Researcher Profile

Researcher Profile

John Richie, PhD

John Richie, PhD

Professor, Department of Public Health Sciences
Division of Epidemiology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
jpr17@psu.edu

Research Interests

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Dr. John Richie's research focuses on the elucidation of factors that regulate cancer risk in individuals and in populations.

Using an interdisciplinary research approach, the aim is to identify the roles and mechanisms of key factors, alone and in combination, that impact cancer risk, with the ultimate goal of utilizing this information in the design and development of targeted prevention strategies.

The major areas of focus include aging, nutrition, tobacco and race/ethnicity as regulators or determinants of cancer risk. Particular emphasis is given to factors related to the generation of and protection against oxidative damage. In an ongoing molecular epidemiology study of tobacco-related cancers in black and white Americans, metabolic and genetic factors that may be responsible, in part, for observed racial differences in tobacco-related cancer rates are being investigated.

In other studies, Dr. Richie's team is examining the role of glutathione, the major endogenous antioxidant in nearly all cells and tissues, in protecting against oxidative damage during aging and its relationship with cancer development at numerous sites.

  • Glutathione
  • Tobacco Products
  • Smoking
  • Neoplasms
  • Smoke
  • Biomarkers
  • Tobacco
  • Oxidative Stress
  • Nicotine
  • Lung Neoplasms
  • Liver
  • Free Radicals
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Recent Publications

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2019

Winkels, R, Van Brakel, L, Van Baar, H, Beelman, RB, Van Duijnhoven, FJB, Geijsen, A, Van Halteren, HK, Hansson, BME, Richie, J, Sun, D, Wesselink, E, Van Zutphen, M, Kampman, E & Kok, DE 2019, 'Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?', Nutrition and cancer. https://doi.org/10.1080/01635581.2019.1637005
Allen, SI, Wasserman, E, Veldheer, S, Yingst, J, Hrabovsky, S, Liao, JJ, Krebs, NM, Horn, K, Reinhart, L, Modesto, J, Putt, K, Evins, AE, Muscat, J, Richie, J & Foulds, J 2019, 'Characteristics of Adult Cigarette Smokers Who "Relight" and the Effects of Exposure to Tobacco Smoke Constituents', Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, vol. 21, no. 9, pp. 1206-1212. https://doi.org/10.1093/ntr/nty138
Gao, X, Sanderson, SM, Dai, Z, Reid, MA, Cooper, DE, Lu, M, Richie, J, Ciccarella, A, Calcagnotto, A, Mikhael, PG, Mentch, SJ, Liu, J, Ables, G, Kirsch, DG, Hsu, DS, Nichenametla, SN & Locasale, JW 2019, 'Dietary methionine influences therapy in mouse cancer models and alters human metabolism', Nature, vol. 572, no. 7769, pp. 397-401. https://doi.org/10.1038/s41586-019-1437-3
Hrabovsky, S, Midya, V, Lester, C, Veldheer, S, Yingst, JM, Allen, SI, Krebs, NM, Liao, JJ, Reinhart, L, Modesto, J, Evins, AE, Richie, J, Muscat, J, Horn, K & Foulds, J 2019, 'Effect of cigarette rod length on smokers switching to SPECTRUM cigarettes', American Journal of Health Behavior, vol. 43, no. 2, pp. 380-392. https://doi.org/10.5993/AJHB.43.2.14
Bitzer, ZT, Goel, R, Reilly, SM, Bhangu, G, Trushin, N, Foulds, J, Muscat, J & Richie, J 2019, 'Emissions of Free Radicals, Carbonyls, and Nicotine from the NIDA Standardized Research Electronic Cigarette and Comparison to Similar Commercial Devices' Chemical Research in Toxicology, vol. 32, no. 1, pp. 130-138. https://doi.org/10.1021/acs.chemrestox.8b00235
Reilly, SM, Bitzer, ZT, Goel, R, Trushin, N & Richie, J 2019, 'Free Radical, Carbonyl, and Nicotine Levels Produced by Juul Electronic Cigarettes', Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, vol. 21, no. 9, pp. 1274-1278. https://doi.org/10.1093/ntr/nty221
Beelman, RB, Kalaras, MD & Richie, J 2019, 'Micronutrients and Bioactive Compounds in Mushrooms: A Recipe for Healthy Aging?', Nutrition Today, vol. 54, no. 1, pp. 16-22. https://doi.org/10.1097/NT.0000000000000315
Yingst, JM, Foulds, J, Veldheer, S, Hrabovsky, S, Trushin, N, Eissenberg, TT, Williams, J, Richie, J, Nichols, TT, Wilson, S & Hobkirk, A 2019, 'Nicotine absorption during electronic cigarette use among regular users', PloS one, vol. 14, no. 7, e0220300. https://doi.org/10.1371/journal.pone.0220300

2018

Goel, R, Trushin, N, Reilly, SM, Bitzer, Z, Muscat, J, Foulds, J & Richie, J 2018, 'A survey of nicotine yields in small cigar smoke: Influence of cigar design and smoking regimens', Nicotine and Tobacco Research, vol. 20, no. 10, pp. 1250-1257. https://doi.org/10.1093/ntr/ntx220
Veldheer, S, Midya, V, Lester, C, Liao, JJ, Yingst, JM, Hrabovsky, S, Allen, SI, Krebs, NM, Reinhart, L, Evins, AE, Horn, K, Richie, J, Muscat, J & Foulds, J 2018, 'Acceptability of Switching from Usual Brand to SPECTRUM Research Cigarettes with Normal Nicotine Content' Tobacco Regulatory Science, vol. 4, no. 1, pp. 573-585.
Kazi, A, Fazzi, A, Krebs, NM, Merchlinski, AJ, Kline, B, Veldheer, S, Richie, J, Foulds, J, Lane, T, Donny, EC & Muscat, J 2018, 'Cigarette Management System: An operating procedures guide to obtaining and managing investigational tobacco products for regulatory science research', Contemporary Clinical Trials Communications, vol. 11, pp. 69-74. https://doi.org/10.1016/j.conctc.2018.05.006
Wasserman, EJ, Reilly, SM, Goel, R, Foulds, J, Richie, J & Muscat, J 2018, 'Comparison of biomarkers of tobacco exposure between premium and discount brand cigarette smokers in the NHANES 2011-2012 special sample', Cancer Epidemiology Biomarkers and Prevention, vol. 27, no. 5, pp. 601-609. https://doi.org/10.1158/1055-9965.EPI-17-0869
Joseph, S, Krebs, NM, Zhu, J, Wert, Y, Goel, R, Reilly, SM, Sun, D, Richie, J, Nikiforov, I, Cheriyath, P & Muscat, J 2018, 'Differences in nicotine dependence, smoke exposure and consumer characteristics between smokers of machine-injected roll-your-own cigarettes and factory-made cigarettes', Drug and Alcohol Dependence, vol. 187, pp. 109-115. https://doi.org/10.1016/j.drugalcdep.2018.01.039
Dong, Z, Sinha, R & Richie, J 2018, 'Disease prevention and delayed aging by dietary sulfur amino acid restriction: Translational implications', Annals of the New York Academy of Sciences, vol. 1418, no. 1, pp. 44-55. https://doi.org/10.1111/nyas.13584
Stennett, A, Krebs, NM, Liao, JJ, Richie, J & Muscat, J 2018, 'Ecological momentary assessment of smoking behaviors in native and converted intermittent smokers', American Journal on Addictions, vol. 27, no. 2, pp. 131-138. https://doi.org/10.1111/ajad.12690
Goel, R, Bitzer, ZT, Reilly, SM, Bhangu, G, Trushin, N, Elias, R, Foulds, J, Muscat, J & Richie, J 2018, 'Effect of Charcoal in Cigarette Filters on Free Radicals in Mainstream Smoke', Chemical Research in Toxicology, vol. 31, no. 8, pp. 745-751. https://doi.org/10.1021/acs.chemrestox.8b00092
Bitzer, ZT, Goel, R, Reilly, SM, Elias, R, Silakov, A, Foulds, J, Muscat, J & Richie, J 2018, 'Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols', Free Radical Biology and Medicine, vol. 120, pp. 72-79. https://doi.org/10.1016/j.freeradbiomed.2018.03.020
Reilly, SM, Goel, R, Trushin, N, Bitzer, ZT, Elias, R, Muscat, J & Richie, J 2018, 'Effects of Charcoal on Carbonyl Delivery from Commercial, Research, and Make-Your-Own Cigarettes', Chemical Research in Toxicology, vol. 31, no. 12, pp. 1339-1347. https://doi.org/10.1021/acs.chemrestox.8b00211
Bitzer, ZT, Goel, R, Reilly, SM, Foulds, J, Muscat, J, Elias, R & Richie, J 2018, 'Effects of Solvent and Temperature on Free Radical Formation in Electronic Cigarette Aerosols', Chemical Research in Toxicology, vol. 31, no. 1, pp. 4-12. https://doi.org/10.1021/acs.chemrestox.7b00116
Foulds, J, Hobkirk, A, Wasserman, E, Richie, J, Veldheer, S, Krebs, NM, Reinhart, L & Muscat, J 2018, 'Estimation of compliance with exclusive smoking of very low nicotine content cigarettes using plasma cotinine', Preventive Medicine, vol. 117, pp. 24-29. https://doi.org/10.1016/j.ypmed.2018.04.011
Goel, R, Bitzer, ZT, Reilly, SM, Foulds, J, Muscat, J, Elias, R & Richie, J 2018, 'Influence of Smoking Puff Parameters and Tobacco Varieties on Free Radicals Yields in Cigarette Mainstream Smoke' Chemical Research in Toxicology, vol. 31, no. 5, pp. 325-331. https://doi.org/10.1021/acs.chemrestox.8b00011
Reilly, SM, Goel, R, Bitzer, Z, Elias, R, Foulds, J, Muscat, J & Richie, J 2018, 'Little cigars, filtered cigars, and their carbonyl delivery relative to cigarettes', Nicotine and Tobacco Research, vol. 20, pp. S969-S106. https://doi.org/10.1093/ntr/ntx274
Sinha, R, Sinha, I, Calcagnotto, A, Trushin, N, Haley, JS, Schell, T & Richie, J 2018, 'Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function', European Journal of Clinical Nutrition, vol. 72, no. 1, pp. 105-111. https://doi.org/10.1038/ejcn.2017.132

2017

Allen, SI, Foulds, J, Pachas, GN, Veldheer, S, Cather, C, Azzouz, N, Hrabovsky, S, Hameed, A, Yingst, J, Hammett, E, Modesto, J, Krebs, NM, Zhu, J, Liao, JJ, Muscat, J, Richie, J & Evins, AE 2017, 'A two-site, two-arm, 34-week, double-blind, parallel-group, randomized controlled trial of reduced nicotine cigarettes in smokers with mood and/or anxiety disorders: trial design and protocol', BMC Public Health, vol. 17, no. 1, pp. 1-13. https://doi.org/10.1186/s12889-016-3946-4
Reilly, SM, Goel, R, Trushin, N, Elias, R, Foulds, J, Muscat, J, Liao, JJ & Richie, J 2017, 'Brand variation in oxidant production in mainstream cigarette smoke: Carbonyls and free radicals', Food and Chemical Toxicology, vol. 106, pp. 147-154. https://doi.org/10.1016/j.fct.2017.05.035
Hobkirk, A, Nichols, TT, Foulds, J, Yingst, JM, Veldheer, S, Hrabovsky, S, Richie, J, Eissenberg, T & Wilson, S 2018, 'Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic cigarette use', Brain Research Bulletin, vol. 138, pp. 56-63. https://doi.org/10.1016/j.brainresbull.2017.05.010
Krebs, NM, Allen, SI, Veldheer, S, Martinez, DJ, Horn, K, Livelsberger, C, Modesto, J, Kuprewicz, R, Wilhelm, A, Hrabovsky, S, Kazi, A, Fazzi, A, Liao, JJ, Zhu, J, Wasserman, E, Reilly, SM, Reinhart, L, Trushin, N, Moyer, RE, Bascom, R, Foulds, J, Richie, J & Muscat, J 2017, 'Correction: Reduced nicotine content cigarettes in smokers of low socioeconomic status: Study protocol for a randomized control trial. [Trials. 18, (2017) (300)] DOI: 10.1186/s13063-017-2038-9' Trials, vol. 18, no. 1, 598. https://doi.org/10.1186/s13063-017-2356-y
Reilly, SM, Goel, R, Bitzer, Z, Elias, R, Foulds, J, Muscat, J & Richie, J 2017, 'Effects of Topography-Related Puff Parameters on Carbonyl Delivery in Mainstream Cigarette Smoke', Chemical Research in Toxicology, vol. 30, no. 7, pp. 1463-1469. https://doi.org/10.1021/acs.chemrestox.7b00104
Chen, K-M, Schell, T, Richie, J, Sun, Y-W, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Kalaras, MD, Richie, J, Calcagnotto, A & Beelman, RB 2017, 'Mushrooms: A rich source of the antioxidants ergothioneine and glutathione', Food Chemistry, vol. 233, pp. 429-433. https://doi.org/10.1016/j.foodchem.2017.04.109
Krebs, NM, Allen, SI, Veldheer, S, Martinez, DJ, Horn, K, Livelsberger, C, Modesto, J, Kuprewicz, R, Wilhelm, A, Hrabovsky, S, Kazi, A, Fazzi, A, Liao, JJ, Zhu, J, Wasserman, E, Reilly, SM, Reinhart, L, Trushin, N, Moyer, RE, Bascom, R, Foulds, J, Richie, J & Muscat, J 2017, 'Reduced nicotine content cigarettes in smokers of low socioeconomic status: Study protocol for a randomized control trial', Trials, vol. 18, no. 1, 300. https://doi.org/10.1186/s13063-017-2038-9
McDonald, A, Bunker, CH, Raman, J, Richie, J & Patrick, AL 2017, 'Serum carotenoid and retinol levels in African-Caribbean Tobagonian men with high prostate cancer risk in comparison with African-American men', British Journal of Nutrition, vol. 117, no. 8, pp. 1128-1136. https://doi.org/10.1017/S0007114517000873
Mattocks, DAL, Mentch, SJ, Shneyder, J, Ables, GP, Sun, D, Richie, J, Locasale, JW & Nichenametla, SN 2017, 'Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice', Experimental Gerontology, vol. 88, pp. 1-8. https://doi.org/10.1016/j.exger.2016.12.003
Manni, A, Richie, J, Schetter, S, Calcagnotto, A, Trushin, N, Aliaga, C & El-Bayoumy, K 2017, 'Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women', European Journal of Clinical Nutrition, vol. 71, no. 6, pp. 762-765. https://doi.org/10.1038/ejcn.2016.273
Goel, R, Bitzer, Z, Reilly, SM, Trushin, N, Foulds, J, Muscat, J, Liao, JJ, Elias, R & Richie, J 2017, 'Variation in Free Radical Yields from U.S. Marketed Cigarettes', Chemical Research in Toxicology, vol. 30, no. 4, pp. 1038-1045. https://doi.org/10.1021/acs.chemrestox.6b00359

2016

Nichols, TT, Foulds, J, Yingst, JM, Veldheer, S, Hrabovsky, S, Richie, J, Eissenberg, T & Wilson, S 2016, 'Cue-reactivity in experienced electronic cigarette users: Novel stimulus videos and a pilot fMRI study', Brain Research Bulletin, vol. 123, pp. 23-32. https://doi.org/10.1016/j.brainresbull.2015.10.003
Mons, U, Muscat, J, Modesto, J, Richie, J & Brenner, H 2016, 'Effect of smoking reduction and cessation on the plasma levels of the oxidative stress biomarker glutathione - Post-hoc analysis of data from a smoking cessation trial', Free Radical Biology and Medicine, vol. 91, pp. 172-177. https://doi.org/10.1016/j.freeradbiomed.2015.12.018
Sandhu, N, Schetter, SE, Liao, J, Hartman, TJ, Richie, JP, McGinley, J, Thompson, HJ, Prokopczyk, B, DuBrock, C, Signori, C, Hamilton, C, Calcagnotto, A, Trushin, N, Aliaga, C, Demers, LM, El-Bayoumy, K & Manni, A 2016, 'Influence of obesity on breast density reduction by omega-3 fatty acids: Evidence from a randomized clinical trial', Cancer Prevention Research, vol. 9, no. 4, pp. 275-282. https://doi.org/10.1158/1940-6207.CAPR-15-0235

2015

Jones, NR, Ashmore, JH, Lee, S, Richie, J, Lazarus, P & Muscat, J 2015, 'Association studies of HFE C282Y and H63D variants with oral cancer risk and iron homeostasis among whites and blacks', Cancers, vol. 7, no. 4, pp. 2386-2396. https://doi.org/10.3390/cancers7040898
El-Bayoumy, K, Sinha, R & Richie, J 2015, Forms of selenium in cancer prevention. in Diversity of Selenium Functions in Health and Disease. CRC Press, pp. 137-172. https://doi.org/10.1201/b18810
Wilson, R, Bortner, JD, Roff, A, Das, A, Battaglioli, EJ, Richie, J, Barnholtz-Sloan, J, Chinchilli, V, Berg, A, Liu, G, Salzberg, AC & El-Bayoumy, K 2015, 'Genetic and environmental influences on plasma vitamin D binding protein concentrations', Translational Research, vol. 165, no. 6, pp. 667-676. https://doi.org/10.1016/j.trsl.2014.08.003
Goel, R, Durand, E, Trushin, N, Prokopczyk, B, Foulds, J, Elias, R & Richie, J 2015, 'Highly Reactive Free Radicals in Electronic Cigarette Aerosols', Chemical Research in Toxicology, vol. 28, no. 9, pp. 1675-1677. https://doi.org/10.1021/acs.chemrestox.5b00220
Richie, J, Nichenametla, S, Neidig, W, Calcagnotto, A, Haley, JS, Schell, T & Muscat, J 2015, 'Randomized controlled trial of oral glutathione supplementation on body stores of glutathione', European Journal of Nutrition, vol. 54, no. 2, pp. 251-263. https://doi.org/10.1007/s00394-014-0706-z
Richie, J & Muscat, J 2015, 'Response to Letter to the Editor from Dr. Guilford' European Journal of Nutrition, vol. 54, no. 5. https://doi.org/10.1007/s00394-015-0873-6
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