Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Jeffrey Maurice Peters, PhD

Jeffrey Maurice Peters, PhD

Distinguished Professor, Veterinary and Biomedical Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Dr. Jeffrey Peters’ laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs). PPARs modulate gene expression through direct and indirect mechanisms. His laboratory group uses genetically modified mouse and human models, high affinity agonists, antagonists and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in cancers. Through their studies, they are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. They are particularly interested in delineating how natural compounds can modulate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy.

  • Peroxisome Proliferator-Activated Receptors
  • Liver
  • Ligands
  • Carcinogenesis
  • Peroxisome Proliferators
  • Gene Expression
  • Cytoplasmic and Nuclear Receptors
  • PPAR alpha
  • Aryl Hydrocarbon Receptors
  • GW0742

Recent Publications


Will, Y & Peters, JM 2024, '2022-2023 Toxicological Sciences: Paper of the Year', Toxicological Sciences, vol. 198, no. 1, pp. 2-3.


Guo, L & Peters, JM 2023, '2021-2022 Toxicological Sciences paper of the year', Toxicological Sciences, vol. 192, no. 1, pp. 1-2.
Zhu, X, Liu, Q, Patterson, AD, Sharma, AK, Amin, SG, Cohen, SM, Gonzalez, FJ & Peters, JM 2023, 'Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice', Metabolites, vol. 13, no. 8, 936.


States, JC & Peters, JM 2022, '2020-2021 Toxicological Sciences Paper of the Year', Toxicological sciences : an official journal of the Society of Toxicology, vol. 186, no. 2, pp. 177-178.
Hirao-Suzuki, M, Takayuki, K, Takiguchi, M, Peters, JM & Takeda, S 2022, 'Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells', Archives of Biochemistry and Biophysics, vol. 731, 109428.
Su, S, Billy, LJ, Chang, S, Gonzalez, FJ, Patterson, AD & Peters, JM 2022, 'The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice', Toxicology, vol. 465, 153056.


Collins, SL, Koo, I, Peters, JM, Smith, PB & Patterson, AD 2021, 'Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics', Annual Review of Analytical Chemistry, vol. 14, pp. 467-487.
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice', Toxicological Sciences, vol. 183, no. 1, pp. 70-80.
Foreman, JE, Koga, T, Kosyk, O, Kang, BH, Zhu, X, Cohen, SM, Billy, LJ, Sharma, AK, Amin, S, Gonzalez, FJ, Rusyn, I & Peters, JM 2021, 'Species Differences between Mouse and Human PPARα in Modulating the Hepatocarcinogenic Effects of Perinatal Exposure to a High-Affinity Human PPARα Agonist in Mice', Toxicological Sciences, vol. 183, no. 1, pp. 81-92.
Koga, T & Peters, JM 2021, 'Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease', Biological and Pharmaceutical Bulletin, vol. 44, no. 11, pp. 1598-1606.


Peters, JM 2020, 'Change is Good: What is New for ToxSci?', Toxicological Sciences, vol. 173, no. 1, pp. 1-2.
Peters, JM 2020, 'Moving forward with ToxSci', Toxicological Sciences, vol. 173, no. 2, pp. 227-228.
Zhang, L, Rimal, B, Nichols, RG, Tian, Y, Smith, PB, Hatzakis, E, Chang, SC, Butenhoff, JL, Peters, JM & Patterson, AD 2020, 'Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice', Toxicology, vol. 431, 152365.