016/j.sleep.2017.11.1126
Mrowczynski, OD, Zacharia, B & Connor, J 2019, 'Exosomes and their implications in central nervous system tumor biology', Progress in Neurobiology, vol. 172, pp. 71-83. https://doi.org/10.1016/j.pneurobio.2018.06.006
Mrowczynski, OD, Madhankumar, A, Sundstrom, J, Zhao, Y, Imamura, Y, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, E, Zacharia, B & Connor, J 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101.
Meadowcroft, M, Cooper, TK, Rupprecht, S, Wright, TC, Neely, EE, Ferenci, M, Kang, W, Yang, QX, Harbaugh, R, Connor, J & McInerney, J 2018, 'Gamma Knife radiosurgery of saccular aneurysms in a rabbit model', Journal of neurosurgery, vol. 129, no. 6, pp. 1530-1540. https://doi.org/10.3171/2017.6.JNS17722
Nixon, AM, Meadowcroft, M, Neely, EB, Snyder, A, Purnell, CJ, Wright, J, Lamendella, R, Nandar, W, Huang, X & Connor, J 2018, 'HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity', Journal of neurochemistry, vol. 145, no. 4, pp. 299-311. https://doi.org/10.1111/jnc.14299
Chiou, B, Neal, EH, Bowman, AB, Lippmann, ES, Simpson, I & Connor, J 2018, 'Pharmaceutical iron formulations do not cross a model of the human blood-brain barrier', PloS one, vol. 13, no. 6, e0198775. https://doi.org/10.1371/journal.pone.0198775
Connor, J 2018, Proteins of iron regulation in the brain in alzheimer's disease. in Iron and Human Disease. CRC Press, pp. 365-394. https://doi.org/10.1201/9781351073899
Chiou, B, Lucassen, E, Sather, M, Kallianpur, A & Connor, J 2018, 'Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis', Glia, vol. 66, no. 7, pp. 1317-1330. https://doi.org/10.1002/glia.23313
Lewis, M, Du, G, Baccon, J, Snyder, A, Murie, B, Cooper, F, Stetter, C, Kong, L, Sica, C, Mailman, R, Connor, J & Huang, X 2018, 'Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes', Movement Disorders, vol. 33, no. 9, pp. 1432-1439. https://doi.org/10.1002/mds.27381
Nixon, AM, Neely, E, Simpson, I & Connor, J 2018, 'The role of HFE genotype in macrophage phenotype', Journal of Neuroinflammation, vol. 15, no. 1, 30. https://doi.org/10.1186/s12974-018-1057-0
Madhankumar, A, Mrowczynski, OD, Slagle-Webb, B, Ravi, V, Bourcier, AJ, Payne, R, Harbaugh, K, Rizk, E & Connor, J 2018, 'Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors', PloS one, vol. 13, no. 1, e0181529. https://doi.org/10.1371/journal.pone.0181529

2017

Lee, S, Zhu, J, Salzberg, AC, Zhang, B, Liu, D, Muscat, J, Langan, ST & Connor, J 2017, 'Analysis of single nucleotide variants of HFE gene and association to survival in the Cancer Genome Atlas GBM data', PloS one, vol. 12, no. 3, e0174778. https://doi.org/10.1371/journal.pone.0174778
Schieffer, KM, Chuang, C, Connor, J, Pawelczyk, JA & Sekhar, D 2017, 'Association of iron deficiency anemia with hearing loss in US adults', JAMA Otolaryngology - Head and Neck Surgery, vol. 143, no. 4, pp. 350-354. https://doi.org/10.1001/jamaoto.2016.3631
Folarin, OR, Snyder, A, Peters, DG, Olopade, F, Connor, J & Olopade, JO 2017, 'Brain metal distribution and neuro-inflammatory profiles after chronic vanadium administration and withdrawal in mice', Frontiers in Neuroanatomy, vol. 11, 58. https://doi.org/10.3389/fnana.2017.00058
Patton, S, Wang, Q, Hulgan, T, Connor, J, Jia, P, Zhao, Z, Letendre, SL, Ellis, RJ, Bush, WS, Samuels, DC, Franklin, DR, Kaur, H, Iudicello, J, Grant, I & Kallianpur, AR 2017, 'Cerebrospinal fluid (CSF) biomarkers of iron status are associated with CSF viral load, antiretroviral therapy, and demographic factors in HIV-infected adults', Fluids and Barriers of the CNS, vol. 14, no. 1, 11. https://doi.org/10.1186/s12987-017-0058-1
Mehta, SR, Pérez-Santiago, J, Hulgan, T, Day, TRC, Barnholtz-Sloan, J, Gittleman, H, Letendre, S, Ellis, R, Heaton, R, Patton, S, Suben, JD, Franklin, D, Rosario, D, Clifford, DB, Collier, AC, Marra, CM, Gelman, BB, McArthur, J, McCutchan, A, Morgello, S, Simpson, D, Connor, J, Grant, I & Kallianpur, A 2017, 'Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment', Journal of Neuroinflammation, vol. 14, no. 1, 72. https://doi.org/10.1186/s12974-017-0848-z
Peters, DG, Purnell, CJ, Haaf, MP, Yang, Q, Connor, J & Meadowcroft, M 2018, 'Dietary lipophilic iron accelerates regional brain iron-load in C57BL6 mice', Brain Structure and Function, vol. 223, no. 3, pp. 1519-1536. https://doi.org/10.1007/s00429-017-1565-1
Nixon, AM & Connor, J 2017, Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response? in Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics. Elsevier Inc., pp. 51-66. https://doi.org/10.1016/B978-0-12-804562-6.00004-X
Bastian, TW, Duck, KA, Michalopoulos, GC, Chen, MJ, Liu, ZJ, Connor, J, Lanier, LM, Sola-Visner, MC & Georgieff, MK 2017, 'Eltrombopag, a thrombopoietin mimetic, crosses the blood–brain barrier and impairs iron-dependent hippocampal neuron dendrite development', Journal of Thrombosis and Haemostasis, vol. 15, no. 3, pp. 565-574. https://doi.org/10.1111/jth.13602
Mrowczynski, OD, Madhankumar, A, Slagle-Webb, B, Lee, S, Zacharia, B & Connor, J 2017, 'HFE genotype affects exosome phenotype in cancer', Biochimica et Biophysica Acta - General Subjects, vol. 1861, no. 8, pp. 1921-1928. https://doi.org/10.1016/j.bbagen.2017.05.014
Madhankumar, A, Mrowczynski, OD, Patel, SR, Weston, CL, Zacharia, B, Glantz, M, Siedlecki, C, Xu, L & Connor, J 2017, 'Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles', Acta Biomaterialia, vol. 58, pp. 205-213. https://doi.org/10.1016/j.actbio.2017.06.002
Meadowcroft, M, Wang, J, Purnell, CJ, Eslinger, P, Neely, EB, Yang, Q & Connor, J 2018, 'Reduced Cerebral White Matter Integrity Assessed by DTI in Cognitively Normal H63D-HFE Polymorphism Carriers' Journal of Neuroimaging, vol. 28, no. 1, pp. 126-133. https://doi.org/10.1111/jon.12461
Duck, KA, Simpson, I & Connor, J 2017, 'Regulatory mechanisms for iron transport across the blood-brain barrier', Biochemical and Biophysical Research Communications, vol. 494, no. 1-2, pp. 70-75. https://doi.org/10.1016/j.bbrc.2017.10.083
Schieffer, KM, Connor, J, Pawelczyk, JA & Sekhar, D 2017, 'The relationship between iron deficiency anemia and sensorineural hearing loss in the pediatric and adolescent population', American Journal of Audiology, vol. 26, no. 2, pp. 155-162. https://doi.org/10.1044/2017_AJA-16-0093

2016

Weston, C, Klobusicky, J, Weston, J, Connor, J, Toms, SA & Marko, NF 2016, 'Aberrations in the iron regulatory gene signature are associated with decreased survival in diffuse infiltrating gliomas' PloS one, vol. 11, no. 11, e0166593. https://doi.org/10.1371/journal.pone.0166593
Lee, EY, Flynn, MR, Du, G, Li, Y, Lewis, M, Herring, AH, Buren, EV, Buren, SV, Kong, L, Fry, RC, Snyder, A, Connor, J, Yang, Q, Mailman, R & Huang, X 2016, 'Increased R2* in the caudate nucleus of asymptomatic welders', Toxicological Sciences, vol. 150, no. 2, kfv331, pp. 369-377. https://doi.org/10.1093/toxsci/kfw003
Connor, J, Patton, S, Oexle, K & Allen, RP 2017, 'Iron and restless legs syndrome: treatment, genetics and pathophysiology', Sleep Medicine, vol. 31, pp. 61-70. https://doi.org/10.1016/j.sleep.2016.07.028
Duck, KA & Connor, J 2016, 'Iron uptake and transport across physiological barriers', BioMetals, vol. 29, no. 4, pp. 573-591. https://doi.org/10.1007/s10534-016-9952-2
Hare, DJ, Raven, EP, Roberts, BR, Bogeski, M, Portbury, SD, McLean, CA, Masters, CL, Connor, J, Bush, AI, Crouch, PJ & Doble, PA 2016, 'Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex', NeuroImage, vol. 137, pp. 124-131. https://doi.org/10.1016/j.neuroimage.2016.05.057
Liu, X, Madhankumar, A, Miller, PA, Duck, KA, Hafenstein, S, Rizk, E, Slagle-Webb, B, Sheehan, JM, Connor, J & Yang, Q 2016, 'MRI contrast agent for targeting glioma: Interleukin-13 labeled liposome encapsulating gadolinium-DTPA', Neuro-Oncology, vol. 18, no. 5, pp. 691-699. https://doi.org/10.1093/neuonc/nov263
Du, G, Liu, T, Lewis, M, Kong, L, Wang, Y, Connor, J, Mailman, R & Huang, X 2016, 'Quantitative susceptibility mapping of the midbrain in Parkinson's disease', Movement Disorders, vol. 31, no. 3, pp. 317-324. https://doi.org/10.1002/mds.26417
Meadowcroft, M, Wang, J, Purnell, CJ, Peters, DG, Eslinger, P, Neely, EB, Gill, DJ, Vasavada, M, Ali-Rahmani, F, Yang, Q & Connor, J 2016, 'Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice', Brain Imaging and Behavior, vol. 10, no. 4, pp. 1231-1242. https://doi.org/10.1007/s11682-015-9494-1
Su, XW, Nandar, W, Neely, EB, Simmons, Z & Connor, J 2016, 'Statins accelerate disease progression and shorten survival in SOD1G93A mice', Muscle and Nerve, vol. 54, no. 2, pp. 284-291. https://doi.org/10.1002/mus.25048
Usende, IL, Leitner, DF, Neely, E, Connor, J & Olopade, JO 2016, 'The Deterioration Seen in Myelin Related Morphophysiology in Vanadium Exposed Rats is Partially Protected by Concurrent Iron Deficiency', Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, vol. 31, no. 1, pp. 11-22.

2015

Simpson, I, Ponnuru, P, Klinger, ME, Myers, RL, Devraj, K, Coe, CL, Lubach, GR, Carruthers, A & Connor, J 2015, 'A novel model for brain iron uptake: Introducing the concept of regulation', Journal of Cerebral Blood Flow and Metabolism, vol. 35, no. 1, pp. 48-57. https://doi.org/10.1038/jcbfm.2014.168
Liu, Y, Neely, E, Simmons, Z & Connor, J 2015, 'Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu' Journal of Neuroscience Research, vol. 93, no. 5, pp. 766-776. https://doi.org/10.1002/jnr.23541
Connor, J, Zhang, X, Nixon, AM, Webb, B & Perno, JR 2015, 'Comparative evaluation of nephrotoxicity and management by macrophages of intravenous pharmaceutical iron formulations', PloS one, vol. 10, no. 5, e0125272. https://doi.org/10.1371/journal.pone.0125272
Meadowcroft, M, Connor, J & Yang, Q 2015, 'Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: A histological perspective' Frontiers in Neuroscience, vol. 9, no. JUL, 00255. https://doi.org/10.3389/fnins.2015.00255
Zhao, L, Hadziahmetovic, M, Wang, C, Xu, X, Song, Y, Jinnah, HA, Wodzinska, J, Iacovelli, J, Wolkow, N, Krajacic, P, Weissberger, AC, Connelly, J, Spino, M, Lee, MK, Connor, J, Giasson, B, Leah Harris, Z & Dunaief, JL 2015, 'Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone', Journal of neurochemistry, vol. 135, no. 5, pp. 958-974. https://doi.org/10.1111/jnc.13292
Buranrat, B & Connor, J 2015, 'Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death', Oncology reports, vol. 34, no. 5, pp. 2790-2796. https://doi.org/10.3892/or.2015.4250
Liu, Y & Connor, J 2015, 'From adaption to death: Endoplasmic reticulum stress as a novel target of selective neurodegeneration?', Neural Regeneration Research, vol. 10, no. 9, pp. 1397-1398. https://doi.org/10.4103/1673-5374.165227
Lee, S, Slagle-Webb, B, Sheehan, JM, Zhu, J, Muscat, J, Glantz, M & Connor, J 2015, 'HFE polymorphisms affect survival of brain tumor patients' Journal of neuro-oncology, vol. 122, no. 1, pp. 97-104. https://doi.org/10.1007/s11060-014-1681-1
Meadowcroft, M, Mutic, NJ, Bigler, DC, Wang, J, Simmons, Z, Connor, J & Yang, Q 2015, 'Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis', Journal of Magnetic Resonance Imaging, vol. 41, no. 3, pp. 665-675. https://doi.org/10.1002/jmri.24582
Schonberg, DL, Miller, TE, Wu, Q, Flavahan, WA, Das, NK, Hale, JS, Hubert, CG, Mack, SC, Jarrar, AM, Karl, RT, Rosager, AM, Nixon, AM, Tesar, PJ, Hamerlik, P, Kristensen, BW, Horbinski, C, Connor, J, Fox, PL, Lathia, JD & Rich, JN 2015, 'Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells', Cancer Cell, vol. 28, no. 4, 2152, pp. 441-455. https://doi.org/10.1016/j.ccell.2015.09.002
Leitner, DF, Todorich, B, Zhang, X & Connor, J 2015, 'Semaphorin4A is cytotoxic to oligodendrocytes and is elevated in microglia and multiple sclerosis', ASN Neuro, vol. 7, no. 3. https://doi.org/10.1177/1759091415587502
Su, XW, Clardy, SL, Stephens, HE, Simmons, Z & Connor, J 2015, 'Serum ferritin is elevated in amyotrophic lateral sclerosis patients', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 16, no. 1-2, pp. 102-107. https://doi.org/10.3109/21678421.2014.984723
Leitner, DF, Stoute, J, Landmesser, M, Neely, E & Connor, J 2015, 'The HFE genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice' International Journal for Parasitology, vol. 45, no. 12, pp. 797-808. https://doi.org/10.1016/j.ijpara.2015.07.003
Meadowcroft, M, Peters, DG, Dewal, RP, Connor, J & Yang, Q 2015, 'The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease', NMR in Biomedicine, vol. 28, no. 3, pp. 297-305. https://doi.org/10.1002/nbm.3247
Mairuae, N, Connor, J, Lee, S, Cheepsunthorn, P & Tongjaroenbuangam, W 2015, 'The effects of okra (Abelmoschus esculentus Linn.) on the cellular events associated with Alzheimer's disease in a stably expressed HFE neuroblastoma SH-SY5Y cell line', Neuroscience letters, vol. 603, pp. 6-11. https://doi.org/10.1016/j.neulet.2015.07.011
Peters, DG, Connor, J & Meadowcroft, M 2015, 'The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin', Neurobiology of Disease, vol. 81, pp. 49-65. https://doi.org/10.1016/j.nbd.2015.08.007

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