John Richie, PhD
Division of Epidemiology
Professor, Department of Pharmacology
Dr. John Richie's research over the past 35 years has focused on elucidating mechanistic links between the biological aging process and the development of aging-related diseases with a particular focus on cancer.
Using an interdisciplinary research approach, a major aim has been on the role of oxidative stress, generated both endogenously through normal metabolism and from environmental exposures such as tobacco, as a mechanism for enhanced susceptibility to diseases during aging. In particular, his research has focused on the critical role of glutathione, the body’s major antioxidant and redox regulator, in protecting against and responding to oxidative challenges.
In addition, he continues to investigate novel dietary interventions involving sulfur amino acid restriction as a means of delaying the aging process and inhibiting the development of chronic diseases.
With the ultimate goal of developing effective disease prevention strategies and improved healthspan, Dr. Richie’s lab continues to translate its laboratory findings by testing promising intervention protocols aimed at enhancing cellular protective mechanisms in both preclinical models and clinical trials.
- Tobacco Products
- Free Radicals
- Oxidative Stress
- Lung Neoplasms