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James Connor, MS, PhD

James Connor, MS, PhD

Distinguished Professor of Neuroscience and Anatomy and Vice Chair for Research, Department of Neurosurgery
Professor, Department of Neural and Behavioral Sciences
Professor, Department of Pediatrics
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
JRC3@psu.edu

Research Interests

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  • Iron
  • Brain
  • Ferritins
  • Transferrin
  • Proteins
  • Neoplasms
  • Restless Legs Syndrome
  • Alzheimer Disease
  • Genes
  • Apoferritins
  • Oligodendroglia
  • Survival
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Recent Publications

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2024

Shenoy, G, Slagle-Webb, B, Khunsriraksakul, C, Pandya Shesh, B, Luo, J, Khristov, V, Smith, N, Mansouri, A, Zacharia, BE, Holder, S, Lathia, JD, Barnholtz-Sloan, JS & Connor, JR 2024, 'Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival', Scientific reports, vol. 14, no. 1, 2389. https://doi.org/10.1038/s41598-024-52492-8
Palsa, K, Neely, EB, Baringer, SL, Helmuth, TB, Simpson, IA & Connor, JR 2024, 'Brain iron acquisition depends on age and sex in iron-deficient mice', FASEB Journal, vol. 38, no. 1, e23331. https://doi.org/10.1096/fj.202301596RR
Troike, KM, Wang, SZ, Silver, DJ, Lee, J, Mulkearns-Hubert, EE, Hajdari, N, Ghosh, PK, Kay, KE, Beilis, JL, Mitchell, SE, Bishop, CW, Hong, ES, Artomov, M, Hubert, CG, Rajappa, P, Connor, JR, Fox, PL, Kristensen, BW & Lathia, JD 2024, 'Homeostatic iron regulatory protein drives glioblastoma growth via tumor cell-intrinsic and sex-specific responses', Neuro-Oncology Advances, vol. 6, no. 1, vdad154. https://doi.org/10.1093/noajnl/vdad154
Levi, UI, Bintu, MM, Daniella, OC, Oyenike, OAF, Agbonu, AO, Adedamola, AM, Ndidi, E, Saka, SF, Gela, BV, Mbagwu, SI, Edem, EE, Olukayode, OJ & James, C 2024, 'Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate', Journal of Chemical Neuroanatomy, vol. 136, 102377. https://doi.org/10.1016/j.jchemneu.2023.102377
Ebea-Ugwuanyi, PO, Vidyasagar, S, Connor, JR, Frazer, DM, Knutson, MD & Collins, JF 2024, 'Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes', British Journal of Haematology, vol. 204, no. 3, pp. 759-773. https://doi.org/10.1111/bjh.19268

2023

Shenoy, G & Connor, JR 2023, 'A closer look at the role of iron in glioblastoma', Neuro-oncology, vol. 25, no. 12, pp. 2136-2149. https://doi.org/10.1093/neuonc/noad136
Shesh, B & Connor, JR 2023, 'A novel view of ferritin in cancer', Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1878, no. 4, 188917. https://doi.org/10.1016/j.bbcan.2023.188917
Baringer, SL, Lukacher, AS, Palsa, K, Kim, H, Lippmann, ES, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo- and holo-transferrin', Journal of neurochemistry, vol. 167, no. 2, pp. 248-261. https://doi.org/10.1111/jnc.15954
Baringer, SL, Palsa, K, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation', Journal of Biomedical Science, vol. 30, no. 1, 36. https://doi.org/10.1186/s12929-023-00934-2
Baringer, SL, Simpson, IA & Connor, JR 2023, 'Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation', Journal of neurochemistry, vol. 165, no. 5, pp. 625-642. https://doi.org/10.1111/jnc.15819
Helmuth, TB, Kumari, R, Palsa, K, Neely, EB, Slagle-Webb, B, Simon, SD & Connor, JR 2023, 'Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage', Stroke, vol. 54, no. 11, pp. 2886-2894. https://doi.org/10.1161/STROKEAHA.123.043799
Palsa, K, Baringer, SL, Shenoy, G, Spiegelman, VS, Simpson, IA & Connor, JR 2023, 'Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status', Journal of Biological Chemistry, vol. 299, no. 2, 102868. https://doi.org/10.1016/j.jbc.2022.102868
Palsa, K, Connor, JR, Flanagan, J & Hines, EA 2023, 'H-ferritin in sows' colostrum- and milk-derived extracellular vesicles: a novel iron delivery concept', Journal of animal science, vol. 101, skad013. https://doi.org/10.1093/jas/skad013
Shenoy, G, Kheirabadi, S, Ataie, Z, Sahu, AP, Palsa, K, Wade, Q, Khunsriraksakul, C, Khristov, V, Slagle-Webb, B, Lathia, JD, Wang, HG, Sheikhi, A & Connor, JR 2023, 'Iron inhibits glioblastoma cell migration and polarization', FASEB Journal, vol. 37, no. 12, e23307. https://doi.org/10.1096/fj.202202157RR
Bhanja, D, Wilding, H, Baroz, A, Trifoi, M, Shenoy, G, Slagle-Webb, B, Hayes, D, Soudagar, Y, Connor, J & Mansouri, A 2023, 'Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability', Cancers, vol. 15, no. 13, 3427. https://doi.org/10.3390/cancers15133427
Pandya Shesh, B, Walter, V, Palsa, K, Slagle-Webb, B, Neely, E, Schell, T & Connor, JR 2023, 'Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma', Journal of neuro-oncology, vol. 164, no. 3, pp. 569-586. https://doi.org/10.1007/s11060-023-04415-2
Pandya Shesh, B, Slagle-Webb, B, Shenoy, G, Khristov, V, Zacharia, BE & Connor, JR 2023, 'Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity', Journal of Cancer Research and Clinical Oncology, vol. 149, no. 12, pp. 9691-9703. https://doi.org/10.1007/s00432-023-04864-2

2022

Du, G, Wang, E, Sica, C, Chen, H, De Jesus, S, Lewis, MM, Kong, L, Connor, J, Mailman, RB & Huang, X 2022, 'Dynamics of Nigral Iron Accumulation in Parkinson's Disease: From Diagnosis to Late Stage', Movement Disorders, vol. 37, no. 8, pp. 1654-1662. https://doi.org/10.1002/mds.29062
Wang, GM, Cioffi, G, Patil, N, Waite, KA, Lanese, R, Ostrom, QT, Kruchko, C, Berens, ME, Connor, JR, Lathia, JD, Rubin, JB & Barnholtz-Sloan, JS 2022, 'Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas', Neuro-oncology, vol. 24, no. 2, pp. 302-310. https://doi.org/10.1093/neuonc/noab199
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665. https://doi.org/10.1227/neu.0000000000002071
Khristov, V, Nesterova, D, Trifoi, M, Clegg, T, Daya, A, Barrett, T, Tufano, E, Shenoy, G, Pandya, B, Beselia, G, Smith, N, Mrowczynski, O, Zacharia, B, Waite, K, Lathia, J, Barnholtz-Sloan, J & Connor, J 2022, 'Plasma IL13Rα2 as a novel liquid biopsy biomarker for glioblastoma', Journal of neuro-oncology, vol. 160, no. 3, pp. 743-752. https://doi.org/10.1007/s11060-022-04196-0
Baringer, SL, Neely, EB, Palsa, K, Simpson, IA & Connor, JR 2022, 'Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein', Fluids and Barriers of the CNS, vol. 19, no. 1, 49. https://doi.org/10.1186/s12987-022-00345-9
Khristov, V, Lin, A, Freedman, Z, Staub, J, Shenoy, G, Mrowczynski, O, Rizk, E, Zacharia, B & Connor, J 2023, 'Tumor-Derived Biomarkers in Liquid Biopsy of Glioblastoma', World neurosurgery, vol. 170, pp. 182-194. https://doi.org/10.1016/j.wneu.2022.11.012

2021

Chen, P, Bornhorst, J, Patton, S, Bagai, K, Nitin, R, Miah, M, Hare, DJ, Kysenius, K, Crouch, PJ, Xiong, L, Rouleau, GA, Schwerdtle, T, Connor, J, Aschner, M, Bowman, AB & Walters, AS 2021, 'A potential role for zinc in restless legs syndrome', Sleep, vol. 44, no. 4, zsaa236. https://doi.org/10.1093/sleep/zsaa236
Lee, SY, Slagle-Webb, B, Schengrund, CL, Zhu, J & Connor, JR 2021, 'Association between iron and cholesterol in neuroblastomas', Anticancer Research, vol. 41, no. 6, pp. 2795-2804. https://doi.org/10.21873/anticanres.15060
Lee, SY, Slagle-Webb, B, Sharma, AK & Connor, JR 2021, 'Biological activity of a thiobarbituric acid compound in neuroblastomas', Anticancer Research, vol. 41, no. 3, pp. 1171-1181. https://doi.org/10.21873/anticanres.14874
Beg, U, Snyder, BM, Madhani, SI, Hamidi, N, Padmanaban, V, Tuanquin, LC, Kruser, TJ, Connor, J & Mansouri, A 2021, 'Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review', World neurosurgery, vol. 151, pp. e839-e856. https://doi.org/10.1016/j.wneu.2021.04.134
Wang, EW, Trojano, ML, Lewis, MM, Du, G, Chen, H, Brown, GL, Jellen, LC, Song, I, Neely, E, Kong, L, Connor, JR & Huang, X 2021, 'HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers', Toxicological Sciences, vol. 181, no. 1, pp. 47-57. https://doi.org/10.1093/toxsci/kfab020
Kaur, H, Bush, WS, Letendre, SL, Ellis, RJ, Heaton, RK, Patton, SM, Connor, JR, Samuels, DC, Franklin, DR, Hulgan, T & Kallianpur, AR 2021, 'Higher CSF Ferritin Heavy-Chain (Fth1) and Transferrin Predict Better Neurocognitive Performance in People with HIV', Molecular Neurobiology, vol. 58, no. 10, pp. 4842-4855. https://doi.org/10.1007/s12035-021-02433-7
Patil, N, Somasundaram, E, Waite, KA, Lathia, JD, Machtay, M, Gilbert, MR, Connor, JR, Rubin, JB, Berens, ME, Buerki, RA, Choi, S, Sloan, AE, Penas-Prado, M, Ashby, LS, Blumenthal, DT, Werner-Wasik, M, Hunter, GK, Flickinger, JC, Wendland, MM, Panet-Raymond, V, Robins, HI, Pugh, SL, Mehta, MP & Barnholtz-Sloan, JS 2021, 'Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Journal of neuro-oncology, vol. 155, no. 3, pp. 363-372. https://doi.org/10.1007/s11060-021-03886-5
Jellen, LC, Lewis, MM, Du, G, Wang, X, Galvis, MLE, Krzyzanowski, S, Capan, CD, Snyder, AM, Connor, JR, Kong, L, Mailman, RB, Brundin, P, Brundin, L & Huang, X 2021, 'Low plasma serotonin linked to higher nigral iron in Parkinson’s disease', Scientific reports, vol. 11, no. 1, 24384. https://doi.org/10.1038/s41598-021-03700-2
Scientific and Medical Advisory Board of the Restless Legs Syndrome Foundation 2021, 'The Management of Restless Legs Syndrome: An Updated Algorithm', Mayo Clinic Proceedings, vol. 96, no. 7, pp. 1921-1937. https://doi.org/10.1016/j.mayocp.2020.12.026
Kang, YJ, Holley, CK, Abidian, MR, Madhankumar, AB, Connor, J & Majd, S 2021, 'Tumor Targeted Delivery of an Anti-Cancer Therapeutic: An In Vitro and In Vivo Evaluation', Advanced Healthcare Materials, vol. 10, no. 2, 2001261. https://doi.org/10.1002/adhm.202001261

2020

Lee, SY, Slagle-Webb, B, Sharma, AK & Connor, JR 2020, 'Characterization of a novel barbituric acid and two thiobarbituric acid compounds for lung cancer treatment', Anticancer Research, vol. 40, no. 11, pp. 6039-6049. https://doi.org/10.21873/anticanres.14625
Connor, JR, Duck, K, Patton, S, Simpson, IA, Trotti, LM, Allen, R, Earley, CJ & Rye, D 2020, 'Evidence for communication of peripheral iron status to cerebrospinal fluid: Clinical implications for therapeutic strategy', Fluids and Barriers of the CNS, vol. 17, no. 1, 28. https://doi.org/10.1186/s12987-020-00190-8
on behalf of the PRESTO Group 2020, 'Gastrectomy case volume and textbook outcome: an analysis of the Population Registry of Esophageal and Stomach Tumours of Ontario (PRESTO)', Gastric Cancer, vol. 23, no. 3, pp. 391-402. https://doi.org/10.1007/s10120-019-01015-w
Johansen, ML, Stetson, LC, Vadmal, V, Waite, K, Berens, ME, Connor, JR, Lathia, J, Rubin, JB & Barnholtz-Sloan, JS 2020, 'Gliomas display distinct sex-based differential methylation patterns based on molecular subtype', Neuro-Oncology Advances, vol. 2, no. 1, pp. 1-12. https://doi.org/10.1093/noajnl/vdaa002
Kim, Y, Stahl, MC, Huang, X & Connor, JR 2020, 'H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity', Journal of neurochemistry, vol. 155, no. 2, pp. 177-190. https://doi.org/10.1111/jnc.15107
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Turaga, SM, Silver, DJ, Bayik, D, Paouri, E, Peng, S, Lauko, A, Alban, TJ, Borjini, N, Stanko, S, Naik, UP, Keri, RA, Connor, JR, Barnholtz-Sloan, JS, Rubin, JB, Berens, M, Davalos, D & Lathia, JD 2020, 'JAM-A functions as a female microglial tumor suppressor in glioblastoma', Neuro-oncology, vol. 22, no. 11, pp. 1591-1601. https://doi.org/10.1093/neuonc/noaa148
Dong, M, Cioffi, G, Wang, J, Waite, KA, Ostrom, QT, Kruchko, C, Lathia, JD, Rubin, JB, Berens, ME, Connor, J & Barnholtz-Sloan, JS 2020, 'Sex differences in cancer incidence and survival: a pan-cancer analysis', Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 7, pp. 1389-1397. https://doi.org/10.1158/1055-9965.EPI-20-0036
Nesterova, DS, Midya, V, Zacharia, BE, Proctor, EA, Lee, SY, Stetson, LC, Lathia, JD, Rubin, JB, Waite, KA, Berens, ME, Barnholtz-Sloan, JS & Connor, JR 2020, 'Sexually dimorphic impact of the iron-regulating gene, HFE, on survival in glioblastoma', Neuro-Oncology Advances, vol. 2, no. 1, vdaa001. https://doi.org/10.1093/noajnl/vdaa001
Song, IY, Snyder, AM, Kim, Y, Neely, EB, Wade, QW & Connor, JR 2020, 'The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity', Toxicology, vol. 441, 152525. https://doi.org/10.1016/j.tox.2020.152525
Kim, Y & Connor, JR 2020, 'The roles of iron and HFE genotype in neurological diseases', Molecular Aspects of Medicine, vol. 75, 100867. https://doi.org/10.1016/j.mam.2020.100867
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