Researcher Profile

Researcher Profile

John Patrick Vanden Heuvel, PhD

John Patrick Vanden Heuvel, PhD

Professor of Veterinary Science, Veterinary and Biomedical Sciences
Scientific Program:Cancer Control
jpv2@psu.edu

Research Interests

  • Peroxisome Proliferator-Activated Receptors
  • Genes
  • Fatty Acids
  • Liver
  • Gene Expression
  • Proteins
  • Conjugated Linoleic Acids
  • Messenger RNA
  • Peroxisome Proliferators
  • Ligands
  • Cytoplasmic and Nuclear Receptors
  • Diet

Recent Publications

2018

Liu, X, Garban, J, Jones, PJ, Vanden Heuvel, JP, Lamarche, B, Jenkins, DJ, Connelly, PW, Couture, P, Pu, S, Fleming, JA, West, SG & Kris-Etherton, PM 2018, 'Diets low in saturated fat with different unsaturated fatty acid profiles similarly increase serum-mediated cholesterol efflux from THP-1 macrophages in a population with or at risk for metabolic syndrome: The Canola Oil Multicenter Intervention Trial' Journal of Nutrition, vol. 148, no. 5, pp. 721-728. https://doi.org/10.1093/jn/nxy040
Tasker, TL, Burgos, WD, Piotrowski, P, Castillo-Meza, L, Blewett, TA, Ganow, KB, Stallworth, A, Delompré, PLM, Goss, GG, Fowler, LB, Vanden Heuvel, JP, Dorman, Jr., FL & Warner, NR 2018, 'Environmental and Human Health Impacts of Spreading Oil and Gas Wastewater on Roads', Environmental Science and Technology, vol. 52, no. 12, pp. 7081-7091. https://doi.org/10.1021/acs.est.8b00716
Reproducibility Project: Cancer Biology 2018, 'Replication study: Systematic identification of genomic markers of drug sensitivity in cancer cells', eLife, vol. 7, e29747. https://doi.org/10.7554/eLife.29747

2017

Hannon, DB, Thompson, JT, Khoo, C, Juturu, V & Vanden Heuvel, JP 2017, 'Effects of cranberry extracts on gene expression in THP-1 cells', Food Science and Nutrition, vol. 5, no. 1, pp. 148-159. https://doi.org/10.1002/fsn3.374

2016

Hinds, TD, Burns, KA, Hosick, PA, McBeth, L, Nestor-Kalinoski, A, Drummond, HA, Alamodi, AA, Hankins, MW, Vanden Heuvel, JP & Stec, DE 2016, 'Biliverdin reductase A attenuates hepatic steatosis by inhibition of Glycogen Synthase Kinase (GSK) 3β phosphorylation of serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α', Journal of Biological Chemistry, vol. 291, no. 48, pp. 25179-25191. https://doi.org/10.1074/jbc.M116.731703
Gillies, PJ & Vanden Heuvel, JP 2016, Nutrigenomic approaches to unraveling the physiological effects of complex foods. in Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition. CRC Press, pp. 105-115.
Reproducibility Project: Cancer Biology 2016, 'Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells', eLife, vol. 5, no. JUNE2016, e13620. https://doi.org/10.7554/eLife.13620
Smith, RW, Coleman, JD, Thompson, JT & Vanden Heuvel, JP 2016, 'Therapeutic potential of GW501516 and the role of Peroxisome proliferator-activated receptor β/δ and B-cell lymphoma 6 in inflammatory signaling in human pancreatic cancer cells' Biochemistry and Biophysics Reports, vol. 8, pp. 395-402. https://doi.org/10.1016/j.bbrep.2016.10.014

2015

Vanden Heuvel, JP, Thompson, JT, Albrecht, P, Mandetta, D, Kamerow, H & Ford, JP 2015, 'Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: Implication for tissue function and oncogenesis' Investigational New Drugs, vol. 33, no. 5, pp. 1003-1011. https://doi.org/10.1007/s10637-015-0259-x

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)