Researcher Profile

Researcher Profile

Jeffrey Maurice Peters, PhD

Jeffrey Maurice Peters, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
jmp21@psu.edu

Research Interests

Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.

  • Peroxisome Proliferator-Activated Receptors
  • Liver
  • Ligands
  • Carcinogenesis
  • Peroxisome Proliferators
  • Gene Expression
  • Cytoplasmic and Nuclear Receptors
  • PPAR alpha
  • Aryl Hydrocarbon Receptors
  • GW0742

Recent Publications

2022

States, JC & Peters, JM 2022, '2020-2021 Toxicological Sciences Paper of the Year', Toxicological sciences : an official journal of the Society of Toxicology, vol. 186, no. 2, pp. 177-178. https://doi.org/10.1093/toxsci/kfac020
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056. https://doi.org/10.1016/j.tox.2021.153056

2021

Collins, SL, Koo, I, Peters, JM, Smith, PB & Patterson, AD 2021, 'Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics', Annual Review of Analytical Chemistry, vol. 14, pp. 467-487. https://doi.org/10.1146/annurev-anchem-091620-015205
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice', Toxicological Sciences, vol. 183, no. 1, pp. 70-80. https://doi.org/10.1093/toxsci/kfab067
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice', Toxicological Sciences, vol. 183, no. 1, pp. 81-92. https://doi.org/10.1093/toxsci/kfab068
Koga, T & Peters, JM 2021, 'Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease', Biological and Pharmaceutical Bulletin, vol. 44, no. 11, pp. 1598-1606. https://doi.org/10.1248/bpb.b21-00486

2020

Peters, JM 2020, 'Change is Good: What is New for ToxSci?', Toxicological Sciences, vol. 173, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfz230
Peters, JM 2020, 'Moving forward with ToxSci', Toxicological Sciences, vol. 173, no. 2, pp. 227-228. https://doi.org/10.1093/toxsci/kfz245
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365. https://doi.org/10.1016/j.tox.2020.152365

2019

Peters, JM 2019, 'Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci', Toxicological Sciences, vol. 170, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfz117
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1. https://doi.org/10.1186/s40246-019-0211-9
Peters, JM, Kim, DJ, Bility, MT, Borland, MG, Zhu, B & Gonzalez, FJ 2019, 'Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer', Molecular Carcinogenesis, vol. 58, no. 9, pp. 1612-1622. https://doi.org/10.1002/mc.23033
Peters, JM, Walter, V, Patterson, AD & Gonzalez, FJ 2019, 'Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis', npj Precision Oncology, vol. 3, no. 1, 26. https://doi.org/10.1038/s41698-019-0098-x

2018

Borland, MG, Kehres, EM, Lee, C, Wagner, AL, Shannon, BE, Albrecht, PP, Zhu, B, Gonzalez, FJ & Peters, JM 2018, 'Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells', Toxicology, vol. 404-405, pp. 25-32. https://doi.org/10.1016/j.tox.2018.05.003
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589. https://doi.org/10.1016/j.bbrc.2018.02.097
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Peters, JM & Gonzalez, FJ 2018, 'The Evolution of Carcinogenesis', Toxicological Sciences, vol. 165, no. 2, pp. 272-276. https://doi.org/10.1093/toxsci/kfy184

Clinical Trials Search


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Adults (age >= 18 years)