Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

John Flanagan, PhD

John Flanagan, PhD

Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Proteins
  • Escherichia coli
  • Peptides
  • X-Rays
  • Adenosine Triphosphatases
  • Mutation
  • DNA
  • Adenosine Triphosphate
  • Amino Acids
  • Nucleic Acids
  • Transfer RNA
  • Dimerization

Recent Publications


Ye, Y, Liang, X, Wang, G, Bewley, MC, Hamamoto, K, Liu, X, Flanagan, JM, Wang, HG, Takahashi, Y & Tian, F 2024, 'Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure', Communications Biology, vol. 7, no. 1, 334.


Palsa, K, Connor, JR, Flanagan, J & Hines, EA 2023, 'H-ferritin in sows' colostrum- and milk-derived extracellular vesicles: a novel iron delivery concept', Journal of animal science, vol. 101, skad013.
Monette, A, Niu, M, Maldonado, RK, Chang, J, Lambert, GS, Flanagan, JM, Cochrane, A, Parent, LJ & Mouland, AJ 2023, 'Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates', Journal of Molecular Biology, vol. 435, no. 16, 168190.
Ye, Y, Tyndall, ER, Bui, V, Bewley, MC, Wang, G, Hong, X, Shen, Y, Flanagan, JM, Wang, HG & Tian, F 2023, 'Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy', Nature communications, vol. 14, no. 1, 5503.
Carkaci-Salli, N, Bewley, MC, Tekin, I, Flanagan, JM & Vrana, KE 2023, 'The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity', Biochemistry and Biophysics Reports, vol. 35, 101527.
Kaddis Maldonado, R, Lambert, GS, Rice, BL, Sudol, M, Flanagan, JM & Parent, LJ 2023, 'The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions', Journal of Molecular Biology, vol. 435, no. 16, 168182.
Ye, Y, Bewley, MC, Wang, HG, Tian, F & Flanagan, JM 2024, 'What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy', Autophagy, vol. 20, no. 3, pp. 709-711.


Ye, Y, Tyndall, ER, Bui, V, Tang, Z, Shen, Y, Jiang, X, Flanagan, JM, Wang, HG & Tian, F 2021, 'An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy', Nature communications, vol. 12, no. 1, 374.
Kumar, R, Christensen, ND, Kaddis Maldonado, RJ, Bewley, MC, Ostman, A, Sudol, M, Chen, EC, Buchkovich, NW, Gontu, A, Surendran Nair, M, Nissly, RH, Minns, AM, Kapur, V, Rossi, R, Kuchipudi, SV, Lindner, SE, Parent, LJ, Flanagan, JM & Buchkovich, NJ 2021, 'Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses', Viruses, vol. 13, no. 10, 1899.


Bewley, MC, Gautam, L, Jagadeeshaprasad, MG, Channe Gowda, D & Flanagan, JM 2020, 'Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding', Journal of Biological Chemistry, vol. 295, no. 52, pp. 18589-18603.