Researcher Profile

Researcher Profile

Jeffrey Maurice Peters, PhD

Jeffrey Maurice Peters, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
jmp21@psu.edu

Research Interests

Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.

  • Peroxisome Proliferator-Activated Receptors
  • Liver
  • Ligands
  • Carcinogenesis
  • Neoplasms
  • Peroxisome Proliferators
  • Genes
  • Gene Expression
  • Cell Proliferation
  • PPAR alpha
  • Cytoplasmic and Nuclear Receptors
  • Keratinocytes

Recent Publications

2019

Peters, JM 2019, 'Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci', Toxicological Sciences, vol. 170, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfz117
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1. https://doi.org/10.1186/s40246-019-0211-9
Peters, JM, Kim, DJ, Bility, MT, Borland, MG, Zhu, B & Gonzalez, FJ 2019, 'Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer', Molecular Carcinogenesis, vol. 58, no. 9, pp. 1612-1622. https://doi.org/10.1002/mc.23033

2018

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Peters, JM & Gonzalez, FJ 2018, 'The Evolution of Carcinogenesis' Toxicological Sciences, vol. 165, no. 2, pp. 272-276. https://doi.org/10.1093/toxsci/kfy184

2017

Peters, JM 2017, 'Flipping a citrate switch on liver cancer cells' Journal of Biological Chemistry, vol. 292, no. 33, pp. 13902-13903. https://doi.org/10.1074/jbc.H117.783860
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2016

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Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical Research in Toxicology, vol. 29, no. 12, pp. 1987-1997. https://doi.org/10.1021/acs.chemrestox.6b00236
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2015

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Yao, PL, Chen, LP, Dobrzanski, TP, Phillips, DA, Zhu, B, Kang, BH, Gonzalez, FJ & Peters, JM 2015, 'Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms', Oncotarget, vol. 6, no. 34, pp. 36319-36337. https://doi.org/10.18632/oncotarget.5415
Park, J, Lee, SE, Hur, J, Hong, EB, Choi, JI, Yang, JM, Kim, JY, Kim, YC, Cho, HJ, Peters, JM, Ryoo, SB, Kim, YT & Kim, HS 2015, 'M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression', Cell Reports, vol. 10, no. 9, pp. 1614-1625. https://doi.org/10.1016/j.celrep.2015.02.024
Yao, PL, Chen, LP, Hess, RA, Müller, R, Gonzalez, FJ & Peters, JM 2015, 'Peroxisome proliferator-activated receptor-D (PPARD) coordinates mouse spermatogenesis by modulating extracellular signal-regulated kinase (ERK)-dependent signaling', Journal of Biological Chemistry, vol. 290, no. 38, pp. 23416-23431. https://doi.org/10.1074/jbc.M115.664508
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