John Flanagan, PhD - Penn State Cancer Institute
Researcher Profile
John Flanagan, PhD
Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies
Research Interests
- Proteins
- Escherichia coli
- Peptides
- X-Rays
- Adenosine Triphosphatases
- Mutation
- DNA
- Adenosine Triphosphate
- Amino Acids
- Nucleic Acids
- Transfer RNA
- Dimerization
Recent Publications
2024
Ye, Y, Liang, X, Wang, G, Bewley, MC, Hamamoto, K, Liu, X, Flanagan, JM, Wang, HG, Takahashi, Y & Tian, F 2024, 'Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure', Communications Biology, vol. 7, no. 1, 334. https://doi.org/10.1038/s42003-024-06026-7
2023
Palsa, K, Connor, JR, Flanagan, J & Hines, EA 2023, 'H-ferritin in sows' colostrum- and milk-derived extracellular vesicles: a novel iron delivery concept', Journal of animal science, vol. 101, skad013. https://doi.org/10.1093/jas/skad013
Monette, A, Niu, M, Maldonado, RK, Chang, J, Lambert, GS, Flanagan, JM, Cochrane, A, Parent, LJ & Mouland, AJ 2023, 'Influence of HIV-1 Genomic RNA on the Formation of Gag Biomolecular Condensates', Journal of Molecular Biology, vol. 435, no. 16, 168190. https://doi.org/10.1016/j.jmb.2023.168190
Ye, Y, Tyndall, ER, Bui, V, Bewley, MC, Wang, G, Hong, X, Shen, Y, Flanagan, JM, Wang, HG & Tian, F 2023, 'Multifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy', Nature communications, vol. 14, no. 1, 5503. https://doi.org/10.1038/s41467-023-41243-4
Carkaci-Salli, N, Bewley, MC, Tekin, I, Flanagan, JM & Vrana, KE 2023, 'The A328 V/E (rs2887147) polymorphisms in human tryptophan hydroxylase 2 compromise enzyme activity', Biochemistry and Biophysics Reports, vol. 35, 101527. https://doi.org/10.1016/j.bbrep.2023.101527
Kaddis Maldonado, R, Lambert, GS, Rice, BL, Sudol, M, Flanagan, JM & Parent, LJ 2023, 'The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions', Journal of Molecular Biology, vol. 435, no. 16, 168182. https://doi.org/10.1016/j.jmb.2023.168182
Ye, Y, Bewley, MC, Wang, HG, Tian, F & Flanagan, JM 2024, 'What’s in an E3: role of highly curved membranes in facilitating LC3–phosphatidylethanolamine conjugation during autophagy', Autophagy, vol. 20, no. 3, pp. 709-711. https://doi.org/10.1080/15548627.2023.2288527
2021
Ye, Y, Tyndall, ER, Bui, V, Tang, Z, Shen, Y, Jiang, X, Flanagan, JM, Wang, HG & Tian, F 2021, 'An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy', Nature communications, vol. 12, no. 1, 374. https://doi.org/10.1038/s41467-020-20607-0
Kumar, R, Christensen, ND, Kaddis Maldonado, RJ, Bewley, MC, Ostman, A, Sudol, M, Chen, EC, Buchkovich, NW, Gontu, A, Surendran Nair, M, Nissly, RH, Minns, AM, Kapur, V, Rossi, R, Kuchipudi, SV, Lindner, SE, Parent, LJ, Flanagan, JM & Buchkovich, NJ 2021, 'Monoclonal antibodies to s and n sars-cov-2 proteins as probes to assess structural and antigenic properties of coronaviruses', Viruses, vol. 13, no. 10, 1899. https://doi.org/10.3390/v13101899
2020
Bewley, MC, Gautam, L, Jagadeeshaprasad, MG, Channe Gowda, D & Flanagan, JM 2020, 'Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding', Journal of Biological Chemistry, vol. 295, no. 52, pp. 18589-18603. https://doi.org/10.1074/jbc.RA120.014676