Researcher Profile

Researcher Profile

Jeffrey Maurice Peters, PhD

Jeffrey Maurice Peters, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis
jmp21@psu.edu

Research Interests

Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.

  • Peroxisome Proliferator-Activated Receptors
  • Liver
  • Ligands
  • Carcinogenesis
  • Neoplasms
  • Peroxisome Proliferators
  • Genes
  • Gene Expression
  • Cell Proliferation
  • PPAR alpha
  • Cytoplasmic and Nuclear Receptors
  • Keratinocytes

Recent Publications

2019

Peters, JM 2019, 'Continuing a Legacy: Adapting to Ensure the Bright Future of ToxSci', Toxicological Sciences, vol. 170, no. 1, pp. 1-2. https://doi.org/10.1093/toxsci/kfz117
Peters, JM, Kim, DJ, Bility, MT, Borland, MG, Zhu, B & Gonzalez, FJ 2019, 'Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer' Molecular Carcinogenesis. https://doi.org/10.1002/mc.23033

2018

Borland, MG, Kehres, EM, Lee, C, Wagner, AL, Shannon, BE, Albrecht, PP, Zhu, B, Gonzalez, FJ & Peters, JM 2018, 'Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells', Toxicology, vol. 404-405, pp. 25-32. https://doi.org/10.1016/j.tox.2018.05.003
Maan, M, Peters, JM, Dutta, M & Patterson, AD 2018, 'Lipid metabolism and lipophagy in cancer', Biochemical and Biophysical Research Communications, vol. 504, no. 3, pp. 582-589. https://doi.org/10.1016/j.bbrc.2018.02.097
Patterson, AD, Gonzalez, FJ, Perdew, GH & Peters, JM 2018, 'Molecular Regulation of Carcinogenesis: Friend and Foe', Toxicological Sciences, vol. 165, no. 2, pp. 277-283. https://doi.org/10.1093/toxsci/kfy185
Peters, JM & Gonzalez, FJ 2018, 'The Evolution of Carcinogenesis' Toxicological Sciences, vol. 165, no. 2, pp. 272-276. https://doi.org/10.1093/toxsci/kfy184

2017

Peters, JM 2017, 'Flipping a citrate switch on liver cancer cells' Journal of Biological Chemistry, vol. 292, no. 33, pp. 13902-13903. https://doi.org/10.1074/jbc.H117.783860
Bagley, BD, Chang, SC, Ehresman, DJ, Eveland, A, Parker, GA, Peters, JM & Butenhoff, JL 2017, 'Four-week dietary supplementation with 10- and/or 15-fold basal choline caused decreased body weight in Sprague Dawley rats', Toxicology and Industrial Health, vol. 33, no. 10, pp. 792-801. https://doi.org/10.1177/0748233717711361
Allen, JN, Dey, A, Nissly, R, Fraser, J, Yu, S, Balandaram, G, Peters, JM & Giblin, PH 2017, 'Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation', Journal of Visualized Experiments, vol. 2017, no. 122, e55445. https://doi.org/10.3791/55445
Borland, MG, Yao, PL, Kehres, EM, Lee, C, Pritzlaff, AM, Ola, E, Wagner, AL, Shannon, BE, Albrecht, PP, Zhu, B, Kang, BH, Robertson, G, Gonzalez, FJ & Peters, JM 2017, 'PPARβ/δ and PPARγ inhibit melanoma tumorigenicity by modulating inflammation and apoptosis', Toxicological Sciences, vol. 159, no. 2, pp. 436-448. https://doi.org/10.1093/toxsci/kfx147
Bagley, BD, Chang, SC, Ehresman, DJ, Eveland, A, Zitzow, JD, Parker, GA, Peters, JM, Wallace, KB & Butenhoff, JL 2017, 'Perfluorooctane sulfonate-induced hepatic steatosis in male sprague dawley rats is not attenuated by dietary choline supplementation', Toxicological Sciences, vol. 160, no. 2, pp. 284-298. https://doi.org/10.1093/toxsci/kfx185
Yao, PL, Chen, L, Dobrzański, TP, Zhu, B, Kang, BH, Müller, R, Gonzalez, FJ & Peters, JM 2017, 'Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation', Molecular Carcinogenesis, vol. 56, no. 5, pp. 1472-1483. https://doi.org/10.1002/mc.22607
Corton, JC, Peters, JM & Klaunig, JE 2018, 'The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions', Archives of Toxicology, vol. 92, no. 1, pp. 83-119. https://doi.org/10.1007/s00204-017-2094-7

2016

Balandaram, G, Kramer, LR, Kang, BH, Murray, IA, Perdew, GH, Gonzalez, FJ & Peters, JM 2016, 'Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice', Toxicology, vol. 363-364, pp. 1-9. https://doi.org/10.1016/j.tox.2016.07.010
Nichols, RG, Hume, NE, Smith, PB, Peters, JM & Patterson, AD 2016, 'Omics Approaches to Probe Microbiota and Drug Metabolism Interactions', Chemical Research in Toxicology, vol. 29, no. 12, pp. 1987-1997. https://doi.org/10.1021/acs.chemrestox.6b00236
Choudhary, M, Ding, JD, Qi, X, Boulton, ME, Yao, PL, Peters, JM & Malek, G 2016, 'PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration', Aging, vol. 8, no. 9, pp. 1952-1978. https://doi.org/10.18632/aging.101031
Zhang, L, Krishnan, P, Ehresman, DJ, Smith, PB, Dutta, M, Bagley, BD, Chang, SC, Butenhoff, JL, Patterson, AD & Peters, JM 2016, 'Perfluorooctane sulfonate-choline ion pair formation: A potential mechanism modulating hepatic steatosis and oxidative stress in mice', Toxicological Sciences, vol. 153, no. 1, kfw120, pp. 186-197. https://doi.org/10.1093/toxsci/kfw120
Yao, PL, Morales, JL, Gonzalez, FJ & Peters, JM 2017, 'Peroxisome proliferator-activated receptor-β/δ modulates mast cell phenotype', Immunology, vol. 150, no. 4, pp. 456-467. https://doi.org/10.1111/imm.12699
Koga, T, Yao, PL, Goudarzi, M, Murray, IA, Balandaram, G, Gonzalez, FJ, Perdew, GH, Fornace, AJ & Peters, JM 2016, 'Regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ modulation of SP1 promoter occupancy', Journal of Biological Chemistry, vol. 291, no. 48, pp. 25255-25263. https://doi.org/10.1074/jbc.M116.755447
Yu, S, Allen, JN, Dey, A, Zhang, L, Balandaram, G, Kennett, MJ, Xia, M, Xiong, N, Peters, JM, Patterson, AD & Giblin, PH 2016, 'The ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis, and hepatosteatosis', Journal of Immunology, vol. 197, no. 1, pp. 256-265. https://doi.org/10.4049/jimmunol.1600450

2015

Peters, JM, Gonzalez, FJ & Müller, R 2015, 'Establishing the Role of PPARβ/δ in Carcinogenesis', Trends in Endocrinology and Metabolism, vol. 26, no. 11, pp. 595-607. https://doi.org/10.1016/j.tem.2015.09.004
Yao, PL, Chen, LP, Dobrzanski, TP, Phillips, DA, Zhu, B, Kang, BH, Gonzalez, FJ & Peters, JM 2015, 'Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms', Oncotarget, vol. 6, no. 34, pp. 36319-36337. https://doi.org/10.18632/oncotarget.5415
Park, J, Lee, SE, Hur, J, Hong, EB, Choi, JI, Yang, JM, Kim, JY, Kim, YC, Cho, HJ, Peters, JM, Ryoo, SB, Kim, YT & Kim, HS 2015, 'M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression', Cell Reports, vol. 10, no. 9, pp. 1614-1625. https://doi.org/10.1016/j.celrep.2015.02.024
Yao, PL, Chen, LP, Hess, RA, Müller, R, Gonzalez, FJ & Peters, JM 2015, 'Peroxisome proliferator-activated receptor-D (PPARD) coordinates mouse spermatogenesis by modulating extracellular signal-regulated kinase (ERK)-dependent signaling', Journal of Biological Chemistry, vol. 290, no. 38, pp. 23416-23431. https://doi.org/10.1074/jbc.M115.664508
Peters, JM, Yao, PL & Gonzalez, FJ 2015, 'Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention', Current Pharmacology Reports, vol. 1, no. 2, pp. 121-128. https://doi.org/10.1007/s40495-015-0026-x

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