Jeffrey Maurice Peters, PhD - Penn State Cancer Institute
Researcher Profile
Jeffrey Maurice Peters, PhD
Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.
- Peroxisome Proliferator-Activated Receptors
- Liver
- Ligands
- Carcinogenesis
- Peroxisome Proliferators
- Gene Expression
- Cytoplasmic and Nuclear Receptors
- PPAR alpha
- Aryl Hydrocarbon Receptors
- GW0742
Recent Publications
2024
Will, Y & Peters, JM 2024, '2022-2023 Toxicological Sciences: Paper of the Year', Toxicological Sciences, vol. 198, no. 1, pp. 2-3. https://doi.org/10.1093/toxsci/kfad126
Zhu, B, Zhu, X, Borland, MG, Ralph, DH, Chiaro, CR, Krausz, KW, Ntambi, JM, Glick, AB, Patterson, AD, Perdew, GH, Gonzalez, FJ & Peters, JM 2024, 'Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids', Biomolecules, vol. 14, no. 6, 606. https://doi.org/10.3390/biom14060606
2023
Guo, L & Peters, JM 2023, '2021-2022 Toxicological Sciences paper of the year', Toxicological Sciences, vol. 192, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfad010
Zhu, X, Liu, Q, Patterson, AD, Sharma, AK, Amin, SG, Cohen, SM, Gonzalez, FJ & Peters, JM 2023, 'Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice', Metabolites, vol. 13, no. 8, 936. https://doi.org/10.3390/metabo13080936
2022
States, JC & Peters, JM 2022, '2020-2021 Toxicological Sciences Paper of the Year', Toxicological sciences : an official journal of the Society of Toxicology, vol. 186, no. 2, pp. 177-178. https://doi.org/10.1093/toxsci/kfac020
Hirao-Suzuki, M, Takayuki, K, Takiguchi, M, Peters, JM & Takeda, S 2022, 'Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells', Archives of Biochemistry and Biophysics, vol. 731, 109428. https://doi.org/10.1016/j.abb.2022.109428
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056. https://doi.org/10.1016/j.tox.2021.153056
2021
Collins, SL, Koo, I, Peters, JM, Smith, PB & Patterson, AD 2021, 'Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics', Annual Review of Analytical Chemistry, vol. 14, pp. 467-487. https://doi.org/10.1146/annurev-anchem-091620-015205
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice', Toxicological Sciences, vol. 183, no. 1, pp. 70-80. https://doi.org/10.1093/toxsci/kfab067
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice', Toxicological Sciences, vol. 183, no. 1, pp. 81-92. https://doi.org/10.1093/toxsci/kfab068
Koga, T & Peters, JM 2021, 'Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease', Biological and Pharmaceutical Bulletin, vol. 44, no. 11, pp. 1598-1606. https://doi.org/10.1248/bpb.b21-00486
2020
Peters, JM 2020, 'Change is Good: What is New for ToxSci?', Toxicological Sciences, vol. 173, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfz230
Peters, JM 2020, 'Moving forward with ToxSci', Toxicological Sciences, vol. 173, no. 2, pp. 227-228. https://doi.org/10.1093/toxsci/kfz245
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365. https://doi.org/10.1016/j.tox.2020.152365