Researcher Profile

Researcher Profile

Jeffrey Maurice Peters, PhD

Jeffrey Maurice Peters, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.

  • Peroxisome Proliferator-Activated Receptors
  • Liver
  • Ligands
  • Carcinogenesis
  • Peroxisome Proliferators
  • Gene Expression
  • Cytoplasmic and Nuclear Receptors
  • Keratinocytes
  • PPAR alpha
  • Aryl Hydrocarbon Receptors
  • GW0742

Recent Publications


Peters, JM 2020, 'Change is Good: What is New for ToxSci?', Toxicological Sciences, vol. 173, no. 1, pp. 1-2.
Peters, JM 2020, 'Moving forward with ToxSci', Toxicological Sciences, vol. 173, no. 2, pp. 227-228.
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365.


Peters, JM 2019, 'Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci', Toxicological Sciences, vol. 170, no. 1, pp. 1-2.
Nichols, RG, Peters, JM & Patterson, AD 2019, 'Interplay Between the Host, the Human Microbiome, and Drug Metabolism', Human genomics, vol. 13, no. 1.
Peters, JM, Kim, DJ, Bility, MT, Borland, MG, Zhu, B & Gonzalez, FJ 2019, 'Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer', Molecular Carcinogenesis, vol. 58, no. 9, pp. 1612-1622.


Borland, MG, Kehres, EM, Lee, C, Wagner, AL, Shannon, BE, Albrecht, PP, Zhu, B, Gonzalez, FJ & Peters, JM 2018, 'Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells', Toxicology, vol. 404-405, pp. 25-32.
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589.
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283.
Peters, JM & Gonzalez, FJ 2018, 'The Evolution of Carcinogenesis', Toxicological Sciences, vol. 165, no. 2, pp. 272-276.


Peters, JM 2017, 'Flipping a citrate switch on liver cancer cells', Journal of Biological Chemistry, vol. 292, no. 33, pp. 13902-13903.
Bagley, BD, Chang, SC, Ehresman, DJ, Eveland, A, Parker, GA, Peters, JM & Butenhoff, JL 2017, 'Four-week dietary supplementation with 10- and/or 15-fold basal choline caused decreased body weight in Sprague Dawley rats', Toxicology and Industrial Health, vol. 33, no. 10, pp. 792-801.
Allen, JN, Dey, A, Nissly, R, Fraser, J, Yu, S, Balandaram, G, Peters, JM & Hankey-Giblin, PA 2017, 'Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation', Journal of Visualized Experiments, vol. 2017, no. 122, e55445.
Borland, MG, Yao, PL, Kehres, EM, Lee, C, Pritzlaff, AM, Ola, E, Wagner, AL, Shannon, BE, Albrecht, PP, Zhu, B, Kang, BH, Robertson, GP, Gonzalez, FJ & Peters, JM 2017, 'PPARβ/δ and PPARγ inhibit melanoma tumorigenicity by modulating inflammation and apoptosis', Toxicological Sciences, vol. 159, no. 2, pp. 436-448.
Bagley, BD, Chang, SC, Ehresman, DJ, Eveland, A, Zitzow, JD, Parker, GA, Peters, JM, Wallace, KB & Butenhoff, JL 2017, 'Perfluorooctane sulfonate-induced hepatic steatosis in male sprague dawley rats is not attenuated by dietary choline supplementation', Toxicological Sciences, vol. 160, no. 2, pp. 284-298.
Yao, PL, Chen, L, Dobrzański, TP, Zhu, B, Kang, BH, Müller, R, Gonzalez, FJ & Peters, JM 2017, 'Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation', Molecular Carcinogenesis, vol. 56, no. 5, pp. 1472-1483.
Corton, JC, Peters, JM & Klaunig, JE 2018, 'The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions', Archives of Toxicology, vol. 92, no. 1, pp. 83-119.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)